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The map label for this gene is panE [C]

Identifier: 229918541

GI number: 229918541

Start: 2790451

End: 2791293

Strand: Direct

Name: panE [C]

Synonym: EAT1b_2828

Alternate gene names: 229918541

Gene position: 2790451-2791293 (Clockwise)

Preceding gene: 229918540

Following gene: 229918542

Centisome position: 93.02

GC content: 50.65

Gene sequence:

>843_bases
ATGATGAACTCCATCAAACGAATTGGTATCATCGGAAACGGAGCGGTCGGATTATTGATGGCATCTTTGCTCGCAAATGA
TTACGACGTGACGCTCTACGGAAGAAGCGGGTCATCTGATCCACTTGTCATCACACGGACCGGCGTGACGGAAGGGACGG
CACGTGTGTCGTTACGTTCCAGTCAGACGCTTCAAGAAACAGACGAGGATCTCTTTTTTGTCACGACGAAAGCCCATCAA
GTCGAAGAAGCGACGGCTCGCCTCTCGGGTAAAGTGCCCGTCTTTATTTGTTCGAATGGGATTGCCCATCTGGAATATGC
GAAACGTCGAGGGTTTCATTTAGGTGTCGTCGAGCATGGGGTGACGAAGCGTGGTCATGAGGTTGAGCATCGTGGACTCG
GACGGATTCGAATTGGAAGCACGTCGGGGCTCCATCCTCTATCATTTCAAGAGAGCCCACTTCACATCGTGTGGGAAGAA
GAAATCGAGCAAGTCGTCATTGAAAAATTGTTTGCCAATGCCATCATCAATCCCATCACGGCGTTATGCCGGGTCTCGAA
CGGCGCGCTCGCCGGCTCACCATATCGTGAAATCGCACAATCGATTTACGATGAGTTGACGCCGTTGTTTGCGCAGCAAG
TCTCGTATTCCTACATCGAAACGATTATCGAACGTACCGCACAGAATCGCTCCTCGATGCTGCGCGATCTTGAAGAAGGT
CGGCCGACCGAGGTGGATGCAATTCTGAAACCGGTGATTGAAAAAGCCGAACAGATGCAGATTTCTCTCACTGTCATTCC
GCTATTACATAAACTGATTCTAGGAGCGAGCGCATCGTGTTAG

Upstream 100 bases:

>100_bases
CTGTTCTCAGGTCGCTCCTTTTTTGTTTGTCATTTTTGGGTCATGGCGAAAAGATGTGGTAAACTTTTTGTGCGAAAATA
GTTCGAATAGGAGGAGGACC

Downstream 100 bases:

>100_bases
TGTATATCGTTTCATTTCCACTCATCTTATGGTTTATGGTGTATATGATACTTAGAAAAATTATGCCGAAATCAATCAAC
TCATTCAAGCTCGCATGCGA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MMNSIKRIGIIGNGAVGLLMASLLANDYDVTLYGRSGSSDPLVITRTGVTEGTARVSLRSSQTLQETDEDLFFVTTKAHQ
VEEATARLSGKVPVFICSNGIAHLEYAKRRGFHLGVVEHGVTKRGHEVEHRGLGRIRIGSTSGLHPLSFQESPLHIVWEE
EIEQVVIEKLFANAIINPITALCRVSNGALAGSPYREIAQSIYDELTPLFAQQVSYSYIETIIERTAQNRSSMLRDLEEG
RPTEVDAILKPVIEKAEQMQISLTVIPLLHKLILGASASC

Sequences:

>Translated_280_residues
MMNSIKRIGIIGNGAVGLLMASLLANDYDVTLYGRSGSSDPLVITRTGVTEGTARVSLRSSQTLQETDEDLFFVTTKAHQ
VEEATARLSGKVPVFICSNGIAHLEYAKRRGFHLGVVEHGVTKRGHEVEHRGLGRIRIGSTSGLHPLSFQESPLHIVWEE
EIEQVVIEKLFANAIINPITALCRVSNGALAGSPYREIAQSIYDELTPLFAQQVSYSYIETIIERTAQNRSSMLRDLEEG
RPTEVDAILKPVIEKAEQMQISLTVIPLLHKLILGASASC
>Mature_280_residues
MMNSIKRIGIIGNGAVGLLMASLLANDYDVTLYGRSGSSDPLVITRTGVTEGTARVSLRSSQTLQETDEDLFFVTTKAHQ
VEEATARLSGKVPVFICSNGIAHLEYAKRRGFHLGVVEHGVTKRGHEVEHRGLGRIRIGSTSGLHPLSFQESPLHIVWEE
EIEQVVIEKLFANAIINPITALCRVSNGALAGSPYREIAQSIYDELTPLFAQQVSYSYIETIIERTAQNRSSMLRDLEEG
RPTEVDAILKPVIEKAEQMQISLTVIPLLHKLILGASASC

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=267, Percent_Identity=27.7153558052434, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 30705; Mature: 30705

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNSIKRIGIIGNGAVGLLMASLLANDYDVTLYGRSGSSDPLVITRTGVTEGTARVSLRS
CCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEECC
SQTLQETDEDLFFVTTKAHQVEEATARLSGKVPVFICSNGIAHLEYAKRRGFHLGVVEHG
CCHHHHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEHHHHC
VTKRGHEVEHRGLGRIRIGSTSGLHPLSFQESPLHIVWEEEIEQVVIEKLFANAIINPIT
CCCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
ALCRVSNGALAGSPYREIAQSIYDELTPLFAQQVSYSYIETIIERTAQNRSSMLRDLEEG
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPTEVDAILKPVIEKAEQMQISLTVIPLLHKLILGASASC
CCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMNSIKRIGIIGNGAVGLLMASLLANDYDVTLYGRSGSSDPLVITRTGVTEGTARVSLRS
CCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEECC
SQTLQETDEDLFFVTTKAHQVEEATARLSGKVPVFICSNGIAHLEYAKRRGFHLGVVEHG
CCHHHHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEHHHHC
VTKRGHEVEHRGLGRIRIGSTSGLHPLSFQESPLHIVWEEEIEQVVIEKLFANAIINPIT
CCCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
ALCRVSNGALAGSPYREIAQSIYDELTPLFAQQVSYSYIETIIERTAQNRSSMLRDLEEG
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPTEVDAILKPVIEKAEQMQISLTVIPLLHKLILGASASC
CCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]