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The map label for this gene is xorIIM [H]

Identifier: 23097628

GI number: 23097628

Start: 183363

End: 185153

Strand: Direct

Name: xorIIM [H]

Synonym: OB0173

Alternate gene names: 23097628

Gene position: 183363-185153 (Clockwise)

Preceding gene: 23097627

Following gene: 23097629

Centisome position: 5.05

GC content: 29.65

Gene sequence:

>1791_bases
ATGGATTCAGTAATTAATAATCGAAAGCCAAAGTATAAATTAATTGATTTGTTTGCAGGTGCTGGAGGGCTTAGTAACGG
TTTTATTCAGACAGGTAAGTTTGAAGTACTGGGAGCTGTCGAAATTAATAAGTCTGCAGCTAAAACATATGTGGAAAATC
ATAATAAAAATGAAGATTTAATAATTAAGAGTGGAAATAGTGGGATGAGCGATGTTTCAAAGATAGATTTTGCTAACTTT
ATCTTAGAAAAAAAAACCTCAGGAGATGAAATAGTAGTCATTGGGGGACCGCCGTGTCAAGGTTTTTCAAATGCTAACAG
ACAAAAGAATTATCTGATATCAGGAAATAACCAATTGGTAAAACAATATGTTAGAGCAATTGATGAAATAAAACCCACTG
CATTTTTATTGGAAAATGTAAGAAGCATGAAATCGGATGTTCATAAGTTTTTCGTTACAGAACATATAGAAGATACTATA
TATTCTTATAGTTCATTAAAGCATTTAAAACAAATCACTAAAAATAGTAAAGAGGGATTAAATAGACTTATTAAGGATGA
TACTATAACTTTGGTTGAAACCAAGTATAGTTTCCTAAAGGATATATTTGAAGGAATATATCACCAAGAGGAATTGGATC
CTATAATAGAAAATAAAATATATATTTCTCGATTAAGAAGCATTGAAAGAAAAACAAATAAATTACAGTCAATAAAGTTG
TTAACTACCAAAGAAAAGAATGAGACGACGCAATTAATAGAGTACTTAGAGAATAAAGTTGAGAAAGATCCCTTAATCAA
ACAATTAAAGATTGATGTAATCATTTCTTCAGCCATTACAATATTAAAATTGGTTGTCAAACAAGAAGTTGATAAAGAAA
ATATAATAAATACGATAGGGCCGTTAATGGATTTAAATACATTTCTTCTCCACTATAAAGAACTTATTGAAGAAAAAATA
ATTTTTTTAAAACCGCTAGATATAAAACAAATGAAGGAAAAAGTATCAGTCATTGCAAAAGTTAAGTCGTATAATATTGT
GGAGTATTTAAAAACTGTTTTTACTTTCTATGATTATAAAATAGATGATAATGTCTTAGATGCGTCATTCTTTGGTGTTC
CGCAGCGTCGAAAAAGATTCATGGTTTTAGGAGTAAGAAAAGATAAAGTGAAGGTTAATAAGGTTAAATTACCTACACAA
TTGAATTGCATAATGACACCATATACAGTTTTTGATGCAATAAGTGATCTAGAAAAAATTTCTCCACAGAAGGAACTAAA
GAATTATATACCAAGTTCATATATAAAAGGCAAAAAGTTATCACCATTACAGTCATATTTTCGGAAATATAATAATAGGA
TATACAATCATATCAGCACTAATAGTAGAGATTTAAGTCTTAAAAGGTTTGAGGCCATCAAAAAAGATGGAGGTAAGAAC
TTTCATAGTTTATCTGATGATTTAAAAACAACATATACAAATTCTGAAAGAACTCAGAATACTATTTATCTGAGACTAAA
TTACCATGAACCTTCACCAACTGTAGTAAACGTTAGAAAATCAATGTGGAATCACCCAAAAAATGCTGTTGCATTAAGTA
TTAGAGAAGCAGCAAGACTCCAATCATTTCGTGATGGTTATATTTTTTATGGAACGAAAGATCAACAGTATCAGCAAGTT
GGGAATGCAGTTCCTCCACTTTTAGCTAGAGGGGTATCAGAACAATTATTGAATATTATTGGGGAGAAGGCACTAATAAC
AATAGAAGAAGAATTTAGTGAAAAACAATAG

Upstream 100 bases:

>100_bases
TACTATCTATTGTTGTTGATTTTATTTTAAATAAACGTTATGCTGCTTAATAAGGTGATTAATAACTTATGAGTGTTTGA
ATTGAAAGGTGAAAATAGTA

Downstream 100 bases:

>100_bases
TTGAAAACTATTGTTTTTTGTTTTGCACTAATTCACAAGAAATGTAATAATTTGTTATAATTTAGCTAAATAGATAGAAT
AATATGCTTTTTATAGACCA

Product: site-specific DNA-methyltransferase

Products: NA

Alternate protein names: M.XorII; Cytosine-specific methyltransferase XorII [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MDSVINNRKPKYKLIDLFAGAGGLSNGFIQTGKFEVLGAVEINKSAAKTYVENHNKNEDLIIKSGNSGMSDVSKIDFANF
ILEKKTSGDEIVVIGGPPCQGFSNANRQKNYLISGNNQLVKQYVRAIDEIKPTAFLLENVRSMKSDVHKFFVTEHIEDTI
YSYSSLKHLKQITKNSKEGLNRLIKDDTITLVETKYSFLKDIFEGIYHQEELDPIIENKIYISRLRSIERKTNKLQSIKL
LTTKEKNETTQLIEYLENKVEKDPLIKQLKIDVIISSAITILKLVVKQEVDKENIINTIGPLMDLNTFLLHYKELIEEKI
IFLKPLDIKQMKEKVSVIAKVKSYNIVEYLKTVFTFYDYKIDDNVLDASFFGVPQRRKRFMVLGVRKDKVKVNKVKLPTQ
LNCIMTPYTVFDAISDLEKISPQKELKNYIPSSYIKGKKLSPLQSYFRKYNNRIYNHISTNSRDLSLKRFEAIKKDGGKN
FHSLSDDLKTTYTNSERTQNTIYLRLNYHEPSPTVVNVRKSMWNHPKNAVALSIREAARLQSFRDGYIFYGTKDQQYQQV
GNAVPPLLARGVSEQLLNIIGEKALITIEEEFSEKQ

Sequences:

>Translated_596_residues
MDSVINNRKPKYKLIDLFAGAGGLSNGFIQTGKFEVLGAVEINKSAAKTYVENHNKNEDLIIKSGNSGMSDVSKIDFANF
ILEKKTSGDEIVVIGGPPCQGFSNANRQKNYLISGNNQLVKQYVRAIDEIKPTAFLLENVRSMKSDVHKFFVTEHIEDTI
YSYSSLKHLKQITKNSKEGLNRLIKDDTITLVETKYSFLKDIFEGIYHQEELDPIIENKIYISRLRSIERKTNKLQSIKL
LTTKEKNETTQLIEYLENKVEKDPLIKQLKIDVIISSAITILKLVVKQEVDKENIINTIGPLMDLNTFLLHYKELIEEKI
IFLKPLDIKQMKEKVSVIAKVKSYNIVEYLKTVFTFYDYKIDDNVLDASFFGVPQRRKRFMVLGVRKDKVKVNKVKLPTQ
LNCIMTPYTVFDAISDLEKISPQKELKNYIPSSYIKGKKLSPLQSYFRKYNNRIYNHISTNSRDLSLKRFEAIKKDGGKN
FHSLSDDLKTTYTNSERTQNTIYLRLNYHEPSPTVVNVRKSMWNHPKNAVALSIREAARLQSFRDGYIFYGTKDQQYQQV
GNAVPPLLARGVSEQLLNIIGEKALITIEEEFSEKQ
>Mature_596_residues
MDSVINNRKPKYKLIDLFAGAGGLSNGFIQTGKFEVLGAVEINKSAAKTYVENHNKNEDLIIKSGNSGMSDVSKIDFANF
ILEKKTSGDEIVVIGGPPCQGFSNANRQKNYLISGNNQLVKQYVRAIDEIKPTAFLLENVRSMKSDVHKFFVTEHIEDTI
YSYSSLKHLKQITKNSKEGLNRLIKDDTITLVETKYSFLKDIFEGIYHQEELDPIIENKIYISRLRSIERKTNKLQSIKL
LTTKEKNETTQLIEYLENKVEKDPLIKQLKIDVIISSAITILKLVVKQEVDKENIINTIGPLMDLNTFLLHYKELIEEKI
IFLKPLDIKQMKEKVSVIAKVKSYNIVEYLKTVFTFYDYKIDDNVLDASFFGVPQRRKRFMVLGVRKDKVKVNKVKLPTQ
LNCIMTPYTVFDAISDLEKISPQKELKNYIPSSYIKGKKLSPLQSYFRKYNNRIYNHISTNSRDLSLKRFEAIKKDGGKN
FHSLSDDLKTTYTNSERTQNTIYLRLNYHEPSPTVVNVRKSMWNHPKNAVALSIREAARLQSFRDGYIFYGTKDQQYQQV
GNAVPPLLARGVSEQLLNIIGEKALITIEEEFSEKQ

Specific function: This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4503351, Length=138, Percent_Identity=36.231884057971, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI195927037, Length=138, Percent_Identity=36.231884057971, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788271, Length=151, Percent_Identity=34.4370860927152, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 68551; Mature: 68551

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSVINNRKPKYKLIDLFAGAGGLSNGFIQTGKFEVLGAVEINKSAAKTYVENHNKNEDL
CCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCEEEEEEEEECHHHHHHHHHCCCCCCCE
IIKSGNSGMSDVSKIDFANFILEKKTSGDEIVVIGGPPCQGFSNANRQKNYLISGNNQLV
EEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCHHHH
KQYVRAIDEIKPTAFLLENVRSMKSDVHKFFVTEHIEDTIYSYSSLKHLKQITKNSKEGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
NRLIKDDTITLVETKYSFLKDIFEGIYHQEELDPIIENKIYISRLRSIERKTNKLQSIKL
HHHHCCCCEEEEHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
LTTKEKNETTQLIEYLENKVEKDPLIKQLKIDVIISSAITILKLVVKQEVDKENIINTIG
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
PLMDLNTFLLHYKELIEEKIIFLKPLDIKQMKEKVSVIAKVKSYNIVEYLKTVFTFYDYK
HHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCE
IDDNVLDASFFGVPQRRKRFMVLGVRKDKVKVNKVKLPTQLNCIMTPYTVFDAISDLEKI
ECCCEECHHHCCCCHHCCEEEEEEEECCCEEEEEEECCCCCCEEECHHHHHHHHHHHHHC
SPQKELKNYIPSSYIKGKKLSPLQSYFRKYNNRIYNHISTNSRDLSLKRFEAIKKDGGKN
CCHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
FHSLSDDLKTTYTNSERTQNTIYLRLNYHEPSPTVVNVRKSMWNHPKNAVALSIREAARL
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEHHHHHHCCCCCCCEEEHHHHHHHH
QSFRDGYIFYGTKDQQYQQVGNAVPPLLARGVSEQLLNIIGEKALITIEEEFSEKQ
HHHCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCC
>Mature Secondary Structure
MDSVINNRKPKYKLIDLFAGAGGLSNGFIQTGKFEVLGAVEINKSAAKTYVENHNKNEDL
CCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCEEEEEEEEECHHHHHHHHHCCCCCCCE
IIKSGNSGMSDVSKIDFANFILEKKTSGDEIVVIGGPPCQGFSNANRQKNYLISGNNQLV
EEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCHHHH
KQYVRAIDEIKPTAFLLENVRSMKSDVHKFFVTEHIEDTIYSYSSLKHLKQITKNSKEGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
NRLIKDDTITLVETKYSFLKDIFEGIYHQEELDPIIENKIYISRLRSIERKTNKLQSIKL
HHHHCCCCEEEEHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
LTTKEKNETTQLIEYLENKVEKDPLIKQLKIDVIISSAITILKLVVKQEVDKENIINTIG
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
PLMDLNTFLLHYKELIEEKIIFLKPLDIKQMKEKVSVIAKVKSYNIVEYLKTVFTFYDYK
HHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCE
IDDNVLDASFFGVPQRRKRFMVLGVRKDKVKVNKVKLPTQLNCIMTPYTVFDAISDLEKI
ECCCEECHHHCCCCHHCCEEEEEEEECCCEEEEEEECCCCCCEEECHHHHHHHHHHHHHC
SPQKELKNYIPSSYIKGKKLSPLQSYFRKYNNRIYNHISTNSRDLSLKRFEAIKKDGGKN
CCHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
FHSLSDDLKTTYTNSERTQNTIYLRLNYHEPSPTVVNVRKSMWNHPKNAVALSIREAARL
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEHHHHHHCCCCCCCEEEHHHHHHHH
QSFRDGYIFYGTKDQQYQQVGNAVPPLLARGVSEQLLNIIGEKALITIEEEFSEKQ
HHHCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8078464 [H]