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The map label for this gene is fabF [H]

Identifier: 229587125

GI number: 229587125

Start: 1095566

End: 1096852

Strand: Direct

Name: fabF [H]

Synonym: RAF_ORF1080

Alternate gene names: 229587125

Gene position: 1095566-1096852 (Clockwise)

Preceding gene: 229587124

Following gene: 229587126

Centisome position: 85.69

GC content: 39.78

Gene sequence:

>1287_bases
ATGTCGAATCAAAGAGTAAATAAAAGAGTAGTTATTACCGGACTTGGACTTGTTACTCCTGTTGGGCTTAATGTTAGCTC
ATCTTGGAAAAATATTGTAGATGGAGTAAGCGGTATAAAAACTATTACAGAATTTGACACTTCTAAACTTGCGTGTAAAA
TTGCCGGACTTATAGATAACTCTGAGAAAGATGGATTTAAACTTGAAAATTTCATACAAGCAGATGACATTAATAGACTA
AGTAAAATGGATAAATTTATCCATTACGGAGTAGCAGCCGCAACCGAAGCAGTTGAAGATAGCGGCTGGTTACCCGACGA
TGAACAATCTCGTGATAGAACCGGCTTGATATTAGGTTCAGGAATCGGTGGGCTTAAAATGATCGAAGATACCTCTATCA
AACTTTATCAAGAAAATAACGGCAAAGTTAGTCCTTTCTTTATCCCCGCTTCATTAATTAATCTTTTATCCGGTCTTGTT
TCTATAAAATACGGTTTTAGCGGTCCAAACCAAACAGCAGTAACAGCTTGCTCTACAGGGGCACATGCTATAGGCGATGC
TATGCGTATGATAAAGCACGGCTATGCCGATGTTATGATCGCAGGCGGTGCGGAAGCTCCAGTTACACCTGTCGGAGTTG
CAGGTTTCGTTGCTGCTAGAGCATTATGTACTAAATATAACGATAATCCTAAAAAAGCCTCAAGACCTTGGGATAAAGAC
CGCAGCGGCTTTGTTATGGGTGAAGGAGCAGGCGTTGTAGTCTTAGAAGAATATGAGCATGCCTTAAATCGAGGGGCTAA
AGTTTACGGTGAAGTTATAGGATACGGCTCTACAGGTGACGCCTATCATATGACAGCTCCACATCCTGAAGGTAGAGGAG
CTTATAGAGCGATGAGAGACGCAATACTAGATGCAACTATCACGCCCGATATGATTGATTATATTAATGCACATGGTACT
TCTACTACACTTGGTGATGGAATAGAATTAGCAGCCGTACAAAAATTATTTTTAGAAGCGAATCCCAAAGTTTTAATGTC
TTCTACTAAATCATCAATAGGACATTTGCTTGGTGCGGCAGGAAGTGTTGAGTTTATCTTTTCAGCTCTTGCAATTAGAG
ACCAGATTGCACCGCCAACCTTAAACTTAGATACCCCTATGGATGAGGTGAATATAGATTTAGTTGCACTTAAAGCTAAG
AAAACTAAGATAGATTACGTGCTTTCCAACTCGTTCGGATTTGGTGGTACTAATGCTAGTTTAGTGATTAAGAGTATACT
CGTTTAA

Upstream 100 bases:

>100_bases
ATGATGAAGCCACTAAAATTAAAACCGTATCCGATGTTATAAAATATATCAAAGAACGCCAATCTTAATCTGCATAAAAA
ATCCCTAATAGATAATAAAA

Downstream 100 bases:

>100_bases
TTTAAAAAATTGGCACAAAGTCCTATAAGCACCGTACTCACGTATTAAGTATACGTTCCGCTCCTCGTCTTATGGACCCC
TTGTGCTTTTCCAAATTAAA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDNSEKDGFKLENFIQADDINRL
SKMDKFIHYGVAAATEAVEDSGWLPDDEQSRDRTGLILGSGIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLV
SIKYGFSGPNQTAVTACSTGAHAIGDAMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKD
RSGFVMGEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRDAILDATITPDMIDYINAHGT
STTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAAGSVEFIFSALAIRDQIAPPTLNLDTPMDEVNIDLVALKAK
KTKIDYVLSNSFGFGGTNASLVIKSILV

Sequences:

>Translated_428_residues
MSNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDNSEKDGFKLENFIQADDINRL
SKMDKFIHYGVAAATEAVEDSGWLPDDEQSRDRTGLILGSGIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLV
SIKYGFSGPNQTAVTACSTGAHAIGDAMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKD
RSGFVMGEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRDAILDATITPDMIDYINAHGT
STTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAAGSVEFIFSALAIRDQIAPPTLNLDTPMDEVNIDLVALKAK
KTKIDYVLSNSFGFGGTNASLVIKSILV
>Mature_427_residues
SNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDNSEKDGFKLENFIQADDINRLS
KMDKFIHYGVAAATEAVEDSGWLPDDEQSRDRTGLILGSGIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLVS
IKYGFSGPNQTAVTACSTGAHAIGDAMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKDR
SGFVMGEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRDAILDATITPDMIDYINAHGTS
TTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAAGSVEFIFSALAIRDQIAPPTLNLDTPMDEVNIDLVALKAKK
TKIDYVLSNSFGFGGTNASLVIKSILV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=426, Percent_Identity=46.9483568075117, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI223972627, Length=202, Percent_Identity=37.6237623762376, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=24.4755244755245, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=52.1428571428571, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788663, Length=430, Percent_Identity=37.2093023255814, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=427, Percent_Identity=37.0023419203747, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=42.9657794676806, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=25.9887005649718, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=441, Percent_Identity=25.8503401360544, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=38.2882882882883, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=43.7647058823529, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI221330659, Length=439, Percent_Identity=24.373576309795, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920632, Length=439, Percent_Identity=24.373576309795, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24581345, Length=437, Percent_Identity=24.4851258581236, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45437; Mature: 45306

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDN
CCCCCCCCEEEEEECHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEHCCC
SEKDGFKLENFIQADDINRLSKMDKFIHYGVAAATEAVEDSGWLPDDEQSRDRTGLILGS
CCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEC
GIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLVSIKYGFSGPNQTAVTACSTG
CCCCCEEEECCEEEEEECCCCEECEEEEHHHHHHHHHHHHEEEECCCCCCCCEEEEECCC
AHAIGDAMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKD
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCCC
RSGFVMGEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRD
CCCEEEECCCCEEEEHHHHHHHHCCHHEEHHHEECCCCCCEEEECCCCCCCCHHHHHHHH
AILDATITPDMIDYINAHGTSTTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAA
HHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCC
GSVEFIFSALAIRDQIAPPTLNLDTPMDEVNIDLVALKAKKTKIDYVLSNSFGFGGTNAS
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCHH
LVIKSILV
HHHHHHCC
>Mature Secondary Structure 
SNQRVNKRVVITGLGLVTPVGLNVSSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDN
CCCCCCCEEEEEECHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEHCCC
SEKDGFKLENFIQADDINRLSKMDKFIHYGVAAATEAVEDSGWLPDDEQSRDRTGLILGS
CCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEC
GIGGLKMIEDTSIKLYQENNGKVSPFFIPASLINLLSGLVSIKYGFSGPNQTAVTACSTG
CCCCCEEEECCEEEEEECCCCEECEEEEHHHHHHHHHHHHEEEECCCCCCCCEEEEECCC
AHAIGDAMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKD
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCCC
RSGFVMGEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRD
CCCEEEECCCCEEEEHHHHHHHHCCHHEEHHHEECCCCCCEEEECCCCCCCCHHHHHHHH
AILDATITPDMIDYINAHGTSTTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAA
HHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCC
GSVEFIFSALAIRDQIAPPTLNLDTPMDEVNIDLVALKAKKTKIDYVLSNSFGFGGTNAS
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCHH
LVIKSILV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]