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The map label for this gene is yciC [H]

Identifier: 229916069

GI number: 229916069

Start: 303291

End: 304490

Strand: Reverse

Name: yciC [H]

Synonym: EAT1b_0337

Alternate gene names: 229916069

Gene position: 304490-303291 (Counterclockwise)

Preceding gene: 229916070

Following gene: 229916068

Centisome position: 10.15

GC content: 51.17

Gene sequence:

>1200_bases
ATGAAACGAATTCCAATTACAGTACTCTCGGGTTATCTTGGTAGCGGAAAGACGACACTGCTCAACCACATCTTACATAA
CCGGGAAGATAAAAAATATGCGGTCATCGTGAACGATATGAGCGAGTTGAACATCGATGAGAAATTGATTGAACAGGGTG
GTTTCTCCCGTACCGATGAAAAATTAGTCGAACTCTCGAACGGGTGCATCTGTTGTACCCTACGTGAGGATTTGCTGACA
GCGGTCTATGAGTTGACAAAGGATCGCGACCTCGATGGCATCATCATCGAGTCTTCTGGTATCTCTGAACCGATTCCCGT
TGCGCAGACATTCACGTATGCCGATGATGCGCTCGGAATCGATTTGACGAGCCGCGTCTATATCGATGCGATGGTCACTG
TCGTCGATGCGTATCGTTTCTTCAAAGATTTCAATTCTGGTGAATCGCTCATGGAACGTCAACAAGCCGTCGATACAGGA
GATGTCCGTGAAGTCGTCGACCTACTCGTCGATCAAGTCGAATTTGCGGATATCATCGTGTTGAATAAGGCAGACCGGGT
GTCTGAAGCGGAACTGCAGGAGATGAAGGGGCTACTTAAGACACTCAACCCGAGCGCCCGATTATTGACTTCAACGTACT
CCGACGTAGCGTTAGACGATCTACTCGACGTCCAGTTGTTCGATTTCGATCAGGCGATGCGTGCGGCGGGATGGATTCAA
GAACTTGAGGCAGAAGAACATACGCCGGAAACGGAAGAGTATGGCATCAGCTCGTTCGTCTACCGTCGTCGTCGACCGTT
CCATCCTGAGCGTTTGATGAATTGGATGGAGCATTACCCTGAAGAAATCGTCCGCGCCAAAGGCTTCTTGTGGATTGCGT
CACGGAACGACCTTGCCTGTCTCTTCTCCCAGGCCGGATACGCATCGACGCTCGAACATGCCGGTCGTTGGTTAGCGACC
CTTCCCGAGAGTGAACGAGAGGCCATGTTCTCCTCAGAACCGGAACTGCGCGAGGACTACATCGAGCCGTACGGAGACCG
ACAGAACGAATTGGTCCTTATCGGTCAACGGATGGACCGGGATGCGGTCGAGCAATCACTTGACGCCTGTTTGTTGACGG
ATGAGGAGATGGTAGCGGAGTGGGATTCGTTCCATGACCCACTTCCTGGTACTGGCCAACTCGTCACCTATTCAGATTGA

Upstream 100 bases:

>100_bases
TCAAAACACGTCCATATGGCGTGTTTTTTTGTTGACAAATCGAATCAGTCGTTTCAATATATAAAAAGTAATGATTACGA
TTTAATGGAGGTTCATCAAT

Downstream 100 bases:

>100_bases
CCGTTTACAAACTGACGAAACATCGCTATACTGTGACTGCATAAGTAACCGCATATCAATGACTGCACTAGGGGTGCTTC
GGCTGAGATGTGAGCATGGC

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKRIPITVLSGYLGSGKTTLLNHILHNREDKKYAVIVNDMSELNIDEKLIEQGGFSRTDEKLVELSNGCICCTLREDLLT
AVYELTKDRDLDGIIIESSGISEPIPVAQTFTYADDALGIDLTSRVYIDAMVTVVDAYRFFKDFNSGESLMERQQAVDTG
DVREVVDLLVDQVEFADIIVLNKADRVSEAELQEMKGLLKTLNPSARLLTSTYSDVALDDLLDVQLFDFDQAMRAAGWIQ
ELEAEEHTPETEEYGISSFVYRRRRPFHPERLMNWMEHYPEEIVRAKGFLWIASRNDLACLFSQAGYASTLEHAGRWLAT
LPESEREAMFSSEPELREDYIEPYGDRQNELVLIGQRMDRDAVEQSLDACLLTDEEMVAEWDSFHDPLPGTGQLVTYSD

Sequences:

>Translated_399_residues
MKRIPITVLSGYLGSGKTTLLNHILHNREDKKYAVIVNDMSELNIDEKLIEQGGFSRTDEKLVELSNGCICCTLREDLLT
AVYELTKDRDLDGIIIESSGISEPIPVAQTFTYADDALGIDLTSRVYIDAMVTVVDAYRFFKDFNSGESLMERQQAVDTG
DVREVVDLLVDQVEFADIIVLNKADRVSEAELQEMKGLLKTLNPSARLLTSTYSDVALDDLLDVQLFDFDQAMRAAGWIQ
ELEAEEHTPETEEYGISSFVYRRRRPFHPERLMNWMEHYPEEIVRAKGFLWIASRNDLACLFSQAGYASTLEHAGRWLAT
LPESEREAMFSSEPELREDYIEPYGDRQNELVLIGQRMDRDAVEQSLDACLLTDEEMVAEWDSFHDPLPGTGQLVTYSD
>Mature_399_residues
MKRIPITVLSGYLGSGKTTLLNHILHNREDKKYAVIVNDMSELNIDEKLIEQGGFSRTDEKLVELSNGCICCTLREDLLT
AVYELTKDRDLDGIIIESSGISEPIPVAQTFTYADDALGIDLTSRVYIDAMVTVVDAYRFFKDFNSGESLMERQQAVDTG
DVREVVDLLVDQVEFADIIVLNKADRVSEAELQEMKGLLKTLNPSARLLTSTYSDVALDDLLDVQLFDFDQAMRAAGWIQ
ELEAEEHTPETEEYGISSFVYRRRRPFHPERLMNWMEHYPEEIVRAKGFLWIASRNDLACLFSQAGYASTLEHAGRWLAT
LPESEREAMFSSEPELREDYIEPYGDRQNELVLIGQRMDRDAVEQSLDACLLTDEEMVAEWDSFHDPLPGTGQLVTYSD

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI146231952, Length=381, Percent_Identity=27.2965879265092, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI148727351, Length=375, Percent_Identity=28.2666666666667, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI33469141, Length=379, Percent_Identity=27.7044854881267, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI126722884, Length=375, Percent_Identity=27.7333333333333, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI223941779, Length=217, Percent_Identity=32.7188940092166, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI223941776, Length=375, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI119120938, Length=145, Percent_Identity=37.9310344827586, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI87082430, Length=301, Percent_Identity=29.2358803986711, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788499, Length=211, Percent_Identity=27.4881516587678, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=231, Percent_Identity=31.1688311688312, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45353; Mature: 45353

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIPITVLSGYLGSGKTTLLNHILHNREDKKYAVIVNDMSELNIDEKLIEQGGFSRTDE
CCCCCEEHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCHHHHHHHCCCCCCHHH
KLVELSNGCICCTLREDLLTAVYELTKDRDLDGIIIESSGISEPIPVAQTFTYADDALGI
HHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHEEECCCCCCCC
DLTSRVYIDAMVTVVDAYRFFKDFNSGESLMERQQAVDTGDVREVVDLLVDQVEFADIIV
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEE
LNKADRVSEAELQEMKGLLKTLNPSARLLTSTYSDVALDDLLDVQLFDFDQAMRAAGWIQ
ECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELEAEEHTPETEEYGISSFVYRRRRPFHPERLMNWMEHYPEEIVRAKGFLWIASRNDLAC
HHHHHCCCCCHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
LFSQAGYASTLEHAGRWLATLPESEREAMFSSEPELREDYIEPYGDRQNELVLIGQRMDR
HHHCCCHHHHHHHCCCEECCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEECCCCH
DAVEQSLDACLLTDEEMVAEWDSFHDPLPGTGQLVTYSD
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEECC
>Mature Secondary Structure
MKRIPITVLSGYLGSGKTTLLNHILHNREDKKYAVIVNDMSELNIDEKLIEQGGFSRTDE
CCCCCEEHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCHHHHHHHCCCCCCHHH
KLVELSNGCICCTLREDLLTAVYELTKDRDLDGIIIESSGISEPIPVAQTFTYADDALGI
HHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHEEECCCCCCCC
DLTSRVYIDAMVTVVDAYRFFKDFNSGESLMERQQAVDTGDVREVVDLLVDQVEFADIIV
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEE
LNKADRVSEAELQEMKGLLKTLNPSARLLTSTYSDVALDDLLDVQLFDFDQAMRAAGWIQ
ECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELEAEEHTPETEEYGISSFVYRRRRPFHPERLMNWMEHYPEEIVRAKGFLWIASRNDLAC
HHHHHCCCCCHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
LFSQAGYASTLEHAGRWLATLPESEREAMFSSEPELREDYIEPYGDRQNELVLIGQRMDR
HHHCCCHHHHHHHCCCEECCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEECCCCH
DAVEQSLDACLLTDEEMVAEWDSFHDPLPGTGQLVTYSD
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]