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The map label for this gene is tlpA [H]

Identifier: 229918412

GI number: 229918412

Start: 2663350

End: 2665122

Strand: Direct

Name: tlpA [H]

Synonym: EAT1b_2697

Alternate gene names: 229918412

Gene position: 2663350-2665122 (Clockwise)

Preceding gene: 229918410

Following gene: 229918414

Centisome position: 88.78

GC content: 50.54

Gene sequence:

>1773_bases
ATGGACGTGAAACGATTGATTAACCCGATGAAGAAGTGGAAAGGCTGGACCATAAAACGAAGTGGTACGAAACAGAAAGG
ACGCTCGTCCCTGAGACGACGGATGTCCATCGCACTCATTCCGACGATCATTGCTCTCGTCATTGTCGGCGCGCTCGGGT
CTTATCAATTGAGACAATCGACTGCTGCTTATGACCGGGTCCTCAGTGAAGGCATGCAGGAGATGCTGCTTGCGGAGAAT
CTATCACTAGCGGTGACGGATGCCGAACGCTATTTGAACTACTATATGCTTGTGGCCAATCCGAAGACGCTCATCAGTTT
ACAGGGAGCTCAAGAGCAGCGAGACGAATTGATGAAGAAACTGAAAGCATCATCATCTGATGAAAAGGTCTTGTCTTGGT
TGGGCGATTTGGAGAAATTTAACGAGCTACTAGACCGTGAGATGAACCGTGCCGTCGAACTTCGTCAACAACAAGACGAA
ATCGGCTATAAGACGGTGCTCAACACAAGTGTGACACCGACGACGGACCGAGTTCGGATGACGGTGACAGACCTTGTTGA
ATACAAGGACGAACTCCTCGCATCCGAGACGAAAGCTGTACAGGCTGAAGCGGAAAGTTCAATCCTCTGGATGCTCATCA
TCAGCATTGGCGGTGTCGTGATTGGAGTTCTGTCTTTACTTGCCTTACAGCGCCTCTTCTTGAAACCAATCAATCGACTT
GGTCGTCAGGCACGCATCATGGCAGAAGGGGATTTGACGGGAGAAGATATCGAGGTCGCCTCTAACGATGAACTAGGAGA
CCTGGTAACGGCATTCAATGAAATGAAGCATAACCTGGTCGGCTTGATTCGTCGGGTTGGAGAAGCGTCGGACAAAGTGA
CCGCTTACTCTGAAGAACTTTACGCAAGCACAGACCATGTCGCGACAACGACCCAAGGCGTCTCTCGATTGTTCGAAGAG
ATGAATGTGGCTGCGCAAGGATCCTCGAAGCGAGCGGAAGAAGGAACGATTGGTGTCAATCAAGCGGTCGATGGTTTGAA
TCAAATCGCTGCGGCATCGCAAGGTGTGAATGAGCAGACGATACATACACTCGAGGCGGCGAACGGTGGACTTGAGACCG
TTCAATTGGCAGAGAAACGAATGCAAGAAATTCGACGTGCCAACGAGCTCACCCAACAGATGGTGAACCGTCTATCGAAT
CAGTCGCTTGAGATTGAAAAGATTACCCGTTCCATCACGGCCATCACGGAACAGACGAACTTACTTGCTTTAAATGCGGC
GATTGAAGCGGCACGTGCGGGTGAACACGGAAAAGGGTTTGCCGTCGTCGCGGCAGAAGTGAGAAAGCTCGCTGAGGAAT
CGAAACAATCCGCCATTCAAATCCAGACCGTCGTCCGTGACATTCAACGTGACACGGAACAAGTCGAATCGGCGTTCGAA
GAATCGAGCGTACATGTGGAGAATGGGGTATCACAGATGGGAGAAGTGGCTGAGGCGTTCCGGGAGATCGTATCGGTCAT
CGAAGAGACGTCGCGTCAAATGAGTGAGATTGCGGCAGCGACAGAGGAAGTGAGTGCCAACACGACTGAAGTTGCTGTCT
CTGTTGAAGATATGTCGACGAACGCCGTCTCGACACAGCGTAGCGTCGAAGAAGCGGGCGCCAATGTTGAGGAACAGCTG
GCAGCCATTCAAGAGATCAACGGTATCGCTGAAACGATGAGTCACATGTCGTCTGAATTAAAAGATGTCGTCCATGTGTT
TAAAACGACATAA

Upstream 100 bases:

>100_bases
AAATTTATCCACCTCATTTCGAAAAATCGATTTGATTCGTGAAAACGTTTGCATTAATGTCAAGTTGAGAAGAAATCCGA
GATGAAGGAGAACGAATGAC

Downstream 100 bases:

>100_bases
AAAATGCCCTGACGTGCGCGTCAGGGCATTGCTCGTTACATTAATAAGATAAGACTTGTCGCCATGACGATCATGCCGGC
GACCATTCCATACATCGAAT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MDVKRLINPMKKWKGWTIKRSGTKQKGRSSLRRRMSIALIPTIIALVIVGALGSYQLRQSTAAYDRVLSEGMQEMLLAEN
LSLAVTDAERYLNYYMLVANPKTLISLQGAQEQRDELMKKLKASSSDEKVLSWLGDLEKFNELLDREMNRAVELRQQQDE
IGYKTVLNTSVTPTTDRVRMTVTDLVEYKDELLASETKAVQAEAESSILWMLIISIGGVVIGVLSLLALQRLFLKPINRL
GRQARIMAEGDLTGEDIEVASNDELGDLVTAFNEMKHNLVGLIRRVGEASDKVTAYSEELYASTDHVATTTQGVSRLFEE
MNVAAQGSSKRAEEGTIGVNQAVDGLNQIAAASQGVNEQTIHTLEAANGGLETVQLAEKRMQEIRRANELTQQMVNRLSN
QSLEIEKITRSITAITEQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAEESKQSAIQIQTVVRDIQRDTEQVESAFE
ESSVHVENGVSQMGEVAEAFREIVSVIEETSRQMSEIAAATEEVSANTTEVAVSVEDMSTNAVSTQRSVEEAGANVEEQL
AAIQEINGIAETMSHMSSELKDVVHVFKTT

Sequences:

>Translated_590_residues
MDVKRLINPMKKWKGWTIKRSGTKQKGRSSLRRRMSIALIPTIIALVIVGALGSYQLRQSTAAYDRVLSEGMQEMLLAEN
LSLAVTDAERYLNYYMLVANPKTLISLQGAQEQRDELMKKLKASSSDEKVLSWLGDLEKFNELLDREMNRAVELRQQQDE
IGYKTVLNTSVTPTTDRVRMTVTDLVEYKDELLASETKAVQAEAESSILWMLIISIGGVVIGVLSLLALQRLFLKPINRL
GRQARIMAEGDLTGEDIEVASNDELGDLVTAFNEMKHNLVGLIRRVGEASDKVTAYSEELYASTDHVATTTQGVSRLFEE
MNVAAQGSSKRAEEGTIGVNQAVDGLNQIAAASQGVNEQTIHTLEAANGGLETVQLAEKRMQEIRRANELTQQMVNRLSN
QSLEIEKITRSITAITEQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAEESKQSAIQIQTVVRDIQRDTEQVESAFE
ESSVHVENGVSQMGEVAEAFREIVSVIEETSRQMSEIAAATEEVSANTTEVAVSVEDMSTNAVSTQRSVEEAGANVEEQL
AAIQEINGIAETMSHMSSELKDVVHVFKTT
>Mature_590_residues
MDVKRLINPMKKWKGWTIKRSGTKQKGRSSLRRRMSIALIPTIIALVIVGALGSYQLRQSTAAYDRVLSEGMQEMLLAEN
LSLAVTDAERYLNYYMLVANPKTLISLQGAQEQRDELMKKLKASSSDEKVLSWLGDLEKFNELLDREMNRAVELRQQQDE
IGYKTVLNTSVTPTTDRVRMTVTDLVEYKDELLASETKAVQAEAESSILWMLIISIGGVVIGVLSLLALQRLFLKPINRL
GRQARIMAEGDLTGEDIEVASNDELGDLVTAFNEMKHNLVGLIRRVGEASDKVTAYSEELYASTDHVATTTQGVSRLFEE
MNVAAQGSSKRAEEGTIGVNQAVDGLNQIAAASQGVNEQTIHTLEAANGGLETVQLAEKRMQEIRRANELTQQMVNRLSN
QSLEIEKITRSITAITEQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAEESKQSAIQIQTVVRDIQRDTEQVESAFE
ESSVHVENGVSQMGEVAEAFREIVSVIEETSRQMSEIAAATEEVSANTTEVAVSVEDMSTNAVSTQRSVEEAGANVEEQL
AAIQEINGIAETMSHMSSELKDVVHVFKTT

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=363, Percent_Identity=30.8539944903581, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788195, Length=310, Percent_Identity=29.6774193548387, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI2367378, Length=338, Percent_Identity=30.4733727810651, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788194, Length=356, Percent_Identity=29.2134831460674, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1789453, Length=386, Percent_Identity=25.1295336787565, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 64875; Mature: 64875

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKRLINPMKKWKGWTIKRSGTKQKGRSSLRRRMSIALIPTIIALVIVGALGSYQLRQS
CCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAAYDRVLSEGMQEMLLAENLSLAVTDAERYLNYYMLVANPKTLISLQGAQEQRDELMKK
HHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHEEEEEECCCCEEEECCCHHHHHHHHHH
LKASSSDEKVLSWLGDLEKFNELLDREMNRAVELRQQQDEIGYKTVLNTSVTPTTDRVRM
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHH
TVTDLVEYKDELLASETKAVQAEAESSILWMLIISIGGVVIGVLSLLALQRLFLKPINRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRQARIMAEGDLTGEDIEVASNDELGDLVTAFNEMKHNLVGLIRRVGEASDKVTAYSEEL
CHHHEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
YASTDHVATTTQGVSRLFEEMNVAAQGSSKRAEEGTIGVNQAVDGLNQIAAASQGVNEQT
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
IHTLEAANGGLETVQLAEKRMQEIRRANELTQQMVNRLSNQSLEIEKITRSITAITEQTN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
LLALNAAIEAARAGEHGKGFAVVAAEVRKLAEESKQSAIQIQTVVRDIQRDTEQVESAFE
CEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESSVHVENGVSQMGEVAEAFREIVSVIEETSRQMSEIAAATEEVSANTTEVAVSVEDMST
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
NAVSTQRSVEEAGANVEEQLAAIQEINGIAETMSHMSSELKDVVHVFKTT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDVKRLINPMKKWKGWTIKRSGTKQKGRSSLRRRMSIALIPTIIALVIVGALGSYQLRQS
CCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAAYDRVLSEGMQEMLLAENLSLAVTDAERYLNYYMLVANPKTLISLQGAQEQRDELMKK
HHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHEEEEEECCCCEEEECCCHHHHHHHHHH
LKASSSDEKVLSWLGDLEKFNELLDREMNRAVELRQQQDEIGYKTVLNTSVTPTTDRVRM
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHH
TVTDLVEYKDELLASETKAVQAEAESSILWMLIISIGGVVIGVLSLLALQRLFLKPINRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRQARIMAEGDLTGEDIEVASNDELGDLVTAFNEMKHNLVGLIRRVGEASDKVTAYSEEL
CHHHEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
YASTDHVATTTQGVSRLFEEMNVAAQGSSKRAEEGTIGVNQAVDGLNQIAAASQGVNEQT
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
IHTLEAANGGLETVQLAEKRMQEIRRANELTQQMVNRLSNQSLEIEKITRSITAITEQTN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
LLALNAAIEAARAGEHGKGFAVVAAEVRKLAEESKQSAIQIQTVVRDIQRDTEQVESAFE
CEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESSVHVENGVSQMGEVAEAFREIVSVIEETSRQMSEIAAATEEVSANTTEVAVSVEDMST
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
NAVSTQRSVEEAGANVEEQLAAIQEINGIAETMSHMSSELKDVVHVFKTT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]