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The map label for this gene is guaA [H]

Identifier: 229917939

GI number: 229917939

Start: 2154974

End: 2156515

Strand: Direct

Name: guaA [H]

Synonym: EAT1b_2218

Alternate gene names: 229917939

Gene position: 2154974-2156515 (Clockwise)

Preceding gene: 229917938

Following gene: 229917940

Centisome position: 71.83

GC content: 49.09

Gene sequence:

>1542_bases
GTGAAAGTAGAACAAGAAATGATTTTGGTGCTTGATTTTGGTGGTCAGTATAACCAGTTGATCACACGTCGTGTCCGTGA
CCTTGGCGTATACAGCGAGTTGCATTCACATAAGATGACGGCAGCGGAGATTCGCGAATTGAACCCGATCGGCATCATCT
TCTCGGGTGGACCGAACAGCGTATACGCGGAAGGCGCATATCGTTGTGATCCAGAGATCTTTGAACTGGGTATTCCAATC
TTCGGGATCTGCTACGGGATGCAACTCATGACGCATCATTTCGGTGGTCGTGTCGAACGTGCCGCTCATCGTGAATACGG
AAAAGCGACATTGTTCTCAACGCCGGAAGCATCAGCGATTTATAACGGGCTTCCAGTCGAACATACAGTATGGATGAGCC
ACGGTGACCTCGTCATGGAAGCACCGGAAGGATTTATCGTCGATGGAACGAACCCGTCTTGCCCGGTCGCTTCAATCAAA
AACGATGAGTTGAAAATGTACGGTGTCCAATACCATCCAGAGGTTCGTCACTCGGAGTACGGAAACGACATCTTAAAAAA
CTTCATCTATGAAGTATGTGGTGCGAAAGGCGAATGGTCGATGGAAAACTTTATCGACCTCGAAGTGGAGAAAATCCGTG
AAATCGTTGGCGATAAGCAAGTTCTTTGTGCGCTTTCGGGCGGTGTCGACTCTTCTGTCGTGGCCGCACTCGTTCATCGC
GCAATCGGTGACCAGTTGACGTGTATGTTTGTCGACCATGGTCTCCTTCGTAAAGGGGAAGCGGATAGCGTCATGAAGAC
GTTCGCAGACGGATTCAACATGAAGGTCATCAAAATCGATGCACAAGAACGTTTCTTGACGAAGTTGGCTGGTGTCTCGG
ACCCTGAGCAAAAACGTAAGATTATCGGAAACGAGTTCATCTACGTATTTGATGAAGAAGCATCGAAACTCGTCGATATG
GACTTCCTCGCACAGGGGACGCTCTACACAGACATCATCGAGAGTGGGACAGACACAGCGCAAACAATCAAATCACACCA
TAACGTCGGTGGATTGCCGGAAGATATGAACTTCACGTTGATCGAACCACTCAACACGCTCTTTAAAGACGAGGTCCGTG
CACTCGGTACAGAACTCGGTCTTCCTGACTATATCGTTTGGCGCCAACCGTTCCCAGGTCCAGGTCTCGGAATTCGTGTC
CTCGGTGAAATCACGGAAGAGAAGTTAGAAATCGTGCGTGAATCTGATGCGATTCTACGTGAAGAAGTGAAGAAAGCTGG
ACTTGAACGCGACATCTGGCAATACTTCACGGTGCTCACGCCGATTCGCTCGGTCGGAGTCATGGGTGACGAGCGTACGT
ATGACTATGCTGTCGGTGTCCGTGCGGTCACTTCAATTGATGGCATGACGTCTGATTGGGCACGTATTCCATGGGATGTG
CTTGAGAAGATCTCTGTCCGGATTGTAAACGAAGTCAGCCACGTTAACCGTGTGCTGTATGATATTACGTCTAAGCCACC
TGCAACAATTGAATGGGAATAA

Upstream 100 bases:

>100_bases
TTCGTATACAAAGAAAAGGGCGTGCTTCTTCTTCGGTTTGGGTTAATCTGGGGGAGAGGCGCGTCCTTTTTTGAGGAGAA
GGCAGAAAGGTGGAGATTTC

Downstream 100 bases:

>100_bases
GCTGAACAGAGGGGATATCCCCTCTGTTTTGTCTTAAAACCGAACATTAACGTTTTTTATCGATGTAAAATCCGTGAATT
TAGTTGACATTCTATTTTCA

Product: GMP synthase, large subunit

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKVEQEMILVLDFGGQYNQLITRRVRDLGVYSELHSHKMTAAEIRELNPIGIIFSGGPNSVYAEGAYRCDPEIFELGIPI
FGICYGMQLMTHHFGGRVERAAHREYGKATLFSTPEASAIYNGLPVEHTVWMSHGDLVMEAPEGFIVDGTNPSCPVASIK
NDELKMYGVQYHPEVRHSEYGNDILKNFIYEVCGAKGEWSMENFIDLEVEKIREIVGDKQVLCALSGGVDSSVVAALVHR
AIGDQLTCMFVDHGLLRKGEADSVMKTFADGFNMKVIKIDAQERFLTKLAGVSDPEQKRKIIGNEFIYVFDEEASKLVDM
DFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMNFTLIEPLNTLFKDEVRALGTELGLPDYIVWRQPFPGPGLGIRV
LGEITEEKLEIVRESDAILREEVKKAGLERDIWQYFTVLTPIRSVGVMGDERTYDYAVGVRAVTSIDGMTSDWARIPWDV
LEKISVRIVNEVSHVNRVLYDITSKPPATIEWE

Sequences:

>Translated_513_residues
MKVEQEMILVLDFGGQYNQLITRRVRDLGVYSELHSHKMTAAEIRELNPIGIIFSGGPNSVYAEGAYRCDPEIFELGIPI
FGICYGMQLMTHHFGGRVERAAHREYGKATLFSTPEASAIYNGLPVEHTVWMSHGDLVMEAPEGFIVDGTNPSCPVASIK
NDELKMYGVQYHPEVRHSEYGNDILKNFIYEVCGAKGEWSMENFIDLEVEKIREIVGDKQVLCALSGGVDSSVVAALVHR
AIGDQLTCMFVDHGLLRKGEADSVMKTFADGFNMKVIKIDAQERFLTKLAGVSDPEQKRKIIGNEFIYVFDEEASKLVDM
DFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMNFTLIEPLNTLFKDEVRALGTELGLPDYIVWRQPFPGPGLGIRV
LGEITEEKLEIVRESDAILREEVKKAGLERDIWQYFTVLTPIRSVGVMGDERTYDYAVGVRAVTSIDGMTSDWARIPWDV
LEKISVRIVNEVSHVNRVLYDITSKPPATIEWE
>Mature_513_residues
MKVEQEMILVLDFGGQYNQLITRRVRDLGVYSELHSHKMTAAEIRELNPIGIIFSGGPNSVYAEGAYRCDPEIFELGIPI
FGICYGMQLMTHHFGGRVERAAHREYGKATLFSTPEASAIYNGLPVEHTVWMSHGDLVMEAPEGFIVDGTNPSCPVASIK
NDELKMYGVQYHPEVRHSEYGNDILKNFIYEVCGAKGEWSMENFIDLEVEKIREIVGDKQVLCALSGGVDSSVVAALVHR
AIGDQLTCMFVDHGLLRKGEADSVMKTFADGFNMKVIKIDAQERFLTKLAGVSDPEQKRKIIGNEFIYVFDEEASKLVDM
DFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMNFTLIEPLNTLFKDEVRALGTELGLPDYIVWRQPFPGPGLGIRV
LGEITEEKLEIVRESDAILREEVKKAGLERDIWQYFTVLTPIRSVGVMGDERTYDYAVGVRAVTSIDGMTSDWARIPWDV
LEKISVRIVNEVSHVNRVLYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=38.1818181818182, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=52.1988527724665, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1789760, Length=156, Percent_Identity=32.6923076923077, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=37.5438596491228, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=37.5438596491228, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=37.5438596491228, Blast_Score=315, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=51.5503875968992, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=36.976320582878, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57479; Mature: 57479

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVEQEMILVLDFGGQYNQLITRRVRDLGVYSELHSHKMTAAEIRELNPIGIIFSGGPNS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCC
VYAEGAYRCDPEIFELGIPIFGICYGMQLMTHHFGGRVERAAHREYGKATLFSTPEASAI
EEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECCCCHHHH
YNGLPVEHTVWMSHGDLVMEAPEGFIVDGTNPSCPVASIKNDELKMYGVQYHPEVRHSEY
HCCCCCCEEEEECCCCEEEECCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCHHHC
GNDILKNFIYEVCGAKGEWSMENFIDLEVEKIREIVGDKQVLCALSGGVDSSVVAALVHR
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCMFVDHGLLRKGEADSVMKTFADGFNMKVIKIDAQERFLTKLAGVSDPEQKRK
HHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCHHHHHH
IIGNEFIYVFDEEASKLVDMDFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMNFTL
HCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEE
IEPLNTLFKDEVRALGTELGLPDYIVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEVKKAGLERDIWQYFTVLTPIRSVGVMGDERTYDYAVGVRAVTSIDGMTSDWARIPWDV
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHCCCHHH
LEKISVRIVNEVSHVNRVLYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
>Mature Secondary Structure
MKVEQEMILVLDFGGQYNQLITRRVRDLGVYSELHSHKMTAAEIRELNPIGIIFSGGPNS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCC
VYAEGAYRCDPEIFELGIPIFGICYGMQLMTHHFGGRVERAAHREYGKATLFSTPEASAI
EEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECCCCHHHH
YNGLPVEHTVWMSHGDLVMEAPEGFIVDGTNPSCPVASIKNDELKMYGVQYHPEVRHSEY
HCCCCCCEEEEECCCCEEEECCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCHHHC
GNDILKNFIYEVCGAKGEWSMENFIDLEVEKIREIVGDKQVLCALSGGVDSSVVAALVHR
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCMFVDHGLLRKGEADSVMKTFADGFNMKVIKIDAQERFLTKLAGVSDPEQKRK
HHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCHHHHHH
IIGNEFIYVFDEEASKLVDMDFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDMNFTL
HCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEE
IEPLNTLFKDEVRALGTELGLPDYIVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEVKKAGLERDIWQYFTVLTPIRSVGVMGDERTYDYAVGVRAVTSIDGMTSDWARIPWDV
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHCCCHHH
LEKISVRIVNEVSHVNRVLYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA