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The map label for this gene is pfbA [H]

Identifier: 23097672

GI number: 23097672

Start: 236812

End: 238371

Strand: Direct

Name: pfbA [H]

Synonym: OB0217

Alternate gene names: 23097672

Gene position: 236812-238371 (Clockwise)

Preceding gene: 23097671

Following gene: 23097673

Centisome position: 6.52

GC content: 35.26

Gene sequence:

>1560_bases
TTGAGTGAAATATATGAAAAGATTAAAGGTACAGCGGAAGAAATAAGAAATTATTTTATTGCTACTAGCCACCCTAGCAT
CATTGGAGATGGTATTAATGATGATACATTGGGAATTCAAGAACTATTAAATTATGCTAAAACATCTGAAGGGATTAGAA
TTGTTTTTCCTCCTGGCCACTACAGACTTACTGCACCTTTGAGGATATATAGTAATACTTTTATCGATGCGCAAAAAGGT
GTGTATTTTAGTAAAGAGCACAACGGAGCTATATTGCTGAACTTGTTATCCACTGATGAAATGGAAGAGTACGGTGGAAA
TAGTAATATTACGATTAAAGGCGGCGAATGGAATGCGAATTATCCTAACTATACTGGAGGAACAAGTTTTGTTCTTGCTC
ATGCTAAGGGAATTCTTATAGAAGATGTTTCTCTGTTGAACCATGGAGGAGGTCACGCAATTGAATTTAACGCTATTTGT
AATGGTATGGTATGGAACAGTAGGTTCTTAGGATTTGATGATCTAAATGGAAGCAGAACATACTCTGAAGCTATACAATT
AGATTTGGCAAAGAGTCGAGGGGTTTTTCCTTGGGGAGGATCGAGTTATGATCATACTCCATGTAAGAACATTATAATCG
AAAACAACTTATTTGATCGCTCCAATCAATTGGGAGGATGGGGGAGAGCGGTAGGTTCGCATTCTGCTACCTATGGTAAA
TGGCATGAAAATGTAATTATAAAAAATAATATAGTTAATAATTGTCTGCAGTGGGCGTTTAGAGCCTACTCTTGGAGAGA
TGTATTTATTGAAGGAAATAAAATCTATAACTGTGGTGGAGGTATAGGTTTAGATTTAAATAACGCAGATGACGAAGATA
GTCACGATGAAGATGGTAATTATACTGGTAAAAGTAATCATTGTGAAAGATTTTCAGTGAAAGGAAATTTAATTGATGGT
GGTGGTGGATATGCGTCAGCAATTAGTGCTGACGGTAATGCCACTGCTAGGATTCGAGCAGTAACTATACAAAGTAATTC
AGTGAATAATTACAACAATAGAGCAGTGTATTTACGACTGTTGGATGAGGTATTAATTAATAATAATATTTTTAATAATA
TTTCTGGCAACGGACTAACGTTGAGTGAAACGTGGATGGTTACAGTTAGTGGAAATTTGTTTAGATCAATAAGATTAAAT
GGAATTACGTGTTTTACAGGAAATAGAGCAATAATTATTTCGAGTAATAATTTTAATTATGTGCGAGAGCATGGCGTATG
GGTAAGTGGCAGTGATTCGGTAAGTATAAGTTGTAATAACTTTATTGGCATAGGATATCTGGAAAAAGGTTCTACATTTC
AAGGGATTCGTATAACTTCAGGTTCCGATCGGATTACAGTAACTGGTAATACATTTAGACAATGGAGTGATACCTACGCA
ATGAATTTTGCCATTTATGTTACATCTACGGTAACGGAATCTATATTGTCTGTTAACAATATGGCGGGTATTCGGATGCA
AATTCCTGCCGGTATATTCGAATATGGAAATTTAAATTAA

Upstream 100 bases:

>100_bases
TATGAAGAGTCATTATCGGGCAAAGAAGCCGAGATGCATTATTATTTATATAATGCTTTTAATGGAGAAATAAGTGGATT
TAATGAGGAGGTTGCTTCTA

Downstream 100 bases:

>100_bases
GATAAATGTTAATTACCATAAAAGAGTAGAAGCGATATAAACATCGTCAAACTGTTAGTTTATGAAGATAGGGGGTAAGA
ATGCTTTATAAAGAGGTGGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MSEIYEKIKGTAEEIRNYFIATSHPSIIGDGINDDTLGIQELLNYAKTSEGIRIVFPPGHYRLTAPLRIYSNTFIDAQKG
VYFSKEHNGAILLNLLSTDEMEEYGGNSNITIKGGEWNANYPNYTGGTSFVLAHAKGILIEDVSLLNHGGGHAIEFNAIC
NGMVWNSRFLGFDDLNGSRTYSEAIQLDLAKSRGVFPWGGSSYDHTPCKNIIIENNLFDRSNQLGGWGRAVGSHSATYGK
WHENVIIKNNIVNNCLQWAFRAYSWRDVFIEGNKIYNCGGGIGLDLNNADDEDSHDEDGNYTGKSNHCERFSVKGNLIDG
GGGYASAISADGNATARIRAVTIQSNSVNNYNNRAVYLRLLDEVLINNNIFNNISGNGLTLSETWMVTVSGNLFRSIRLN
GITCFTGNRAIIISSNNFNYVREHGVWVSGSDSVSISCNNFIGIGYLEKGSTFQGIRITSGSDRITVTGNTFRQWSDTYA
MNFAIYVTSTVTESILSVNNMAGIRMQIPAGIFEYGNLN

Sequences:

>Translated_519_residues
MSEIYEKIKGTAEEIRNYFIATSHPSIIGDGINDDTLGIQELLNYAKTSEGIRIVFPPGHYRLTAPLRIYSNTFIDAQKG
VYFSKEHNGAILLNLLSTDEMEEYGGNSNITIKGGEWNANYPNYTGGTSFVLAHAKGILIEDVSLLNHGGGHAIEFNAIC
NGMVWNSRFLGFDDLNGSRTYSEAIQLDLAKSRGVFPWGGSSYDHTPCKNIIIENNLFDRSNQLGGWGRAVGSHSATYGK
WHENVIIKNNIVNNCLQWAFRAYSWRDVFIEGNKIYNCGGGIGLDLNNADDEDSHDEDGNYTGKSNHCERFSVKGNLIDG
GGGYASAISADGNATARIRAVTIQSNSVNNYNNRAVYLRLLDEVLINNNIFNNISGNGLTLSETWMVTVSGNLFRSIRLN
GITCFTGNRAIIISSNNFNYVREHGVWVSGSDSVSISCNNFIGIGYLEKGSTFQGIRITSGSDRITVTGNTFRQWSDTYA
MNFAIYVTSTVTESILSVNNMAGIRMQIPAGIFEYGNLN
>Mature_518_residues
SEIYEKIKGTAEEIRNYFIATSHPSIIGDGINDDTLGIQELLNYAKTSEGIRIVFPPGHYRLTAPLRIYSNTFIDAQKGV
YFSKEHNGAILLNLLSTDEMEEYGGNSNITIKGGEWNANYPNYTGGTSFVLAHAKGILIEDVSLLNHGGGHAIEFNAICN
GMVWNSRFLGFDDLNGSRTYSEAIQLDLAKSRGVFPWGGSSYDHTPCKNIIIENNLFDRSNQLGGWGRAVGSHSATYGKW
HENVIIKNNIVNNCLQWAFRAYSWRDVFIEGNKIYNCGGGIGLDLNNADDEDSHDEDGNYTGKSNHCERFSVKGNLIDGG
GGYASAISADGNATARIRAVTIQSNSVNNYNNRAVYLRLLDEVLINNNIFNNISGNGLTLSETWMVTVSGNLFRSIRLNG
ITCFTGNRAIIISSNNFNYVREHGVWVSGSDSVSISCNNFIGIGYLEKGSTFQGIRITSGSDRITVTGNTFRQWSDTYAM
NFAIYVTSTVTESILSVNNMAGIRMQIPAGIFEYGNLN

Specific function: Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 PbH1 repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR006626
- InterPro:   IPR012334
- InterPro:   IPR011050 [H]

Pfam domain/function: PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 57099; Mature: 56968

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIYEKIKGTAEEIRNYFIATSHPSIIGDGINDDTLGIQELLNYAKTSEGIRIVFPPGH
CHHHHHHHCCCHHHHHHEEEEECCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
YRLTAPLRIYSNTFIDAQKGVYFSKEHNGAILLNLLSTDEMEEYGGNSNITIKGGEWNAN
EEEEEEEEEECCCEEECCCCEEEEECCCCEEEEEEECCCCHHHHCCCCEEEEECCCCCCC
YPNYTGGTSFVLAHAKGILIEDVSLLNHGGGHAIEFNAICNGMVWNSRFLGFDDLNGSRT
CCCCCCCCEEEEEECCCEEEEEEHHHCCCCCCEEEECCEECCEEECCEECCCCCCCCCCC
YSEAIQLDLAKSRGVFPWGGSSYDHTPCKNIIIENNLFDRSNQLGGWGRAVGSHSATYGK
HHHHHEEEEHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCC
WHENVIIKNNIVNNCLQWAFRAYSWRDVFIEGNKIYNCGGGIGLDLNNADDEDSHDEDGN
CCCCEEEECHHHHHHHHHHHHCCCEEEEEEECCEEEECCCEEEEECCCCCCCCCCCCCCC
YTGKSNHCERFSVKGNLIDGGGGYASAISADGNATARIRAVTIQSNSVNNYNNRAVYLRL
CCCCCCCCEEEEEECEEEECCCCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCEEEEEE
LDEVLINNNIFNNISGNGLTLSETWMVTVSGNLFRSIRLNGITCFTGNRAIIISSNNFNY
HHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEECEEEEEECCEEEEEECCCCCE
VREHGVWVSGSDSVSISCNNFIGIGYLEKGSTFQGIRITSGSDRITVTGNTFRQWSDTYA
EECCCEEEECCCEEEEEECCEEEEEEEECCCCCCEEEEECCCCEEEECCCCHHHCCCCEE
MNFAIYVTSTVTESILSVNNMAGIRMQIPAGIFEYGNLN
EEEEEEEEHHHHHHHHHHCCCCCEEEECCCCEECCCCCC
>Mature Secondary Structure 
SEIYEKIKGTAEEIRNYFIATSHPSIIGDGINDDTLGIQELLNYAKTSEGIRIVFPPGH
HHHHHHHCCCHHHHHHEEEEECCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
YRLTAPLRIYSNTFIDAQKGVYFSKEHNGAILLNLLSTDEMEEYGGNSNITIKGGEWNAN
EEEEEEEEEECCCEEECCCCEEEEECCCCEEEEEEECCCCHHHHCCCCEEEEECCCCCCC
YPNYTGGTSFVLAHAKGILIEDVSLLNHGGGHAIEFNAICNGMVWNSRFLGFDDLNGSRT
CCCCCCCCEEEEEECCCEEEEEEHHHCCCCCCEEEECCEECCEEECCEECCCCCCCCCCC
YSEAIQLDLAKSRGVFPWGGSSYDHTPCKNIIIENNLFDRSNQLGGWGRAVGSHSATYGK
HHHHHEEEEHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCC
WHENVIIKNNIVNNCLQWAFRAYSWRDVFIEGNKIYNCGGGIGLDLNNADDEDSHDEDGN
CCCCEEEECHHHHHHHHHHHHCCCEEEEEEECCEEEECCCEEEEECCCCCCCCCCCCCCC
YTGKSNHCERFSVKGNLIDGGGGYASAISADGNATARIRAVTIQSNSVNNYNNRAVYLRL
CCCCCCCCEEEEEECEEEECCCCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCEEEEEE
LDEVLINNNIFNNISGNGLTLSETWMVTVSGNLFRSIRLNGITCFTGNRAIIISSNNFNY
HHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEECEEEEEECCEEEEEECCCCCE
VREHGVWVSGSDSVSISCNNFIGIGYLEKGSTFQGIRITSGSDRITVTGNTFRQWSDTYA
EECCCEEEECCCEEEEEECCEEEEEEEECCCCCCEEEEECCCCEEEECCCCHHHCCCCEE
MNFAIYVTSTVTESILSVNNMAGIRMQIPAGIFEYGNLN
EEEEEEEEHHHHHHHHHHCCCCCEEEECCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11544234 [H]