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The map label for this gene is serS

Identifier: 23097467

GI number: 23097467

Start: 15503

End: 16777

Strand: Direct

Name: serS

Synonym: OB0012

Alternate gene names: 23097467

Gene position: 15503-16777 (Clockwise)

Preceding gene: 23097466

Following gene: 23097468

Centisome position: 0.43

GC content: 37.96

Gene sequence:

>1275_bases
ATGTTAGATATGAAATATCTACGCCAAAATTTTGAAGAAGTACAGCAACGTTTACAGCATCGTGGAGAAGATTTAGCAGA
TTTAGATAAATTTGGTGAACTAGATACGAATCGTCGTCAATTAATTGCAGAAACAGAGAAGTTAAAGGCTCAACGAAATG
AAGCTACAAAGAAAATATCTGAACTTAAAAGAGAGAAAAAAGATGCTGAACCTGCAATTAAAGAGATGCGAGAAGTTGGC
CAAGAAATTGCTACACTGGATAAACAATTGAAGGATATTGAAGAAAAACTAGAACAAATCATGCTGTCGATTCCAAATTT
GCCTCATGAGAGCGTTCCTGTTGGTGAAGATGAAGAAGATAATATTGAAGCAAGAAAATGGGGAGAGGCGCCTAATTTTG
CTTTTGAAGCACTACCTCATTGGGATGTTGCGACAAATCTAGACATTATAGATTTTGAGCGTGCGGGTAAAGTAACAGGA
AGTCGTTTTGTTTTTTATAAAGGCTTAGGTGCAAGACTAGAGAGAGCATTATGGAACTTTATGATGGATTTACATGCAGA
TGAGCATGGCTATCAAGAAATGCTTCCACCATACATTGTAAATCGTTCAAGTATGACTGGAACAGGGCAGCTTCCTAAAT
TTGAAGAGGATGCGTTTAAATTAGAAGAATGGGATTATTTTATGGTTCCAACAGCAGAAGTACCAGTGACTAACTATCAT
CGAGAAGAAATACTTGGAATCGATGACCTCCCTAAAAAGTATGTAGCATTCAGTGCTAGCTTTCGTTCTGAAGCTGGATC
TGCTGGACGCGATACACGTGGATTAATTCGCCAACATCAGTTTAATAAAGTAGAACTAGTTAATTTCGTAAAACCAGAGG
ACTCTTATGACGTATTAGAAAGGTTAACAGGGGAAGCAGAAAAAGTATTACAACTGTTAAAACTTCCATACCGCGTAATG
AGTATGTGTACAGGAGATTTAGGATTTACCGCTGCGAAGAAATACGATATTGAAGTATGGATTCCAAGTCAAGAAACTTA
CCGAGAAATTTCTTCTTGCTCTAATTTTGAGGATTTCCAAGCACGACGTGCAGGTATTCGTTTCCGACGTGAAGCAAATG
GGAAACCGGAATTTGTGCATACATTAAATGGTTCTGGTTTAGCGATTGGACGTACAGTAGCAGCAATCTTAGAAAATTAT
CAGCAAGAAGATGGTACTGTCGTCGTACCTGAAGTTTTACGTCCATACATGGGTGGAAAAGAAATTATTGGGTAA

Upstream 100 bases:

>100_bases
CAATCAGGGTGGCAACGCGGGAATTAATACTCTCGTCCCTTTTTACAGGGACGGGAGTTTTTTGTTTTGATTTGTTATAT
ATTAAAGGAGGAATTAGAAC

Downstream 100 bases:

>100_bases
ACTAATAATAAATCGCTCTCTTGATCTTCGGTTAAACACACCCTAGATCAAGAGAGTATATAAAAAAATAGGTTTTATAA
ATTTTTTTACTATATTTTGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDMKYLRQNFEEVQQRLQHRGEDLADLDKFGELDTNRRQLIAETEKLKAQRNEATKKISELKREKKDAEPAIKEMREVG
QEIATLDKQLKDIEEKLEQIMLSIPNLPHESVPVGEDEEDNIEARKWGEAPNFAFEALPHWDVATNLDIIDFERAGKVTG
SRFVFYKGLGARLERALWNFMMDLHADEHGYQEMLPPYIVNRSSMTGTGQLPKFEEDAFKLEEWDYFMVPTAEVPVTNYH
REEILGIDDLPKKYVAFSASFRSEAGSAGRDTRGLIRQHQFNKVELVNFVKPEDSYDVLERLTGEAEKVLQLLKLPYRVM
SMCTGDLGFTAAKKYDIEVWIPSQETYREISSCSNFEDFQARRAGIRFRREANGKPEFVHTLNGSGLAIGRTVAAILENY
QQEDGTVVVPEVLRPYMGGKEIIG

Sequences:

>Translated_424_residues
MLDMKYLRQNFEEVQQRLQHRGEDLADLDKFGELDTNRRQLIAETEKLKAQRNEATKKISELKREKKDAEPAIKEMREVG
QEIATLDKQLKDIEEKLEQIMLSIPNLPHESVPVGEDEEDNIEARKWGEAPNFAFEALPHWDVATNLDIIDFERAGKVTG
SRFVFYKGLGARLERALWNFMMDLHADEHGYQEMLPPYIVNRSSMTGTGQLPKFEEDAFKLEEWDYFMVPTAEVPVTNYH
REEILGIDDLPKKYVAFSASFRSEAGSAGRDTRGLIRQHQFNKVELVNFVKPEDSYDVLERLTGEAEKVLQLLKLPYRVM
SMCTGDLGFTAAKKYDIEVWIPSQETYREISSCSNFEDFQARRAGIRFRREANGKPEFVHTLNGSGLAIGRTVAAILENY
QQEDGTVVVPEVLRPYMGGKEIIG
>Mature_424_residues
MLDMKYLRQNFEEVQQRLQHRGEDLADLDKFGELDTNRRQLIAETEKLKAQRNEATKKISELKREKKDAEPAIKEMREVG
QEIATLDKQLKDIEEKLEQIMLSIPNLPHESVPVGEDEEDNIEARKWGEAPNFAFEALPHWDVATNLDIIDFERAGKVTG
SRFVFYKGLGARLERALWNFMMDLHADEHGYQEMLPPYIVNRSSMTGTGQLPKFEEDAFKLEEWDYFMVPTAEVPVTNYH
REEILGIDDLPKKYVAFSASFRSEAGSAGRDTRGLIRQHQFNKVELVNFVKPEDSYDVLERLTGEAEKVLQLLKLPYRVM
SMCTGDLGFTAAKKYDIEVWIPSQETYREISSCSNFEDFQARRAGIRFRREANGKPEFVHTLNGSGLAIGRTVAAILENY
QQEDGTVVVPEVLRPYMGGKEIIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=338, Percent_Identity=38.1656804733728, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI8923421, Length=439, Percent_Identity=31.2072892938497, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI225579074, Length=443, Percent_Identity=30.4740406320542, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=53.1322505800464, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17539260, Length=465, Percent_Identity=31.1827956989247, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=338, Percent_Identity=30.1775147928994, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=392, Percent_Identity=34.4387755102041, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6321799, Length=435, Percent_Identity=32.4137931034483, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=31.6916488222698, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17737985, Length=363, Percent_Identity=32.5068870523416, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_OCEIH (Q8EU77)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_690933.1
- ProteinModelPortal:   Q8EU77
- SMR:   Q8EU77
- GeneID:   1015029
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0012
- NMPDR:   fig|221109.1.peg.12
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- BioCyc:   OIHE221109:OB0012-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48708; Mature: 48708

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDMKYLRQNFEEVQQRLQHRGEDLADLDKFGELDTNRRQLIAETEKLKAQRNEATKKIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ELKREKKDAEPAIKEMREVGQEIATLDKQLKDIEEKLEQIMLSIPNLPHESVPVGEDEED
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NIEARKWGEAPNFAFEALPHWDVATNLDIIDFERAGKVTGSRFVFYKGLGARLERALWNF
CCHHHHCCCCCCCHHHCCCCCCCCCCCCEEEHHHCCCCCCCEEEEECCHHHHHHHHHHHH
MMDLHADEHGYQEMLPPYIVNRSSMTGTGQLPKFEEDAFKLEEWDYFMVPTAEVPVTNYH
HHHHCCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCC
REEILGIDDLPKKYVAFSASFRSEAGSAGRDTRGLIRQHQFNKVELVNFVKPEDSYDVLE
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
RLTGEAEKVLQLLKLPYRVMSMCTGDLGFTAAKKYDIEVWIPSQETYREISSCSNFEDFQ
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHCCCHHHHH
ARRAGIRFRREANGKPEFVHTLNGSGLAIGRTVAAILENYQQEDGTVVVPEVLRPYMGGK
HHHHCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCH
EIIG
HCCC
>Mature Secondary Structure
MLDMKYLRQNFEEVQQRLQHRGEDLADLDKFGELDTNRRQLIAETEKLKAQRNEATKKIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ELKREKKDAEPAIKEMREVGQEIATLDKQLKDIEEKLEQIMLSIPNLPHESVPVGEDEED
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NIEARKWGEAPNFAFEALPHWDVATNLDIIDFERAGKVTGSRFVFYKGLGARLERALWNF
CCHHHHCCCCCCCHHHCCCCCCCCCCCCEEEHHHCCCCCCCEEEEECCHHHHHHHHHHHH
MMDLHADEHGYQEMLPPYIVNRSSMTGTGQLPKFEEDAFKLEEWDYFMVPTAEVPVTNYH
HHHHCCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCC
REEILGIDDLPKKYVAFSASFRSEAGSAGRDTRGLIRQHQFNKVELVNFVKPEDSYDVLE
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
RLTGEAEKVLQLLKLPYRVMSMCTGDLGFTAAKKYDIEVWIPSQETYREISSCSNFEDFQ
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHCCCHHHHH
ARRAGIRFRREANGKPEFVHTLNGSGLAIGRTVAAILENYQQEDGTVVVPEVLRPYMGGK
HHHHCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCH
EIIG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376