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The map label for this gene is cyoB [H]

Identifier: 229586610

GI number: 229586610

Start: 466004

End: 466921

Strand: Direct

Name: cyoB [H]

Synonym: RAF_ORF0436

Alternate gene names: 229586610

Gene position: 466004-466921 (Clockwise)

Preceding gene: 229586608

Following gene: 229586612

Centisome position: 36.45

GC content: 33.22

Gene sequence:

>918_bases
ATGAGTTCCTTAGTAAGACCAATCAATTTAGGTAAAATTAATCATTCACAAAGTACTGTTAAAGACTATATTTTACTTAT
GAAACCGCGTGTAATGTCGCTTGTGATTTTTACGGGTTTTGTAGGTATGTGGCTTGCTCCTTATTCTGTGCATCCGTTTA
TTGCTGGTATTGCAGTTGTTTGCATAGCGCTTGGGGCAGGTAGTGCAGGGGCAATTAATATGTGGTACGATAGAGACATC
GATAGCTTAATGAAACGTACCCAAAAAAGACCGATAGTAAGAGGAGTTATAGAATCTGATGAAGCTTTATCTTTTGGTTT
GATAACGGGATTTTTTGCAGTATTTTTTATGGCTTTATGTGTTAATCTACTTGCATCCTTTTTACTGCTATTCACTATTT
TTTATTATATCTGTATTTATACTATTTGGTTAAAGCGTCGTTCTATACAAAATATCGTTATTGGCGGAGTATCGGGAGCA
TTACCTCCTGTGATAGGTTATGCAGCGGTAAGCAATACTATATCTCTAGAGTCGATTATATTATTTTTGATTATTTTTAT
TTGGACGCCGCCGCATTCATGGGCTCTTGCTTTATTCTGTAACGATGACTATAAAAACTGTAAAGTACCGATGATGCCTG
CAGTAAAGGGGACTTTATATACTAAAAAACAAATTCTAATTTACAGTATTCTTTTATTTATTGTTTCGCTAATGCCTTTT
TTTATTGGAATGAATAATTTTATATATTTAATAATTTCTGGTATCCTTGGGGTAGTATTTCTATATTATGCCGGTTCTTT
ATTCTATGACACCCCTGATAACAAACAAGCTAAACGATTTTTTGCCTATTCGATATTTTACTTGTTTTTTATATTTTTAC
TCTTGTACTCAACTAACACTATATCCACTATTAGCTGA

Upstream 100 bases:

>100_bases
TATTATTTGAATTACAAAAAAATATATACATTTCTTGCATCAAAGTCAATCATTGATTTTTAACCTAAAACTTTTTATAT
TTAATTAAAAAATATTTCAT

Downstream 100 bases:

>100_bases
GAGATAATAGTGTTGGGTTACTTTTATAGAAGCTAAAATTGAAACCCAACGTGAAGAAACATATCATAAGTGTATTTTCA
TGCAAGTGATTTTTTATTTA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSSLVRPINLGKINHSQSTVKDYILLMKPRVMSLVIFTGFVGMWLAPYSVHPFIAGIAVVCIALGAGSAGAINMWYDRDI
DSLMKRTQKRPIVRGVIESDEALSFGLITGFFAVFFMALCVNLLASFLLLFTIFYYICIYTIWLKRRSIQNIVIGGVSGA
LPPVIGYAAVSNTISLESIILFLIIFIWTPPHSWALALFCNDDYKNCKVPMMPAVKGTLYTKKQILIYSILLFIVSLMPF
FIGMNNFIYLIISGILGVVFLYYAGSLFYDTPDNKQAKRFFAYSIFYLFFIFLLLYSTNTISTIS

Sequences:

>Translated_305_residues
MSSLVRPINLGKINHSQSTVKDYILLMKPRVMSLVIFTGFVGMWLAPYSVHPFIAGIAVVCIALGAGSAGAINMWYDRDI
DSLMKRTQKRPIVRGVIESDEALSFGLITGFFAVFFMALCVNLLASFLLLFTIFYYICIYTIWLKRRSIQNIVIGGVSGA
LPPVIGYAAVSNTISLESIILFLIIFIWTPPHSWALALFCNDDYKNCKVPMMPAVKGTLYTKKQILIYSILLFIVSLMPF
FIGMNNFIYLIISGILGVVFLYYAGSLFYDTPDNKQAKRFFAYSIFYLFFIFLLLYSTNTISTIS
>Mature_304_residues
SSLVRPINLGKINHSQSTVKDYILLMKPRVMSLVIFTGFVGMWLAPYSVHPFIAGIAVVCIALGAGSAGAINMWYDRDID
SLMKRTQKRPIVRGVIESDEALSFGLITGFFAVFFMALCVNLLASFLLLFTIFYYICIYTIWLKRRSIQNIVIGGVSGAL
PPVIGYAAVSNTISLESIILFLIIFIWTPPHSWALALFCNDDYKNCKVPMMPAVKGTLYTKKQILIYSILLFIVSLMPFF
IGMNNFIYLIISGILGVVFLYYAGSLFYDTPDNKQAKRFFAYSIFYLFFIFLLLYSTNTISTIS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=285, Percent_Identity=29.8245614035088, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786631, Length=227, Percent_Identity=32.5991189427313, Blast_Score=131, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71998235, Length=270, Percent_Identity=27.7777777777778, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=261, Percent_Identity=30.6513409961686, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19921064, Length=276, Percent_Identity=28.9855072463768, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34355; Mature: 34223

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLVRPINLGKINHSQSTVKDYILLMKPRVMSLVIFTGFVGMWLAPYSVHPFIAGIAVV
CCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
CIALGAGSAGAINMWYDRDIDSLMKRTQKRPIVRGVIESDEALSFGLITGFFAVFFMALC
HHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VNLLASFLLLFTIFYYICIYTIWLKRRSIQNIVIGGVSGALPPVIGYAAVSNTISLESII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCHHHHHHH
LFLIIFIWTPPHSWALALFCNDDYKNCKVPMMPAVKGTLYTKKQILIYSILLFIVSLMPF
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FIGMNNFIYLIISGILGVVFLYYAGSLFYDTPDNKQAKRFFAYSIFYLFFIFLLLYSTNT
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ISTIS
CCCCC
>Mature Secondary Structure 
SSLVRPINLGKINHSQSTVKDYILLMKPRVMSLVIFTGFVGMWLAPYSVHPFIAGIAVV
CCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
CIALGAGSAGAINMWYDRDIDSLMKRTQKRPIVRGVIESDEALSFGLITGFFAVFFMALC
HHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VNLLASFLLLFTIFYYICIYTIWLKRRSIQNIVIGGVSGALPPVIGYAAVSNTISLESII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCHHHHHHH
LFLIIFIWTPPHSWALALFCNDDYKNCKVPMMPAVKGTLYTKKQILIYSILLFIVSLMPF
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FIGMNNFIYLIISGILGVVFLYYAGSLFYDTPDNKQAKRFFAYSIFYLFFIFLLLYSTNT
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ISTIS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA