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The map label for this gene is adhA [H]

Identifier: 229917524

GI number: 229917524

Start: 1766602

End: 1767630

Strand: Reverse

Name: adhA [H]

Synonym: EAT1b_1799

Alternate gene names: 229917524

Gene position: 1767630-1766602 (Counterclockwise)

Preceding gene: 229917529

Following gene: 229917523

Centisome position: 58.92

GC content: 51.7

Gene sequence:

>1029_bases
ATGAAAGCAGTCGTTGTCAATTCAGCAAGCAAAGCCAACATCGAAGTCGTTGAAAAGGAATTACGTCCATTACAAGCAGG
CGAAGCGCTCGTCGATGTCGAGTATTGTGGCGTGTGTCACACGGACCTTCACGTCGCCGCGGGTGACTTCGGAGATGTCC
AAGGACGTGTGCTCGGTCATGAAGGGATCGGGATCGTATCTCAAATCGCCGACGATGTTAAGAGTTTGAAAGTTGGAGAT
CGTGTCAGTATCGCTTGGATGTATCATGCATGTGGTCGCTGTGAATATTGTACGACAGGCCGGGAGACTTTCTGCCGAAA
CGTACAAAATGCCGGCTATAGCGTTGACGGTGGGATGGCCGAGCAAAGTATCGTTGTCGCCGACTATGCCGTCAAAGTAC
CTGATGGATTGGATCCTGCGCAAGCTTCGAGCATCACATGTGCCGGCGTCACGACGTATAAAGCCATCAAAGTCGCAGAC
GTGAAGCCTGGGGAGACGGTCGTCATCTATGGTTGTGGTGGACTCGGGAACCTAGCCATCCAATATGCGAAACACGTCTT
CAACGCGCACGTCATCGCCGTGGATTTGAACGATGATAAGCTCGAACTCGCAAAAGAGAGTGGAGCTGATTTGACGATCA
ACCCATCGACTGATGGAGATGCAGCTGACATCGTACAAGAGAAGTTCGGTGGGGCCCACGCTGCTGTCGTCACAGCCGTC
TCAAAAGTCGCCTTCAATTCAGCGGTCAATGCCGTCCGAGCTTGTGGGAAAGTGGTCGCGGTCGGTCTTCCTTCTGAAAC
GATGGACTTGAACATCCCTCGCCTCGTCCTCGATGGAATCGAAGTCGTCGGTTCACTTGTAGGGACACGGAAAGACTTAG
AAGAAGCCTTCCAGTTCGGGGCAGAAGGACTCGTCGTACCGGTCGTTCATAAACGTTGTCTACACGAGGTGCAAGACGTG
TTCGAAGAGATGGAACAAGGGAAAATTCAAGGACGGATGGTCATCGACTTCAAAAATAAAGACTGCTAA

Upstream 100 bases:

>100_bases
ATAAAGCGCTTTCATTCCATTTTTTGTGATATTCTGACGGTGTGATTGAGAAGGGTTTTCCATCAGGTTCACTAAATTCT
CACAAGGAGTGTGTTCAAAC

Downstream 100 bases:

>100_bases
TCAAAACGGGGCCATGTGCCCCGTTTTGTTCTAGATTGACGTTGACGGGGTATAGTTGCTTTTGTATAGTTAGGAACGTC
TAAAAGCCGGAAATGAAAGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKAVVVNSASKANIEVVEKELRPLQAGEALVDVEYCGVCHTDLHVAAGDFGDVQGRVLGHEGIGIVSQIADDVKSLKVGD
RVSIAWMYHACGRCEYCTTGRETFCRNVQNAGYSVDGGMAEQSIVVADYAVKVPDGLDPAQASSITCAGVTTYKAIKVAD
VKPGETVVIYGCGGLGNLAIQYAKHVFNAHVIAVDLNDDKLELAKESGADLTINPSTDGDAADIVQEKFGGAHAAVVTAV
SKVAFNSAVNAVRACGKVVAVGLPSETMDLNIPRLVLDGIEVVGSLVGTRKDLEEAFQFGAEGLVVPVVHKRCLHEVQDV
FEEMEQGKIQGRMVIDFKNKDC

Sequences:

>Translated_342_residues
MKAVVVNSASKANIEVVEKELRPLQAGEALVDVEYCGVCHTDLHVAAGDFGDVQGRVLGHEGIGIVSQIADDVKSLKVGD
RVSIAWMYHACGRCEYCTTGRETFCRNVQNAGYSVDGGMAEQSIVVADYAVKVPDGLDPAQASSITCAGVTTYKAIKVAD
VKPGETVVIYGCGGLGNLAIQYAKHVFNAHVIAVDLNDDKLELAKESGADLTINPSTDGDAADIVQEKFGGAHAAVVTAV
SKVAFNSAVNAVRACGKVVAVGLPSETMDLNIPRLVLDGIEVVGSLVGTRKDLEEAFQFGAEGLVVPVVHKRCLHEVQDV
FEEMEQGKIQGRMVIDFKNKDC
>Mature_342_residues
MKAVVVNSASKANIEVVEKELRPLQAGEALVDVEYCGVCHTDLHVAAGDFGDVQGRVLGHEGIGIVSQIADDVKSLKVGD
RVSIAWMYHACGRCEYCTTGRETFCRNVQNAGYSVDGGMAEQSIVVADYAVKVPDGLDPAQASSITCAGVTTYKAIKVAD
VKPGETVVIYGCGGLGNLAIQYAKHVFNAHVIAVDLNDDKLELAKESGADLTINPSTDGDAADIVQEKFGGAHAAVVTAV
SKVAFNSAVNAVRACGKVVAVGLPSETMDLNIPRLVLDGIEVVGSLVGTRKDLEEAFQFGAEGLVVPVVHKRCLHEVQDV
FEEMEQGKIQGRMVIDFKNKDC

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=29.041095890411, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=29.3150684931507, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4501929, Length=356, Percent_Identity=29.4943820224719, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI262073058, Length=360, Percent_Identity=25.5555555555556, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI71743840, Length=360, Percent_Identity=25.5555555555556, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI71565154, Length=251, Percent_Identity=31.8725099601594, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=26.7045454545455, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=26.7045454545455, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156627571, Length=312, Percent_Identity=25.9615384615385, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=68.4365781710914, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1787863, Length=334, Percent_Identity=28.4431137724551, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790045, Length=348, Percent_Identity=26.4367816091954, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786518, Length=352, Percent_Identity=27.8409090909091, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786552, Length=356, Percent_Identity=29.2134831460674, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082401, Length=329, Percent_Identity=27.9635258358663, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI226510992, Length=313, Percent_Identity=28.7539936102236, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788073, Length=322, Percent_Identity=28.8819875776398, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87082125, Length=329, Percent_Identity=26.1398176291793, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788075, Length=331, Percent_Identity=25.9818731117825, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790718, Length=311, Percent_Identity=27.9742765273312, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=272, Percent_Identity=28.3088235294118, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788407, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=37.3493975903614, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71988145, Length=315, Percent_Identity=36.8253968253968, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=36.8253968253968, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17562876, Length=256, Percent_Identity=31.640625, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=192, Percent_Identity=33.8541666666667, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=241, Percent_Identity=30.7053941908714, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=243, Percent_Identity=30.4526748971193, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=214, Percent_Identity=30.3738317757009, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=38.801261829653, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319621, Length=317, Percent_Identity=37.8548895899054, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=36.7952522255193, Blast_Score=205, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6323961, Length=317, Percent_Identity=38.1703470031546, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320033, Length=357, Percent_Identity=29.6918767507003, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319949, Length=352, Percent_Identity=28.4090909090909, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323980, Length=337, Percent_Identity=26.1127596439169, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=285, Percent_Identity=30.8771929824561, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=285, Percent_Identity=30.5263157894737, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=289, Percent_Identity=23.8754325259516, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=312, Percent_Identity=25.9615384615385, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=329, Percent_Identity=23.7082066869301, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=229, Percent_Identity=30.5676855895196, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17737897, Length=221, Percent_Identity=30.316742081448, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737895, Length=248, Percent_Identity=29.0322580645161, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36192; Mature: 36192

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVNSASKANIEVVEKELRPLQAGEALVDVEYCGVCHTDLHVAAGDFGDVQGRVLGH
CCEEEECCCCCCHHHHHHHHHCCHHCCCEEEEEHHCCEECCCCEEECCCCCCCCCEEECC
EGIGIVSQIADDVKSLKVGDRVSIAWMYHACGRCEYCTTGRETFCRNVQNAGYSVDGGMA
CCCHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHCCEECCCCCC
EQSIVVADYAVKVPDGLDPAQASSITCAGVTTYKAIKVADVKPGETVVIYGCGGLGNLAI
CCEEEEEEEEEECCCCCCCCCCCCEEEECEEEEEEEEEEECCCCCEEEEEECCCHHHHHH
QYAKHVFNAHVIAVDLNDDKLELAKESGADLTINPSTDGDAADIVQEKFGGAHAAVVTAV
HHHHHHHCEEEEEEECCCCHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHH
SKVAFNSAVNAVRACGKVVAVGLPSETMDLNIPRLVLDGIEVVGSLVGTRKDLEEAFQFG
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AEGLVVPVVHKRCLHEVQDVFEEMEQGKIQGRMVIDFKNKDC
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MKAVVVNSASKANIEVVEKELRPLQAGEALVDVEYCGVCHTDLHVAAGDFGDVQGRVLGH
CCEEEECCCCCCHHHHHHHHHCCHHCCCEEEEEHHCCEECCCCEEECCCCCCCCCEEECC
EGIGIVSQIADDVKSLKVGDRVSIAWMYHACGRCEYCTTGRETFCRNVQNAGYSVDGGMA
CCCHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHCCEECCCCCC
EQSIVVADYAVKVPDGLDPAQASSITCAGVTTYKAIKVADVKPGETVVIYGCGGLGNLAI
CCEEEEEEEEEECCCCCCCCCCCCEEEECEEEEEEEEEEECCCCCEEEEEECCCHHHHHH
QYAKHVFNAHVIAVDLNDDKLELAKESGADLTINPSTDGDAADIVQEKFGGAHAAVVTAV
HHHHHHHCEEEEEEECCCCHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHH
SKVAFNSAVNAVRACGKVVAVGLPSETMDLNIPRLVLDGIEVVGSLVGTRKDLEEAFQFG
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AEGLVVPVVHKRCLHEVQDVFEEMEQGKIQGRMVIDFKNKDC
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]