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The map label for this gene is mutS2 [H]

Identifier: 23097694

GI number: 23097694

Start: 268552

End: 270456

Strand: Direct

Name: mutS2 [H]

Synonym: OB0239

Alternate gene names: 23097694

Gene position: 268552-270456 (Clockwise)

Preceding gene: 23097693

Following gene: 23097695

Centisome position: 7.4

GC content: 33.02

Gene sequence:

>1905_bases
ATGAATAATGCAACTTTCGATAAGTTACAATACAATGAATTAAAACAAATAATTAATTCTTACTGTGTTAGTGGATTAGG
TAAACAATTGCTAGATAAATTAGAACCAAGTTCAAATATAAACGTAGTTAAGAATCGTTTGAATGAAACAACAGAAGCGC
GAAAAATCATAGATGCTAAGGGGCATATCCCATTTTTAGGAGTATCTAACATTGATAGCATCATTCAAAATATTGAAAAG
GATATAATTCTTGATCCGAGTGATCTGATAAGTGTGTCAGACTTTTTAAGAGGTTGTAGAAAAATTAAATCGTTTATGAT
GGAAAAAGAATTTTTTGCTCCAGTACTAGCATCTTATGCTAATTCAATGACTGAATTTCAGCATGTCGAGGAAGAAATTG
ATTTCTCGATCAAAGGCAATAGTGTTAACTCAGCTGCAAGTAGAGAATTAAAGAGAATTCGAAACAAAATTGATATAGCA
GAAGAAAGAATAAAAGATCGCTTAAATAAATTTTTAAATAATGATACGAACAAGAAGTATATTCAAGAGGCCTTTATTAG
TAAAAAAGATGATCGTTATACGATTCCTATTAAGGCTTCTTATAAAAATCAAGTTTCAGGTACCATCATTGATGTATCAT
CTAAAGGTTCCACTGTGTTTATGGAGCCAAGTACAGTTACCAAGTTAGGTGGGGAACTTGCGAGTTTAAGAGCTGAAGAG
GCAATAGAAGAATATCAAGTACTTGCTACTTTATCTGGGATGATTTTAGAGAATATTTATGAAATCAAGATTAACATGGA
GCTTATAAGTCAATATGATATGGTCTTTGCAAAAGCCAAGTTCAGTAAGGAGATTGATGGTTCAGAGCCTAAATTAAACG
ATTATGGTTATATAAAATTGGTGGATTGCAAGCATCCGCTCTTAGTAGGAGAAGCTGTACCACTTAATTTTGAAATTGGC
CAAGATTATCGTAGCCTAATTATCACGGGACCTAATGCTGGCGGTAAGACGATTGTATTAAAAACAATTGGATTACTGAC
TTTAGCAACCATGTCAGGTTTCCATATTGCTGCAAGTAAGGAAACGGAAATAGCCGTATTTGAAAACATCTATGCAGATA
TTGGGGACAATCAAAGTATAGAAAATGCGCTAAGTACATTTTCATCTCATATGAAAAACCTCTCAGAGATAATGCGGTTA
TCAAATAATAACACCCTTTTACTATTCGATGAAATCGGCAGTGGGACAGAACCGAATGAAGGGTCTGCACTTGCAATATC
AATTCTAGAAGAATTTTATCACATGGGATGCATTACTGTAGCAACAACTCATTATGGTGAAATTAAGCGGTTCTCAGAAA
TACACGATGACTTTATGAACGCAGCAATGCGATTTGATAATGATACATTGGAGCCTTTGTATCAACTAGTAATAGGAAAA
TCAGGAGAAAGTAATGCACTTTGGATTTCTAGAAAAATGAATGTTCCAGAGAATATTTTACAAAGAGCGAGTCAGTATAT
GCAGAACAAAGGATATCAATTAGAGCGTGTCAATGAAAATAAAATACGGAAACCTAAAATCAAAAAAGAGAAAAGTGTTC
AGTATAAGTATGAATATAGTAAAGGTGACCGTGTGAAGTTATTAGAACATGATGATATTGGGATTGTATATAAAGAGATG
GATAGTTCCTATAATGTTGTTGTGTATTATAAAGGAGAATTTATTGACGTACATGTGAAGCGAATTTCTTTAGATATCTC
GGCAAAGGAATTATATCCAGCAGGCTATGATTTAGAGACATTGTTTGTTGATCATAAAACAAAGAAAATGGAACATGATT
TGGAACGAGGTTCAAAAAAAGCACTTCGAAAAGTAGAAAAAGAAATTAGAAAGAATAGAGAATGA

Upstream 100 bases:

>100_bases
ATTTGAAATTTATAACATTCTATAGTTGAGTTATCATTGAAATCTAATGCGTAGGTATCTTCATTCTCGAACTAAAATAT
AAGAATGAGGAGATTACAAA

Downstream 100 bases:

>100_bases
GAATTATTTTTTAGCATTTTCAGGAGAGTATTGCATCATTGTAAACAAGGTCTATGTGCTCAGTAGCTTTTGACTATGCA
AAACACCTTCGATTGTACGG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MNNATFDKLQYNELKQIINSYCVSGLGKQLLDKLEPSSNINVVKNRLNETTEARKIIDAKGHIPFLGVSNIDSIIQNIEK
DIILDPSDLISVSDFLRGCRKIKSFMMEKEFFAPVLASYANSMTEFQHVEEEIDFSIKGNSVNSAASRELKRIRNKIDIA
EERIKDRLNKFLNNDTNKKYIQEAFISKKDDRYTIPIKASYKNQVSGTIIDVSSKGSTVFMEPSTVTKLGGELASLRAEE
AIEEYQVLATLSGMILENIYEIKINMELISQYDMVFAKAKFSKEIDGSEPKLNDYGYIKLVDCKHPLLVGEAVPLNFEIG
QDYRSLIITGPNAGGKTIVLKTIGLLTLATMSGFHIAASKETEIAVFENIYADIGDNQSIENALSTFSSHMKNLSEIMRL
SNNNTLLLFDEIGSGTEPNEGSALAISILEEFYHMGCITVATTHYGEIKRFSEIHDDFMNAAMRFDNDTLEPLYQLVIGK
SGESNALWISRKMNVPENILQRASQYMQNKGYQLERVNENKIRKPKIKKEKSVQYKYEYSKGDRVKLLEHDDIGIVYKEM
DSSYNVVVYYKGEFIDVHVKRISLDISAKELYPAGYDLETLFVDHKTKKMEHDLERGSKKALRKVEKEIRKNRE

Sequences:

>Translated_634_residues
MNNATFDKLQYNELKQIINSYCVSGLGKQLLDKLEPSSNINVVKNRLNETTEARKIIDAKGHIPFLGVSNIDSIIQNIEK
DIILDPSDLISVSDFLRGCRKIKSFMMEKEFFAPVLASYANSMTEFQHVEEEIDFSIKGNSVNSAASRELKRIRNKIDIA
EERIKDRLNKFLNNDTNKKYIQEAFISKKDDRYTIPIKASYKNQVSGTIIDVSSKGSTVFMEPSTVTKLGGELASLRAEE
AIEEYQVLATLSGMILENIYEIKINMELISQYDMVFAKAKFSKEIDGSEPKLNDYGYIKLVDCKHPLLVGEAVPLNFEIG
QDYRSLIITGPNAGGKTIVLKTIGLLTLATMSGFHIAASKETEIAVFENIYADIGDNQSIENALSTFSSHMKNLSEIMRL
SNNNTLLLFDEIGSGTEPNEGSALAISILEEFYHMGCITVATTHYGEIKRFSEIHDDFMNAAMRFDNDTLEPLYQLVIGK
SGESNALWISRKMNVPENILQRASQYMQNKGYQLERVNENKIRKPKIKKEKSVQYKYEYSKGDRVKLLEHDDIGIVYKEM
DSSYNVVVYYKGEFIDVHVKRISLDISAKELYPAGYDLETLFVDHKTKKMEHDLERGSKKALRKVEKEIRKNRE
>Mature_634_residues
MNNATFDKLQYNELKQIINSYCVSGLGKQLLDKLEPSSNINVVKNRLNETTEARKIIDAKGHIPFLGVSNIDSIIQNIEK
DIILDPSDLISVSDFLRGCRKIKSFMMEKEFFAPVLASYANSMTEFQHVEEEIDFSIKGNSVNSAASRELKRIRNKIDIA
EERIKDRLNKFLNNDTNKKYIQEAFISKKDDRYTIPIKASYKNQVSGTIIDVSSKGSTVFMEPSTVTKLGGELASLRAEE
AIEEYQVLATLSGMILENIYEIKINMELISQYDMVFAKAKFSKEIDGSEPKLNDYGYIKLVDCKHPLLVGEAVPLNFEIG
QDYRSLIITGPNAGGKTIVLKTIGLLTLATMSGFHIAASKETEIAVFENIYADIGDNQSIENALSTFSSHMKNLSEIMRL
SNNNTLLLFDEIGSGTEPNEGSALAISILEEFYHMGCITVATTHYGEIKRFSEIHDDFMNAAMRFDNDTLEPLYQLVIGK
SGESNALWISRKMNVPENILQRASQYMQNKGYQLERVNENKIRKPKIKKEKSVQYKYEYSKGDRVKLLEHDDIGIVYKEM
DSSYNVVVYYKGEFIDVHVKRISLDISAKELYPAGYDLETLFVDHKTKKMEHDLERGSKKALRKVEKEIRKNRE

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=343, Percent_Identity=26.8221574344023, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI26638666, Length=292, Percent_Identity=27.0547945205479, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4505253, Length=292, Percent_Identity=27.0547945205479, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI36949366, Length=386, Percent_Identity=22.7979274611399, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4504191, Length=298, Percent_Identity=22.8187919463087, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI26638664, Length=292, Percent_Identity=26.3698630136986, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262231786, Length=226, Percent_Identity=31.4159292035398, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4557761, Length=182, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789089, Length=342, Percent_Identity=24.2690058479532, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=383, Percent_Identity=23.4986945169713, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17539736, Length=295, Percent_Identity=21.3559322033898, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534743, Length=269, Percent_Identity=23.4200743494424, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=209, Percent_Identity=24.8803827751196, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=230, Percent_Identity=26.9565217391304, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319935, Length=365, Percent_Identity=26.5753424657534, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321912, Length=252, Percent_Identity=24.6031746031746, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320302, Length=220, Percent_Identity=23.1818181818182, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321109, Length=257, Percent_Identity=26.4591439688716, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584320, Length=433, Percent_Identity=28.6374133949192, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664545, Length=225, Percent_Identity=27.1111111111111, Blast_Score=93, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 72070; Mature: 72070

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNATFDKLQYNELKQIINSYCVSGLGKQLLDKLEPSSNINVVKNRLNETTEARKIIDAK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GHIPFLGVSNIDSIIQNIEKDIILDPSDLISVSDFLRGCRKIKSFMMEKEFFAPVLASYA
CCCCEEECCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSMTEFQHVEEEIDFSIKGNSVNSAASRELKRIRNKIDIAEERIKDRLNKFLNNDTNKKY
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEAFISKKDDRYTIPIKASYKNQVSGTIIDVSSKGSTVFMEPSTVTKLGGELASLRAEE
HHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHH
AIEEYQVLATLSGMILENIYEIKINMELISQYDMVFAKAKFSKEIDGSEPKLNDYGYIKL
HHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VDCKHPLLVGEAVPLNFEIGQDYRSLIITGPNAGGKTIVLKTIGLLTLATMSGFHIAASK
EECCCCEEECCEECCEEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCEEEEECC
ETEIAVFENIYADIGDNQSIENALSTFSSHMKNLSEIMRLSNNNTLLLFDEIGSGTEPNE
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GSALAISILEEFYHMGCITVATTHYGEIKRFSEIHDDFMNAAMRFDNDTLEPLYQLVIGK
CCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
SGESNALWISRKMNVPENILQRASQYMQNKGYQLERVNENKIRKPKIKKEKSVQYKYEYS
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEC
KGDRVKLLEHDDIGIVYKEMDSSYNVVVYYKGEFIDVHVKRISLDISAKELYPAGYDLET
CCCEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEEEEEEEEEEEEHHHCCCCCCCEEE
LFVDHKTKKMEHDLERGSKKALRKVEKEIRKNRE
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNATFDKLQYNELKQIINSYCVSGLGKQLLDKLEPSSNINVVKNRLNETTEARKIIDAK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GHIPFLGVSNIDSIIQNIEKDIILDPSDLISVSDFLRGCRKIKSFMMEKEFFAPVLASYA
CCCCEEECCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSMTEFQHVEEEIDFSIKGNSVNSAASRELKRIRNKIDIAEERIKDRLNKFLNNDTNKKY
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEAFISKKDDRYTIPIKASYKNQVSGTIIDVSSKGSTVFMEPSTVTKLGGELASLRAEE
HHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHH
AIEEYQVLATLSGMILENIYEIKINMELISQYDMVFAKAKFSKEIDGSEPKLNDYGYIKL
HHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VDCKHPLLVGEAVPLNFEIGQDYRSLIITGPNAGGKTIVLKTIGLLTLATMSGFHIAASK
EECCCCEEECCEECCEEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCEEEEECC
ETEIAVFENIYADIGDNQSIENALSTFSSHMKNLSEIMRLSNNNTLLLFDEIGSGTEPNE
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GSALAISILEEFYHMGCITVATTHYGEIKRFSEIHDDFMNAAMRFDNDTLEPLYQLVIGK
CCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
SGESNALWISRKMNVPENILQRASQYMQNKGYQLERVNENKIRKPKIKKEKSVQYKYEYS
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEC
KGDRVKLLEHDDIGIVYKEMDSSYNVVVYYKGEFIDVHVKRISLDISAKELYPAGYDLET
CCCEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEEEEEEEEEEEEHHHCCCCCCCEEE
LFVDHKTKKMEHDLERGSKKALRKVEKEIRKNRE
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA