Click here to switch to the map view.

The map label for this gene is cadA [H]

Identifier: 23097731

GI number: 23097731

Start: 308304

End: 310439

Strand: Reverse

Name: cadA [H]

Synonym: OB0276

Alternate gene names: 23097731

Gene position: 310439-308304 (Counterclockwise)

Preceding gene: 23097732

Following gene: 23097730

Centisome position: 8.55

GC content: 37.69

Gene sequence:

>2136_bases
ATGTCTCATAGTCAAATTAATTCTAGTCCTAATGTAGAAACATATCGAATACAGGGGTTAAGTTGTACGAACTGTGCAGC
AAAATTTGAAAACAACGTAAGAAAATTACCCGGAGTAGAGAATGCCCAAGTAAATTTTGGAGCATCAAAGGTATATGTAG
AGGGAAACACAACCATACAAGATTTAGAAAAAGCAGGATCATTCGAAAATCTCAAAATCACAAACGATAGAGAACGTAAA
TCCGAGAAAACGATTTCCTTTTGGAAACAAAAGGATAATATCCGTCTCTATATTGCCGCGTTTATTATTGTTATCAGTCT
TATCGCTAGTTATTCCTTAAATGAACAAAGCATTATCCCCACTATAGGTTTCGGTGCAGCAATTCTGATTGGCGGATATT
CTCTATTTATGAAAGGACTAAAGAATTTAATCCAATTCCAGTTCGATATGAATACATTAATGACGATCGCCGTTATTGGT
GCAGCATTAATTGGAGAATGGTTAGAAGGTGCAGCTGTCGTCATTCTATTTGCGATAAGTGAAGCATTAGAGCGATTTTC
TATGGATAAAGCAAGACAATCCATTCAGTCCTTAATGGACATTGCACCAAACGAAGCGCTTATACGCAGAGATAATATAG
AGCAAACAATCGATGTCAACGATATACAGATAAACGATATTATGATTGTGAAACCAGGACAAAAGATAGCGATGGATGGC
ATTGTCATAAAAGGTTCTTCGTCTGTAAACCAATCAGCTATAACAGGTGAAAGCATTCCTGTTGCTCGTATGACAGATGA
TGAAGTCTTTGCAGGTACATTTAATGAAGATGGATTATTAGAGATACGTGTTACGAAAAAAGTGGAAGACACTACTATTT
CCAAGATTATTCATCTTGTTGAGGAGGCACAGGCAGAACGTGCTCCTTCACAAGCTTTCGTAGATAAATTTGCTAAGTAC
TATACTCCAGTAATCATGCTCATTGCTCTCATGGTGGCGATTGTTCCTTCTGCTATTACAGGAGATTGGAGTACATGGAT
ATATCAAGGCTTAGCTATATTAGTCGTCGGTTGCCCTTGTGCACTTGTCATCTCTACACCCGTTGCGATTGTTACTGCAA
TCGGTAATGCTGCTAAAAATGGTGTATTAATTAAAGGTGGCGTGTATTTAGAAGAAACTGGTTCATTACAATCAATTGCT
TTTGATAAAACAGGAACATTAACAGAAGGTGTGCCACATGTTACGGATATTGTTTCCTATCAAGGCGAGGAAGGTTCTAA
CTTATCACTCATCGCCGCAATTGAAAATGGATCCCAGCATCCACTAGCTGCTGCGATTATACGTAAAGCAAATGAGGATA
ATATTACCTTCAAAAATGTGGAGATGGAGAACTTCAAATCGATCACAGGAAAAGGTGTTCAAGCTACGATAGACAACAAA
GATTATTATGTTGGAAGCCCTGATTTCTTTAAAGAGTTACAAACCTCCATCGATCCGACTATCGTACAACAAATAGAAGA
TATGCAATTAGAAGGAAAAACAGTGATTATTCTAGGGACTCATCAAGACATTCTCTCGTTATATGCCATCGCAGACAAGG
TTAGAGCAGCATCAAAACATGTAGTGACTAAGCTAAATAAACTTGGAATGAGCACTGTCATGCTAACTGGTGACAACCAA
AACACTGCTTCAGCTATCGGAAAGCAAGTAGGAGTTACCAATGTTAAATCAAATCTATTGCCAGAAGATAAGTTGAAGTA
TATTAAAGAGTTAACAAACAACGATCAAAAAACAGCGATGGTAGGAGATGGAATTAACGATTCTCCAGCACTTGCAGCTT
CTACTGTAGGTATTGCCATGGGTGGTGCAGGTACCGATACCGCTTTAGAAACCGCTGATATTGTATTAATGTCAGATGAC
CTTAATAAATTGCCATATACAATGAACTTGAGTCGTAAAACGCTACGAATTATTAAAGAAAACATTATCTTTTCATTAGG
CATAAAACTAGCAGCCCTACTGCTCGTTATTCCAGGATGGTTAACGCTTTGGTTAGCGATTTTTGCAGATATTGGTGCTA
CATTAATCGTAACGCTTAACAGCTTACGATTACTTCGAGTAAAAGATGATGTATAA

Upstream 100 bases:

>100_bases
TACCGTAAAGAAGGAAAGCTCGCTTTCTACTCTCTAGATGATGATCATATTCGCCAACTTGTATCCATAGCACTAATCCA
TCATCAAGAGGTGGAAAATC

Downstream 100 bases:

>100_bases
ACTATAAAGGAGTCAATGTATGAAGGATTATACACAGCTAACTTCTATTGAAATGGTTAGAGAATTTACAAGAGACAACC
GATTATCATTCATATATATT

Product: cadmium-transporting ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MSHSQINSSPNVETYRIQGLSCTNCAAKFENNVRKLPGVENAQVNFGASKVYVEGNTTIQDLEKAGSFENLKITNDRERK
SEKTISFWKQKDNIRLYIAAFIIVISLIASYSLNEQSIIPTIGFGAAILIGGYSLFMKGLKNLIQFQFDMNTLMTIAVIG
AALIGEWLEGAAVVILFAISEALERFSMDKARQSIQSLMDIAPNEALIRRDNIEQTIDVNDIQINDIMIVKPGQKIAMDG
IVIKGSSSVNQSAITGESIPVARMTDDEVFAGTFNEDGLLEIRVTKKVEDTTISKIIHLVEEAQAERAPSQAFVDKFAKY
YTPVIMLIALMVAIVPSAITGDWSTWIYQGLAILVVGCPCALVISTPVAIVTAIGNAAKNGVLIKGGVYLEETGSLQSIA
FDKTGTLTEGVPHVTDIVSYQGEEGSNLSLIAAIENGSQHPLAAAIIRKANEDNITFKNVEMENFKSITGKGVQATIDNK
DYYVGSPDFFKELQTSIDPTIVQQIEDMQLEGKTVIILGTHQDILSLYAIADKVRAASKHVVTKLNKLGMSTVMLTGDNQ
NTASAIGKQVGVTNVKSNLLPEDKLKYIKELTNNDQKTAMVGDGINDSPALAASTVGIAMGGAGTDTALETADIVLMSDD
LNKLPYTMNLSRKTLRIIKENIIFSLGIKLAALLLVIPGWLTLWLAIFADIGATLIVTLNSLRLLRVKDDV

Sequences:

>Translated_711_residues
MSHSQINSSPNVETYRIQGLSCTNCAAKFENNVRKLPGVENAQVNFGASKVYVEGNTTIQDLEKAGSFENLKITNDRERK
SEKTISFWKQKDNIRLYIAAFIIVISLIASYSLNEQSIIPTIGFGAAILIGGYSLFMKGLKNLIQFQFDMNTLMTIAVIG
AALIGEWLEGAAVVILFAISEALERFSMDKARQSIQSLMDIAPNEALIRRDNIEQTIDVNDIQINDIMIVKPGQKIAMDG
IVIKGSSSVNQSAITGESIPVARMTDDEVFAGTFNEDGLLEIRVTKKVEDTTISKIIHLVEEAQAERAPSQAFVDKFAKY
YTPVIMLIALMVAIVPSAITGDWSTWIYQGLAILVVGCPCALVISTPVAIVTAIGNAAKNGVLIKGGVYLEETGSLQSIA
FDKTGTLTEGVPHVTDIVSYQGEEGSNLSLIAAIENGSQHPLAAAIIRKANEDNITFKNVEMENFKSITGKGVQATIDNK
DYYVGSPDFFKELQTSIDPTIVQQIEDMQLEGKTVIILGTHQDILSLYAIADKVRAASKHVVTKLNKLGMSTVMLTGDNQ
NTASAIGKQVGVTNVKSNLLPEDKLKYIKELTNNDQKTAMVGDGINDSPALAASTVGIAMGGAGTDTALETADIVLMSDD
LNKLPYTMNLSRKTLRIIKENIIFSLGIKLAALLLVIPGWLTLWLAIFADIGATLIVTLNSLRLLRVKDDV
>Mature_710_residues
SHSQINSSPNVETYRIQGLSCTNCAAKFENNVRKLPGVENAQVNFGASKVYVEGNTTIQDLEKAGSFENLKITNDRERKS
EKTISFWKQKDNIRLYIAAFIIVISLIASYSLNEQSIIPTIGFGAAILIGGYSLFMKGLKNLIQFQFDMNTLMTIAVIGA
ALIGEWLEGAAVVILFAISEALERFSMDKARQSIQSLMDIAPNEALIRRDNIEQTIDVNDIQINDIMIVKPGQKIAMDGI
VIKGSSSVNQSAITGESIPVARMTDDEVFAGTFNEDGLLEIRVTKKVEDTTISKIIHLVEEAQAERAPSQAFVDKFAKYY
TPVIMLIALMVAIVPSAITGDWSTWIYQGLAILVVGCPCALVISTPVAIVTAIGNAAKNGVLIKGGVYLEETGSLQSIAF
DKTGTLTEGVPHVTDIVSYQGEEGSNLSLIAAIENGSQHPLAAAIIRKANEDNITFKNVEMENFKSITGKGVQATIDNKD
YYVGSPDFFKELQTSIDPTIVQQIEDMQLEGKTVIILGTHQDILSLYAIADKVRAASKHVVTKLNKLGMSTVMLTGDNQN
TASAIGKQVGVTNVKSNLLPEDKLKYIKELTNNDQKTAMVGDGINDSPALAASTVGIAMGGAGTDTALETADIVLMSDDL
NKLPYTMNLSRKTLRIIKENIIFSLGIKLAALLLVIPGWLTLWLAIFADIGATLIVTLNSLRLLRVKDDV

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=773, Percent_Identity=27.9430789133247, Blast_Score=300, Evalue=5e-81,
Organism=Homo sapiens, GI55743073, Length=711, Percent_Identity=28.9732770745429, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI115529486, Length=557, Percent_Identity=26.9299820466786, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI118498343, Length=623, Percent_Identity=23.5955056179775, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI48762691, Length=180, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI48762689, Length=180, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI48762685, Length=205, Percent_Identity=32.1951219512195, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI48762687, Length=180, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI21361181, Length=257, Percent_Identity=24.124513618677, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI237681109, Length=257, Percent_Identity=24.124513618677, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI297374799, Length=327, Percent_Identity=24.1590214067278, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI237681111, Length=257, Percent_Identity=24.124513618677, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI83700225, Length=327, Percent_Identity=24.1590214067278, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI4502271, Length=250, Percent_Identity=23.6, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1789879, Length=718, Percent_Identity=38.0222841225627, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1786691, Length=745, Percent_Identity=30.738255033557, Blast_Score=311, Evalue=1e-85,
Organism=Escherichia coli, GI1786914, Length=535, Percent_Identity=28.2242990654206, Blast_Score=149, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17556548, Length=795, Percent_Identity=27.9245283018868, Blast_Score=262, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71997262, Length=599, Percent_Identity=21.5358931552588, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71997275, Length=599, Percent_Identity=21.5358931552588, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71997269, Length=593, Percent_Identity=21.4165261382799, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193203354, Length=190, Percent_Identity=27.8947368421053, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203356, Length=205, Percent_Identity=27.3170731707317, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559224, Length=251, Percent_Identity=23.9043824701195, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557486, Length=307, Percent_Identity=24.1042345276873, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320475, Length=545, Percent_Identity=32.8440366972477, Blast_Score=251, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6319772, Length=544, Percent_Identity=29.2279411764706, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6321430, Length=620, Percent_Identity=23.0645161290323, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6325221, Length=620, Percent_Identity=22.9032258064516, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321271, Length=204, Percent_Identity=29.9019607843137, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321432, Length=263, Percent_Identity=26.9961977186312, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221329854, Length=554, Percent_Identity=27.6173285198556, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24668704, Length=152, Percent_Identity=30.2631578947368, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366617, Length=152, Percent_Identity=30.2631578947368, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668708, Length=152, Percent_Identity=30.2631578947368, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668696, Length=152, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161085803, Length=152, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 77062; Mature: 76931

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSQINSSPNVETYRIQGLSCTNCAAKFENNVRKLPGVENAQVNFGASKVYVEGNTTIQ
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCHHHCCCCCCCEEECCCEEEEECCCCCHH
DLEKAGSFENLKITNDRERKSEKTISFWKQKDNIRLYIAAFIIVISLIASYSLNEQSIIP
HHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCC
TIGFGAAILIGGYSLFMKGLKNLIQFQFDMNTLMTIAVIGAALIGEWLEGAAVVILFAIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EALERFSMDKARQSIQSLMDIAPNEALIRRDNIEQTIDVNDIQINDIMIVKPGQKIAMDG
HHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCEECCCEEEEEEEEEECCCCEEEECC
IVIKGSSSVNQSAITGESIPVARMTDDEVFAGTFNEDGLLEIRVTKKVEDTTISKIIHLV
EEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHH
EEAQAERAPSQAFVDKFAKYYTPVIMLIALMVAIVPSAITGDWSTWIYQGLAILVVGCPC
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
ALVISTPVAIVTAIGNAAKNGVLIKGGVYLEETGSLQSIAFDKTGTLTEGVPHVTDIVSY
HEEHHCHHHHHHHHCCCCCCCEEEECCEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHC
QGEEGSNLSLIAAIENGSQHPLAAAIIRKANEDNITFKNVEMENFKSITGKGVQATIDNK
CCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCEEEEECCC
DYYVGSPDFFKELQTSIDPTIVQQIEDMQLEGKTVIILGTHQDILSLYAIADKVRAASKH
CEECCCHHHHHHHHHCCCHHHHHHHHHCEECCCEEEEEECHHHHHHHHHHHHHHHHHHHH
VVTKLNKLGMSTVMLTGDNQNTASAIGKQVGVTNVKSNLLPEDKLKYIKELTNNDQKTAM
HHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
VGDGINDSPALAASTVGIAMGGAGTDTALETADIVLMSDDLNKLPYTMNLSRKTLRIIKE
ECCCCCCCCCHHHHHHEEEECCCCCCCHHCCEEEEEEECCCCCCCEEECCCHHHHHHHHH
NIIFSLGIKLAALLLVIPGWLTLWLAIFADIGATLIVTLNSLRLLRVKDDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEECCC
>Mature Secondary Structure 
SHSQINSSPNVETYRIQGLSCTNCAAKFENNVRKLPGVENAQVNFGASKVYVEGNTTIQ
CCCCCCCCCCCEEEEECCCCHHHHHHHHHCCHHHCCCCCCCEEECCCEEEEECCCCCHH
DLEKAGSFENLKITNDRERKSEKTISFWKQKDNIRLYIAAFIIVISLIASYSLNEQSIIP
HHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCC
TIGFGAAILIGGYSLFMKGLKNLIQFQFDMNTLMTIAVIGAALIGEWLEGAAVVILFAIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EALERFSMDKARQSIQSLMDIAPNEALIRRDNIEQTIDVNDIQINDIMIVKPGQKIAMDG
HHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCEECCCEEEEEEEEEECCCCEEEECC
IVIKGSSSVNQSAITGESIPVARMTDDEVFAGTFNEDGLLEIRVTKKVEDTTISKIIHLV
EEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHH
EEAQAERAPSQAFVDKFAKYYTPVIMLIALMVAIVPSAITGDWSTWIYQGLAILVVGCPC
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
ALVISTPVAIVTAIGNAAKNGVLIKGGVYLEETGSLQSIAFDKTGTLTEGVPHVTDIVSY
HEEHHCHHHHHHHHCCCCCCCEEEECCEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHC
QGEEGSNLSLIAAIENGSQHPLAAAIIRKANEDNITFKNVEMENFKSITGKGVQATIDNK
CCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCEEEEECCC
DYYVGSPDFFKELQTSIDPTIVQQIEDMQLEGKTVIILGTHQDILSLYAIADKVRAASKH
CEECCCHHHHHHHHHCCCHHHHHHHHHCEECCCEEEEEECHHHHHHHHHHHHHHHHHHHH
VVTKLNKLGMSTVMLTGDNQNTASAIGKQVGVTNVKSNLLPEDKLKYIKELTNNDQKTAM
HHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
VGDGINDSPALAASTVGIAMGGAGTDTALETADIVLMSDDLNKLPYTMNLSRKTLRIIKE
ECCCCCCCCCHHHHHHEEEECCCCCCCHHCCEEEEEEECCCCCCCEEECCCHHHHHHHHH
NIIFSLGIKLAALLLVIPGWLTLWLAIFADIGATLIVTLNSLRLLRVKDDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1321115 [H]