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The map label for this gene is dnaA

Identifier: 229917455

GI number: 229917455

Start: 1699111

End: 1700490

Strand: Reverse

Name: dnaA

Synonym: EAT1b_1730

Alternate gene names: 229917455

Gene position: 1700490-1699111 (Counterclockwise)

Preceding gene: 229917460

Following gene: 229917454

Centisome position: 56.68

GC content: 46.16

Gene sequence:

>1380_bases
TTGAAGAATGCTCGCGAGATTTGGAGAAATGTCTTATCGGTAATCGAGGAAGAAGAACGAACTCCAAAAGCCAGTTTTGA
CATGTGGTTAAAATCAACCGAGGGGATATCGTTGATGGGAACGACGCTCGTTGTGTCGGCACCCGCCAGTTTTATCGTCA
CGTGGTTAGAGCGACAGTATCTCTCTCTGTTACAAGATACGGTTGAAGAGATCACAAACAACAAGCTTGAAATTCATTTC
ATCGAGGAATCTCAAGCACACAAGTATGCTCCAGCGGATGGATCGTCAAATGAGTCCATCGCCGTGACAGAAACAAAAGA
ACAGCCCGTGCTATTACCTTCAAAAGAGGAAGGGGATCTTGGTCAACTGAATGACAAATACATTTTCGAGACGTTTGTCA
TCGGATCGGGGAACCGTTTTGCCCACGCCGCATCACTTGCTGTCGCTGAAGCACCTGCACGCGCCTATAACCCGCTCTTC
ATTTACGGAGGCGTTGGACTTGGTAAAACACATTTGATGCATGCGATTGGTCATTATGTAAAAGGTCAAAAACCGGGGGC
TCGCATTGCCTATGTCTCTTCTGAGAAGTTCACAAATGAATTTATCAATTCGATTCGGGATAATAAGACCGGTGAGTTTC
GGAACCGTTATCGAAACATTGATGTACTATTGATTGATGATATTCAGTTTTTAGCAGGGAAAGAACAAACCCAAGAAGAG
TTTTTCCACACATTCAATGCGTTGCACAACGATCAGAAACAAATCGTGATTTCGAGTGATCGACCACCAAAAGAAATCCC
GACGCTAGAAGATCGACTTCGTTCACGCTTCGAGTGGGGCTTAATCACAGACATCACGCCACCGGACCTTGAGACGCGAA
TTGCGATTCTCCGCAAAAAAGCGACGGCGGAAGGGCTTGATATCTCGAATGAAGTCATGCTGTATATCGCGAATCAAATC
GATACGAACATTCGGGAACTAGAAGGGGCGCTGACACGAGTCGTCGCTTATGCAAAACTTGTCGGGCGACCAATCGACCC
GGACGTGGCAGCCGAAGCGCTTCATAATATCATGCCTGTCCAGGAAGCGAAGAAAATTGTCATTCGCGACATTCAAGAAG
TTGTCGGTCAACACTTCAACATTCAAGTAGAAGAATTGAACTCGAAAAAGCGAACCAAGACGTTGGCATTCCCACGTCAA
ATCGCAATGTATCTCTCGCGGGAGATGACGGAGAGTTCCTTGCCAAAAATCGGGGAAGAGTTCGGAGGGCGTGATCATAC
GACCGTGATTCACGCGCATGAGAAAATTAGCACCCTTCTAAAGAACGATGTGGAAATGCAAGAGACGATTCAAACGTTGA
AGAAGGCACTTTCTAACTAA

Upstream 100 bases:

>100_bases
TTTGTTCTCTGGGGATAACCCTAGTTTCTACTATAGAATAGTGTATGTGTATATCGTGTGAATAAGTTTTACCCAACATG
TGAGTAAAGGAGGTCTTTCA

Downstream 100 bases:

>100_bases
TGAAGGATTCTCTGTGGATATCCTGTGGATAAACCACCCTAGTTATCCACAAGTTATTCACAGGCGAAATGGCTTAATAC
GTATGTCTTAGGGGACTTAT

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKNAREIWRNVLSVIEEEERTPKASFDMWLKSTEGISLMGTTLVVSAPASFIVTWLERQYLSLLQDTVEEITNNKLEIHF
IEESQAHKYAPADGSSNESIAVTETKEQPVLLPSKEEGDLGQLNDKYIFETFVIGSGNRFAHAASLAVAEAPARAYNPLF
IYGGVGLGKTHLMHAIGHYVKGQKPGARIAYVSSEKFTNEFINSIRDNKTGEFRNRYRNIDVLLIDDIQFLAGKEQTQEE
FFHTFNALHNDQKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKATAEGLDISNEVMLYIANQI
DTNIRELEGALTRVVAYAKLVGRPIDPDVAAEALHNIMPVQEAKKIVIRDIQEVVGQHFNIQVEELNSKKRTKTLAFPRQ
IAMYLSREMTESSLPKIGEEFGGRDHTTVIHAHEKISTLLKNDVEMQETIQTLKKALSN

Sequences:

>Translated_459_residues
MKNAREIWRNVLSVIEEEERTPKASFDMWLKSTEGISLMGTTLVVSAPASFIVTWLERQYLSLLQDTVEEITNNKLEIHF
IEESQAHKYAPADGSSNESIAVTETKEQPVLLPSKEEGDLGQLNDKYIFETFVIGSGNRFAHAASLAVAEAPARAYNPLF
IYGGVGLGKTHLMHAIGHYVKGQKPGARIAYVSSEKFTNEFINSIRDNKTGEFRNRYRNIDVLLIDDIQFLAGKEQTQEE
FFHTFNALHNDQKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKATAEGLDISNEVMLYIANQI
DTNIRELEGALTRVVAYAKLVGRPIDPDVAAEALHNIMPVQEAKKIVIRDIQEVVGQHFNIQVEELNSKKRTKTLAFPRQ
IAMYLSREMTESSLPKIGEEFGGRDHTTVIHAHEKISTLLKNDVEMQETIQTLKKALSN
>Mature_459_residues
MKNAREIWRNVLSVIEEEERTPKASFDMWLKSTEGISLMGTTLVVSAPASFIVTWLERQYLSLLQDTVEEITNNKLEIHF
IEESQAHKYAPADGSSNESIAVTETKEQPVLLPSKEEGDLGQLNDKYIFETFVIGSGNRFAHAASLAVAEAPARAYNPLF
IYGGVGLGKTHLMHAIGHYVKGQKPGARIAYVSSEKFTNEFINSIRDNKTGEFRNRYRNIDVLLIDDIQFLAGKEQTQEE
FFHTFNALHNDQKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKATAEGLDISNEVMLYIANQI
DTNIRELEGALTRVVAYAKLVGRPIDPDVAAEALHNIMPVQEAKKIVIRDIQEVVGQHFNIQVEELNSKKRTKTLAFPRQ
IAMYLSREMTESSLPKIGEEFGGRDHTTVIHAHEKISTLLKNDVEMQETIQTLKKALSN

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=467, Percent_Identity=41.3276231263383, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI226510964, Length=170, Percent_Identity=24.7058823529412, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_EXISA (C4KZZ3)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002886101.1
- GeneID:   7870777
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_1730
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51869; Mature: 51869

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAREIWRNVLSVIEEEERTPKASFDMWLKSTEGISLMGTTLVVSAPASFIVTWLERQY
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCEEEEECCHHHHHHHHHHHH
LSLLQDTVEEITNNKLEIHFIEESQAHKYAPADGSSNESIAVTETKEQPVLLPSKEEGDL
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCC
GQLNDKYIFETFVIGSGNRFAHAASLAVAEAPARAYNPLFIYGGVGLGKTHLMHAIGHYV
CCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHH
KGQKPGARIAYVSSEKFTNEFINSIRDNKTGEFRNRYRNIDVLLIDDIQFLAGKEQTQEE
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHHHCCHHHHHH
FFHTFNALHNDQKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKK
HHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHH
ATAEGLDISNEVMLYIANQIDTNIRELEGALTRVVAYAKLVGRPIDPDVAAEALHNIMPV
HHHCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH
QEAKKIVIRDIQEVVGQHFNIQVEELNSKKRTKTLAFPRQIAMYLSREMTESSLPKIGEE
HHHHHHHHHHHHHHHCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGGRDHTTVIHAHEKISTLLKNDVEMQETIQTLKKALSN
HCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNAREIWRNVLSVIEEEERTPKASFDMWLKSTEGISLMGTTLVVSAPASFIVTWLERQY
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCEEEEECCHHHHHHHHHHHH
LSLLQDTVEEITNNKLEIHFIEESQAHKYAPADGSSNESIAVTETKEQPVLLPSKEEGDL
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCC
GQLNDKYIFETFVIGSGNRFAHAASLAVAEAPARAYNPLFIYGGVGLGKTHLMHAIGHYV
CCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHH
KGQKPGARIAYVSSEKFTNEFINSIRDNKTGEFRNRYRNIDVLLIDDIQFLAGKEQTQEE
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHHHCCHHHHHH
FFHTFNALHNDQKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKK
HHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHH
ATAEGLDISNEVMLYIANQIDTNIRELEGALTRVVAYAKLVGRPIDPDVAAEALHNIMPV
HHHCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH
QEAKKIVIRDIQEVVGQHFNIQVEELNSKKRTKTLAFPRQIAMYLSREMTESSLPKIGEE
HHHHHHHHHHHHHHHCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGGRDHTTVIHAHEKISTLLKNDVEMQETIQTLKKALSN
HCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA