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The map label for this gene is yvcT [H]

Identifier: 229917568

GI number: 229917568

Start: 1814730

End: 1815692

Strand: Direct

Name: yvcT [H]

Synonym: EAT1b_1843

Alternate gene names: 229917568

Gene position: 1814730-1815692 (Clockwise)

Preceding gene: 229917567

Following gene: 229917573

Centisome position: 60.49

GC content: 51.4

Gene sequence:

>963_bases
ATGAAGAAACGAATCTATATTACGCGTCGCTTGCCGGAAGAGGCAGTCGAACCGCTTCGCGAACACTACGATGTAAGCAT
GTGGGAGCAGGAAGGGGAAAGTGTGCCGCGAGATGTGCTGTTAGAAGAAGCGTCATCTGCGCATGCGCTTTGGACCATGC
TCAGTGACACGATTGACCGTGAAGTGTTTGAGTGTGCCACACAGTTAGAGGTCGTCTCCAATTTGGCGGTCGGATATAAC
AATATCGATTTGAACGCAGCGAAAGAGCATGGTGTCATCGTCACGAATACACCGGATGTCTTGACGGAAACGACAGCAGA
TTTGACGTTTGGGCTCATGATGATGACCGCACGACGTCTCGGAGAGGCGGAACGTGACTTGCGCGCCGGGGAGTGGAAAT
CCTGGCTGCCGATGGGCTACGTCGGGATGGACCTTTATCAAGCGAAATTGGGTATCATCGGCATGGGACGAATCGGTGAA
GCGGTCGCACGTCGTGCAAGAGGGTTTGATATGGAGGTTCTATATCATAACCGGACACGGCGTCATGAGTCGGAGTCGAT
GTATGGCTTCACTTATGCGGAACTCGATGAGCTGTTGGCGCAATCTGATTTCGTCGTCGTTCTCGCGCCGCTCACGGACG
AGACACGGGGCATGCTCGGAGCCGAAGAGTTTGCAAAAATGAAAGAAACCTCGATTTTCATCAATGTCGCTCGTGGAGAA
ATCATCGATGAACAGGCGCTATACGAAGCACTTAAATCGAAGAAGATTTGGGGAGCCGGGTTAGACGTATTCACGAAAGA
ACCAATCGACCTCGACCATCCATTATTGACGCTTCCGAACGTGACGACGTTGCCACATATCGGGAGTGCCTCGATTCGGA
CACGTCTGGCAATGATGGCATTGAATCGTGATGCCATCGCCAATGTACTCGAAGGGAAAGAACCTAAAAATCGTTTGACG
TAA

Upstream 100 bases:

>100_bases
ACTGTTTGAACAGTATTTGAAGCAAAAGCCGAAGTCGGATCAACCCTCTTAACGCTTTCCATTTGTTAGACTACAAGTAA
GTGTAGAGAGGGGGAGAAAG

Downstream 100 bases:

>100_bases
GAAGAGCCTGACGCACCCGCGTCAGGCTCTTTCTATTAGAAACGTCGGATATTATCCGGATCTTCGACGTCATTTCGATA
AGCGCGATCGTCGAGACCAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: 2KR [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKKRIYITRRLPEEAVEPLREHYDVSMWEQEGESVPRDVLLEEASSAHALWTMLSDTIDREVFECATQLEVVSNLAVGYN
NIDLNAAKEHGVIVTNTPDVLTETTADLTFGLMMMTARRLGEAERDLRAGEWKSWLPMGYVGMDLYQAKLGIIGMGRIGE
AVARRARGFDMEVLYHNRTRRHESESMYGFTYAELDELLAQSDFVVVLAPLTDETRGMLGAEEFAKMKETSIFINVARGE
IIDEQALYEALKSKKIWGAGLDVFTKEPIDLDHPLLTLPNVTTLPHIGSASIRTRLAMMALNRDAIANVLEGKEPKNRLT

Sequences:

>Translated_320_residues
MKKRIYITRRLPEEAVEPLREHYDVSMWEQEGESVPRDVLLEEASSAHALWTMLSDTIDREVFECATQLEVVSNLAVGYN
NIDLNAAKEHGVIVTNTPDVLTETTADLTFGLMMMTARRLGEAERDLRAGEWKSWLPMGYVGMDLYQAKLGIIGMGRIGE
AVARRARGFDMEVLYHNRTRRHESESMYGFTYAELDELLAQSDFVVVLAPLTDETRGMLGAEEFAKMKETSIFINVARGE
IIDEQALYEALKSKKIWGAGLDVFTKEPIDLDHPLLTLPNVTTLPHIGSASIRTRLAMMALNRDAIANVLEGKEPKNRLT
>Mature_320_residues
MKKRIYITRRLPEEAVEPLREHYDVSMWEQEGESVPRDVLLEEASSAHALWTMLSDTIDREVFECATQLEVVSNLAVGYN
NIDLNAAKEHGVIVTNTPDVLTETTADLTFGLMMMTARRLGEAERDLRAGEWKSWLPMGYVGMDLYQAKLGIIGMGRIGE
AVARRARGFDMEVLYHNRTRRHESESMYGFTYAELDELLAQSDFVVVLAPLTDETRGMLGAEEFAKMKETSIFINVARGE
IIDEQALYEALKSKKIWGAGLDVFTKEPIDLDHPLLTLPNVTTLPHIGSASIRTRLAMMALNRDAIANVLEGKEPKNRLT

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=313, Percent_Identity=42.4920127795527, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI23308577, Length=261, Percent_Identity=33.7164750957854, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI145580578, Length=284, Percent_Identity=31.3380281690141, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI4557499, Length=284, Percent_Identity=31.3380281690141, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI145580575, Length=284, Percent_Identity=31.3380281690141, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=31.6205533596838, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=31.6205533596838, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI87082289, Length=319, Percent_Identity=41.3793103448276, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1787645, Length=274, Percent_Identity=30.6569343065693, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789279, Length=294, Percent_Identity=28.9115646258503, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87081824, Length=140, Percent_Identity=32.8571428571429, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=299, Percent_Identity=29.0969899665552, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=30.3149606299213, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=37.603305785124, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=277, Percent_Identity=32.129963898917, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=293, Percent_Identity=30.7167235494881, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=248, Percent_Identity=27.4193548387097, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=177, Percent_Identity=30.5084745762712, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=147, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=149, Percent_Identity=32.2147651006711, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=42.0382165605096, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI28574286, Length=309, Percent_Identity=38.5113268608414, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI45552429, Length=307, Percent_Identity=37.1335504885993, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45551003, Length=307, Percent_Identity=37.1335504885993, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI28574284, Length=307, Percent_Identity=37.1335504885993, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24585514, Length=307, Percent_Identity=37.1335504885993, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI28574282, Length=307, Percent_Identity=37.1335504885993, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=32.7974276527331, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19921140, Length=276, Percent_Identity=32.2463768115942, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646446, Length=303, Percent_Identity=28.0528052805281, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646448, Length=303, Percent_Identity=28.0528052805281, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646452, Length=303, Percent_Identity=28.0528052805281, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646450, Length=303, Percent_Identity=28.0528052805281, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI62472511, Length=303, Percent_Identity=28.0528052805281, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.215 [H]

Molecular weight: Translated: 36035; Mature: 36035

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRIYITRRLPEEAVEPLREHYDVSMWEQEGESVPRDVLLEEASSAHALWTMLSDTIDR
CCCEEEEEECCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
EVFECATQLEVVSNLAVGYNNIDLNAAKEHGVIVTNTPDVLTETTADLTFGLMMMTARRL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
GEAERDLRAGEWKSWLPMGYVGMDLYQAKLGIIGMGRIGEAVARRARGFDMEVLYHNRTR
CHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCEEECCHHHHHHHHHHCCCCEEEEECCHHH
RHESESMYGFTYAELDELLAQSDFVVVLAPLTDETRGMLGAEEFAKMKETSIFINVARGE
CCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHCCCCHHHHHHHHHCEEEEEECCCC
IIDEQALYEALKSKKIWGAGLDVFTKEPIDLDHPLLTLPNVTTLPHIGSASIRTRLAMMA
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHH
LNRDAIANVLEGKEPKNRLT
HCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKRIYITRRLPEEAVEPLREHYDVSMWEQEGESVPRDVLLEEASSAHALWTMLSDTIDR
CCCEEEEEECCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
EVFECATQLEVVSNLAVGYNNIDLNAAKEHGVIVTNTPDVLTETTADLTFGLMMMTARRL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
GEAERDLRAGEWKSWLPMGYVGMDLYQAKLGIIGMGRIGEAVARRARGFDMEVLYHNRTR
CHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCEEECCHHHHHHHHHHCCCCEEEEECCHHH
RHESESMYGFTYAELDELLAQSDFVVVLAPLTDETRGMLGAEEFAKMKETSIFINVARGE
CCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHCCCCHHHHHHHHHCEEEEEECCCC
IIDEQALYEALKSKKIWGAGLDVFTKEPIDLDHPLLTLPNVTTLPHIGSASIRTRLAMMA
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHH
LNRDAIANVLEGKEPKNRLT
HCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]