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The map label for this gene is nuoN1 [H]

Identifier: 229586858

GI number: 229586858

Start: 757598

End: 758974

Strand: Direct

Name: nuoN1 [H]

Synonym: RAF_ORF0726

Alternate gene names: 229586858

Gene position: 757598-758974 (Clockwise)

Preceding gene: 229586855

Following gene: 229586862

Centisome position: 59.25

GC content: 30.36

Gene sequence:

>1377_bases
ATGCTACTGCTACTTCCTGAAATAACTTTGACTTTAATAGCACTTTTAGGGCAGTTTTTTGCCGTAATGATCCCAAATAA
AAATAGAATTATTTCTAATATCATTATTTTACTATGCATATTATCAATTTTTCTTACCTTTAAATACTCAAGTTATGAAG
GAGTATGGTACTCATTTGCTACCGGAATAAATATCGGTATTAGTAAAAGCATAGTGCTACTATTCACTATTATCTCCATG
ATTATATACCGTGATTACTCTATTCTTGTTGCTGATGAATTAAAGTTTGAATTTATTACTTTAATGTTATTATCGGTTGT
AGGTATTTTTGTTGCAATTTCATCACGGAATTTTCTATTATTATTCTGCGGTATGGAGCTTACTGCTTTAACTTCATATG
CACTTGCAGGATTCAAATTAAATGATATGAAATCATCGGAAGGTGCTTTAAAATATTTTATCTTAGGTAGTTTAGTTAGT
TGTTTATCATTATTCGGTATTTCTTTTATATACGGATTCGGCGGAAGCCTACAATTTGAGGATATCTTATATAAACTAAA
TGATAATTCCGGAATGAATCTTGGTTTAATAATCGGTATTATACTATTTTTAAGTAGTATTTTCTTTAAACTCTCAAGTG
TTCCACTCCATTTTTGGGTCCCTGACGTATATGAAGGATCACCGATTACTTCGGTTACTTATTTCAACGCTGCCTCAAAA
ATAGGTATGGTTATTGTTTTATTAAATATCAGCAAATTAATTATAGGTAATTACTATCCTATTAATTATAATTTAATAAA
GATAATTGCTATATTATCTATGCTGTTTGGAGCTTTTGGAGCCATTCGTCAAACTTCTCTAAAAAGATTAATGGCTTATA
GTACTATTTTAAATATCGGTTATGTATTAATCGGCGTTCTTCTGCATAATCAAGAAGGATATAAAGCAGCTCTGCTATAT
ATTCTAATATATGCGGTAGGGAGTATAGGATTTTTTACTTGCTTAATTATACTGCTCGGTAAAGACGTCGATAAAGCTAG
TTTTAAAACTATACAAGGAATTGCAGAGTATCATAAAACTATAGCTGCCGTAATTAGCATAGTTATGTTTTCAATGATTG
GAATCCCTCCTCTTACAGGATTTTTCGGTAAATATTACCTTTTTTACCAAGCAATTAATCAAGAAGAATTCGCATTAGCT
TATTGTGGTATTTTTACCAGCGTAGTTGCTGCGTTTTATTATCTTAAAGTAGTAAAAGCCATGTATTTTTCTAAAAAGAT
TGAGATAATTAAGCTGCCGATGCAATATGGGCTTTTACTGATTAATTACTTAGTTGTAGGCTTCTTGTTGCTTGGTTCAT
TTATTATCTCGTTTTAG

Upstream 100 bases:

>100_bases
ATTAGAGGTAGTATTAAAGTGCAATATTATATATAAGTTTGTTGATAAAAAATGATTTATTTACTAATATTTATATTTCT
ATAAATAATATTAGTTTTAT

Downstream 100 bases:

>100_bases
CCGGTGTAGACTTTTTATTAACAACACTAACTACAGTAGTTTGAGTAGGCTTCATAATCTTTTCTTTTAGATTCTTTATA
TGTTTTAGATTTTCTTCATC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MLLLLPEITLTLIALLGQFFAVMIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFATGINIGISKSIVLLFTIISM
IIYRDYSILVADELKFEFITLMLLSVVGIFVAISSRNFLLLFCGMELTALTSYALAGFKLNDMKSSEGALKYFILGSLVS
CLSLFGISFIYGFGGSLQFEDILYKLNDNSGMNLGLIIGIILFLSSIFFKLSSVPLHFWVPDVYEGSPITSVTYFNAASK
IGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLY
ILIYAVGSIGFFTCLIILLGKDVDKASFKTIQGIAEYHKTIAAVISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFALA
YCGIFTSVVAAFYYLKVVKAMYFSKKIEIIKLPMQYGLLLINYLVVGFLLLGSFIISF

Sequences:

>Translated_458_residues
MLLLLPEITLTLIALLGQFFAVMIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFATGINIGISKSIVLLFTIISM
IIYRDYSILVADELKFEFITLMLLSVVGIFVAISSRNFLLLFCGMELTALTSYALAGFKLNDMKSSEGALKYFILGSLVS
CLSLFGISFIYGFGGSLQFEDILYKLNDNSGMNLGLIIGIILFLSSIFFKLSSVPLHFWVPDVYEGSPITSVTYFNAASK
IGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLY
ILIYAVGSIGFFTCLIILLGKDVDKASFKTIQGIAEYHKTIAAVISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFALA
YCGIFTSVVAAFYYLKVVKAMYFSKKIEIIKLPMQYGLLLINYLVVGFLLLGSFIISF
>Mature_458_residues
MLLLLPEITLTLIALLGQFFAVMIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFATGINIGISKSIVLLFTIISM
IIYRDYSILVADELKFEFITLMLLSVVGIFVAISSRNFLLLFCGMELTALTSYALAGFKLNDMKSSEGALKYFILGSLVS
CLSLFGISFIYGFGGSLQFEDILYKLNDNSGMNLGLIIGIILFLSSIFFKLSSVPLHFWVPDVYEGSPITSVTYFNAASK
IGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLY
ILIYAVGSIGFFTCLIILLGKDVDKASFKTIQGIAEYHKTIAAVISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFALA
YCGIFTSVVAAFYYLKVVKAMYFSKKIEIIKLPMQYGLLLINYLVVGFLLLGSFIISF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=325, Percent_Identity=23.3846153846154, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI145693160, Length=348, Percent_Identity=30.4597701149425, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788614, Length=394, Percent_Identity=23.0964467005076, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788613, Length=348, Percent_Identity=24.7126436781609, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788831, Length=229, Percent_Identity=28.82096069869, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788827, Length=331, Percent_Identity=24.773413897281, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788829, Length=274, Percent_Identity=23.3576642335766, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51045; Mature: 51045

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLLPEITLTLIALLGQFFAVMIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFA
CEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHH
TGINIGISKSIVLLFTIISMIIYRDYSILVADELKFEFITLMLLSVVGIFVAISSRNFLL
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LFCGMELTALTSYALAGFKLNDMKSSEGALKYFILGSLVSCLSLFGISFIYGFGGSLQFE
EEECCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DILYKLNDNSGMNLGLIIGIILFLSSIFFKLSSVPLHFWVPDVYEGSPITSVTYFNAASK
HHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCHHH
IGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVLIGVLLHNQEGYKAALLYILIYAVGSIGFFTCLIILLGKDVDKASFKTIQGIAEYHKT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IAAVISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFALAYCGIFTSVVAAFYYLKVVKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MYFSKKIEIIKLPMQYGLLLINYLVVGFLLLGSFIISF
HHHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLLLPEITLTLIALLGQFFAVMIPNKNRIISNIIILLCILSIFLTFKYSSYEGVWYSFA
CEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHH
TGINIGISKSIVLLFTIISMIIYRDYSILVADELKFEFITLMLLSVVGIFVAISSRNFLL
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LFCGMELTALTSYALAGFKLNDMKSSEGALKYFILGSLVSCLSLFGISFIYGFGGSLQFE
EEECCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DILYKLNDNSGMNLGLIIGIILFLSSIFFKLSSVPLHFWVPDVYEGSPITSVTYFNAASK
HHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCHHH
IGMVIVLLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVLIGVLLHNQEGYKAALLYILIYAVGSIGFFTCLIILLGKDVDKASFKTIQGIAEYHKT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IAAVISIVMFSMIGIPPLTGFFGKYYLFYQAINQEEFALAYCGIFTSVVAAFYYLKVVKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MYFSKKIEIIKLPMQYGLLLINYLVVGFLLLGSFIISF
HHHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]