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The map label for this gene is icd [H]

Identifier: 229916396

GI number: 229916396

Start: 618065

End: 619336

Strand: Reverse

Name: icd [H]

Synonym: EAT1b_0666

Alternate gene names: 229916396

Gene position: 619336-618065 (Counterclockwise)

Preceding gene: 229916397

Following gene: 229916395

Centisome position: 20.65

GC content: 46.23

Gene sequence:

>1272_bases
ATGTTGACACAAGGACAAAAGATTACAGTTGAAAACGGTGTATTGAACGTACCAAACGTACCGACCGTACCATTCATTAT
CGGTGACGGAACAGGTCCTGACATTTGGAATGCGGCTGTTCGCGTCTTTGACGCTGCGGTTGAAAAAGCATACGGCGGCG
ACAAGAAAATCGAATGGATGGAAGTATACGCTGGGGAAAAAGCATATAACGAAAAAGGCGAATGGCTCCCGACAGAGACA
CTTGATCAAATTCGTGAGTACTTGATCGCCATCAAAGGACCACTTACGACTCCAGTCGGTGGAGGAATTCGTTCATTGAA
CGTCGCACTTCGCCAAGAACTCGATTTATATACATGCCTTCGCCCAGTTCGTTACTTCACGGGTGTTCCATCACCAGTAA
AACGTCCTGAAGATACAGACATGGTCATCTTCCGTGAAAACACTGAAGATATCTATGCTGGAATCGAGTACGCTTCAGGA
AGCGATGAAGTGAAAAAACTCATCAAATTCTTGCAAGACGAGATGAATGTCAATAAGATTCGTTTCCCAGAAACATCAGG
AATCGGAATCAAGCCAGTTTCTTCTGAAGGAACAGAGCGTTTGGTTCGTGCAGCAATTGAATATGCGATTGCGAACAACC
GTAAATCTTTAACGCTCGTTCACAAAGGGAACATCATGAAGTTCACAGAAGGCGCCTTCAAAAACTGGGGTTATGCACTC
GCTGAAGCGGAATACGGCGACAAAGTGTTCACATGGGCACAGTATGACCGTATCAAAGAAGAATCTGGTGAAGCAGCTGC
TAACGAAGCTCAGTCGAAAGCGGAAGCTGAAGGGAAAATTATCGTCAAAGATTCAATCGCTGATATCTTCCTCCAGCAGA
TTTTGACACGTCCACGTGAGTTCGACGTCGTTGCGACGATGAACTTGAACGGTGACTATATCTCAGATGCCCTTGCTGCT
CAAGTAGGTGGAATCGGGATTGCACCTGGTGCGAACATCAACTACATCACAGGTCACGCGATCTTCGAAGCGACACACGG
TACAGCTCCGAAATACGCAGGTCTCGATAAAGTAAACCCATCTTCAGTCATCCTTTCAGGTGAGATGATGCTCCGCCACA
TGAACTGGAACGAAGCGGCTGACCTCATCATCAACTCAATGGAGAAAACGATCGCTTCGAAAGTTGTCACATACGACTTC
GCACGTCTCATGGACGGCGCGACAGAAGTGAAATGTTCAGAGTTCGCGGATGAATTGATTAAAAACATGTAA

Upstream 100 bases:

>100_bases
TTAATTCGAGACACATTTTAGACAAAAGTTTGGTAAACTAACAAGTGACGTAGGTCGGCGCACGCGTCGACCTACAGTAA
TGTACTTAGGGGGATTCATT

Downstream 100 bases:

>100_bases
GACGCCCGAGGAGGAGAGCTCATGATTCGTCGTAACAAAATTTCTGTTATTGGAAGTGGCTTCACCGGTGCAACGACTGC
ACTGTACTTGGCTCAACGTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLTQGQKITVENGVLNVPNVPTVPFIIGDGTGPDIWNAAVRVFDAAVEKAYGGDKKIEWMEVYAGEKAYNEKGEWLPTET
LDQIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYTCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYASG
SDEVKKLIKFLQDEMNVNKIRFPETSGIGIKPVSSEGTERLVRAAIEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYAL
AEAEYGDKVFTWAQYDRIKEESGEAAANEAQSKAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAA
QVGGIGIAPGANINYITGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEKTIASKVVTYDF
ARLMDGATEVKCSEFADELIKNM

Sequences:

>Translated_423_residues
MLTQGQKITVENGVLNVPNVPTVPFIIGDGTGPDIWNAAVRVFDAAVEKAYGGDKKIEWMEVYAGEKAYNEKGEWLPTET
LDQIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYTCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYASG
SDEVKKLIKFLQDEMNVNKIRFPETSGIGIKPVSSEGTERLVRAAIEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYAL
AEAEYGDKVFTWAQYDRIKEESGEAAANEAQSKAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAA
QVGGIGIAPGANINYITGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEKTIASKVVTYDF
ARLMDGATEVKCSEFADELIKNM
>Mature_423_residues
MLTQGQKITVENGVLNVPNVPTVPFIIGDGTGPDIWNAAVRVFDAAVEKAYGGDKKIEWMEVYAGEKAYNEKGEWLPTET
LDQIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYTCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYASG
SDEVKKLIKFLQDEMNVNKIRFPETSGIGIKPVSSEGTERLVRAAIEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYAL
AEAEYGDKVFTWAQYDRIKEESGEAAANEAQSKAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAA
QVGGIGIAPGANINYITGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEKTIASKVVTYDF
ARLMDGATEVKCSEFADELIKNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=406, Percent_Identity=31.0344827586207, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI28178816, Length=402, Percent_Identity=27.363184079602, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI28178821, Length=368, Percent_Identity=27.9891304347826, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI4758582, Length=365, Percent_Identity=27.9452054794521, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI28178838, Length=365, Percent_Identity=27.9452054794521, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=29.6482412060301, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787381, Length=422, Percent_Identity=67.2985781990521, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1788101, Length=386, Percent_Identity=30.0518134715026, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081683, Length=403, Percent_Identity=23.8213399503722, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=31.7948717948718, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI25144293, Length=378, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=308, Percent_Identity=29.5454545454545, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=419, Percent_Identity=25.5369928400955, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324709, Length=407, Percent_Identity=31.6953316953317, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324291, Length=408, Percent_Identity=28.6764705882353, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322097, Length=377, Percent_Identity=28.3819628647215, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643268, Length=402, Percent_Identity=32.5870646766169, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24643270, Length=402, Percent_Identity=32.5870646766169, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24661184, Length=400, Percent_Identity=31.25, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161078635, Length=376, Percent_Identity=26.8617021276596, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161078633, Length=318, Percent_Identity=28.6163522012579, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24650122, Length=318, Percent_Identity=28.6163522012579, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078639, Length=318, Percent_Identity=28.6163522012579, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078637, Length=318, Percent_Identity=28.6163522012579, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281362242, Length=410, Percent_Identity=26.8292682926829, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24648872, Length=410, Percent_Identity=26.8292682926829, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46613; Mature: 46613

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQGQKITVENGVLNVPNVPTVPFIIGDGTGPDIWNAAVRVFDAAVEKAYGGDKKIEWM
CCCCCCEEEEECCEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
EVYAGEKAYNEKGEWLPTETLDQIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYTCL
EEECCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYASGSDEVKKLIKFLQDEMNVNKI
HHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCEEECCCHHHHHHHHHHHHHHCCCCEE
RFPETSGIGIKPVSSEGTERLVRAAIEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYAL
ECCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHCCCEEE
AEAEYGDKVFTWAQYDRIKEESGEAAANEAQSKAEAEGKIIVKDSIADIFLQQILTRPRE
EECCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCC
FDVVATMNLNGDYISDALAAQVGGIGIAPGANINYITGHAIFEATHGTAPKYAGLDKVNP
EEEEEEEECCCHHHHHHHHHHHCCEEECCCCCEEEEECCEEEEECCCCCCCCCCCCCCCC
SSVILSGEMMLRHMNWNEAADLIINSMEKTIASKVVTYDFARLMDGATEVKCSEFADELI
CCEEEEHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KNM
HCC
>Mature Secondary Structure
MLTQGQKITVENGVLNVPNVPTVPFIIGDGTGPDIWNAAVRVFDAAVEKAYGGDKKIEWM
CCCCCCEEEEECCEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
EVYAGEKAYNEKGEWLPTETLDQIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYTCL
EEECCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYASGSDEVKKLIKFLQDEMNVNKI
HHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCEEECCCHHHHHHHHHHHHHHCCCCEE
RFPETSGIGIKPVSSEGTERLVRAAIEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYAL
ECCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHCCCEEE
AEAEYGDKVFTWAQYDRIKEESGEAAANEAQSKAEAEGKIIVKDSIADIFLQQILTRPRE
EECCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCC
FDVVATMNLNGDYISDALAAQVGGIGIAPGANINYITGHAIFEATHGTAPKYAGLDKVNP
EEEEEEEECCCHHHHHHHHHHHCCEEECCCCCEEEEECCEEEEECCCCCCCCCCCCCCCC
SSVILSGEMMLRHMNWNEAADLIINSMEKTIASKVVTYDFARLMDGATEVKCSEFADELI
CCEEEEHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KNM
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]