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The map label for this gene is fabG [H]

Identifier: 229916411

GI number: 229916411

Start: 634902

End: 635627

Strand: Reverse

Name: fabG [H]

Synonym: EAT1b_0681

Alternate gene names: 229916411

Gene position: 635627-634902 (Counterclockwise)

Preceding gene: 229916413

Following gene: 229916410

Centisome position: 21.19

GC content: 52.2

Gene sequence:

>726_bases
ATGAAACATGTAATGATTACATCTGGTGCCAAAGGGATCGGACGCGTCGTGACGGAGCGTCTGTTACAAGATGGTTGGCA
CGTTAGCATTTTGCAACGGAATCCAATCGACTGGGAACATGAGCGGATACATATGATCGAGGCCGGATTGACGGACCGCG
AACAACTGCTCTCTGCCTATGAGCAAGCGGTCGAACGGTTTGGTGAACCGGACGCTTTGATTTTAAATGCAGGTCCATAT
ATCTTTGAACGGAAACCGCTCGTCGAATTGACGGACGACGAGTGGGACGAAGTACTCACGGGCAACCTGTCCGCCTCATT
TTGGTTAATGCGTCGAGCGCTTCCTTCCATGCGCTCGAATCGATTTGGACGCATCATCTCGTATGGATTTCCGGAAAGTG
GGACGGCGCCTGGCTGGATTCATCGTTCTGCGTTTGCCGCTGCAAAGACGGGACTCGTCAGTTTGACAAAATCGGTCGCA
TTGGAAGAGGCACCGTTCGGGATTACGGCTAACATGGTCAACCCGGGCAATATCGTCGGCTCGCAAAAGGAGATGCGCAT
TGAGGAGGCGGAAGTGGATGAAGGAACTCCGGTCGGTCGACACGGGACGGGAGAAGATATCGCGCGTTTGATTTCGTTCT
TATTACAAGAAGACTCGGATATGATCACAGGAGCCATCATCGATGTGACAGGTGGCGTCAACGTCGTCCATCAATACCGG
AAGTGA

Upstream 100 bases:

>100_bases
CATGAAAATGAGTGAATTTTTTCATGGTGATGTTCACGACATGTCCAAGTTTGGAATTCGTGTGAAAGAACGGGTAAAAT
AAGGCGGAGGAGGTAGGACG

Downstream 100 bases:

>100_bases
GGGGAACGCGATGAAGATCGGAGTGGTCACGGACGTTCATGGAAATCTCGAAGCGTTGGAGGCTGCGCTCCAAGTCATGG
ATACAGAGCGGGTCGACGTC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKHVMITSGAKGIGRVVTERLLQDGWHVSILQRNPIDWEHERIHMIEAGLTDREQLLSAYEQAVERFGEPDALILNAGPY
IFERKPLVELTDDEWDEVLTGNLSASFWLMRRALPSMRSNRFGRIISYGFPESGTAPGWIHRSAFAAAKTGLVSLTKSVA
LEEAPFGITANMVNPGNIVGSQKEMRIEEAEVDEGTPVGRHGTGEDIARLISFLLQEDSDMITGAIIDVTGGVNVVHQYR
K

Sequences:

>Translated_241_residues
MKHVMITSGAKGIGRVVTERLLQDGWHVSILQRNPIDWEHERIHMIEAGLTDREQLLSAYEQAVERFGEPDALILNAGPY
IFERKPLVELTDDEWDEVLTGNLSASFWLMRRALPSMRSNRFGRIISYGFPESGTAPGWIHRSAFAAAKTGLVSLTKSVA
LEEAPFGITANMVNPGNIVGSQKEMRIEEAEVDEGTPVGRHGTGEDIARLISFLLQEDSDMITGAIIDVTGGVNVVHQYR
K
>Mature_241_residues
MKHVMITSGAKGIGRVVTERLLQDGWHVSILQRNPIDWEHERIHMIEAGLTDREQLLSAYEQAVERFGEPDALILNAGPY
IFERKPLVELTDDEWDEVLTGNLSASFWLMRRALPSMRSNRFGRIISYGFPESGTAPGWIHRSAFAAAKTGLVSLTKSVA
LEEAPFGITANMVNPGNIVGSQKEMRIEEAEVDEGTPVGRHGTGEDIARLISFLLQEDSDMITGAIIDVTGGVNVVHQYR
K

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.0155642023346, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=26.984126984127, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=29.1497975708502, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=28.90625, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI66933014, Length=232, Percent_Identity=25.4310344827586, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4503301, Length=205, Percent_Identity=27.3170731707317, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI59889578, Length=199, Percent_Identity=27.6381909547739, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=24.5901639344262, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=27.8225806451613, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=32.0987654320988, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=26.8, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=28.5123966942149, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789208, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=26.8, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI2367365, Length=244, Percent_Identity=26.6393442622951, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=24.7011952191235, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=24.6913580246914, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=25.4901960784314, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786812, Length=243, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=27.843137254902, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=26.6409266409266, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=27.9693486590038, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=237, Percent_Identity=26.1603375527426, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=26.5384615384615, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=25.4032258064516, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=27.9850746268657, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=24.812030075188, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=27.0916334661355, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=25.3787878787879, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=25.7692307692308, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=25.5639097744361, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=262, Percent_Identity=25.5725190839695, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=115, Percent_Identity=36.5217391304348, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=29.0836653386454, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=27.2357723577236, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=25.4098360655738, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=25.6916996047431, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26726; Mature: 26726

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVMITSGAKGIGRVVTERLLQDGWHVSILQRNPIDWEHERIHMIEAGLTDREQLLSAY
CCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHEEEEECCCCCCHHHHHHHH
EQAVERFGEPDALILNAGPYIFERKPLVELTDDEWDEVLTGNLSASFWLMRRALPSMRSN
HHHHHHHCCCCEEEEECCCCEECCCCCEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHCC
RFGRIISYGFPESGTAPGWIHRSAFAAAKTGLVSLTKSVALEEAPFGITANMVNPGNIVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
SQKEMRIEEAEVDEGTPVGRHGTGEDIARLISFLLQEDSDMITGAIIDVTGGVNVVHQYR
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHC
K
C
>Mature Secondary Structure
MKHVMITSGAKGIGRVVTERLLQDGWHVSILQRNPIDWEHERIHMIEAGLTDREQLLSAY
CCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHEEEEECCCCCCHHHHHHHH
EQAVERFGEPDALILNAGPYIFERKPLVELTDDEWDEVLTGNLSASFWLMRRALPSMRSN
HHHHHHHCCCCEEEEECCCCEECCCCCEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHCC
RFGRIISYGFPESGTAPGWIHRSAFAAAKTGLVSLTKSVALEEAPFGITANMVNPGNIVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
SQKEMRIEEAEVDEGTPVGRHGTGEDIARLISFLLQEDSDMITGAIIDVTGGVNVVHQYR
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]