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The map label for this gene is frdA [H]

Identifier: 229047207

GI number: 229047207

Start: 3178594

End: 3180411

Strand: Direct

Name: frdA [H]

Synonym: VV3097

Alternate gene names: 229047207

Gene position: 3178594-3180411 (Clockwise)

Preceding gene: 37681280

Following gene: 37681282

Centisome position: 94.76

GC content: 50.5

Gene sequence:

>1818_bases
GTGCAAACTATCATCACAGATATCGCAGTCATCGGCGCAGGCGGCGCTGGTCTTCGTACTGCTATTGCAGCGGCTGAAGC
AAACCCGGATCTGGAAGTAGCCTTAATTTCTAAGGTTTACCCAATGCGTTCCCATACGGTCGCAGCAGAGGGTGGCTCAG
CAGCAGTTATCAAGGATGAGGATAGCCTAGACAATCACTTCAACGATACCGTTGGTGGTGGTGACTGGCTTTGTGAACAG
GATGTTGTTGAATACTTTGTTGAAAACGCGACGCGCGAAATGATCCAAATGGAGCAATGGGGTTGCCCATGGAGCCGTAA
GGAGAATGGCGAAGTCAACGTTCGTCGCTTTGGCGGTATGAAAGTTGAGCGTACGTGGTTTGCGGCAGACAAAACTGGCT
TCCACATGCTACACACCCTATTCCAAACTTCGATGAAGTACTCAAACATCAAACGCTTTGATGAGTACTTTGTGGTGGAT
CTGCTTGTTGATGAAGGTGAAGTTCAAGGCCTGATCGCCATCCATATGGCAGAAGGTGAGTTGGTCACGATCAAAGCAAA
ATCAGTGGTACTTGCCACAGGTGGTGCTGGTCGTGTTTACCACTGCAATACCAACGGCGGTATCGTAACGGGCGATGGTA
TGGCCATGGCTTACCGTCACGGCGTTCCTCTACGTGATATGGAATTCGTGCAATACCACCCAACGGGCCTACCAGGCACT
GGTATCCTGATGACCGAAGGTTGTCGTGGTGAAGGCGGTATCATTGTCAACAAAAATGGCTACCGTTACTTGCAAGACTA
CGGCATGGGCCCAGAAACACCGGTTGGCCAGCCGAAGAACAAATACATGGAACTTGGTCCACGTGACAAAGTTTCTCAAG
CATTCTGGCACGAGCAGCAGAAAGGCAACACCATCAAGCACCCACTCGGTGACGTGGTACACCTAGACTTGCGCCACCTA
GGTGAAGAGTATCTGCAAGAACGTCTACCGTTCATTTGTGAACTCGCCAAAGCGTATGTCAACGTTGACCCAGCAAAAGA
GCCGATTCCAATTCGTCCAACCGTTCACTACACCATGGGTGGTATTGAAACGGACAAACAGTGTGAAACACGCATTAAAG
GCCTGTTCGCGGTGGGAGAATGTGCTTCTGTTGGCCTGCACGGTGCAAACCGCCTTGGTTCGAACTCACTAGCAGAATTT
GTGGTGTTTGGCCGCGTTGCGGGTGAGCAAGCGGTGAAACGCGCAGCTGAATTCAAAGGCTGGAATGAAGCGTCTATCGC
CGCACAAGTGAAAGCGGTTGAAGAGCGTATCGCTGCGCTAATGAACCAAGAAGGCGATGAAAACTGGGCAGATATCCGCA
CGGAAATGGGTCACACCATGGAAGCGGGCTGTGGTATCTACCGCCAAGAAGATTTGATGCAAGCGACTATCGATAAGATC
ACAGAGCTTAAAGCGCGTTATAAGCGTATCAGCATCAAAGATAAAGGCAAAGTGTTCAACACCGACCTTCTCTACGCAAT
CGAAGTGGGTTACGGCCTAGAAGTGGCGGAAGCAATGGTTCACTCCGCGATTCTACGTAAAGAATCTCGTGGTGCTCACC
AACGTCTTGACGACGGCTGTACCGATCGTGATGACGTGAACTTCCTCAAGCACTCTTTGGCTTTCTTCCAAGAAGATCAA
GCACCAAACATCAGCTACAGCGACGTGACCATCACTAAGTCTCAGCCTAAAGCACGTTTGTATGGTGAAGCAGCAGAGAA
AGCTGCCGCAGAAGAAGCCGCTAAGGCCGCAGAGAAAAACGCAGAGGAGCAAGCATAA

Upstream 100 bases:

>100_bases
TTCTACACTGTCACTACTACTTTTGGGGAGTATGCGTTTGCCTACGCCCCTATCTCACAATAACAAGCGGATTTCCGCAC
TCACACACTGGAGGATAACT

Downstream 100 bases:

>100_bases
TGTCGGCAAACCGCATTCAAAAAGTAGACATTCTGCGTTACGACCCAGCAACAGACGCAGAACCTCGTTTTCAGGCTTTC
GAAGTCCCGTTTGATGAAAC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MQTIITDIAVIGAGGAGLRTAIAAAEANPDLEVALISKVYPMRSHTVAAEGGSAAVIKDEDSLDNHFNDTVGGGDWLCEQ
DVVEYFVENATREMIQMEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYSNIKRFDEYFVVD
LLVDEGEVQGLIAIHMAEGELVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGQPKNKYMELGPRDKVSQAFWHEQQKGNTIKHPLGDVVHLDLRHL
GEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETDKQCETRIKGLFAVGECASVGLHGANRLGSNSLAEF
VVFGRVAGEQAVKRAAEFKGWNEASIAAQVKAVEERIAALMNQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQATIDKI
TELKARYKRISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDGCTDRDDVNFLKHSLAFFQEDQ
APNISYSDVTITKSQPKARLYGEAAEKAAAEEAAKAAEKNAEEQA

Sequences:

>Translated_605_residues
MQTIITDIAVIGAGGAGLRTAIAAAEANPDLEVALISKVYPMRSHTVAAEGGSAAVIKDEDSLDNHFNDTVGGGDWLCEQ
DVVEYFVENATREMIQMEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYSNIKRFDEYFVVD
LLVDEGEVQGLIAIHMAEGELVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGQPKNKYMELGPRDKVSQAFWHEQQKGNTIKHPLGDVVHLDLRHL
GEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETDKQCETRIKGLFAVGECASVGLHGANRLGSNSLAEF
VVFGRVAGEQAVKRAAEFKGWNEASIAAQVKAVEERIAALMNQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQATIDKI
TELKARYKRISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDGCTDRDDVNFLKHSLAFFQEDQ
APNISYSDVTITKSQPKARLYGEAAEKAAAEEAAKAAEKNAEEQA
>Mature_605_residues
MQTIITDIAVIGAGGAGLRTAIAAAEANPDLEVALISKVYPMRSHTVAAEGGSAAVIKDEDSLDNHFNDTVGGGDWLCEQ
DVVEYFVENATREMIQMEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYSNIKRFDEYFVVD
LLVDEGEVQGLIAIHMAEGELVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGQPKNKYMELGPRDKVSQAFWHEQQKGNTIKHPLGDVVHLDLRHL
GEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETDKQCETRIKGLFAVGECASVGLHGANRLGSNSLAEF
VVFGRVAGEQAVKRAAEFKGWNEASIAAQVKAVEERIAALMNQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQATIDKI
TELKARYKRISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDGCTDRDDVNFLKHSLAFFQEDQ
APNISYSDVTITKSQPKARLYGEAAEKAAAEEAAKAAEKNAEEQA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=529, Percent_Identity=38.9413988657845, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=74.3986254295533, Blast_Score=891, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=540, Percent_Identity=41.1111111111111, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788928, Length=556, Percent_Identity=32.1942446043165, Blast_Score=252, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17505833, Length=528, Percent_Identity=38.6363636363636, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17550100, Length=540, Percent_Identity=38.5185185185185, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI71986328, Length=432, Percent_Identity=26.3888888888889, Blast_Score=110, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322416, Length=563, Percent_Identity=39.6092362344583, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322701, Length=553, Percent_Identity=39.0596745027125, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320788, Length=490, Percent_Identity=26.1224489795918, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137288, Length=543, Percent_Identity=38.4898710865562, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655642, Length=543, Percent_Identity=38.4898710865562, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655647, Length=543, Percent_Identity=38.4898710865562, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24663005, Length=528, Percent_Identity=37.5, Blast_Score=344, Evalue=8e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66647; Mature: 66647

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIITDIAVIGAGGAGLRTAIAAAEANPDLEVALISKVYPMRSHTVAAEGGSAAVIKDE
CCCHHEEHHEECCCCCHHHHHHHHHCCCCCEEEEEHHHHCCCCCCEEEECCCCEEEEECC
DSLDNHFNDTVGGGDWLCEQDVVEYFVENATREMIQMEQWGCPWSRKENGEVNVRRFGGM
CCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KVERTWFAADKTGFHMLHTLFQTSMKYSNIKRFDEYFVVDLLVDEGEVQGLIAIHMAEGE
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEEEECCC
LVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
EEEEEECEEEEEECCCCEEEEECCCCCEEECCCEEEHHHCCCCCCCCHHEEECCCCCCCC
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGQPKNKYMELGPRDKVSQAFWHEQQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KGNTIKHPLGDVVHLDLRHLGEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETDKQCETRIKGLFAVGECASVGLHGANRLGSNSLAEFVVFGRVAGEQAVKRAAEFKG
CCCCCHHHHHHHHHHHEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
WNEASIAAQVKAVEERIAALMNQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQATIDKI
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHH
TELKARYKRISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDGC
HHHHHHHHEECCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCC
TDRDDVNFLKHSLAFFQEDQAPNISYSDVTITKSQPKARLYGEAAEKAAAEEAAKAAEKN
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
AEEQA
CCCCC
>Mature Secondary Structure
MQTIITDIAVIGAGGAGLRTAIAAAEANPDLEVALISKVYPMRSHTVAAEGGSAAVIKDE
CCCHHEEHHEECCCCCHHHHHHHHHCCCCCEEEEEHHHHCCCCCCEEEECCCCEEEEECC
DSLDNHFNDTVGGGDWLCEQDVVEYFVENATREMIQMEQWGCPWSRKENGEVNVRRFGGM
CCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KVERTWFAADKTGFHMLHTLFQTSMKYSNIKRFDEYFVVDLLVDEGEVQGLIAIHMAEGE
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEEEECCC
LVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
EEEEEECEEEEEECCCCEEEEECCCCCEEECCCEEEHHHCCCCCCCCHHEEECCCCCCCC
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGQPKNKYMELGPRDKVSQAFWHEQQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KGNTIKHPLGDVVHLDLRHLGEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETDKQCETRIKGLFAVGECASVGLHGANRLGSNSLAEFVVFGRVAGEQAVKRAAEFKG
CCCCCHHHHHHHHHHHEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
WNEASIAAQVKAVEERIAALMNQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQATIDKI
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHH
TELKARYKRISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDGC
HHHHHHHHEECCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCC
TDRDDVNFLKHSLAFFQEDQAPNISYSDVTITKSQPKARLYGEAAEKAAAEEAAKAAEKN
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
AEEQA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]