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The map label for this gene is ycgO [H]

Identifier: 229916097

GI number: 229916097

Start: 326696

End: 328183

Strand: Direct

Name: ycgO [H]

Synonym: EAT1b_0366

Alternate gene names: 229916097

Gene position: 326696-328183 (Clockwise)

Preceding gene: 229916096

Following gene: 229916098

Centisome position: 10.89

GC content: 47.04

Gene sequence:

>1488_bases
ATGAACGGAATTTTAGTGTCCATTGTCGTGTACATGGCACTGATGGTCTTGCTTGGGATCATCGCGTATCGGAGAACAAG
CAGTATCGGAGATTACATGTTAGGTGGTCGGGCGCTTGGTCCCGGGGTCGCCGCCTTATCTGCCGGTGCATCAGACATGA
GTGGATGGCTCTTAATGGGATTACCTGGTGCAATGTATGCGTCAGGGATTTCAAGTGGCTGGATTGTCATCGGGTTGACG
ATCGGCGCCTATTTGAACTGGTTATTGGTCGCACCAAGATTGCGCATTTATTCATACATATCGGATGATGCGATCACAAT
CCCAGACTTCTTTGAGAAGCGATTTAAAGACACAAAAGGTGTGTTGCGTTCATTTTCAGCTGCTGTCACGTTAATTTTTT
TCACACTTTATGCGACAAGCGGATTCGTCGCCGGCGGTCGCCTATTCAATGCCGTCTTCGACATTGAATTTGTAACGGGA
GTCGTCATTCTCGCTTCCATCATTATTCTGTACACTTTCATCGGTGGATTTTTAGCAGTAAGCTGGACAGATTTTGTTCA
AGGATTGATCATGCTGTTTGCCCTTATTTTTGTACCTGCCATCGCCATTATGGCAACTGATGGTGTATCAAATGCTTTAG
ACACGGTACGAAATATTGATGAAGCGTTACTTGATCCGTGGACGGGGCAATCACTTATCGGAATCATTTCACTATTTGCG
TGGGGGCTCGGCTATTTCGGCCAGCCACACATCATCGTCCGTTTTATGGCAATCGGAAAGCTCGAGGACATTAAGACGGC
ACGTCGAATCGGGATCTCATGGATGGTCTTCACCGTTGTCGGGGCGATGGCGACCGGATTATTCGGTCTCGCCTATTACA
CACAACAAGGCCTCACCATCGATAATCCGGAGAACGTTTTTATCAACCTATCTGACTTATTATTCCCGGATTTGGTGACT
GGTGTATTATTGGCTGCTCTTCTCGCCGCCATCATGTCGACCATCTCCTCTCAATTGCTCGTCTCGTCGAGTGCCGCGAC
GACAGACTTTTATCAGAAGTTCTTCCGTAAAGAAGCGGGAGACCGTGAACTCGTCATGGTCGGTCGGATTACGGTCATTC
TCGTATCCGTCATATCGATTATTCTTGCACTCGATGCAGACGACACCATCTTAAACCTTGTTGGTTATGCTTGGGCAGGG
TTTGGTTCATCATTTGGTCCGCTCATCTTGTTCAGTCTGTTTTGGAAACGAACGACGCGTCAAGGCGCGCTTGCTGGAAT
GTTGACTGGAGCCTTTGTCGTCATTCTATGGAAGAACTATGCCGCTTCTCTTTTCGGAACGTTTGGGACATTGTATGAAA
TGATTCCAGCATTCTTCCTGTCGTCACTTGCCATCTATATTGTGAGTTTGGTGACACCGCCACCAAATGAGGTCATTCAA
CGTGAGTTTGACCAAATGCAAGACATGGTCAAAGAACATATCAAATAA

Upstream 100 bases:

>100_bases
ATATCTTTACATTCCCCCTCTTGTTGTGACAATATTTTGACAAAGTGATACTCTATCACTGAAAGCGTTTTCATATTTTT
TATCTTTCGGGGGGATGTTG

Downstream 100 bases:

>100_bases
ATCTCATGACAGGTCAAAAACGACCTGTCTTTATTTATTTAGGCAGGATTTTTCTTAATTATCGACGAATTTTAGGGTTA
TCGTACGAATCTGTCGTGAA

Product: sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNGILVSIVVYMALMVLLGIIAYRRTSSIGDYMLGGRALGPGVAALSAGASDMSGWLLMGLPGAMYASGISSGWIVIGLT
IGAYLNWLLVAPRLRIYSYISDDAITIPDFFEKRFKDTKGVLRSFSAAVTLIFFTLYATSGFVAGGRLFNAVFDIEFVTG
VVILASIIILYTFIGGFLAVSWTDFVQGLIMLFALIFVPAIAIMATDGVSNALDTVRNIDEALLDPWTGQSLIGIISLFA
WGLGYFGQPHIIVRFMAIGKLEDIKTARRIGISWMVFTVVGAMATGLFGLAYYTQQGLTIDNPENVFINLSDLLFPDLVT
GVLLAALLAAIMSTISSQLLVSSSAATTDFYQKFFRKEAGDRELVMVGRITVILVSVISIILALDADDTILNLVGYAWAG
FGSSFGPLILFSLFWKRTTRQGALAGMLTGAFVVILWKNYAASLFGTFGTLYEMIPAFFLSSLAIYIVSLVTPPPNEVIQ
REFDQMQDMVKEHIK

Sequences:

>Translated_495_residues
MNGILVSIVVYMALMVLLGIIAYRRTSSIGDYMLGGRALGPGVAALSAGASDMSGWLLMGLPGAMYASGISSGWIVIGLT
IGAYLNWLLVAPRLRIYSYISDDAITIPDFFEKRFKDTKGVLRSFSAAVTLIFFTLYATSGFVAGGRLFNAVFDIEFVTG
VVILASIIILYTFIGGFLAVSWTDFVQGLIMLFALIFVPAIAIMATDGVSNALDTVRNIDEALLDPWTGQSLIGIISLFA
WGLGYFGQPHIIVRFMAIGKLEDIKTARRIGISWMVFTVVGAMATGLFGLAYYTQQGLTIDNPENVFINLSDLLFPDLVT
GVLLAALLAAIMSTISSQLLVSSSAATTDFYQKFFRKEAGDRELVMVGRITVILVSVISIILALDADDTILNLVGYAWAG
FGSSFGPLILFSLFWKRTTRQGALAGMLTGAFVVILWKNYAASLFGTFGTLYEMIPAFFLSSLAIYIVSLVTPPPNEVIQ
REFDQMQDMVKEHIK
>Mature_495_residues
MNGILVSIVVYMALMVLLGIIAYRRTSSIGDYMLGGRALGPGVAALSAGASDMSGWLLMGLPGAMYASGISSGWIVIGLT
IGAYLNWLLVAPRLRIYSYISDDAITIPDFFEKRFKDTKGVLRSFSAAVTLIFFTLYATSGFVAGGRLFNAVFDIEFVTG
VVILASIIILYTFIGGFLAVSWTDFVQGLIMLFALIFVPAIAIMATDGVSNALDTVRNIDEALLDPWTGQSLIGIISLFA
WGLGYFGQPHIIVRFMAIGKLEDIKTARRIGISWMVFTVVGAMATGLFGLAYYTQQGLTIDNPENVFINLSDLLFPDLVT
GVLLAALLAAIMSTISSQLLVSSSAATTDFYQKFFRKEAGDRELVMVGRITVILVSVISIILALDADDTILNLVGYAWAG
FGSSFGPLILFSLFWKRTTRQGALAGMLTGAFVVILWKNYAASLFGTFGTLYEMIPAFFLSSLAIYIVSLVTPPPNEVIQ
REFDQMQDMVKEHIK

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=492, Percent_Identity=48.780487804878, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI110835708, Length=543, Percent_Identity=26.3351749539595, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI109659839, Length=564, Percent_Identity=23.5815602836879, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI109659836, Length=548, Percent_Identity=23.9051094890511, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=22.5941422594142, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI206597487, Length=520, Percent_Identity=23.2692307692308, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI206597483, Length=445, Percent_Identity=24.2696629213483, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI11141885, Length=550, Percent_Identity=25.6363636363636, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4507031, Length=552, Percent_Identity=23.1884057971014, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4507033, Length=414, Percent_Identity=26.5700483091787, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787251, Length=486, Percent_Identity=50.8230452674897, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1790503, Length=492, Percent_Identity=26.0162601626016, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87082237, Length=438, Percent_Identity=27.6255707762557, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790113, Length=388, Percent_Identity=26.8041237113402, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539284, Length=460, Percent_Identity=25.6521739130435, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221459584, Length=377, Percent_Identity=26.525198938992, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221459586, Length=383, Percent_Identity=26.1096605744125, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221459588, Length=434, Percent_Identity=24.6543778801843, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648033, Length=391, Percent_Identity=24.2966751918159, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356865, Length=391, Percent_Identity=24.2966751918159, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24645928, Length=359, Percent_Identity=27.8551532033426, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24640370, Length=446, Percent_Identity=25.3363228699552, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53740; Mature: 53740

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGILVSIVVYMALMVLLGIIAYRRTSSIGDYMLGGRALGPGVAALSAGASDMSGWLLMG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHCCCCCCCCEEEEC
LPGAMYASGISSGWIVIGLTIGAYLNWLLVAPRLRIYSYISDDAITIPDFFEKRFKDTKG
CCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLRSFSAAVTLIFFTLYATSGFVAGGRLFNAVFDIEFVTGVVILASIIILYTFIGGFLAV
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWTDFVQGLIMLFALIFVPAIAIMATDGVSNALDTVRNIDEALLDPWTGQSLIGIISLFA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WGLGYFGQPHIIVRFMAIGKLEDIKTARRIGISWMVFTVVGAMATGLFGLAYYTQQGLTI
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
DNPENVFINLSDLLFPDLVTGVLLAALLAAIMSTISSQLLVSSSAATTDFYQKFFRKEAG
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
DRELVMVGRITVILVSVISIILALDADDTILNLVGYAWAGFGSSFGPLILFSLFWKRTTR
CCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QGALAGMLTGAFVVILWKNYAASLFGTFGTLYEMIPAFFLSSLAIYIVSLVTPPPNEVIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
REFDQMQDMVKEHIK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGILVSIVVYMALMVLLGIIAYRRTSSIGDYMLGGRALGPGVAALSAGASDMSGWLLMG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHCCCCCCCCEEEEC
LPGAMYASGISSGWIVIGLTIGAYLNWLLVAPRLRIYSYISDDAITIPDFFEKRFKDTKG
CCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLRSFSAAVTLIFFTLYATSGFVAGGRLFNAVFDIEFVTGVVILASIIILYTFIGGFLAV
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWTDFVQGLIMLFALIFVPAIAIMATDGVSNALDTVRNIDEALLDPWTGQSLIGIISLFA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WGLGYFGQPHIIVRFMAIGKLEDIKTARRIGISWMVFTVVGAMATGLFGLAYYTQQGLTI
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
DNPENVFINLSDLLFPDLVTGVLLAALLAAIMSTISSQLLVSSSAATTDFYQKFFRKEAG
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
DRELVMVGRITVILVSVISIILALDADDTILNLVGYAWAGFGSSFGPLILFSLFWKRTTR
CCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QGALAGMLTGAFVVILWKNYAASLFGTFGTLYEMIPAFFLSSLAIYIVSLVTPPPNEVIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
REFDQMQDMVKEHIK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]