Click here to switch to the map view.

The map label for this gene is polC [H]

Identifier: 229916087

GI number: 229916087

Start: 318377

End: 318943

Strand: Direct

Name: polC [H]

Synonym: EAT1b_0356

Alternate gene names: 229916087

Gene position: 318377-318943 (Clockwise)

Preceding gene: 229916086

Following gene: 229916093

Centisome position: 10.61

GC content: 49.21

Gene sequence:

>567_bases
ATGAACCATACCATTCTCGCACTTGACGTGGAGACCGCTAACCGTGATAGTCGCAGCATCTGTTCTGTCGGATGGAGCAT
CCTTCAAAATGGTGATGTGGTCGAAACCGACCAGCGACTCGTCAATCCGGAGGAAGACTTTGATATGGGTAACATCCGCG
TCCATGGCATCCGTCCGAGTGACGTGTGGGATGCACCGGCATTACCGGAAGTACTCTCCTCTCTTTACCCGATTTTACGG
GAAGTGGACCTCGTCATCGCACATAACGCCTCATTTGACATGGGTGCCTTGAGAAAGGCGATTGTAAAATATGATCTATT
CGATTTCCCGACAATCGAGTACGGTTGCACCGTCAAACTGTCACGTAAACTGTATCCAGGGCTCCCGAACCATAAATTGA
ACACGATGGCAGAACACTTGAACGTGCCGTTTATTCATCATGATGCCGCGGAAGATGCTCGTGTATGCGCGCTACTTATG
CGAGACATGATGCAAAAAACCGGCATCACAAGCCCCAAAGAATTACATCGCTATACGTCCGTCAAAACAGGAACGCTCGC
ATATTAA

Upstream 100 bases:

>100_bases
CGTTGTGCGGAAGCTTGCCGAACACTTGTTGCCGCTTAAGCACGACATTCGTCTAACTTTCTGTTAGACTTTTTTTATTG
CTTACGAAAGAAGGTAAACT

Downstream 100 bases:

>100_bases
ACCGGTCATGAAATCATGACCGGTCATTTTTTGAATATCCATCTTTTTTGAATATAATAACTGACGAAAAAGAGAAAGCT
ATCGACGACTACTTTTAAGA

Product: exonuclease RNase T and DNA polymerase III

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MNHTILALDVETANRDSRSICSVGWSILQNGDVVETDQRLVNPEEDFDMGNIRVHGIRPSDVWDAPALPEVLSSLYPILR
EVDLVIAHNASFDMGALRKAIVKYDLFDFPTIEYGCTVKLSRKLYPGLPNHKLNTMAEHLNVPFIHHDAAEDARVCALLM
RDMMQKTGITSPKELHRYTSVKTGTLAY

Sequences:

>Translated_188_residues
MNHTILALDVETANRDSRSICSVGWSILQNGDVVETDQRLVNPEEDFDMGNIRVHGIRPSDVWDAPALPEVLSSLYPILR
EVDLVIAHNASFDMGALRKAIVKYDLFDFPTIEYGCTVKLSRKLYPGLPNHKLNTMAEHLNVPFIHHDAAEDARVCALLM
RDMMQKTGITSPKELHRYTSVKTGTLAY
>Mature_188_residues
MNHTILALDVETANRDSRSICSVGWSILQNGDVVETDQRLVNPEEDFDMGNIRVHGIRPSDVWDAPALPEVLSSLYPILR
EVDLVIAHNASFDMGALRKAIVKYDLFDFPTIEYGCTVKLSRKLYPGLPNHKLNTMAEHLNVPFIHHDAAEDARVCALLM
RDMMQKTGITSPKELHRYTSVKTGTLAY

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 21147; Mature: 21147

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHTILALDVETANRDSRSICSVGWSILQNGDVVETDQRLVNPEEDFDMGNIRVHGIRPS
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCHHHHCCCCCCCCCCCEEEEECCCC
DVWDAPALPEVLSSLYPILREVDLVIAHNASFDMGALRKAIVKYDLFDFPTIEYGCTVKL
CCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
SRKLYPGLPNHKLNTMAEHLNVPFIHHDAAEDARVCALLMRDMMQKTGITSPKELHRYTS
CCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
VKTGTLAY
CCCCCCCC
>Mature Secondary Structure
MNHTILALDVETANRDSRSICSVGWSILQNGDVVETDQRLVNPEEDFDMGNIRVHGIRPS
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCHHHHCCCCCCCCCCCEEEEECCCC
DVWDAPALPEVLSSLYPILREVDLVIAHNASFDMGALRKAIVKYDLFDFPTIEYGCTVKL
CCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
SRKLYPGLPNHKLNTMAEHLNVPFIHHDAAEDARVCALLMRDMMQKTGITSPKELHRYTS
CCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
VKTGTLAY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]