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The map label for this gene is comEC [H]

Identifier: 229916359

GI number: 229916359

Start: 580933

End: 583050

Strand: Reverse

Name: comEC [H]

Synonym: EAT1b_0629

Alternate gene names: 229916359

Gene position: 583050-580933 (Counterclockwise)

Preceding gene: 229916360

Following gene: 229916357

Centisome position: 19.44

GC content: 50.05

Gene sequence:

>2118_bases
ATGCCGCTGTTTCCATTATTTGCGGTACTCATTGTAACTGGTCTGACAGAAGGATTCTATTTGGTCTCTGTGGTCGCTAG
TGTCTTTTATCTGGTCACACGACGTGGGCAAGGCCTGTATGCGAAAGCCGGAGTGATTGGACTCATCTGTATCGCATCGT
TCCATACGACCCCTACAGAATCGTTACCGTCAGACACGATTGCCTTCTCAATCGAAAATCGAAAAGAGAATGGGAAATCG
GTAAGACTATACGGGAACGTAGACAATCTTCAGGGCGTCTTACGAGGACGCGAACTAAATCGCGGACGACCAGGAGAGAC
GTGCCTCGTGCAAATCGAAATAGAGGCGTTTCAACCGTTACGAAACACCGGGGGATTTGATGAACGGGCTTGGGCACGGA
GTTCAAACGTATCCTTTAAAGGGAAGGTGAAGCGAATCGACACGTGTCGTCCGACGGCAGGGTGGGACGGTCGGATGCTA
CGTTGGAAAGAGCGAAAACTTCAGCAAATTGAGCATCGTCATCGTGCGGATGTCGCATTATATATGGAGGCATTGTTGTT
CGGAGAGAGTCGAATGCTAGACGAACAGACCTCATTTTCTTATCGTGTGACGGGCCTTCTTCATCTTCTTGTGATTTCCG
GTTCGCATATTGCTATGTTGATCGTGGCCATGCGCATATTGTTGCAGCCGATCCCTATTCGACGTGAAACGAAGACGGTA
CTGATGATCTTTAGTATTACGATGTTCGGATGGATGACTGGTTTTTCCCCACCTGTCGCAAGAGCTGTCGTCGTCGCAGA
TGCGATCCTCTTTCTCTCTCTTTTCGGTGTGACGATTCGAGACCCGATTCGGCTCTTGAGTTGGTGTGCGGCGGGCATGT
TGGCCGTTCAACCGTTCCTTCTCACGAATCTGGGTTTCCAATTGACGGTCGGGATGACCTTCTTTTTGTTAGTCACGAGA
CAAATCTGGACAGGACTAATCGAGTTGTCCGTTATCGCACAGCTGTTTGGGCTGATTGTACTATGGCAAGTACAACCGGT
TCTATCCGTCGCGGCACCGATATGGAATCTCGTGATGGCCATCTGTATCTCATGGATCATCATGCCACTCGCATTTGTCA
CATGGATGATTCCTTCGATTGCCCCGTTGTTCATGGTTGTCTTGGACGCGATTCATGGAATGTTCACTCTCCACGATGAT
TTACGACCTTGGCTTCCGTTGCACGATCTGGCGTTGCCGTCGCAAATCGCATTGTGGCTAGGGTTATGGGGGAGCTTGAC
GCTGATGAATCGAAAACGATGGATCGGATGGGGGGCGGCTATCATGACATGTGGGTTGATTGCGGGATGGTCAGAATGGT
CGGAATCCTCCCGGGTGACCTTTTTGGATGTCGGGCAAGGTGATGCAATCGTCGTAGAATCGGGAAGAACGATTGGTGTC
ATTGATGTAGGGGGCGTATTTCAAGATCCAAACGAGCAAAAGCGAAGCACATTTGACCCGGGGGAAGATGTACTGGCCCC
TTATTTATGGAAACGTGGGGAGCGTTCGCTTGATTTTGTCCTGTTGACCCATGCGGATCATGACCACATCGGCGGATTAG
AGGGATTATTGAAGGTAGTGACGGTGGAAGAGCTTTGGATATCAAAAGAAGTGGCGAATGCTGAAAAACGAGAAGAACTG
CTACACTTAGCAGCGGCCAATGATGTATCGGTCCATTATCTCGAGGCAGACGATTGGCCGACGCCATGGATGTGGATTGT
GGCACCGAATCGCCCACACGAAGATGAAAATGATCATTCGATCAGCCTGTACATGAACGTAGGTGGCATGCGGTATCTAT
TGACAGGAGATTTGCCGATAGAAGGAGAAGCCGAGTTACCGACGCTTGACGTCGACGTATTTAAACTAGGGCATCACGGA
TCCGATACGTCGTCGGGAGAAGAGCTGCTTGAGCGAATCGATCCAGAATGGGTCATTGCGAGTGTCGGTTCGAACAATCG
GTATGGACATCCGCACGAGGAGACGTTACGACGGGTTGTGGGGAAACGTCTATTACGAACCGATTTGAACGGGATGATTG
TCTGTGAAGAGAACATGTGTCGGGGGATCATCGAGTAG

Upstream 100 bases:

>100_bases
GCGAACGGTCCATTTAAAACATATGAAGCGCTAGGTGATGTGAAGGGGTTCGGCGAAAAGACATTAGAAAGTATGAAGCC
ATATTTATTGGTACCTTAAG

Downstream 100 bases:

>100_bases
CACGGCATAAAATGTGATACACTAAAAAACGATTGCTCCCCCGGGGCAATCGTTTGAACACTTATAGACTTAAGAACTTG
ATGATGACACCGATGAAGAA

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 705; Mature: 704

Protein sequence:

>705_residues
MPLFPLFAVLIVTGLTEGFYLVSVVASVFYLVTRRGQGLYAKAGVIGLICIASFHTTPTESLPSDTIAFSIENRKENGKS
VRLYGNVDNLQGVLRGRELNRGRPGETCLVQIEIEAFQPLRNTGGFDERAWARSSNVSFKGKVKRIDTCRPTAGWDGRML
RWKERKLQQIEHRHRADVALYMEALLFGESRMLDEQTSFSYRVTGLLHLLVISGSHIAMLIVAMRILLQPIPIRRETKTV
LMIFSITMFGWMTGFSPPVARAVVVADAILFLSLFGVTIRDPIRLLSWCAAGMLAVQPFLLTNLGFQLTVGMTFFLLVTR
QIWTGLIELSVIAQLFGLIVLWQVQPVLSVAAPIWNLVMAICISWIIMPLAFVTWMIPSIAPLFMVVLDAIHGMFTLHDD
LRPWLPLHDLALPSQIALWLGLWGSLTLMNRKRWIGWGAAIMTCGLIAGWSEWSESSRVTFLDVGQGDAIVVESGRTIGV
IDVGGVFQDPNEQKRSTFDPGEDVLAPYLWKRGERSLDFVLLTHADHDHIGGLEGLLKVVTVEELWISKEVANAEKREEL
LHLAAANDVSVHYLEADDWPTPWMWIVAPNRPHEDENDHSISLYMNVGGMRYLLTGDLPIEGEAELPTLDVDVFKLGHHG
SDTSSGEELLERIDPEWVIASVGSNNRYGHPHEETLRRVVGKRLLRTDLNGMIVCEENMCRGIIE

Sequences:

>Translated_705_residues
MPLFPLFAVLIVTGLTEGFYLVSVVASVFYLVTRRGQGLYAKAGVIGLICIASFHTTPTESLPSDTIAFSIENRKENGKS
VRLYGNVDNLQGVLRGRELNRGRPGETCLVQIEIEAFQPLRNTGGFDERAWARSSNVSFKGKVKRIDTCRPTAGWDGRML
RWKERKLQQIEHRHRADVALYMEALLFGESRMLDEQTSFSYRVTGLLHLLVISGSHIAMLIVAMRILLQPIPIRRETKTV
LMIFSITMFGWMTGFSPPVARAVVVADAILFLSLFGVTIRDPIRLLSWCAAGMLAVQPFLLTNLGFQLTVGMTFFLLVTR
QIWTGLIELSVIAQLFGLIVLWQVQPVLSVAAPIWNLVMAICISWIIMPLAFVTWMIPSIAPLFMVVLDAIHGMFTLHDD
LRPWLPLHDLALPSQIALWLGLWGSLTLMNRKRWIGWGAAIMTCGLIAGWSEWSESSRVTFLDVGQGDAIVVESGRTIGV
IDVGGVFQDPNEQKRSTFDPGEDVLAPYLWKRGERSLDFVLLTHADHDHIGGLEGLLKVVTVEELWISKEVANAEKREEL
LHLAAANDVSVHYLEADDWPTPWMWIVAPNRPHEDENDHSISLYMNVGGMRYLLTGDLPIEGEAELPTLDVDVFKLGHHG
SDTSSGEELLERIDPEWVIASVGSNNRYGHPHEETLRRVVGKRLLRTDLNGMIVCEENMCRGIIE
>Mature_704_residues
PLFPLFAVLIVTGLTEGFYLVSVVASVFYLVTRRGQGLYAKAGVIGLICIASFHTTPTESLPSDTIAFSIENRKENGKSV
RLYGNVDNLQGVLRGRELNRGRPGETCLVQIEIEAFQPLRNTGGFDERAWARSSNVSFKGKVKRIDTCRPTAGWDGRMLR
WKERKLQQIEHRHRADVALYMEALLFGESRMLDEQTSFSYRVTGLLHLLVISGSHIAMLIVAMRILLQPIPIRRETKTVL
MIFSITMFGWMTGFSPPVARAVVVADAILFLSLFGVTIRDPIRLLSWCAAGMLAVQPFLLTNLGFQLTVGMTFFLLVTRQ
IWTGLIELSVIAQLFGLIVLWQVQPVLSVAAPIWNLVMAICISWIIMPLAFVTWMIPSIAPLFMVVLDAIHGMFTLHDDL
RPWLPLHDLALPSQIALWLGLWGSLTLMNRKRWIGWGAAIMTCGLIAGWSEWSESSRVTFLDVGQGDAIVVESGRTIGVI
DVGGVFQDPNEQKRSTFDPGEDVLAPYLWKRGERSLDFVLLTHADHDHIGGLEGLLKVVTVEELWISKEVANAEKREELL
HLAAANDVSVHYLEADDWPTPWMWIVAPNRPHEDENDHSISLYMNVGGMRYLLTGDLPIEGEAELPTLDVDVFKLGHHGS
DTSSGEELLERIDPEWVIASVGSNNRYGHPHEETLRRVVGKRLLRTDLNGMIVCEENMCRGIIE

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=671, Percent_Identity=22.8017883755589, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 78977; Mature: 78846

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFPLFAVLIVTGLTEGFYLVSVVASVFYLVTRRGQGLYAKAGVIGLICIASFHTTPTE
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCC
SLPSDTIAFSIENRKENGKSVRLYGNVDNLQGVLRGRELNRGRPGETCLVQIEIEAFQPL
CCCCCEEEEEEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHH
RNTGGFDERAWARSSNVSFKGKVKRIDTCRPTAGWDGRMLRWKERKLQQIEHRHRADVAL
HCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YMEALLFGESRMLDEQTSFSYRVTGLLHLLVISGSHIAMLIVAMRILLQPIPIRRETKTV
HHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHH
LMIFSITMFGWMTGFSPPVARAVVVADAILFLSLFGVTIRDPIRLLSWCAAGMLAVQPFL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LTNLGFQLTVGMTFFLLVTRQIWTGLIELSVIAQLFGLIVLWQVQPVLSVAAPIWNLVMA
HHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ICISWIIMPLAFVTWMIPSIAPLFMVVLDAIHGMFTLHDDLRPWLPLHDLALPSQIALWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHCCHHHHHHHH
GLWGSLTLMNRKRWIGWGAAIMTCGLIAGWSEWSESSRVTFLDVGQGDAIVVESGRTIGV
HHHHCEEEECCCHHCCCCHHHHHHHHHHCCHHHCCCCCEEEEECCCCCEEEEECCCEEEE
IDVGGVFQDPNEQKRSTFDPGEDVLAPYLWKRGERSLDFVLLTHADHDHIGGLEGLLKVV
EEECCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHH
TVEELWISKEVANAEKREELLHLAAANDVSVHYLEADDWPTPWMWIVAPNRPHEDENDHS
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCE
ISLYMNVGGMRYLLTGDLPIEGEAELPTLDVDVFKLGHHGSDTSSGEELLERIDPEWVIA
EEEEEECCCEEEEEECCCCCCCCCCCCEECHHHEEECCCCCCCCCHHHHHHHCCCCEEEE
SVGSNNRYGHPHEETLRRVVGKRLLRTDLNGMIVCEENMCRGIIE
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCC
>Mature Secondary Structure 
PLFPLFAVLIVTGLTEGFYLVSVVASVFYLVTRRGQGLYAKAGVIGLICIASFHTTPTE
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCC
SLPSDTIAFSIENRKENGKSVRLYGNVDNLQGVLRGRELNRGRPGETCLVQIEIEAFQPL
CCCCCEEEEEEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHH
RNTGGFDERAWARSSNVSFKGKVKRIDTCRPTAGWDGRMLRWKERKLQQIEHRHRADVAL
HCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YMEALLFGESRMLDEQTSFSYRVTGLLHLLVISGSHIAMLIVAMRILLQPIPIRRETKTV
HHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHH
LMIFSITMFGWMTGFSPPVARAVVVADAILFLSLFGVTIRDPIRLLSWCAAGMLAVQPFL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LTNLGFQLTVGMTFFLLVTRQIWTGLIELSVIAQLFGLIVLWQVQPVLSVAAPIWNLVMA
HHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ICISWIIMPLAFVTWMIPSIAPLFMVVLDAIHGMFTLHDDLRPWLPLHDLALPSQIALWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHCCHHHHHHHH
GLWGSLTLMNRKRWIGWGAAIMTCGLIAGWSEWSESSRVTFLDVGQGDAIVVESGRTIGV
HHHHCEEEECCCHHCCCCHHHHHHHHHHCCHHHCCCCCEEEEECCCCCEEEEECCCEEEE
IDVGGVFQDPNEQKRSTFDPGEDVLAPYLWKRGERSLDFVLLTHADHDHIGGLEGLLKVV
EEECCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHH
TVEELWISKEVANAEKREELLHLAAANDVSVHYLEADDWPTPWMWIVAPNRPHEDENDHS
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCE
ISLYMNVGGMRYLLTGDLPIEGEAELPTLDVDVFKLGHHGSDTSSGEELLERIDPEWVIA
EEEEEECCCEEEEEECCCCCCCCCCCCEECHHHEEECCCCCCCCCHHHHHHHCCCCEEEE
SVGSNNRYGHPHEETLRRVVGKRLLRTDLNGMIVCEENMCRGIIE
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]