Click here to switch to the map view.

The map label for this gene is thyX [H]

Identifier: 229586558

GI number: 229586558

Start: 405908

End: 406792

Strand: Direct

Name: thyX [H]

Synonym: RAF_ORF0379

Alternate gene names: 229586558

Gene position: 405908-406792 (Clockwise)

Preceding gene: 229586557

Following gene: 229586559

Centisome position: 31.75

GC content: 37.18

Gene sequence:

>885_bases
ATGCATAACACCACAAAAAGAGTAACAGTTCCGGCACTTGAAGAAATCTTATATGAGCCTATAAAAGTGTTAGATTACGG
CTTTATTAGAGTGATCGACTATATGGGGGATGATAGTGCTATAGTACAAGCAGCTCGTGTTTCTTACGGTAAGGGTACGA
AGCAATTAAACCAAGATAAAGGGCTGATAAACTACTTGCTTCGTCATTATCATACCACTCCTTTTGAGATGTGTGATATC
AAGTTCCATATTAAACTACCGATATTTATTGCAAGGCAATGGATTAGGCATAGAACAGCTAGCGTTAACGAATATTCGGC
AAGGTATTCTATTTTAGGTAATGAATTTTATCTACCTGAACCGGCAAATATTGCTTCCCAATCTGCTGTAAATAAACAAT
GTAGGGAAGGGGATAGCTTACCGAAAGAAGTGGCTGAAAAGGTCCTTGCAATTTTAGAGGAAGATGCTAGACAGTGCTAC
GGGCATTATAAGGAACTGATGAATGCCGATGAAGAGGGTAATATTATAGATGAGAACGCCACAGGGATAGCAAGAGAGCT
TGCTCGTATGAATTTAACTTTAAATTATTATACGGAATGGTATTGGAAGATTAATTTACATAATTTACTTCATTTTTTAA
GATTGCGAGCCGACCCTCACGCTCAATATGAAATTAGAGTTTATGCTGAAAAGATGCTTGAGATAGTCAAAGCTTGGGTT
CCTTTTGTTTACGAAGCGTTTGAAGAATATCGTTTGCAGGGAGCAAACATTTCACGTAAAGGTTTGGATGTAATTAAAAG
AATGATAAACGGTGAAAAAGTTACCCATGGAACTAGTGATATGACTAAGAGAGAATGGGAAGAACTGATGAAGATTTTTG
GGTAA

Upstream 100 bases:

>100_bases
TTTTCCATAACTTTATGTCATTGCCACGAAAGCGGGAATGACATAAAACGAGCAATGCAACAACGCAGTAATGTAAAGAA
AAACATAAAGGATAAATAGA

Downstream 100 bases:

>100_bases
TATATGTCATTCCTGTGAAAGCAGGAATGACATACAACAACCATAACGGAATTTGATAAAAAGGAGTATTTTAAGTGAGA
AATATTATATATTTTATATT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MHNTTKRVTVPALEEILYEPIKVLDYGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDI
KFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPANIASQSAVNKQCREGDSLPKEVAEKVLAILEEDARQCY
GHYKELMNADEEGNIIDENATGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWV
PFVYEAFEEYRLQGANISRKGLDVIKRMINGEKVTHGTSDMTKREWEELMKIFG

Sequences:

>Translated_294_residues
MHNTTKRVTVPALEEILYEPIKVLDYGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDI
KFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPANIASQSAVNKQCREGDSLPKEVAEKVLAILEEDARQCY
GHYKELMNADEEGNIIDENATGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWV
PFVYEAFEEYRLQGANISRKGLDVIKRMINGEKVTHGTSDMTKREWEELMKIFG
>Mature_294_residues
MHNTTKRVTVPALEEILYEPIKVLDYGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDI
KFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPANIASQSAVNKQCREGDSLPKEVAEKVLAILEEDARQCY
GHYKELMNADEEGNIIDENATGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWV
PFVYEAFEEYRLQGANISRKGLDVIKRMINGEKVTHGTSDMTKREWEELMKIFG

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 34360; Mature: 34360

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNTTKRVTVPALEEILYEPIKVLDYGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDK
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCH
GLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPE
HHHHHHHHHHCCCCHHEEEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHEECCEEECCC
PANIASQSAVNKQCREGDSLPKEVAEKVLAILEEDARQCYGHYKELMNADEEGNIIDENA
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCH
TGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWV
HHHHHHHHHHCCEEEEEEEEEEEEEHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHH
PFVYEAFEEYRLQGANISRKGLDVIKRMINGEKVTHGTSDMTKREWEELMKIFG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHNTTKRVTVPALEEILYEPIKVLDYGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDK
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCH
GLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPE
HHHHHHHHHHCCCCHHEEEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHEECCEEECCC
PANIASQSAVNKQCREGDSLPKEVAEKVLAILEEDARQCYGHYKELMNADEEGNIIDENA
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCH
TGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWV
HHHHHHHHHHCCEEEEEEEEEEEEEHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHH
PFVYEAFEEYRLQGANISRKGLDVIKRMINGEKVTHGTSDMTKREWEELMKIFG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]