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The map label for this gene is glmS [H]

Identifier: 229917315

GI number: 229917315

Start: 1540757

End: 1542553

Strand: Reverse

Name: glmS [H]

Synonym: EAT1b_1590

Alternate gene names: 229917315

Gene position: 1542553-1540757 (Counterclockwise)

Preceding gene: 229917316

Following gene: 229917314

Centisome position: 51.42

GC content: 53.76

Gene sequence:

>1797_bases
ATGTGTGGAATTGTAGGAATGATTGGGAATACCGGAGCGAAGGAAGTCCTTCTCAAAGGTCTTGAAAAACTCGAGTACCG
TGGTTATGACTCGGCAGGTCTTGCGTTGATGCATGAGAATGTCAACGTTCACAAAGAAGTCGGTCGCATTGCTGCGCTAC
GCGAAATCATCCCAGCAGAAGTAGACGGCACGATTGGAATCGGCCACACACGTTGGGCGACACACGGGGTACCGAGCGTG
CCGAACGCCCACCCGCACCAAAGTACGACAGGACGCTTCACGCTCGTGCATAACGGCGTAATCGAGAACGACGAAATCAT
CAAGAAGACGCTCGACGTCCCGTTCCTTTCAGAGACGGACACGGAAGTCATCGTCCAGCTCATGGAGAAGCACTTCGTCG
AGCTCGGCGATGTCGAGGCGGCGTTCCGCAAGACGCTCTCGGACCTCCACGGTTCGTATGCGATCGCGATGATCGACTCA
GAGGACAAAGAACGCCTCTATATCGGGAAGAACAAGTCACCGCTCCTCGTCGGACTCGGTGACGGCACGTTCAACGTCGT
CGCATCAGACGCGATGGCGATGCTCCAGGTGACGGACCAGTACCTCGAGCTCCACGACGGTGAGATCGTCATCCTCACAC
GTGAGTCGGCGACGATCAAGACGCTCGACGGTGACGTGCTCGAGCGTGCGCCATACACGGCCGAGATCGATGCATCGGAC
ATCGAGAAGGGCACGTACGCGCACTACATGTTGAAGGAGATGGACGAGCAGCCGGCCGTCATCCGCAACATCATCCAGCA
CTACCAGAACGAGAACGGCGACATCGAGCTCGCAGAAGGCGTGCGTGAACTCGTCTCGGAAGCAGACCGCGTCTATATCG
TCGCATGTGGTACGAGTTACCACGCTGGTCTTGTCGGGAAGCAATTGATCGAGCGCGTTGCAGGTGTACCGACTGAAGTA
CACGTCGCATCAGAGTTCGGTTACAACATGCCACTTTTGACAGAGAAGCCACTCTTCCTCTTCATCTCACAATCAGGTGA
GACAGCGGACAGCCGTGCCGTGCTCGTCGAAGTGAAAAAATTGGGCCATAAAGCGCTCACGTTAACAAACGTGGCAGGAT
CGACATTGTCACGTGAAGCGAACGAGACGATGCTCCTCCACGCAGGACCAGAGATTGCGGTCGCGTCGACGAAAGCATAC
ACGGCACAGATTGCCGTTCTCGCGATTCTTGCATACGACATCGCTCGTGCGAACGGGAAGAAACTTCCGTTTGATCTCAT
GCAGGAACTCGCACTCGTTGCGACAACGATGGACTCGATCATGGCACAAAAAGAAATCTTTGAAGAGCTTGCAGATAAGT
TCTTGAAAGAGTCACGTAACGCATTCTTCCTCGGACGTGGATTGGATTCATATGTAGGTCTCGAAGGCGCATTGAAGCTG
AAAGAGATTTCATATATCCAAGCAGAAGGGTACCCAGGTGGGGAACTCAAACACGGTCCGATTGCCTTGATTGAAGATGG
GACACCGGTCATCACGCTCGTGTCTCAACCGAACACACACCTCAACATCCGTGGAAACATCAAGGAAGTTGTGGCGCGTG
GTGCCATCGCATGTACGATTTCAATGGAAGGAATGGAACATGAGAACGACGCATTCGTTCTTCCGCGTGTTGAACCACTT
CTCACGCCACTCGTGACGGTTCTTCCACTTCAACTCATCTCGTACTATGCAGCACTTGCTCGCGACTGTGATGTCGACAA
GCCACGTAACTTGGCGAAGTCTGTAACGGTTGAATAA

Upstream 100 bases:

>100_bases
ACGCCCGGGCGACCGGACGGACAAAGAAGCGTGTACTGACAGCTCTTAGAAAAAGCCCGTTTCCTTTTTCGAGAAATCGA
AGAATAGAGGAGATTTGTTT

Downstream 100 bases:

>100_bases
TGTTCAAGACCAAAATCTTTCGGGATTTTGGTCTTTTTTGTTGCAATGAGTTAACAAATCATCGCAATGTTCTCAAAAAC
GTCTGTTTCTTCAAAAGAGG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MCGIVGMIGNTGAKEVLLKGLEKLEYRGYDSAGLALMHENVNVHKEVGRIAALREIIPAEVDGTIGIGHTRWATHGVPSV
PNAHPHQSTTGRFTLVHNGVIENDEIIKKTLDVPFLSETDTEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDS
EDKERLYIGKNKSPLLVGLGDGTFNVVASDAMAMLQVTDQYLELHDGEIVILTRESATIKTLDGDVLERAPYTAEIDASD
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELAEGVRELVSEADRVYIVACGTSYHAGLVGKQLIERVAGVPTEV
HVASEFGYNMPLLTEKPLFLFISQSGETADSRAVLVEVKKLGHKALTLTNVAGSTLSREANETMLLHAGPEIAVASTKAY
TAQIAVLAILAYDIARANGKKLPFDLMQELALVATTMDSIMAQKEIFEELADKFLKESRNAFFLGRGLDSYVGLEGALKL
KEISYIQAEGYPGGELKHGPIALIEDGTPVITLVSQPNTHLNIRGNIKEVVARGAIACTISMEGMEHENDAFVLPRVEPL
LTPLVTVLPLQLISYYAALARDCDVDKPRNLAKSVTVE

Sequences:

>Translated_598_residues
MCGIVGMIGNTGAKEVLLKGLEKLEYRGYDSAGLALMHENVNVHKEVGRIAALREIIPAEVDGTIGIGHTRWATHGVPSV
PNAHPHQSTTGRFTLVHNGVIENDEIIKKTLDVPFLSETDTEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDS
EDKERLYIGKNKSPLLVGLGDGTFNVVASDAMAMLQVTDQYLELHDGEIVILTRESATIKTLDGDVLERAPYTAEIDASD
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELAEGVRELVSEADRVYIVACGTSYHAGLVGKQLIERVAGVPTEV
HVASEFGYNMPLLTEKPLFLFISQSGETADSRAVLVEVKKLGHKALTLTNVAGSTLSREANETMLLHAGPEIAVASTKAY
TAQIAVLAILAYDIARANGKKLPFDLMQELALVATTMDSIMAQKEIFEELADKFLKESRNAFFLGRGLDSYVGLEGALKL
KEISYIQAEGYPGGELKHGPIALIEDGTPVITLVSQPNTHLNIRGNIKEVVARGAIACTISMEGMEHENDAFVLPRVEPL
LTPLVTVLPLQLISYYAALARDCDVDKPRNLAKSVTVE
>Mature_598_residues
MCGIVGMIGNTGAKEVLLKGLEKLEYRGYDSAGLALMHENVNVHKEVGRIAALREIIPAEVDGTIGIGHTRWATHGVPSV
PNAHPHQSTTGRFTLVHNGVIENDEIIKKTLDVPFLSETDTEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDS
EDKERLYIGKNKSPLLVGLGDGTFNVVASDAMAMLQVTDQYLELHDGEIVILTRESATIKTLDGDVLERAPYTAEIDASD
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELAEGVRELVSEADRVYIVACGTSYHAGLVGKQLIERVAGVPTEV
HVASEFGYNMPLLTEKPLFLFISQSGETADSRAVLVEVKKLGHKALTLTNVAGSTLSREANETMLLHAGPEIAVASTKAY
TAQIAVLAILAYDIARANGKKLPFDLMQELALVATTMDSIMAQKEIFEELADKFLKESRNAFFLGRGLDSYVGLEGALKL
KEISYIQAEGYPGGELKHGPIALIEDGTPVITLVSQPNTHLNIRGNIKEVVARGAIACTISMEGMEHENDAFVLPRVEPL
LTPLVTVLPLQLISYYAALARDCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=32.3572474377745, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=32.7485380116959, Blast_Score=311, Evalue=1e-84,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=40.9090909090909, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1788651, Length=236, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=434, Percent_Identity=34.7926267281106, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=35.9447004608295, Blast_Score=231, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=35.9447004608295, Blast_Score=231, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322745, Length=452, Percent_Identity=32.3008849557522, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=27.7389277389277, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323730, Length=235, Percent_Identity=33.1914893617021, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=33.5260115606936, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI28573187, Length=273, Percent_Identity=28.9377289377289, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24659598, Length=255, Percent_Identity=27.843137254902, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24659604, Length=250, Percent_Identity=28.4, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65205; Mature: 65205

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGMIGNTGAKEVLLKGLEKLEYRGYDSAGLALMHENVNVHKEVGRIAALREIIPAE
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
VDGTIGIGHTRWATHGVPSVPNAHPHQSTTGRFTLVHNGVIENDEIIKKTLDVPFLSETD
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCC
TEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDSEDKERLYIGKNKSPLLVGLG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEC
DGTFNVVASDAMAMLQVTDQYLELHDGEIVILTRESATIKTLDGDVLERAPYTAEIDASD
CCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHHHCCCCEEECCHHH
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELAEGVRELVSEADRVYIVACGTSY
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEEEEECCCC
HAGLVGKQLIERVAGVPTEVHVASEFGYNMPLLTEKPLFLFISQSGETADSRAVLVEVKK
CHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
LGHKALTLTNVAGSTLSREANETMLLHAGPEIAVASTKAYTAQIAVLAILAYDIARANGK
CCCCEEEEECCCCCHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
KLPFDLMQELALVATTMDSIMAQKEIFEELADKFLKESRNAFFLGRGLDSYVGLEGALKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCEEE
KEISYIQAEGYPGGELKHGPIALIEDGTPVITLVSQPNTHLNIRGNIKEVVARGAIACTI
EEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCEEEECCCHHHHHHCCEEEEEE
SMEGMEHENDAFVLPRVEPLLTPLVTVLPLQLISYYAALARDCDVDKPRNLAKSVTVE
EECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGMIGNTGAKEVLLKGLEKLEYRGYDSAGLALMHENVNVHKEVGRIAALREIIPAE
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
VDGTIGIGHTRWATHGVPSVPNAHPHQSTTGRFTLVHNGVIENDEIIKKTLDVPFLSETD
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCC
TEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDSEDKERLYIGKNKSPLLVGLG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEC
DGTFNVVASDAMAMLQVTDQYLELHDGEIVILTRESATIKTLDGDVLERAPYTAEIDASD
CCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHHHCCCCEEECCHHH
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELAEGVRELVSEADRVYIVACGTSY
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEEEEECCCC
HAGLVGKQLIERVAGVPTEVHVASEFGYNMPLLTEKPLFLFISQSGETADSRAVLVEVKK
CHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
LGHKALTLTNVAGSTLSREANETMLLHAGPEIAVASTKAYTAQIAVLAILAYDIARANGK
CCCCEEEEECCCCCHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
KLPFDLMQELALVATTMDSIMAQKEIFEELADKFLKESRNAFFLGRGLDSYVGLEGALKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCEEE
KEISYIQAEGYPGGELKHGPIALIEDGTPVITLVSQPNTHLNIRGNIKEVVARGAIACTI
EEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCEEEECCCHHHHHHCCEEEEEE
SMEGMEHENDAFVLPRVEPLLTPLVTVLPLQLISYYAALARDCDVDKPRNLAKSVTVE
EECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]