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The map label for this gene is msrAB [H]

Identifier: 229917492

GI number: 229917492

Start: 1734520

End: 1735026

Strand: Direct

Name: msrAB [H]

Synonym: EAT1b_1767

Alternate gene names: 229917492

Gene position: 1734520-1735026 (Clockwise)

Preceding gene: 229917491

Following gene: 229917493

Centisome position: 57.82

GC content: 49.9

Gene sequence:

>507_bases
GTGATTCCAATCGAAACAATCTATTTAGCGGGCGGATGTCTATGGGGCGTTCAAGAATTTGTGAGGACATTACCTGGCGT
CCTTTCAACTGAAGCGGGACGTGCGAACGGAACGACGGACACGTTGGACGGGGAATATGACGGATACGCGGAGTGCGTCA
GAACGACGTTCGATCCGGACGTGGTGACGGTCAATGATTTGATGGGCTATTTATTTGAAATCATCGACCCATACAGCATC
AACCAACAAGGGATTGATGTCGGAGAGAAGTATCGAACGGGCGTCTACAGTGAGGAGTCACGACATGTGGTGGAGGCACA
GGCGTTCATTGATCGACGCTCGGATGCGAAACGGATTGCTGTTGAAGTCAAGCCGCTCACGAACTATGTGCGAAGTGCGG
ACGAGCATCAGGACCGCCTGACGCGTTGTCCGGATGATTATTGCCATATTCCGAAAGACTTATTAACAAAATATCAGAAC
GTATCATCATCAAAGCGTCTCTTCTGA

Upstream 100 bases:

>100_bases
AGCAGAGCGCACATTATATCCAAAGAGATGAGCCATACTTGATTGTAGAAGCAATTCAAGAGTTACTAATGAAGTGATAC
ATAAACGGATAAGATGAGGA

Downstream 100 bases:

>100_bases
GATGCTTTTTTTCATTTTTTCCCAAATGAGTAAAGCTAAATGGACGCGTTTCATGTCTAATGAGTGTAAGGGAAAAAACG
AAAAGGGGGACGTTCGATGA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MIPIETIYLAGGCLWGVQEFVRTLPGVLSTEAGRANGTTDTLDGEYDGYAECVRTTFDPDVVTVNDLMGYLFEIIDPYSI
NQQGIDVGEKYRTGVYSEESRHVVEAQAFIDRRSDAKRIAVEVKPLTNYVRSADEHQDRLTRCPDDYCHIPKDLLTKYQN
VSSSKRLF

Sequences:

>Translated_168_residues
MIPIETIYLAGGCLWGVQEFVRTLPGVLSTEAGRANGTTDTLDGEYDGYAECVRTTFDPDVVTVNDLMGYLFEIIDPYSI
NQQGIDVGEKYRTGVYSEESRHVVEAQAFIDRRSDAKRIAVEVKPLTNYVRSADEHQDRLTRCPDDYCHIPKDLLTKYQN
VSSSKRLF
>Mature_168_residues
MIPIETIYLAGGCLWGVQEFVRTLPGVLSTEAGRANGTTDTLDGEYDGYAECVRTTFDPDVVTVNDLMGYLFEIIDPYSI
NQQGIDVGEKYRTGVYSEESRHVVEAQAFIDRRSDAKRIAVEVKPLTNYVRSADEHQDRLTRCPDDYCHIPKDLLTKYQN
VSSSKRLF

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=28.476821192053, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=28.476821192053, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=27.3885350318471, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 18995; Mature: 18995

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPIETIYLAGGCLWGVQEFVRTLPGVLSTEAGRANGTTDTLDGEYDGYAECVRTTFDPD
CCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
VVTVNDLMGYLFEIIDPYSINQQGIDVGEKYRTGVYSEESRHVVEAQAFIDRRSDAKRIA
EEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEE
VEVKPLTNYVRSADEHQDRLTRCPDDYCHIPKDLLTKYQNVSSSKRLF
EEEHHHHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIPIETIYLAGGCLWGVQEFVRTLPGVLSTEAGRANGTTDTLDGEYDGYAECVRTTFDPD
CCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
VVTVNDLMGYLFEIIDPYSINQQGIDVGEKYRTGVYSEESRHVVEAQAFIDRRSDAKRIA
EEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEE
VEVKPLTNYVRSADEHQDRLTRCPDDYCHIPKDLLTKYQNVSSSKRLF
EEEHHHHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA