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The map label for this gene is pepP [H]

Identifier: 229586815

GI number: 229586815

Start: 711953

End: 713791

Strand: Direct

Name: pepP [H]

Synonym: RAF_ORF0681

Alternate gene names: 229586815

Gene position: 711953-713791 (Clockwise)

Preceding gene: 229586814

Following gene: 229586819

Centisome position: 55.68

GC content: 33.88

Gene sequence:

>1839_bases
ATGACGGCTCAGCCAGCGGGCAAGGACATAAGAGATATAAACATGAAAAAAATCCGCATTAATCTGCTTAGAAATTTATT
CACAGAATATGATATAGACGGTTATATAATTCCGTCTAACGATAAATATATGAGTGAATATGTTCCAAGCTATGCAAAGA
GACTTGAATATATAACAGGTTTTACTGGTTCAAACGGTATAGCTATTATATATAAAGATACAGCATTATTCTTTACCGAT
GGACGTTATTTAGAGCAAGCAAATAAAGAGCTGGATTTAGAGCTTTTTAAGCTTTTTGACTTAAAAGATATATCTAAGTT
TGGTAAAGATGCAAAAATAGGATATGATTCTGAATTATTTACTTATCCCACTATATCAAATTTAAAGTTTAATTTTCAGA
AGATTAATGGAAATTTAGTTGATAAGATTTGGCCAAATCAGCCACTAGAGCCAAACTCTAAAGTTTATTTGCATGATATT
AGGTTGGCGGGCGTTAGTCATACTGATAAAATAAGTAAATGTCGTGAAATTTTTTTGGATTCCCGCTTTTGCAGGAATGA
CATAGAGGAAAGCGGGAATGACACCGAGCAATCTGCCTTAGTCATTCTCGATAGCTCCTCCATATGTTGGTTACTAAATT
TGCGTGCCAGTGACGTTGCTTATACGCCTTTAATGTTTGCAAAAGTTATACTCACTTCTACACAATTATATTTGTTTATA
AATCCTACAAGAATCGATGCCGAAATTATTAATGCTCGTCCTGAAATAACGATTTTACCGGAAGAAGAATTTGAAAATAT
TTTAAGAGATAGCGAGAATACACATCTTTCCAAACCAGCTTATAGAATTTTTATTGATGATACTATAGCATCTGTTCATA
TAATGGACTTAGTAGCTGATAAAAAAGTACAAAAAATTACCGATCCATGCTTAATGCTTAAAGCTTGTAAGAACGATGTA
GAAATTAAGCATACAATCGATTTGCATATTAAAGATGCAGTAGCTTTATGTGAATTTTTTGCTGATTTTTCTCAATGTCA
TCCCCGTGAAAACGGGGATCCAGAAAAACATAATAACGAATTGACCGAGTATTCCCTCGGTTTAAAGCTTACAGAGCAAC
GAGCTAAACAAGAGGGATATGTTTCGGATAGTTTTCCTGCTATTTGCGGATTTCAGGAAAATAGTGCTATTATTCATTAT
AGAGCTGACCAAAAAACTGCTAAAAAAATTGAAGGGCAGGGGATATTACTGATAGATTCCGGCGGTCAGTATCAAGGTGC
TACTACCGATATAACTAGAACAATAGTAATAGGTACACCGACAGATGAGCAGAAAAAGCGTTATACGCAAGTACTTAAAG
GACATATTGCTTTAGCTAAAGCCAAATTCCCAAAAAATATCATCGCAGGAGCTAATCTTGATATACTCGCTCGGCAATAT
TTATGGCAAGAAATGCTAGATTATCCACACGGTACAGGGCATGGGGTAGGGAGCTTCTTAAGTGTTCACGAAGGACCGCA
AAGCATAAATCTTCGTAATAAAACAATACTTAAAGCAGGTATGATCTTATCTAATGAACCGGGGTTTTATGTTCCTGGAA
AATATGGTATTAGGATTGAGAATTTGATGTATGTAAAAGACAATAATGGATGGCTTGAGTTTGAGACCTTAAGCCTAGTG
CCTTATTCTAGTAAATTGACTGATATGAAACTACTTAATATTGATGAAATAAACTATATCAAGGAATATTATAACAAAAT
TAGAGCTAAAATTTATGATTTATTATCCACGCAAGCGAGGAATTGGCTTAATAATGAAATAAATTTATATTGTAATTGA

Upstream 100 bases:

>100_bases
ACAAGCAGCATGGCAATCCAGAAAAAATAATAAAAAAATTCTGTAAATCAGAATTTTTTAACTGGATTGCTTCGTCAATT
ACTTAAGTAATTTCCTTGCA

Downstream 100 bases:

>100_bases
CGTTTCCGTCATTTATTGGTATAAAGTCTATACATTTCTAATTTTCTACTTCTAAATATTGGGACGTCGCCAAGTGGTAA
GGCAACGGTTTTTGGTATCG

Product: Aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MTAQPAGKDIRDINMKKIRINLLRNLFTEYDIDGYIIPSNDKYMSEYVPSYAKRLEYITGFTGSNGIAIIYKDTALFFTD
GRYLEQANKELDLELFKLFDLKDISKFGKDAKIGYDSELFTYPTISNLKFNFQKINGNLVDKIWPNQPLEPNSKVYLHDI
RLAGVSHTDKISKCREIFLDSRFCRNDIEESGNDTEQSALVILDSSSICWLLNLRASDVAYTPLMFAKVILTSTQLYLFI
NPTRIDAEIINARPEITILPEEEFENILRDSENTHLSKPAYRIFIDDTIASVHIMDLVADKKVQKITDPCLMLKACKNDV
EIKHTIDLHIKDAVALCEFFADFSQCHPRENGDPEKHNNELTEYSLGLKLTEQRAKQEGYVSDSFPAICGFQENSAIIHY
RADQKTAKKIEGQGILLIDSGGQYQGATTDITRTIVIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIIAGANLDILARQY
LWQEMLDYPHGTGHGVGSFLSVHEGPQSINLRNKTILKAGMILSNEPGFYVPGKYGIRIENLMYVKDNNGWLEFETLSLV
PYSSKLTDMKLLNIDEINYIKEYYNKIRAKIYDLLSTQARNWLNNEINLYCN

Sequences:

>Translated_612_residues
MTAQPAGKDIRDINMKKIRINLLRNLFTEYDIDGYIIPSNDKYMSEYVPSYAKRLEYITGFTGSNGIAIIYKDTALFFTD
GRYLEQANKELDLELFKLFDLKDISKFGKDAKIGYDSELFTYPTISNLKFNFQKINGNLVDKIWPNQPLEPNSKVYLHDI
RLAGVSHTDKISKCREIFLDSRFCRNDIEESGNDTEQSALVILDSSSICWLLNLRASDVAYTPLMFAKVILTSTQLYLFI
NPTRIDAEIINARPEITILPEEEFENILRDSENTHLSKPAYRIFIDDTIASVHIMDLVADKKVQKITDPCLMLKACKNDV
EIKHTIDLHIKDAVALCEFFADFSQCHPRENGDPEKHNNELTEYSLGLKLTEQRAKQEGYVSDSFPAICGFQENSAIIHY
RADQKTAKKIEGQGILLIDSGGQYQGATTDITRTIVIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIIAGANLDILARQY
LWQEMLDYPHGTGHGVGSFLSVHEGPQSINLRNKTILKAGMILSNEPGFYVPGKYGIRIENLMYVKDNNGWLEFETLSLV
PYSSKLTDMKLLNIDEINYIKEYYNKIRAKIYDLLSTQARNWLNNEINLYCN
>Mature_611_residues
TAQPAGKDIRDINMKKIRINLLRNLFTEYDIDGYIIPSNDKYMSEYVPSYAKRLEYITGFTGSNGIAIIYKDTALFFTDG
RYLEQANKELDLELFKLFDLKDISKFGKDAKIGYDSELFTYPTISNLKFNFQKINGNLVDKIWPNQPLEPNSKVYLHDIR
LAGVSHTDKISKCREIFLDSRFCRNDIEESGNDTEQSALVILDSSSICWLLNLRASDVAYTPLMFAKVILTSTQLYLFIN
PTRIDAEIINARPEITILPEEEFENILRDSENTHLSKPAYRIFIDDTIASVHIMDLVADKKVQKITDPCLMLKACKNDVE
IKHTIDLHIKDAVALCEFFADFSQCHPRENGDPEKHNNELTEYSLGLKLTEQRAKQEGYVSDSFPAICGFQENSAIIHYR
ADQKTAKKIEGQGILLIDSGGQYQGATTDITRTIVIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIIAGANLDILARQYL
WQEMLDYPHGTGHGVGSFLSVHEGPQSINLRNKTILKAGMILSNEPGFYVPGKYGIRIENLMYVKDNNGWLEFETLSLVP
YSSKLTDMKLLNIDEINYIKEYYNKIRAKIYDLLSTQARNWLNNEINLYCN

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=635, Percent_Identity=34.3307086614173, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI93141226, Length=621, Percent_Identity=30.5958132045089, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI264681565, Length=635, Percent_Identity=33.3858267716535, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1788728, Length=199, Percent_Identity=29.6482412060301, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=607, Percent_Identity=30.8072487644152, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI25149105, Length=606, Percent_Identity=27.8877887788779, Blast_Score=243, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6322999, Length=664, Percent_Identity=33.7349397590361, Blast_Score=306, Evalue=5e-84,
Organism=Drosophila melanogaster, GI17137632, Length=614, Percent_Identity=33.8762214983713, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI161078230, Length=614, Percent_Identity=28.9902280130293, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI21357287, Length=614, Percent_Identity=28.9902280130293, Blast_Score=249, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 69863; Mature: 69731

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQPAGKDIRDINMKKIRINLLRNLFTEYDIDGYIIPSNDKYMSEYVPSYAKRLEYITG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCC
FTGSNGIAIIYKDTALFFTDGRYLEQANKELDLELFKLFDLKDISKFGKDAKIGYDSELF
CCCCCCEEEEEECEEEEEECCHHHHHCCCCCCCHHHHHHCHHHHHHCCCCCCCCCCCCEE
TYPTISNLKFNFQKINGNLVDKIWPNQPLEPNSKVYLHDIRLAGVSHTDKISKCREIFLD
ECCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHC
SRFCRNDIEESGNDTEQSALVILDSSSICWLLNLRASDVAYTPLMFAKVILTSTQLYLFI
CHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEE
NPTRIDAEIINARPEITILPEEEFENILRDSENTHLSKPAYRIFIDDTIASVHIMDLVAD
CCCEECHHEECCCCCEEECCHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
KKVQKITDPCLMLKACKNDVEIKHTIDLHIKDAVALCEFFADFSQCHPRENGDPEKHNNE
HHHHHHCCHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LTEYSLGLKLTEQRAKQEGYVSDSFPAICGFQENSAIIHYRADQKTAKKIEGQGILLIDS
CHHEEECEEEHHHHHHHCCCCCCCCCEEECCCCCCEEEEEECCCHHHHHHCCCEEEEEEC
GGQYQGATTDITRTIVIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIIAGANLDILARQY
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEHHCCCCHHCCCCCHHHHHHHH
LWQEMLDYPHGTGHGVGSFLSVHEGPQSINLRNKTILKAGMILSNEPGFYVPGKYGIRIE
HHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCEEECCCCEEECCCCCEEEE
NLMYVKDNNGWLEFETLSLVPYSSKLTDMKLLNIDEINYIKEYYNKIRAKIYDLLSTQAR
EEEEEECCCCEEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
NWLNNEINLYCN
HHCCCCEEEEEC
>Mature Secondary Structure 
TAQPAGKDIRDINMKKIRINLLRNLFTEYDIDGYIIPSNDKYMSEYVPSYAKRLEYITG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCC
FTGSNGIAIIYKDTALFFTDGRYLEQANKELDLELFKLFDLKDISKFGKDAKIGYDSELF
CCCCCCEEEEEECEEEEEECCHHHHHCCCCCCCHHHHHHCHHHHHHCCCCCCCCCCCCEE
TYPTISNLKFNFQKINGNLVDKIWPNQPLEPNSKVYLHDIRLAGVSHTDKISKCREIFLD
ECCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHC
SRFCRNDIEESGNDTEQSALVILDSSSICWLLNLRASDVAYTPLMFAKVILTSTQLYLFI
CHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEE
NPTRIDAEIINARPEITILPEEEFENILRDSENTHLSKPAYRIFIDDTIASVHIMDLVAD
CCCEECHHEECCCCCEEECCHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
KKVQKITDPCLMLKACKNDVEIKHTIDLHIKDAVALCEFFADFSQCHPRENGDPEKHNNE
HHHHHHCCHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LTEYSLGLKLTEQRAKQEGYVSDSFPAICGFQENSAIIHYRADQKTAKKIEGQGILLIDS
CHHEEECEEEHHHHHHHCCCCCCCCCEEECCCCCCEEEEEECCCHHHHHHCCCEEEEEEC
GGQYQGATTDITRTIVIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIIAGANLDILARQY
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEHHCCCCHHCCCCCHHHHHHHH
LWQEMLDYPHGTGHGVGSFLSVHEGPQSINLRNKTILKAGMILSNEPGFYVPGKYGIRIE
HHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCEEECCCCEEECCCCCEEEE
NLMYVKDNNGWLEFETLSLVPYSSKLTDMKLLNIDEINYIKEYYNKIRAKIYDLLSTQAR
EEEEEECCCCEEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
NWLNNEINLYCN
HHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]