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The map label for this gene is msrA [H]

Identifier: 229916078

GI number: 229916078

Start: 311170

End: 311694

Strand: Direct

Name: msrA [H]

Synonym: EAT1b_0347

Alternate gene names: 229916078

Gene position: 311170-311694 (Clockwise)

Preceding gene: 229916077

Following gene: 229916079

Centisome position: 10.37

GC content: 49.9

Gene sequence:

>525_bases
ATGGAAAAAGCAACATTCGCAGGCGGCTGTTTTTGGTGCATGGTGACACCATTTGAAGAATTACCAGGGATTGAAGGTAT
CGTGTCCGGCTATATGGGCGGACAGGTCGACAATCCAACATATGAACAAGTGAAAACCGGGACGACGGGGCACCTCGAGG
TCGTTCAAATCACATATGATCCAGCATTATTCTCGTATGAACGTCTTCTTGAGCTGTATTGGATTCAGACAGACCCAACG
GACGATGGTGGTCAATTCCAAGACCGGGGACCTCAGTATGCCCCAGCCATCTTCTATCACACCGAAGAACAACGAGTCGC
GGCTGATGCGAGTCGCGATGTGTTGGCAGCAAGTGGTCGATTCACGGCTCCGATCGTCACGAAAATCATTCCGGCGACGA
CGTTCTTCGCTGCAGAAGACTACCATCAGGATTATCATAAAAAGAATCCGAAGCATTATAAGGAGGACCGGGCCATCTCG
GGACGCGACGAGTTTATCGAGGAAAACTGGACGAAAACCGTATAA

Upstream 100 bases:

>100_bases
TACGACCAGCAAGGGAAACCTTGGACGATATGACGAAAGCGCTCATGTCATCCGACGTGAGCGCTTTTTTGTTGAATGAC
GATTTGGAGGGAACGACAGT

Downstream 100 bases:

>100_bases
CGGTCATCAGACGCGAATGTTAGCATTCGCGTCTTTTAATTAGCACATTAATCGGGAATTGGGAAATAACCGTTCATACA
TCCGAAAAGGAGGACTCATA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MEKATFAGGCFWCMVTPFEELPGIEGIVSGYMGGQVDNPTYEQVKTGTTGHLEVVQITYDPALFSYERLLELYWIQTDPT
DDGGQFQDRGPQYAPAIFYHTEEQRVAADASRDVLAASGRFTAPIVTKIIPATTFFAAEDYHQDYHKKNPKHYKEDRAIS
GRDEFIEENWTKTV

Sequences:

>Translated_174_residues
MEKATFAGGCFWCMVTPFEELPGIEGIVSGYMGGQVDNPTYEQVKTGTTGHLEVVQITYDPALFSYERLLELYWIQTDPT
DDGGQFQDRGPQYAPAIFYHTEEQRVAADASRDVLAASGRFTAPIVTKIIPATTFFAAEDYHQDYHKKNPKHYKEDRAIS
GRDEFIEENWTKTV
>Mature_174_residues
MEKATFAGGCFWCMVTPFEELPGIEGIVSGYMGGQVDNPTYEQVKTGTTGHLEVVQITYDPALFSYERLLELYWIQTDPT
DDGGQFQDRGPQYAPAIFYHTEEQRVAADASRDVLAASGRFTAPIVTKIIPATTFFAAEDYHQDYHKKNPKHYKEDRAIS
GRDEFIEENWTKTV

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=41.025641025641, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=41.025641025641, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609993, Length=152, Percent_Identity=38.8157894736842, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=45.7516339869281, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=33.1034482758621, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=31.4814814814815, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664627, Length=148, Percent_Identity=35.8108108108108, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664631, Length=148, Percent_Identity=35.1351351351351, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=34.965034965035, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19702; Mature: 19702

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKATFAGGCFWCMVTPFEELPGIEGIVSGYMGGQVDNPTYEQVKTGTTGHLEVVQITYD
CCCCCCCCCEEEEEECCHHHCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEEC
PALFSYERLLELYWIQTDPTDDGGQFQDRGPQYAPAIFYHTEEQRVAADASRDVLAASGR
CHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCEEECCCC
FTAPIVTKIIPATTFFAAEDYHQDYHKKNPKHYKEDRAISGRDEFIEENWTKTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MEKATFAGGCFWCMVTPFEELPGIEGIVSGYMGGQVDNPTYEQVKTGTTGHLEVVQITYD
CCCCCCCCCEEEEEECCHHHCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEEC
PALFSYERLLELYWIQTDPTDDGGQFQDRGPQYAPAIFYHTEEQRVAADASRDVLAASGR
CHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCEEECCCC
FTAPIVTKIIPATTFFAAEDYHQDYHKKNPKHYKEDRAISGRDEFIEENWTKTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]