| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
Click here to switch to the map view.
The map label for this gene is dxs2 [H]
Identifier: 229576790
GI number: 229576790
Start: 3780820
End: 3782658
Strand: Reverse
Name: dxs2 [H]
Synonym: BCG_3450c
Alternate gene names: 229576790
Gene position: 3782658-3780820 (Counterclockwise)
Preceding gene: 121639306
Following gene: 121639304
Centisome position: 86.47
GC content: 63.73
Gene sequence:
>1839_bases ATGACAACCACGATTCGCAACGGACGCGGGGACTTGATTACCGCGATCGGCGGACCTTGCGATGTGCAGGCATTGCCCGA AAGCCAGCTGCCAGAGCTGGCCGTGCAGATGCGTCGGCGGCTCATAGAAACAGTGACGGCTACCGGTGGCCATCTCGGCG CGGGACTTGGCATGGTAGAGCTGACCATCGCATTGCATCGGGTGTTCACCTCGCCACACGACATCGTGGTGTTCGACACC GGGCACCAAACCTATCCGCACAAGCTGCTCACCGGCCGCGGTAAAGACTTCGCCACGCTGCGCCAGGCCGATGGTCTATC GGGGTATCCCAACCGCCATGAATCGCCACATGACTGGGTCGAGAACTCCCATGCCTCGGTCAGCCTCGCCTGGGTGGACG GCATCGCCAAAGCATTGGCCCTGCAGGGGCAATGCGACCGACGTGTCATCGCGGTGATCGGTGATGGCGCCCTCACCGGG GGCGTGGCATGGGAGGGCCTGAACAACCTCGGTGCCGCTACCCGGCCCGTGATCGTCGTGCTCAATGACAATGGCCGCTC CTACGACCCCACCGCTGGGGCTCTTGCGGCACACCTAGAAGAACTTCGCGTCGGCACACCCCGAGGGCCGAACCTCTTTG AGAACATGGGATTTACCTACATCGGTCCGGTCGATGGGCACAACATCCCCGACACGTGCGCGGTTCTACGAAAAGCGGCC GCGGCAGCTAGGCCCGTTGTTGTTCACGCAGTGACTAGTAAGGGCCGGGGTTATCCTCCAGCCGAAGCTGACGAGAGGGA CCATATGCACGCCTACGGGGTGGTCGACATTGCCACCGGCCTCGCTAGCACACCCAGTCAGCGGAGCTGGACCGACGTGT TCGAGGACGAAATCGCGCGCATTGCTGACGACCGATCCGACGTCGTCGGGCTGACCGCGGCGATGCGTCTGCCCACTGGT CTAGGCGCGCTGTCGAGGCGATACCCGCATCGGGTGTTCGATTCGGGCATCGCCGAACAACACCTGTTGGCCAGCGCGGC CGGGCTAGCTGCCGCGGGAACCCATCCCGTTGTCGCGGTGTACTCGACGTTTCTGCACCGCGCCTTTGACCAACTTCTGT TCGACATCGGGCTGCACCGGTTACCCGTGACGCTGGTGCTGGACCGGGCTGGGGTAACCGGGCCCGACGGACCCAGCCAT CACGGTTTGTGGGATCTGGCGCTGCTGGCCTGCGTGCCCGGGTTTCAGATCGCCTGTCCGCGCGACGCGCCTCGGCTACG ACAACAGTTGCGTACCGCGATCGCGACCGCGGCTCCCACCGCCGTGCGTTTCCCCAAAGGGGCGCCGGGCGAACCGATCA CGGCCGAACACACCATCGGTGGCCTCGACGTCTTGCATACACCACCACCGCATTGGCGACCCGACGTGCTCTTGGTCGCA GTGGGTGCCATGAGTCGACCATGCATGGACGCCGCCCGGTGCCTCAGCGAGGAGCAGATCGGGGTGACAGTCGTTGATCC ACAATGGGTCTGGCCAATCAGCCCGGCACTGACCGAGCTGGCTGGCCGCCATCGGATCACCGTGTGTGTCGAAGATGCGA TTGCCGACGTGGGAATCGGCGCGCACCTTAGCCACCACATCGGGCGGACACACCCGCGGACGCGCACCTACACACTGGGA CTGCCACCGGCCTACATTCCCCACGCCAGCCGCGACCACATCCTTTCCAGCCACGGACTCACCGGCCCCGCAATCCGCAT AAGATGCAAATCACTACTTAACACACTACATGAAGTCCCTGGACCCGAAGACCATCCTGATTCCGGCGATAGTTATTAA
Upstream 100 bases:
>100_bases TGATTGATGCACTTCGCGGATACGCCTCGATCACCGTGGTGGAACGCTCGATAGCGACCGAGACGGTGCGATTCGGCCTT CCCAAACAGGTTCGCGCGCA
Downstream 100 bases:
>100_bases GAGGAAGCATGAACTTGGTTAGCGAAAAAGAATTCTTGGATCTTCCTCTAGTATCCGTAGCAGAGATTGTACGTTGCCGT GGACCGAAGGTATCCGTCTT
Product: 1-deoxy-D-xylulose-5-phosphate synthase
Products: NA
Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]
Number of amino acids: Translated: 612; Mature: 611
Protein sequence:
>612_residues MTTTIRNGRGDLITAIGGPCDVQALPESQLPELAVQMRRRLIETVTATGGHLGAGLGMVELTIALHRVFTSPHDIVVFDT GHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTG GVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAA AAARPVVVHAVTSKGRGYPPAEADERDHMHAYGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMRLPTG LGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSH HGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVA VGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLG LPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNTLHEVPGPEDHPDSGDSY
Sequences:
>Translated_612_residues MTTTIRNGRGDLITAIGGPCDVQALPESQLPELAVQMRRRLIETVTATGGHLGAGLGMVELTIALHRVFTSPHDIVVFDT GHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTG GVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAA AAARPVVVHAVTSKGRGYPPAEADERDHMHAYGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMRLPTG LGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSH HGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVA VGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLG LPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNTLHEVPGPEDHPDSGDSY >Mature_611_residues TTTIRNGRGDLITAIGGPCDVQALPESQLPELAVQMRRRLIETVTATGGHLGAGLGMVELTIALHRVFTSPHDIVVFDTG HQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGG VAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAAA AARPVVVHAVTSKGRGYPPAEADERDHMHAYGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMRLPTGL GALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSHH GLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVAV GAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLGL PPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNTLHEVPGPEDHPDSGDSY
Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]
COG id: COG1154
COG function: function code HI; Deoxyxylulose-5-phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transketolase family. DXPS subfamily [H]
Homologues:
Organism=Homo sapiens, GI205277463, Length=452, Percent_Identity=24.1150442477876, Blast_Score=89, Evalue=1e-17, Organism=Homo sapiens, GI4507521, Length=452, Percent_Identity=24.1150442477876, Blast_Score=89, Evalue=1e-17, Organism=Homo sapiens, GI133778974, Length=457, Percent_Identity=24.2888402625821, Blast_Score=70, Evalue=6e-12, Organism=Escherichia coli, GI1786622, Length=612, Percent_Identity=35.4575163398693, Blast_Score=353, Evalue=2e-98, Organism=Caenorhabditis elegans, GI17539652, Length=489, Percent_Identity=24.5398773006135, Blast_Score=88, Evalue=1e-17, Organism=Drosophila melanogaster, GI45551847, Length=446, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=8e-23, Organism=Drosophila melanogaster, GI45550715, Length=446, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=8e-23, Organism=Drosophila melanogaster, GI24645119, Length=446, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=1e-22, Organism=Drosophila melanogaster, GI24666278, Length=494, Percent_Identity=25.1012145748988, Blast_Score=100, Evalue=3e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005477 - InterPro: IPR011766 - InterPro: IPR009014 - InterPro: IPR015941 - InterPro: IPR005475 - InterPro: IPR020826 - InterPro: IPR005476 - InterPro: IPR005474 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]
EC number: =2.2.1.7 [H]
Molecular weight: Translated: 65297; Mature: 65166
Theoretical pI: Translated: 6.85; Mature: 6.85
Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTTTIRNGRGDLITAIGGPCDVQALPESQLPELAVQMRRRLIETVTATGGHLGAGLGMVE CCCCEECCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCHHHH LTIALHRVFTSPHDIVVFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWV HHHHHHHHHCCCCCEEEECCCCCCCCCHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHH ENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVIVV CCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHCHHHCCCCCCCEEEE LNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAA ECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHHH AAARPVVVHAVTSKGRGYPPAEADERDHMHAYGVVDIATGLASTPSQRSWTDVFEDEIAR HHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH IADDRSDVVGLTAAMRLPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAV HHCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHCHHHCCCCCHHHH YSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACP HHHHHHHHHHHHHHHHCHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECC RDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVA CCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEE VGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIG ECCCCCCHHHHHHHCCCCCCCEEEECCCEECCCCHHHHHHCCCCEEEEEEEHHHHHCCCC AHLSHHIGRTHPRTRTYTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNTLHEVP HHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCHHCCCCCCCHHHHHHHHHHHHHHHCC GPEDHPDSGDSY CCCCCCCCCCCC >Mature Secondary Structure TTTIRNGRGDLITAIGGPCDVQALPESQLPELAVQMRRRLIETVTATGGHLGAGLGMVE CCCEECCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCHHHH LTIALHRVFTSPHDIVVFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWV HHHHHHHHHCCCCCEEEECCCCCCCCCHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHH ENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVIVV CCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHCHHHCCCCCCCEEEE LNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAA ECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHHH AAARPVVVHAVTSKGRGYPPAEADERDHMHAYGVVDIATGLASTPSQRSWTDVFEDEIAR HHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH IADDRSDVVGLTAAMRLPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAV HHCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHCHHHCCCCCHHHH YSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACP HHHHHHHHHHHHHHHHCHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECC RDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVA CCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEE VGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIG ECCCCCCHHHHHHHCCCCCCCEEEECCCEECCCCHHHHHHCCCCEEEEEEEHHHHHCCCC AHLSHHIGRTHPRTRTYTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNTLHEVP HHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCHHCCCCCCCHHHHHHHHHHHHHHHCC GPEDHPDSGDSY CCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA