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The map label for this gene is gcvT

Identifier: 229259641

GI number: 229259641

Start: 354018

End: 355133

Strand: Reverse

Name: gcvT

Synonym: LIC10311

Alternate gene names: 229259641

Gene position: 355133-354018 (Counterclockwise)

Preceding gene: 45656218

Following gene: 45656214

Centisome position: 8.3

GC content: 37.19

Gene sequence:

>1116_bases
ATGTCCCAAGATAAAAAAACACCTCTTTACGAAACTCATCGCACTTTGGGTGCTAAAATGATTCCGTTCGGTGGTTGGGA
CATGCCAGTCCAATATTCTGGAATCATTGCAGAACATAACGCGACTAGAGAGGCCGCTGGACTTTTTGACGTTTCTCATA
TGGGCGAAATTTTTATTACCGGAAATCCTAAATCGATTCTTCTTTTTTTAGAATCGATTACCTGTAATTCAGTCGCCTCT
CTTTCCGATTTTCAAGTCCAGTATAACGCGATCTTAAATCAAAACGGCGGGCTTGTTGACGACGTAACAATCTATAAATT
TTCTTCTGAAAAATACATGATTTGTTCTAACGCTTCTAACTATGAAGCAGTTACAGAACACCTACTCGAACATCTTCCAA
TATCGGGAGTAAAAGTAGATAATCAAAGTTTACAATGGCATCAGATTGCTTTGCAAGGCCCAAAAGCGAACGAGATTTTT
TCTAAATTTTTAAAAAGAGATTTAGATTCGATTCAATATTATCGTTTTATGTTACTCCCCTATCAAGGAGAAGAAATCAT
CGTTTCTAGAACCGGTTATACGGGAGAAGATGGTTTTGAAATTTATTCTTCCATTCCAATAGGTTTAAAACTTTGGAATG
AACTTTTAGAATTCGGAAAACCTTATGGACTACTTCCTTGTGGACTTGGTGCAAGAGATACCCTAAGAATCGAAGCAAAA
TACCCACTTTATGGTCACGAATTAAACGATCAATGGACCCCGATTGAATCCGGAATCGGTTGGATCGTTAAGGAAAAAGA
AAATCCTTACTTTTCTTCCGAAAAAATTCTTTTTCAAAAAAAGAACGGAGTTCCCTCTAAAATCGTTTCATTCGCATTAA
CGGAAGCTGGTGTTCCAAGAGAAAACTTTCGAGTTTTAGATTCTCAAGGAAACGAAATCGGTAAAACTACTTCGGGCACT
TTTTCTCCTTCCTTAAAAAAAGGAATTGGTTTGGCCTTAATACAATCCGAAAAAATCAAGGACGGAGAACCGATCCAGAT
CGAAATTCGAGAACAACCGAAACAAGCCATTATAACAATGAAACCTTTTATTCCAGGCAGCATTAGAAAAAACTAA

Upstream 100 bases:

>100_bases
TTTGACAATTATACCCCGAGTCATAATGAATCGGAAATTTTCTTTAAAAATCAATTTGTCCCTGTATGGAACTGGTAAAA
ATTGGTACATGGAAAACCTT

Downstream 100 bases:

>100_bases
ATTAGGAAAAACAAATTATGGCAGAAACACAGGCTCCCACAGGTTATCTTTTCTCCGAAAAACACGAATGGGTAAAAGTA
GAAGGAGACATGGCTCTTAT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFITGNPKSILLFLESITCNSVAS
LSDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASNYEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIF
SKFLKRDLDSIQYYRFMLLPYQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAK
YPLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPRENFRVLDSQGNEIGKTTSGT
FSPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITMKPFIPGSIRKN

Sequences:

>Translated_371_residues
MSQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFITGNPKSILLFLESITCNSVAS
LSDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASNYEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIF
SKFLKRDLDSIQYYRFMLLPYQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAK
YPLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPRENFRVLDSQGNEIGKTTSGT
FSPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITMKPFIPGSIRKN
>Mature_370_residues
SQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFITGNPKSILLFLESITCNSVASL
SDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASNYEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIFS
KFLKRDLDSIQYYRFMLLPYQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAKY
PLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPRENFRVLDSQGNEIGKTTSGTF
SPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITMKPFIPGSIRKN

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=30.9782608695652, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI257796258, Length=356, Percent_Identity=30.8988764044944, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=29.041095890411, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI257796256, Length=303, Percent_Identity=28.3828382838284, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI194306651, Length=325, Percent_Identity=24.9230769230769, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI24797151, Length=334, Percent_Identity=22.1556886227545, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI197927446, Length=358, Percent_Identity=22.3463687150838, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI21361378, Length=358, Percent_Identity=22.3463687150838, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789272, Length=362, Percent_Identity=34.8066298342541, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=31.0344827586207, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71994045, Length=390, Percent_Identity=22.5641025641026, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71994052, Length=390, Percent_Identity=22.5641025641026, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI32563613, Length=349, Percent_Identity=23.2091690544413, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=34.1902313624679, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=31.413612565445, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28571104, Length=275, Percent_Identity=23.6363636363636, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_LEPIC (Q72VI6)

Other databases:

- EMBL:   AE016823
- ProteinModelPortal:   Q72VI6
- SMR:   Q72VI6
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10311
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- BioCyc:   LINT267671:LIC_10311-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 41583; Mature: 41452

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFIT
CCCCCCCCHHHHHHHCCCEECCCCCCCCCEEECCEEEECCCCHHHHCEEECCCCCCEEEE
GNPKSILLFLESITCNSVASLSDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASN
CCCCEEEEEEEECCCCCCCCCHHHEEEEEEEECCCCCEEEEEEEEEECCCCEEEECCCCC
YEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIFSKFLKRDLDSIQYYRFMLLP
HHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEEE
YQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAK
ECCCEEEEEECCCCCCCCHHEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEE
YPLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPR
CCCCCCCCCCCCCCHHCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCH
ENFRVLDSQGNEIGKTTSGTFSPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITM
HHCEEECCCCCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCCCEEEEECCCCCEEEEEE
KPFIPGSIRKN
CCCCCCCCCCC
>Mature Secondary Structure 
SQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFIT
CCCCCCCHHHHHHHCCCEECCCCCCCCCEEECCEEEECCCCHHHHCEEECCCCCCEEEE
GNPKSILLFLESITCNSVASLSDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASN
CCCCEEEEEEEECCCCCCCCCHHHEEEEEEEECCCCCEEEEEEEEEECCCCEEEECCCCC
YEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIFSKFLKRDLDSIQYYRFMLLP
HHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEEE
YQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAK
ECCCEEEEEECCCCCCCCHHEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEE
YPLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPR
CCCCCCCCCCCCCCHHCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCH
ENFRVLDSQGNEIGKTTSGTFSPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITM
HHCEEECCCCCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCCCEEEEECCCCCEEEEEE
KPFIPGSIRKN
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA