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The map label for this gene is yqeC [H]

Identifier: 229916947

GI number: 229916947

Start: 1199169

End: 1200050

Strand: Direct

Name: yqeC [H]

Synonym: EAT1b_1221

Alternate gene names: 229916947

Gene position: 1199169-1200050 (Clockwise)

Preceding gene: 229916946

Following gene: 229916948

Centisome position: 39.97

GC content: 55.1

Gene sequence:

>882_bases
ATGGAAATTGGTTTGATTGGTTTAGGTAAGATGGGTTACAACTTGGCACTCAACTTGAGCGACCACGGACACACGGTCGT
CGGGACGGACGTCGGGGACGTCACATCGGACGCCTTTACGATTGTGCCGACACTTGAGGAAGTCGTGAGCAAGTTGTCGA
TGCCACGCATTATCTGGACGATGGTCCCTGCCGGAGACGTCACGGAAGCGGTGCTCGCGGAATTGTATGAGCGACTCGAA
CCGGGCGACATCGTGATTGACGGGGGGAACTCGAATTACAAGCTCTCGGTCGCGCGCGCCGAACAGTTCGCCGAAAAAGA
GATCAAATTCTTCGACTGCGGAACGAGCGGTGGGACGGACGGGGCTCGAAACGGTGCCTGTACGATGGTCGGGGGTGACG
CGGATGCGTGGCCGACAATTGAACCAATCTTTAAAGACTTGTCTGTCGAGAACGGCTACTTGTATACGGGTCCTGCCGGA
AGCGGTCATTTCTTGAAGATGATCCATAACGGCATCGAGTATGGGATGATGCAGGCGATTGCCGAAGGATTCGATATCTT
GGAGAAGAGCCCGTTCGACTACGACTATGAACAAGTCGCTCGTGTATGGAATCACGGGTCGGTCGTCCGGTCATGGCTCA
TGGAACTCACGGAGAATGCCTTCAAGAAAGATGCGAAGCTCGATGAGATTCGTGGGGTCATGCATTCATCCGGTGAAGGT
AAATGGACGATCGAGACGGCACTCGACCTTCAAGCCACGGCACCGGTCATTGCCCTGTCGCTCATGATGCGCTATCGTTC
ACTCGAAGACGACACGTTCTCAGGAAAAGTCGTCGCCGCGCTCCGCAACGAGTTCGGTGGGCACGCGGTCGTCAAGAAGT
AA

Upstream 100 bases:

>100_bases
CATTACTCGAAAAAAATTCCGTAATCATACTTGTAAATCGAATTTATTTTGATATGATGAACACAGAGACGGAAAAAAAT
TCTTTTTCAGGGGTGACAAT

Downstream 100 bases:

>100_bases
CATGTGTGGAAAAGGTCACGGGGACATGGCCTTTCCCTTTGTTAAAAACTGTAAACGGTTACATATTCGGAATTTAGGGG
GAATACTCAATGTCTGGCTC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MEIGLIGLGKMGYNLALNLSDHGHTVVGTDVGDVTSDAFTIVPTLEEVVSKLSMPRIIWTMVPAGDVTEAVLAELYERLE
PGDIVIDGGNSNYKLSVARAEQFAEKEIKFFDCGTSGGTDGARNGACTMVGGDADAWPTIEPIFKDLSVENGYLYTGPAG
SGHFLKMIHNGIEYGMMQAIAEGFDILEKSPFDYDYEQVARVWNHGSVVRSWLMELTENAFKKDAKLDEIRGVMHSSGEG
KWTIETALDLQATAPVIALSLMMRYRSLEDDTFSGKVVAALRNEFGGHAVVKK

Sequences:

>Translated_293_residues
MEIGLIGLGKMGYNLALNLSDHGHTVVGTDVGDVTSDAFTIVPTLEEVVSKLSMPRIIWTMVPAGDVTEAVLAELYERLE
PGDIVIDGGNSNYKLSVARAEQFAEKEIKFFDCGTSGGTDGARNGACTMVGGDADAWPTIEPIFKDLSVENGYLYTGPAG
SGHFLKMIHNGIEYGMMQAIAEGFDILEKSPFDYDYEQVARVWNHGSVVRSWLMELTENAFKKDAKLDEIRGVMHSSGEG
KWTIETALDLQATAPVIALSLMMRYRSLEDDTFSGKVVAALRNEFGGHAVVKK
>Mature_293_residues
MEIGLIGLGKMGYNLALNLSDHGHTVVGTDVGDVTSDAFTIVPTLEEVVSKLSMPRIIWTMVPAGDVTEAVLAELYERLE
PGDIVIDGGNSNYKLSVARAEQFAEKEIKFFDCGTSGGTDGARNGACTMVGGDADAWPTIEPIFKDLSVENGYLYTGPAG
SGHFLKMIHNGIEYGMMQAIAEGFDILEKSPFDYDYEQVARVWNHGSVVRSWLMELTENAFKKDAKLDEIRGVMHSSGEG
KWTIETALDLQATAPVIALSLMMRYRSLEDDTFSGKVVAALRNEFGGHAVVKK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=312, Percent_Identity=35.8974358974359, Blast_Score=148, Evalue=5e-36,
Organism=Escherichia coli, GI1788341, Length=301, Percent_Identity=35.5481727574751, Blast_Score=160, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17542558, Length=292, Percent_Identity=38.6986301369863, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321695, Length=291, Percent_Identity=38.4879725085911, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6321977, Length=304, Percent_Identity=37.5, Blast_Score=165, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24639279, Length=299, Percent_Identity=35.7859531772575, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 31882; Mature: 31882

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGLIGLGKMGYNLALNLSDHGHTVVGTDVGDVTSDAFTIVPTLEEVVSKLSMPRIIWT
CCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCEEEEE
MVPAGDVTEAVLAELYERLEPGDIVIDGGNSNYKLSVARAEQFAEKEIKFFDCGTSGGTD
ECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEHHHHHHHHHHCCEEEECCCCCCCC
GARNGACTMVGGDADAWPTIEPIFKDLSVENGYLYTGPAGSGHFLKMIHNGIEYGMMQAI
CCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AEGFDILEKSPFDYDYEQVARVWNHGSVVRSWLMELTENAFKKDAKLDEIRGVMHSSGEG
HHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
KWTIETALDLQATAPVIALSLMMRYRSLEDDTFSGKVVAALRNEFGGHAVVKK
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MEIGLIGLGKMGYNLALNLSDHGHTVVGTDVGDVTSDAFTIVPTLEEVVSKLSMPRIIWT
CCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCEEEEE
MVPAGDVTEAVLAELYERLEPGDIVIDGGNSNYKLSVARAEQFAEKEIKFFDCGTSGGTD
ECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEHHHHHHHHHHCCEEEECCCCCCCC
GARNGACTMVGGDADAWPTIEPIFKDLSVENGYLYTGPAGSGHFLKMIHNGIEYGMMQAI
CCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AEGFDILEKSPFDYDYEQVARVWNHGSVVRSWLMELTENAFKKDAKLDEIRGVMHSSGEG
HHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
KWTIETALDLQATAPVIALSLMMRYRSLEDDTFSGKVVAALRNEFGGHAVVKK
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]