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The map label for this gene is lysC [H]

Identifier: 229259768

GI number: 229259768

Start: 2954876

End: 2956231

Strand: Reverse

Name: lysC [H]

Synonym: VC0395_A2809

Alternate gene names: 229259768

Gene position: 2956231-2954876 (Counterclockwise)

Preceding gene: 147675121

Following gene: 147675705

Centisome position: 97.76

GC content: 50.59

Gene sequence:

>1356_bases
GTGAGCACATTTAACGTCGCCAAATTTGGTGGTACTAGTGTCGCCAACTTTGAAGCCATGAGCCGTTGTTCGGCCATTAT
CGAAAACAATCCACAAACACGCTTAGTGGTCAGCAGCGCCTGCTCTGGGGTGACCAATTTATTGGTCGAACTCGCCAATG
GCGTGGCCTCAACTGAACGCCGCCAAGCCATTTTGCAACAGTTGGCCGATATCCATTATGTGATTATCGACCAGCTCGCC
GATCCGACACGCGTCGAAAAAGAAGTCAAAGCCGTGCTAGATTCTGTGGCCAGTGCTGCAGAAGCGGCGTCATTTCAATC
CAGTAAAAAACTGACCGACCATCTCGTCGCCTGTGGTGAGCTCATCTCCACCTACATCCTCACTCAACTGATGCGTGAGC
GTGGTGTCGACGCGGTACGTTTTGATATCCGCGAAGTGCTACGCACTGACGATCATTACGGTCGCGCCGAACCTCAATTG
AAAGAAATCGCTCAATTAGCCAAAGAAAAACTGGTGCCACTGTGTGAGCAATATGTCGTCGTGACTCAAGGTTTTATCGG
CTCTGATGCGCAAGGTAATACCACCACTTTAGGCCGCGGCGGCAGTGATTATTCAGCCGCTTTGATTGCCGAAGCCGTGC
AAGCAAGTGGTTTAGAGATTTGGACTGACGTACCGGGAATCTACAGTACCGATCCACGTATCGCGCCAAAAGCGGCGCCG
ATTCCTGAGATAAGCTTTAGCGAAGCCTCAGAAATGGCCAATTTTGGTGCCAAGATTTTGCATCCATCCACCTTGCTTCC
AGCGGTACGCCATGGCATTCCCGTGTTTGTTGGCTCATCAAAAGAACCGGAAAAAGGTGGCACTTGGATCCGTAAACAAG
TCGAAAGCGCGCCACTGTATCGCGCACTTGCACTACGCTGTAATCAAACCATGGTGACACTGCGTAGCGCGCAGATGTTC
CATGCTTACGGTTTCCTCGCCAAAGTGTTCGAAATTCTCGCCAAGCATAAAATTTCGGTCGATCTCATCACCACATCAGA
AATCAGCGTGTCACTGACACTGGATAAAACCGATACCTCAGGCGGTGCGCCAGAATTGCCTGAAGCGGTGCGCGCCGAGT
TAGAGGAGCTATGTACGGTCGAAGTCGAATACAACCTGTGTCTGATTGCTCTGATCGGCAACAAGATGAAAGAGAGCCGC
GGCTACGCGAAGCAAGTGTTCAGTGTATTGGAAGATTACAACCTCCGTATGATTTGCTATGGCGCCAGCGCGCATAACCT
CTGTTTCTTGCTGCATGAATCTGTCTCTAAACAAGCGGTGCAGAAGCTGCATAAAGAGCTGTTTGAGCAAGAGTAA

Upstream 100 bases:

>100_bases
TAGTCACTCCTCTATTTTGCTCTATAAAAAACACTCTCTTCACAACATTGGACGTTGGGTTACCAACAACTCGTTTTTCA
GGAAGTCTGGGAGAATTGCC

Downstream 100 bases:

>100_bases
AATCAAACTCACGAGATAAAACCAGAGGCCACATGATGTGGCCTCTTTTATTGTGGATGGAGGTCTTACTGATTAAGCAT
CAAGGTTAGGCGCTAGCCAC

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSTFNVAKFGGTSVANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLLVELANGVASTERRQAILQQLADIHYVIIDQLA
DPTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGELISTYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQL
KEIAQLAKEKLVPLCEQYVVVTQGFIGSDAQGNTTTLGRGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAP
IPEISFSEASEMANFGAKILHPSTLLPAVRHGIPVFVGSSKEPEKGGTWIRKQVESAPLYRALALRCNQTMVTLRSAQMF
HAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPELPEAVRAELEELCTVEVEYNLCLIALIGNKMKESR
GYAKQVFSVLEDYNLRMICYGASAHNLCFLLHESVSKQAVQKLHKELFEQE

Sequences:

>Translated_451_residues
MSTFNVAKFGGTSVANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLLVELANGVASTERRQAILQQLADIHYVIIDQLA
DPTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGELISTYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQL
KEIAQLAKEKLVPLCEQYVVVTQGFIGSDAQGNTTTLGRGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAP
IPEISFSEASEMANFGAKILHPSTLLPAVRHGIPVFVGSSKEPEKGGTWIRKQVESAPLYRALALRCNQTMVTLRSAQMF
HAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPELPEAVRAELEELCTVEVEYNLCLIALIGNKMKESR
GYAKQVFSVLEDYNLRMICYGASAHNLCFLLHESVSKQAVQKLHKELFEQE
>Mature_450_residues
STFNVAKFGGTSVANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLLVELANGVASTERRQAILQQLADIHYVIIDQLAD
PTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGELISTYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQLK
EIAQLAKEKLVPLCEQYVVVTQGFIGSDAQGNTTTLGRGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAPI
PEISFSEASEMANFGAKILHPSTLLPAVRHGIPVFVGSSKEPEKGGTWIRKQVESAPLYRALALRCNQTMVTLRSAQMFH
AYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPELPEAVRAELEELCTVEVEYNLCLIALIGNKMKESRG
YAKQVFSVLEDYNLRMICYGASAHNLCFLLHESVSKQAVQKLHKELFEQE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=54.6666666666667, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1786183, Length=471, Percent_Identity=29.723991507431, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1790376, Length=466, Percent_Identity=26.1802575107296, Blast_Score=118, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6320893, Length=502, Percent_Identity=30.2788844621514, Blast_Score=183, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49213; Mature: 49082

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFNVAKFGGTSVANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLLVELANGVASTER
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
RQAILQQLADIHYVIIDQLADPTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISTYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQLKEIAQLAKEKLVPLCEQYVV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VTQGFIGSDAQGNTTTLGRGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAP
HHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCC
IPEISFSEASEMANFGAKILHPSTLLPAVRHGIPVFVGSSKEPEKGGTWIRKQVESAPLY
CCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCHHH
RALALRCNQTMVTLRSAQMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCC
GGAPELPEAVRAELEELCTVEVEYNLCLIALIGNKMKESRGYAKQVFSVLEDYNLRMICY
CCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHCCHHHHHHHHHHCCCEEEEEE
GASAHNLCFLLHESVSKQAVQKLHKELFEQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STFNVAKFGGTSVANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLLVELANGVASTER
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
RQAILQQLADIHYVIIDQLADPTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISTYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQLKEIAQLAKEKLVPLCEQYVV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VTQGFIGSDAQGNTTTLGRGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAP
HHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCC
IPEISFSEASEMANFGAKILHPSTLLPAVRHGIPVFVGSSKEPEKGGTWIRKQVESAPLY
CCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCHHH
RALALRCNQTMVTLRSAQMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCC
GGAPELPEAVRAELEELCTVEVEYNLCLIALIGNKMKESRGYAKQVFSVLEDYNLRMICY
CCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHCCHHHHHHHHHHCCCEEEEEE
GASAHNLCFLLHESVSKQAVQKLHKELFEQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]