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The map label for this gene is rnc [H]

Identifier: 229918600

GI number: 229918600

Start: 2852217

End: 2852996

Strand: Direct

Name: rnc [H]

Synonym: EAT1b_2887

Alternate gene names: 229918600

Gene position: 2852217-2852996 (Clockwise)

Preceding gene: 229918599

Following gene: 229918602

Centisome position: 95.08

GC content: 49.62

Gene sequence:

>780_bases
ATGACAAAAGACAAACGACGGTTTGACCGTCAAGGGTCGGCGCAGCGACGTCGGCGTCAGGAGATGGAACGAGCACGCAT
CTTGGAACTATTTAAATCATTGGAAGAACGGTTAGACGTTCAATTTTCGAATCACGACTTGTTGATGCAGGCGTTCACAC
ACTCATCTTATGTGAATGAGCAACGCGGGTTACGAAAAGACAATGAACGTTTAGAATTTTTAGGGGATGCTGTTTTAGAA
CTGACCGTATCTCGCTTTCTCTATGAGACTTATCCGGAGCGCTCCGAGGGGGAATTGACGAAATTACGAGCGGCGATCGT
ATGCGAACCGTCACTCGTGAATTTTGCGGAAGCTTTTGCTTTCTCTGACTTCATCTTGCTTGGGAAAGGTGAAGAGTTGA
CCGGTGGACGAAAACGTCCGGCACTGCTTGCCGACGTGTTCGAATCCTATATCGGTGCTCTTTATTTGGACCAGGGAATT
GAGGCCGTCGAACGATTCCTCGCCGAAGCGGTTTTTCCGAAAGTCTTAGCGGGAGTATTTGAAGAACAGACGGATTTCAA
GAGCCAGTTACAGGAGAGCGTTCAACGGGAAGGACTCGGACCTGTTTCGTATGAGATTATCGAAGAACGCGGACCGGCGC
ATAGCCGGGAATTCGTCGCACATGCACGCCTCAGTGACGACATCGTCGGTGAAGGGGTCGGACGTTCGAAAAAAGAAGCC
GAGCAATTGGCTGCCAAAGAAGCGCTTATTGCCTTTAACCGGCGCTACGCAGATTTATAA

Upstream 100 bases:

>100_bases
TGTTGGCGACGTAGTGGCTTACATCGAAACAAAATTGTAATCAAGCCATCCCACCGCTCGGTTCCGGGCGGTGGGCTTGT
GCTTATTCATGGAGGGAACT

Downstream 100 bases:

>100_bases
ACAAAAGGAGTGGACCGCCTAGGGATCCACTCCTTTTCATGTCAATTGACCGAGTTCTTCGACGATACCATCGACTTCCG
ACAAAGAGAGCGAAGAGCGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTKDKRRFDRQGSAQRRRRQEMERARILELFKSLEERLDVQFSNHDLLMQAFTHSSYVNEQRGLRKDNERLEFLGDAVLE
LTVSRFLYETYPERSEGELTKLRAAIVCEPSLVNFAEAFAFSDFILLGKGEELTGGRKRPALLADVFESYIGALYLDQGI
EAVERFLAEAVFPKVLAGVFEEQTDFKSQLQESVQREGLGPVSYEIIEERGPAHSREFVAHARLSDDIVGEGVGRSKKEA
EQLAAKEALIAFNRRYADL

Sequences:

>Translated_259_residues
MTKDKRRFDRQGSAQRRRRQEMERARILELFKSLEERLDVQFSNHDLLMQAFTHSSYVNEQRGLRKDNERLEFLGDAVLE
LTVSRFLYETYPERSEGELTKLRAAIVCEPSLVNFAEAFAFSDFILLGKGEELTGGRKRPALLADVFESYIGALYLDQGI
EAVERFLAEAVFPKVLAGVFEEQTDFKSQLQESVQREGLGPVSYEIIEERGPAHSREFVAHARLSDDIVGEGVGRSKKEA
EQLAAKEALIAFNRRYADL
>Mature_258_residues
TKDKRRFDRQGSAQRRRRQEMERARILELFKSLEERLDVQFSNHDLLMQAFTHSSYVNEQRGLRKDNERLEFLGDAVLEL
TVSRFLYETYPERSEGELTKLRAAIVCEPSLVNFAEAFAFSDFILLGKGEELTGGRKRPALLADVFESYIGALYLDQGIE
AVERFLAEAVFPKVLAGVFEEQTDFKSQLQESVQREGLGPVSYEIIEERGPAHSREFVAHARLSDDIVGEGVGRSKKEAE
QLAAKEALIAFNRRYADL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=246, Percent_Identity=30.8943089430894, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI155030236, Length=246, Percent_Identity=30.8943089430894, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788920, Length=214, Percent_Identity=34.5794392523364, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17506883, Length=168, Percent_Identity=37.5, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=168, Percent_Identity=37.5, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17552834, Length=165, Percent_Identity=32.7272727272727, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323895, Length=232, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=238, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17738129, Length=267, Percent_Identity=29.2134831460674, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 29602; Mature: 29471

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDKRRFDRQGSAQRRRRQEMERARILELFKSLEERLDVQFSNHDLLMQAFTHSSYVNE
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
QRGLRKDNERLEFLGDAVLELTVSRFLYETYPERSEGELTKLRAAIVCEPSLVNFAEAFA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
FSDFILLGKGEELTGGRKRPALLADVFESYIGALYLDQGIEAVERFLAEAVFPKVLAGVF
HHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEQTDFKSQLQESVQREGLGPVSYEIIEERGPAHSREFVAHARLSDDIVGEGVGRSKKEA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
EQLAAKEALIAFNRRYADL
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKDKRRFDRQGSAQRRRRQEMERARILELFKSLEERLDVQFSNHDLLMQAFTHSSYVNE
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
QRGLRKDNERLEFLGDAVLELTVSRFLYETYPERSEGELTKLRAAIVCEPSLVNFAEAFA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
FSDFILLGKGEELTGGRKRPALLADVFESYIGALYLDQGIEAVERFLAEAVFPKVLAGVF
HHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEQTDFKSQLQESVQREGLGPVSYEIIEERGPAHSREFVAHARLSDDIVGEGVGRSKKEA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
EQLAAKEALIAFNRRYADL
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA