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The map label for this gene is mdtG [H]

Identifier: 229918514

GI number: 229918514

Start: 2766736

End: 2767908

Strand: Reverse

Name: mdtG [H]

Synonym: EAT1b_2801

Alternate gene names: 229918514

Gene position: 2767908-2766736 (Counterclockwise)

Preceding gene: 229918515

Following gene: 229918511

Centisome position: 92.27

GC content: 52.94

Gene sequence:

>1173_bases
ATGGTTGTTTGGATCGGTAGCTTCTTGACCGCCGCGTCGATGAGTCTCGTCCTTCCATTCCTCCCATTGTTCATCGAACA
ACTCGGGGTAAAGGATCCGGACCACGTCGTCACTTGGTCTGCGATCGCGTTCGGCGCCACGTTCCTCGTGGCCGCCATCG
TCTCTCCGATGTGGGGACGCTTGGCTGACCGAAAAGGAAGAAAGCTGATGCTCATCCGAGCCAGTCTCGGGATGGCCATC
GTCATGTTCCTCATCAGCTTCGTCCAAGACGTATATCAACTCGTCGGGTTGCGTTTACTCATGGGAGCCGTGTCTGGATT
TATTTCAGCCGGCATCACGTTGGTCGCATCTCAAACACCAAAAGAGAAAAGTGGCTGGGCGCTCGGTACCCTGTCAACCG
GTGGAATCACTGGTGGTCTACTCGGTCCCCTCATCGGCGGACTGCTCGCAGACTGGATTGGGCTTCGATCCGTTTTTCTC
TTTACCGGAAGTGCACTCTTCCTGACGTTCCTCATCACGCTTTGGTTCGTAAAAGAAGATTTTGTCCCAGTGAAACGCGA
AGAACTCGCGTCGATGAAATCGATTTTTGCCTCACTGCGACATCCACAGTTGATTGTCGGTCTGTTTGTGACAACGTTCC
TCATTCAGTTCTCGACACAATCCATCGGACCACTCTTGACGTTATACGTACGTGAATTGAATCCGAACACTACCGCGCTC
GCCTTCATGGCAGGGATTGTCGCCTCTGCTCCGGGACTGGCCGCTCTCGTTTCGGCGCAGTGTCTCGGACGGTTATCGGA
CAGACACGGAGCAGAGCGCATCTTGTTTTGGGCACTGCTCCTCTATAGCCTCTTCTTGATTCCGCAAGCATTCGTTACCT
CAACGACTCAACTCATCTTGTTGCGTTTCGGAATCGGGTTCGCAACGGCCGCCTTGATGCCGTCCGTTCAATCGCTACTG
CGCCAGCATACGCCGGTCTCTGCGACGGGGCGCATCTTTTCATACAATCAGTCCGCTCAGTTCATGGGGAATCTACTCGG
ACCGCTATTTGGATCCCAAATCGTGGCACACTTCGGATTTTCTGCCCTGTTCATCATCACGGGATTGATTATGATCTCGA
ATGCCTTTTTAGAACGGACGAACGTCCAGTCGTTACAACTCGATACAAAATAA

Upstream 100 bases:

>100_bases
TGGACTTTTTAGTTCACAAAGTGTAGTATATAGAGTGTTGACTACAAATTGAATAAGAAAGGTCGTGACGCTTACGATAC
CTCTATGGAAACGAAATTTA

Downstream 100 bases:

>100_bases
CGCCGAGCACGAAGCTCGGCGTTATTTGTGTATATCGCTTATAGTAAATCAGCCGCCAATCGTGCAAGGGATGAACGTTC
CCCTTTCACGAGTTGCACGT

Product: major facilitator superfamily MFS_1

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MVVWIGSFLTAASMSLVLPFLPLFIEQLGVKDPDHVVTWSAIAFGATFLVAAIVSPMWGRLADRKGRKLMLIRASLGMAI
VMFLISFVQDVYQLVGLRLLMGAVSGFISAGITLVASQTPKEKSGWALGTLSTGGITGGLLGPLIGGLLADWIGLRSVFL
FTGSALFLTFLITLWFVKEDFVPVKREELASMKSIFASLRHPQLIVGLFVTTFLIQFSTQSIGPLLTLYVRELNPNTTAL
AFMAGIVASAPGLAALVSAQCLGRLSDRHGAERILFWALLLYSLFLIPQAFVTSTTQLILLRFGIGFATAALMPSVQSLL
RQHTPVSATGRIFSYNQSAQFMGNLLGPLFGSQIVAHFGFSALFIITGLIMISNAFLERTNVQSLQLDTK

Sequences:

>Translated_390_residues
MVVWIGSFLTAASMSLVLPFLPLFIEQLGVKDPDHVVTWSAIAFGATFLVAAIVSPMWGRLADRKGRKLMLIRASLGMAI
VMFLISFVQDVYQLVGLRLLMGAVSGFISAGITLVASQTPKEKSGWALGTLSTGGITGGLLGPLIGGLLADWIGLRSVFL
FTGSALFLTFLITLWFVKEDFVPVKREELASMKSIFASLRHPQLIVGLFVTTFLIQFSTQSIGPLLTLYVRELNPNTTAL
AFMAGIVASAPGLAALVSAQCLGRLSDRHGAERILFWALLLYSLFLIPQAFVTSTTQLILLRFGIGFATAALMPSVQSLL
RQHTPVSATGRIFSYNQSAQFMGNLLGPLFGSQIVAHFGFSALFIITGLIMISNAFLERTNVQSLQLDTK
>Mature_390_residues
MVVWIGSFLTAASMSLVLPFLPLFIEQLGVKDPDHVVTWSAIAFGATFLVAAIVSPMWGRLADRKGRKLMLIRASLGMAI
VMFLISFVQDVYQLVGLRLLMGAVSGFISAGITLVASQTPKEKSGWALGTLSTGGITGGLLGPLIGGLLADWIGLRSVFL
FTGSALFLTFLITLWFVKEDFVPVKREELASMKSIFASLRHPQLIVGLFVTTFLIQFSTQSIGPLLTLYVRELNPNTTAL
AFMAGIVASAPGLAALVSAQCLGRLSDRHGAERILFWALLLYSLFLIPQAFVTSTTQLILLRFGIGFATAALMPSVQSLL
RQHTPVSATGRIFSYNQSAQFMGNLLGPLFGSQIVAHFGFSALFIITGLIMISNAFLERTNVQSLQLDTK

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=375, Percent_Identity=52.2666666666667, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI87082404, Length=379, Percent_Identity=23.7467018469657, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161078541, Length=343, Percent_Identity=25.9475218658892, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42142; Mature: 42142

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVWIGSFLTAASMSLVLPFLPLFIEQLGVKDPDHVVTWSAIAFGATFLVAAIVSPMWGR
CEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
LADRKGRKLMLIRASLGMAIVMFLISFVQDVYQLVGLRLLMGAVSGFISAGITLVASQTP
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
KEKSGWALGTLSTGGITGGLLGPLIGGLLADWIGLRSVFLFTGSALFLTFLITLWFVKED
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FVPVKREELASMKSIFASLRHPQLIVGLFVTTFLIQFSTQSIGPLLTLYVRELNPNTTAL
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AFMAGIVASAPGLAALVSAQCLGRLSDRHGAERILFWALLLYSLFLIPQAFVTSTTQLIL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRFGIGFATAALMPSVQSLLRQHTPVSATGRIFSYNQSAQFMGNLLGPLFGSQIVAHFGF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SALFIITGLIMISNAFLERTNVQSLQLDTK
HHHHHHHHHHHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MVVWIGSFLTAASMSLVLPFLPLFIEQLGVKDPDHVVTWSAIAFGATFLVAAIVSPMWGR
CEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
LADRKGRKLMLIRASLGMAIVMFLISFVQDVYQLVGLRLLMGAVSGFISAGITLVASQTP
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
KEKSGWALGTLSTGGITGGLLGPLIGGLLADWIGLRSVFLFTGSALFLTFLITLWFVKED
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FVPVKREELASMKSIFASLRHPQLIVGLFVTTFLIQFSTQSIGPLLTLYVRELNPNTTAL
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AFMAGIVASAPGLAALVSAQCLGRLSDRHGAERILFWALLLYSLFLIPQAFVTSTTQLIL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRFGIGFATAALMPSVQSLLRQHTPVSATGRIFSYNQSAQFMGNLLGPLFGSQIVAHFGF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SALFIITGLIMISNAFLERTNVQSLQLDTK
HHHHHHHHHHHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA