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The map label for this gene is ltaE [H]

Identifier: 229917151

GI number: 229917151

Start: 1394436

End: 1395494

Strand: Reverse

Name: ltaE [H]

Synonym: EAT1b_1425

Alternate gene names: 229917151

Gene position: 1395494-1394436 (Counterclockwise)

Preceding gene: 229917152

Following gene: 229917144

Centisome position: 46.52

GC content: 49.39

Gene sequence:

>1059_bases
ATGGAGCGATTGTTAGATACGTACCGTCAGACAGCTGTTCAGTTGAGCGGTCACGGCAAACGGGAAATCGGGGTGTTGAA
ACGCGCGTTTGAACAGGTGCGTGACGATGAGCCGAGTGACCAGTATGGACAGGGGGAAACGATTCGCCAGTTCGAAGAGA
AGATGGCACAAGTTCTTGGGAAAGAGTCAGCGGTATTCTTTCCGAGCGGCACGATGGCGCAACAAATCGCACTACGCATT
TGGTGTGACGAAACAGAGAAGAACACGGTCGCGTATCATCCACTCTGCCACCTTGAAATCCATGAACAGGACGGCTTGAA
AGAGTTGCATCAGATCGAACCGATTTTAGTCGGGGACGAAAATCGGTTGATGACGCTCGAAGAGATTCAAGCGTTACCGG
ACATCGCGTGTCTGTTGCTCGAACTGCCACAACGAGAAATCGGCGGGGAATTGCCGACGTTCGAGGAACTTGTGGCGATT
CATGAACACTGTCGTGAGAAAGGGATTCATCTACATCTGGATGGTGCACGACTGTTCGAATCGCTTCCGTATTATGAAAA
AGAGGCATCTGAGATTTGTGCGCTCTTTGATAGCGTATACGTCTCGTTTTATAAAGGAATCGGTGGCATTGCCGGTGCCA
TCCTTGCTGGACCGAAGGCATTTTGTGACACGTCGAAAGTATGGAAGCGACGCTACGGTGGTGACTTGATCAGCTTATAT
CCATACATCATGTCCGCGGATTATTATTATGAGCTACGAAAAGACAAGATGGCCGAGTATCGAAACGAGGCCGTCCGCTT
GGCAGCGCGCTTCAATGAACTCGATGGCGTGTGGACGACTCCACGCATCCCGGTCACGAATATGTTCCATCTTCATTTTC
AAGGGGAGAAGGAAGAAATTGGTGAGAAAATTGCGCGCATCCAAGAAGAAACAGGAGTAGGCATTACGGGGTATCTTGTT
GAAAAAGACGGACACTGTTCAACCGAAGTAAGCATCGGAGATACGTTTGAACGGATTACGCGAGAACAGCTTGATAGATT
GTTTCGGCAGTTCAGATGA

Upstream 100 bases:

>100_bases
ACGCGGAAAGTACGCGGTAAACTCATCGTCCGAATTCGCGACTGAGTAGAGGGCTCCCTGTTATACTGACAGGGAGTTTA
TTTGTCGAGGAGGGGAATAA

Downstream 100 bases:

>100_bases
ATCAAAACATGCACCATTCCTTTTCGGGAACGGTGCATGTTTTTTACTGGCTTACAATCGCTTCGAGACGATCCAGTTGG
GAAGTGAACCCTTCGACAGC

Product: aromatic amino acid beta-eliminating lyase/threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MERLLDTYRQTAVQLSGHGKREIGVLKRAFEQVRDDEPSDQYGQGETIRQFEEKMAQVLGKESAVFFPSGTMAQQIALRI
WCDETEKNTVAYHPLCHLEIHEQDGLKELHQIEPILVGDENRLMTLEEIQALPDIACLLLELPQREIGGELPTFEELVAI
HEHCREKGIHLHLDGARLFESLPYYEKEASEICALFDSVYVSFYKGIGGIAGAILAGPKAFCDTSKVWKRRYGGDLISLY
PYIMSADYYYELRKDKMAEYRNEAVRLAARFNELDGVWTTPRIPVTNMFHLHFQGEKEEIGEKIARIQEETGVGITGYLV
EKDGHCSTEVSIGDTFERITREQLDRLFRQFR

Sequences:

>Translated_352_residues
MERLLDTYRQTAVQLSGHGKREIGVLKRAFEQVRDDEPSDQYGQGETIRQFEEKMAQVLGKESAVFFPSGTMAQQIALRI
WCDETEKNTVAYHPLCHLEIHEQDGLKELHQIEPILVGDENRLMTLEEIQALPDIACLLLELPQREIGGELPTFEELVAI
HEHCREKGIHLHLDGARLFESLPYYEKEASEICALFDSVYVSFYKGIGGIAGAILAGPKAFCDTSKVWKRRYGGDLISLY
PYIMSADYYYELRKDKMAEYRNEAVRLAARFNELDGVWTTPRIPVTNMFHLHFQGEKEEIGEKIARIQEETGVGITGYLV
EKDGHCSTEVSIGDTFERITREQLDRLFRQFR
>Mature_352_residues
MERLLDTYRQTAVQLSGHGKREIGVLKRAFEQVRDDEPSDQYGQGETIRQFEEKMAQVLGKESAVFFPSGTMAQQIALRI
WCDETEKNTVAYHPLCHLEIHEQDGLKELHQIEPILVGDENRLMTLEEIQALPDIACLLLELPQREIGGELPTFEELVAI
HEHCREKGIHLHLDGARLFESLPYYEKEASEICALFDSVYVSFYKGIGGIAGAILAGPKAFCDTSKVWKRRYGGDLISLY
PYIMSADYYYELRKDKMAEYRNEAVRLAARFNELDGVWTTPRIPVTNMFHLHFQGEKEEIGEKIARIQEETGVGITGYLV
EKDGHCSTEVSIGDTFERITREQLDRLFRQFR

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=243, Percent_Identity=28.3950617283951, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193206520, Length=204, Percent_Identity=25.9803921568627, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193206522, Length=204, Percent_Identity=25.9803921568627, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193206524, Length=204, Percent_Identity=25.9803921568627, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320789, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355439, Length=216, Percent_Identity=27.3148148148148, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 40412; Mature: 40412

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLLDTYRQTAVQLSGHGKREIGVLKRAFEQVRDDEPSDQYGQGETIRQFEEKMAQVLG
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHC
KESAVFFPSGTMAQQIALRIWCDETEKNTVAYHPLCHLEIHEQDGLKELHQIEPILVGDE
CCCEEECCCCHHHHHHHHHEEECCCCCCEEEECCEEEEEECCCCCHHHHHHCCCEEECCC
NRLMTLEEIQALPDIACLLLELPQREIGGELPTFEELVAIHEHCREKGIHLHLDGARLFE
CCEEEHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHH
SLPYYEKEASEICALFDSVYVSFYKGIGGIAGAILAGPKAFCDTSKVWKRRYGGDLISLY
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCHHHHH
PYIMSADYYYELRKDKMAEYRNEAVRLAARFNELDGVWTTPRIPVTNMFHLHFQGEKEEI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHH
GEKIARIQEETGVGITGYLVEKDGHCSTEVSIGDTFERITREQLDRLFRQFR
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERLLDTYRQTAVQLSGHGKREIGVLKRAFEQVRDDEPSDQYGQGETIRQFEEKMAQVLG
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHC
KESAVFFPSGTMAQQIALRIWCDETEKNTVAYHPLCHLEIHEQDGLKELHQIEPILVGDE
CCCEEECCCCHHHHHHHHHEEECCCCCCEEEECCEEEEEECCCCCHHHHHHCCCEEECCC
NRLMTLEEIQALPDIACLLLELPQREIGGELPTFEELVAIHEHCREKGIHLHLDGARLFE
CCEEEHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHH
SLPYYEKEASEICALFDSVYVSFYKGIGGIAGAILAGPKAFCDTSKVWKRRYGGDLISLY
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCHHHHH
PYIMSADYYYELRKDKMAEYRNEAVRLAARFNELDGVWTTPRIPVTNMFHLHFQGEKEEI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHH
GEKIARIQEETGVGITGYLVEKDGHCSTEVSIGDTFERITREQLDRLFRQFR
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]