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The map label for this gene is maeA [H]

Identifier: 229170802

GI number: 229170802

Start: 1756261

End: 1757952

Strand: Direct

Name: maeA [H]

Synonym: Psyr_1561

Alternate gene names: 229170802

Gene position: 1756261-1757952 (Clockwise)

Preceding gene: 66044805

Following gene: 66044807

Centisome position: 28.82

GC content: 60.17

Gene sequence:

>1692_bases
ATGACCAAAACTTCGCGACCTTTGTACATTTCCTATGCAGGACCCTCACTGCTGGAAATGCCCCTGCTGAACAAAGGCAG
TGCCTTCACCCCGCAAGAGCGGGTCGAATTCAATCTGATTGGTCTCCTGCCGCAGAACGTAGAGACGATCGAAGAGCAAG
TCACCCGGGTCTACAGCCAGTACAAACAGTGTGCGAGCGACCTGGACAAGCATATCTACCTGCGTTCGATCCAGGACAAC
AACGAAACCCTGTTTTTCCGTCTGCTCGACTCCCACCTGGACGAGATGCTGCCGATCATCTACACGCCGACGGTGGGGCA
GGCCTGTCAGGAATTCTCCAAGATCTACCGCACGCATCGCGGCCTGTTCATTTCCTACCCCGAGCGTGACCGCATCGATG
ACATTTTGCGCAGCGCGACCAAGGATCGGATCAAGATCATTGTCGTGACCGACAGCGAGCGAATTCTCGGCCTGGGCGAT
CAGGGCATCGGCGGCATGGGCATTCCGATCGGCAAACTGTCGTTGTACACCGCTTGCGGCGGGATCAGCCCGGCGTACAC
GCTGCCGATCGTGCTGGATGTCGGCACCAACAATCGTGAGCTGCTGGACGACCCGATGTACATGGGCTGGCGTCACGAGC
GGGTATCGGGCAAGGAATACGAAGACTTCATCGCGCTGTTCATCGACGCGGTGCAGCGTCGCTGGCCGGACGTGCTGTTG
CAGTTTGAAGATTTCGCCCAGTCCAACGCCATGCCGCTGCTCGAAAAGTATCGCGACGAACTGTGCTGCTTCAACGATGA
CATCCAGGGCACCGCTTCGGTTGCCGTGGGTACGTTGCTGGCGGCCTGCAAGGCCAAGAATGAAACCCTCGGCCAGCAGA
AGGTGGTGTTTGTCGGAGCCGGTTCGGCAGGCTGCGGGATCGCCGAGCACATCATCGCAGCGATGCGCATTGAAGGCCTG
AGCGAAAGCGAAGCGCGCAAACGTATTTTCATGGTTGATCGTTTCGGCCTGTTGACCGAAAGCATGGACAACCTGCTCGA
CTTCCAGAAACGACTGGCGCAAAAGACCGCCGACGTGTCTGGCTGGACTGCCGGCTCGGAAGCCTTCCCACAGTTGCTCG
ACGTGGTCACCCACGCCGGCGCCACCGTAATGATCGGTGTGTCCGGGCAGCGCGGTCTGTTCACCGAGCAGGTGATTCGC
GAACTGCACAAGCATTGCGCCAAACCCCTGGTCATGCCGCTGTCCAATCCGACGTCCAAAGTGGAAGCCACGCCGGAAGA
AATCCTGCGCTGGACCGACGGCAATGCGCTGGTGGCCACCGGCAGTCCGTTTGCGCCAGTGGAAATCAACGGTCGCACGG
TGCATATCGCGCAGTGCAACAACTCCTACATCTTTCCGGGCATCGGCCTCGGCGTGGTGGCCTGCAAGGCATCGCGCATC
ACTGACCGGATGCTCATGGCGGCGTCCAATGCGCTGGCCGAGTGCTCGCCGATGGTGACAGGGAAGGGCGATGCGGTGTT
GCCGCCGCTCAAGGAAATCCAGCAGGTCAGCCGCAAGATCGCGTTGGCTGTGGCCAGGGAAGCGCAGGCCGAAGGGCTGG
CGCTGGAAACCACCGAAGAGGCACTGCTTGAGGCCATCGAGCGTAATTTCTGGTTGCCGGGCTACCGGGCCTACCGCCGT
CGCTCGGTCTGA

Upstream 100 bases:

>100_bases
GAGAACTGGCGACAAGAAAAAACAACAAGAACTGAGCCAGGCTGCCCGCCCCGGTCGACGTAAAGAATTAATGAGTAGAC
GAAAAAGGCGATTAGAGAAA

Downstream 100 bases:

>100_bases
TCAGGCGCATTTGAAAGGATGACGTCTCCGCAAGCTTGCTTGCGGAGACACGCTGCTCTGCAAATGCGGTAATGCTGCAA
CGAATTTCTTTACAGTGAAA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTKTSRPLYISYAGPSLLEMPLLNKGSAFTPQERVEFNLIGLLPQNVETIEEQVTRVYSQYKQCASDLDKHIYLRSIQDN
NETLFFRLLDSHLDEMLPIIYTPTVGQACQEFSKIYRTHRGLFISYPERDRIDDILRSATKDRIKIIVVTDSERILGLGD
QGIGGMGIPIGKLSLYTACGGISPAYTLPIVLDVGTNNRELLDDPMYMGWRHERVSGKEYEDFIALFIDAVQRRWPDVLL
QFEDFAQSNAMPLLEKYRDELCCFNDDIQGTASVAVGTLLAACKAKNETLGQQKVVFVGAGSAGCGIAEHIIAAMRIEGL
SESEARKRIFMVDRFGLLTESMDNLLDFQKRLAQKTADVSGWTAGSEAFPQLLDVVTHAGATVMIGVSGQRGLFTEQVIR
ELHKHCAKPLVMPLSNPTSKVEATPEEILRWTDGNALVATGSPFAPVEINGRTVHIAQCNNSYIFPGIGLGVVACKASRI
TDRMLMAASNALAECSPMVTGKGDAVLPPLKEIQQVSRKIALAVAREAQAEGLALETTEEALLEAIERNFWLPGYRAYRR
RSV

Sequences:

>Translated_563_residues
MTKTSRPLYISYAGPSLLEMPLLNKGSAFTPQERVEFNLIGLLPQNVETIEEQVTRVYSQYKQCASDLDKHIYLRSIQDN
NETLFFRLLDSHLDEMLPIIYTPTVGQACQEFSKIYRTHRGLFISYPERDRIDDILRSATKDRIKIIVVTDSERILGLGD
QGIGGMGIPIGKLSLYTACGGISPAYTLPIVLDVGTNNRELLDDPMYMGWRHERVSGKEYEDFIALFIDAVQRRWPDVLL
QFEDFAQSNAMPLLEKYRDELCCFNDDIQGTASVAVGTLLAACKAKNETLGQQKVVFVGAGSAGCGIAEHIIAAMRIEGL
SESEARKRIFMVDRFGLLTESMDNLLDFQKRLAQKTADVSGWTAGSEAFPQLLDVVTHAGATVMIGVSGQRGLFTEQVIR
ELHKHCAKPLVMPLSNPTSKVEATPEEILRWTDGNALVATGSPFAPVEINGRTVHIAQCNNSYIFPGIGLGVVACKASRI
TDRMLMAASNALAECSPMVTGKGDAVLPPLKEIQQVSRKIALAVAREAQAEGLALETTEEALLEAIERNFWLPGYRAYRR
RSV
>Mature_562_residues
TKTSRPLYISYAGPSLLEMPLLNKGSAFTPQERVEFNLIGLLPQNVETIEEQVTRVYSQYKQCASDLDKHIYLRSIQDNN
ETLFFRLLDSHLDEMLPIIYTPTVGQACQEFSKIYRTHRGLFISYPERDRIDDILRSATKDRIKIIVVTDSERILGLGDQ
GIGGMGIPIGKLSLYTACGGISPAYTLPIVLDVGTNNRELLDDPMYMGWRHERVSGKEYEDFIALFIDAVQRRWPDVLLQ
FEDFAQSNAMPLLEKYRDELCCFNDDIQGTASVAVGTLLAACKAKNETLGQQKVVFVGAGSAGCGIAEHIIAAMRIEGLS
ESEARKRIFMVDRFGLLTESMDNLLDFQKRLAQKTADVSGWTAGSEAFPQLLDVVTHAGATVMIGVSGQRGLFTEQVIRE
LHKHCAKPLVMPLSNPTSKVEATPEEILRWTDGNALVATGSPFAPVEINGRTVHIAQCNNSYIFPGIGLGVVACKASRIT
DRMLMAASNALAECSPMVTGKGDAVLPPLKEIQQVSRKIALAVAREAQAEGLALETTEEALLEAIERNFWLPGYRAYRRR
SV

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=538, Percent_Identity=44.0520446096654, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI62420882, Length=558, Percent_Identity=42.6523297491039, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI62420880, Length=558, Percent_Identity=42.6523297491039, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI239049447, Length=558, Percent_Identity=42.6523297491039, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI4505145, Length=560, Percent_Identity=41.6071428571429, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI270265879, Length=470, Percent_Identity=44.2553191489362, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI87081919, Length=562, Percent_Identity=64.7686832740214, Blast_Score=746, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=526, Percent_Identity=43.9163498098859, Blast_Score=409, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322823, Length=560, Percent_Identity=44.2857142857143, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI281362672, Length=518, Percent_Identity=44.2084942084942, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI21356279, Length=518, Percent_Identity=44.2084942084942, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI281362674, Length=518, Percent_Identity=44.2084942084942, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24646386, Length=514, Percent_Identity=43.1906614785992, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646388, Length=514, Percent_Identity=43.1906614785992, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI78707242, Length=531, Percent_Identity=37.8531073446328, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78707238, Length=531, Percent_Identity=37.8531073446328, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78707240, Length=515, Percent_Identity=37.8640776699029, Blast_Score=359, Evalue=4e-99,
Organism=Drosophila melanogaster, GI281363505, Length=535, Percent_Identity=33.6448598130841, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI78707236, Length=535, Percent_Identity=33.6448598130841, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI78707232, Length=504, Percent_Identity=34.7222222222222, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI281363503, Length=533, Percent_Identity=33.3958724202627, Blast_Score=342, Evalue=5e-94,
Organism=Drosophila melanogaster, GI19922384, Length=549, Percent_Identity=28.7795992714025, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62285; Mature: 62154

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTSRPLYISYAGPSLLEMPLLNKGSAFTPQERVEFNLIGLLPQNVETIEEQVTRVYSQ
CCCCCCCEEEEECCCCHHCCCCCCCCCCCCCHHHCEEEEEECCCCCHHHHHHHHHHHHHH
YKQCASDLDKHIYLRSIQDNNETLFFRLLDSHLDEMLPIIYTPTVGQACQEFSKIYRTHR
HHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHC
GLFISYPERDRIDDILRSATKDRIKIIVVTDSERILGLGDQGIGGMGIPIGKLSLYTACG
CEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHCC
GISPAYTLPIVLDVGTNNRELLDDPMYMGWRHERVSGKEYEDFIALFIDAVQRRWPDVLL
CCCCCEEEEEEEEECCCCHHHHCCCHHCCCEECCCCCCHHHHHHHHHHHHHHHHCHHHHH
QFEDFAQSNAMPLLEKYRDELCCFNDDIQGTASVAVGTLLAACKAKNETLGQQKVVFVGA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
GSAGCGIAEHIIAAMRIEGLSESEARKRIFMVDRFGLLTESMDNLLDFQKRLAQKTADVS
CCCCCCHHHHHHHHHHHCCCCHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GWTAGSEAFPQLLDVVTHAGATVMIGVSGQRGLFTEQVIRELHKHCAKPLVMPLSNPTSK
CCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCC
VEATPEEILRWTDGNALVATGSPFAPVEINGRTVHIAQCNNSYIFPGIGLGVVACKASRI
CCCCHHHHHEECCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHHHHHHHH
TDRMLMAASNALAECSPMVTGKGDAVLPPLKEIQQVSRKIALAVAREAQAEGLALETTEE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECHHH
ALLEAIERNFWLPGYRAYRRRSV
HHHHHHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure 
TKTSRPLYISYAGPSLLEMPLLNKGSAFTPQERVEFNLIGLLPQNVETIEEQVTRVYSQ
CCCCCCEEEEECCCCHHCCCCCCCCCCCCCHHHCEEEEEECCCCCHHHHHHHHHHHHHH
YKQCASDLDKHIYLRSIQDNNETLFFRLLDSHLDEMLPIIYTPTVGQACQEFSKIYRTHR
HHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHC
GLFISYPERDRIDDILRSATKDRIKIIVVTDSERILGLGDQGIGGMGIPIGKLSLYTACG
CEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHCC
GISPAYTLPIVLDVGTNNRELLDDPMYMGWRHERVSGKEYEDFIALFIDAVQRRWPDVLL
CCCCCEEEEEEEEECCCCHHHHCCCHHCCCEECCCCCCHHHHHHHHHHHHHHHHCHHHHH
QFEDFAQSNAMPLLEKYRDELCCFNDDIQGTASVAVGTLLAACKAKNETLGQQKVVFVGA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
GSAGCGIAEHIIAAMRIEGLSESEARKRIFMVDRFGLLTESMDNLLDFQKRLAQKTADVS
CCCCCCHHHHHHHHHHHCCCCHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GWTAGSEAFPQLLDVVTHAGATVMIGVSGQRGLFTEQVIRELHKHCAKPLVMPLSNPTSK
CCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCC
VEATPEEILRWTDGNALVATGSPFAPVEINGRTVHIAQCNNSYIFPGIGLGVVACKASRI
CCCCHHHHHEECCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHHHHHHHH
TDRMLMAASNALAECSPMVTGKGDAVLPPLKEIQQVSRKIALAVAREAQAEGLALETTEE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECHHH
ALLEAIERNFWLPGYRAYRRRSV
HHHHHHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA