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The map label for this gene is pepA

Identifier: 229586382

GI number: 229586382

Start: 190240

End: 191742

Strand: Direct

Name: pepA

Synonym: RAF_ORF0173

Alternate gene names: 229586382

Gene position: 190240-191742 (Clockwise)

Preceding gene: 229586380

Following gene: 229586383

Centisome position: 14.88

GC content: 37.79

Gene sequence:

>1503_bases
ATGCTTAACGTAAATTTTGTGAATGAAGAATCATCTACTAATCAAGGTCTAGTAGTTTTTATTGATGAACAGTTAAAGCT
TGATAGTAATTTAATAGGACTTGATCAACAACATCATGGATTAATTTCTAAAACTATTCAGAATAAACTGCAATTTACCG
GTAAATATGGACAGATCAAGGTTATTCCGTCCGTCATTAAATCAGGCGAGGTTAGATATTTGATAATAGCAGGTCTTGGG
AATGAAGAAAAATTAACTGAAGCAAAAATTGAAGAGTTAGGCGGCAAAATCTTACAGCATGCAACCGGTTGTAAAATTTC
TACTATTGGCTTGAAACTTACAAATAGAATTAGCAGGTTTACATCTCAAACATTTGCATCTTTAGTTGCTAGCGGTGCGT
TTCTTGCTTCTTACAGATTTGATAAATATAGAACTACCTTAAAAGAAGCAGAGAAGTTCGCAGTAGAGTCAATTGAAATT
TTTACTGATAATAGCACTGAAACGGCAAAATTATTTGAAATCAAAAAATTAATTGCTGAAGCAGTATTTTTTACAAGAGA
TATAAGTAATGAACCGTCAAATATTAAAACTCCTCAAGTTTATGCCGAAAGAATAGTTGATAGACTTGAACCGCTAGGGG
TAGATGTTGATGTTATCGGTGAACGTGAGATGAAAAACCTTGGTATGGGAGCGTTACTTGGTGTGGGGCAAGGTTCACAA
AACGAGTCAAAGTTAGTGGTGATGGAATATAAAGGTGGCAGTAAAGATGCTCCGACTATTGCTTTGGTCGGTAAAGGAGT
GATTTTTGATACAGGCGGTATTTCATTAAAACCGTCAAGTGATATGCACTTAATGCGATACGATATGGGAGGTTCTGCAG
CAGTTGTGGGTACCATCATTGCGGTTGCTGGTCAAAAATTACCTATAAATATAGTCGGTGTTGTAGGGCTTGTCGAAAAT
ATGCCGTCCGGTAATGCACAGCGTCCAGGGGATGTAGTAACTACCATGTCAGGGCAAACTGCCGAAGTTTTAAATACCGA
TGCAGAAGGGCGGTTAGTACTTGCTGATGCTGTTTGGTATGCACAAGAAAAATTTAAGCCTAAATGCGTGATTGACGTTG
CAACTCTAACAGGAGCAATAACCATAGCACTTGGTAATACATATGCTGGTTGTTTTTCCAATAATGATGAGTTAGCTGAT
AAGTTAATAAAAGTAGGGGAAGAAGTTAATGAAAAACTTTGGAGAATGCCGCTGCATGATGAGTATGATGCAATGATTAA
CTCCGACATAGCCGATATGGCAAATATCGGGAACGTACCGAGAGCTGCCGGAAGCTGCATAGCTGCACATTTCATTAAAC
GTTTCATTAAAGATGGAGTAGATTGGGCTCATTTAGATATAGCAGGCGTTGCAAATAGTAATAAAGCTTCAGCACTCGGT
CCTAAGGGGGCAGTAGGATACGGCGTGAGATTACTAGAGAAATTTATCAAAGAATATACTTAA

Upstream 100 bases:

>100_bases
TATTTAATGAGATTTTGTTTTAAACCAATATATAATACTTGCAAAGTTTTATCACGATAAATAGAATGATCCAAAGTCAA
AAATAATATAAGGAGTAAAT

Downstream 100 bases:

>100_bases
ATGCTATTCTTGCGTTGCATTGCCTGCATGGATACCGAGTCGTCATTGCGAGCAGCCTTAGGCTGCGTGGCAATCTCGTC
AAATATCCTGAGATTGCTTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLNVNFVNEESSTNQGLVVFIDEQLKLDSNLIGLDQQHHGLISKTIQNKLQFTGKYGQIKVIPSVIKSGEVRYLIIAGLG
NEEKLTEAKIEELGGKILQHATGCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEI
FTDNSTETAKLFEIKKLIAEAVFFTRDISNEPSNIKTPQVYAERIVDRLEPLGVDVDVIGEREMKNLGMGALLGVGQGSQ
NESKLVVMEYKGGSKDAPTIALVGKGVIFDTGGISLKPSSDMHLMRYDMGGSAAVVGTIIAVAGQKLPINIVGVVGLVEN
MPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKCVIDVATLTGAITIALGNTYAGCFSNNDELAD
KLIKVGEEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPRAAGSCIAAHFIKRFIKDGVDWAHLDIAGVANSNKASALG
PKGAVGYGVRLLEKFIKEYT

Sequences:

>Translated_500_residues
MLNVNFVNEESSTNQGLVVFIDEQLKLDSNLIGLDQQHHGLISKTIQNKLQFTGKYGQIKVIPSVIKSGEVRYLIIAGLG
NEEKLTEAKIEELGGKILQHATGCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEI
FTDNSTETAKLFEIKKLIAEAVFFTRDISNEPSNIKTPQVYAERIVDRLEPLGVDVDVIGEREMKNLGMGALLGVGQGSQ
NESKLVVMEYKGGSKDAPTIALVGKGVIFDTGGISLKPSSDMHLMRYDMGGSAAVVGTIIAVAGQKLPINIVGVVGLVEN
MPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKCVIDVATLTGAITIALGNTYAGCFSNNDELAD
KLIKVGEEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPRAAGSCIAAHFIKRFIKDGVDWAHLDIAGVANSNKASALG
PKGAVGYGVRLLEKFIKEYT
>Mature_500_residues
MLNVNFVNEESSTNQGLVVFIDEQLKLDSNLIGLDQQHHGLISKTIQNKLQFTGKYGQIKVIPSVIKSGEVRYLIIAGLG
NEEKLTEAKIEELGGKILQHATGCKISTIGLKLTNRISRFTSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEI
FTDNSTETAKLFEIKKLIAEAVFFTRDISNEPSNIKTPQVYAERIVDRLEPLGVDVDVIGEREMKNLGMGALLGVGQGSQ
NESKLVVMEYKGGSKDAPTIALVGKGVIFDTGGISLKPSSDMHLMRYDMGGSAAVVGTIIAVAGQKLPINIVGVVGLVEN
MPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWYAQEKFKPKCVIDVATLTGAITIALGNTYAGCFSNNDELAD
KLIKVGEEVNEKLWRMPLHDEYDAMINSDIADMANIGNVPRAAGSCIAAHFIKRFIKDGVDWAHLDIAGVANSNKASALG
PKGAVGYGVRLLEKFIKEYT

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=379, Percent_Identity=39.3139841688654, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI47155554, Length=378, Percent_Identity=32.2751322751323, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1790710, Length=504, Percent_Identity=40.2777777777778, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=35.7366771159875, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=350, Percent_Identity=33.1428571428571, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=452, Percent_Identity=27.8761061946903, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24661038, Length=479, Percent_Identity=32.5678496868476, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21355725, Length=376, Percent_Identity=34.0425531914894, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129969, Length=485, Percent_Identity=29.2783505154639, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24662227, Length=513, Percent_Identity=28.8499025341131, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161077148, Length=351, Percent_Identity=32.1937321937322, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI20130057, Length=351, Percent_Identity=32.1937321937322, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI20129963, Length=461, Percent_Identity=29.7180043383948, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI21355645, Length=454, Percent_Identity=29.5154185022026, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24662223, Length=454, Percent_Identity=29.5154185022026, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19922386, Length=491, Percent_Identity=29.938900203666, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21357381, Length=358, Percent_Identity=34.9162011173184, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379063, Length=358, Percent_Identity=34.9162011173184, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379062, Length=358, Percent_Identity=34.9162011173184, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24646701, Length=363, Percent_Identity=26.4462809917355, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=363, Percent_Identity=26.4462809917355, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=363, Percent_Identity=26.4462809917355, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_RICAE (C3PMI0)

Other databases:

- EMBL:   CP001612
- RefSeq:   YP_002844883.1
- ProteinModelPortal:   C3PMI0
- SMR:   C3PMI0
- MEROPS:   M17.003
- GeneID:   7815181
- GenomeReviews:   CP001612_GR
- KEGG:   raf:RAF_ORF0173
- OMA:   NMHLMRY
- ProtClustDB:   PRK00913
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54027; Mature: 54027

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 277-277 ACT_SITE 351-351

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVNFVNEESSTNQGLVVFIDEQLKLDSNLIGLDQQHHGLISKTIQNKLQFTGKYGQIK
CEEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEE
VIPSVIKSGEVRYLIIAGLGNEEKLTEAKIEELGGKILQHATGCKISTIGLKLTNRISRF
EEHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHH
TSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNSTETAKLFEIKKLIAE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHH
AVFFTRDISNEPSNIKTPQVYAERIVDRLEPLGVDVDVIGEREMKNLGMGALLGVGQGSQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCEEECCCCCC
NESKLVVMEYKGGSKDAPTIALVGKGVIFDTGGISLKPSSDMHLMRYDMGGSAAVVGTII
CCCEEEEEEECCCCCCCCEEEEEECCEEEECCCEEECCCCCCEEEEECCCCCHHHHHHHH
AVAGQKLPINIVGVVGLVENMPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWY
HHCCCCCCEEEEEHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCEEEEHHHHH
AQEKFKPKCVIDVATLTGAITIALGNTYAGCFSNNDELADKLIKVGEEVNEKLWRMPLHD
HHHHCCCEEEEEEEHHCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
EYDAMINSDIADMANIGNVPRAAGSCIAAHFIKRFIKDGVDWAHLDIAGVANSNKASALG
CHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCC
PKGAVGYGVRLLEKFIKEYT
CCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNVNFVNEESSTNQGLVVFIDEQLKLDSNLIGLDQQHHGLISKTIQNKLQFTGKYGQIK
CEEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEE
VIPSVIKSGEVRYLIIAGLGNEEKLTEAKIEELGGKILQHATGCKISTIGLKLTNRISRF
EEHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHH
TSQTFASLVASGAFLASYRFDKYRTTLKEAEKFAVESIEIFTDNSTETAKLFEIKKLIAE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHH
AVFFTRDISNEPSNIKTPQVYAERIVDRLEPLGVDVDVIGEREMKNLGMGALLGVGQGSQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCEEECCCCCC
NESKLVVMEYKGGSKDAPTIALVGKGVIFDTGGISLKPSSDMHLMRYDMGGSAAVVGTII
CCCEEEEEEECCCCCCCCEEEEEECCEEEECCCEEECCCCCCEEEEECCCCCHHHHHHHH
AVAGQKLPINIVGVVGLVENMPSGNAQRPGDVVTTMSGQTAEVLNTDAEGRLVLADAVWY
HHCCCCCCEEEEEHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCEEEEHHHHH
AQEKFKPKCVIDVATLTGAITIALGNTYAGCFSNNDELADKLIKVGEEVNEKLWRMPLHD
HHHHCCCEEEEEEEHHCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
EYDAMINSDIADMANIGNVPRAAGSCIAAHFIKRFIKDGVDWAHLDIAGVANSNKASALG
CHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCC
PKGAVGYGVRLLEKFIKEYT
CCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA