Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 228966604

GI number: 228966604

Start: 1354962

End: 1356278

Strand: Direct

Name: hemA [H]

Synonym: BRADO1266

Alternate gene names: 228966604

Gene position: 1354962-1356278 (Clockwise)

Preceding gene: 146338356

Following gene: 146338358

Centisome position: 18.17

GC content: 64.31

Gene sequence:

>1317_bases
ATGGATTACGAGGCGATGTTCCGCGGCTCCCTGGCCGAATTGCGCGGCGAGGGCGCATACCGCGTCTTTGCCGATCTCGA
GCGCATGGTGGGCGCATTTCCACGGGCGATCTACCGCCGGGACGGCGTTGCGAAAGTCGTGACGATCTGGTGCTCCAACG
ACTATCTCGGCATGGGTGAGAACCCGCAGGTGCTCGGTGCGATGCACCGCGCTCTCGATCGCAGCGGCGCCGGCGCCGGA
GGCACGCGCAACATCTCCGGCACGAGTCATGCTCACGTCATGCTGGAGGCGGAACTCGCCGCGCTCCACGGCAAACCGGC
CGCGCTGTTGTTCAACTCGGGCTACGCCTCGAATTGGGCGACGCTCGGCACGCTCGGTGCAAGACTGCCGAACTGCGTGA
TGTTCTCCGACGAGCTCAACCATGCCTCGATCATCGAGGGCATCCGGCACAGCCGCTGCGAGGTACGGATCTTCAAGCAC
AATGATGTCGCTGACCTGCGAGCGAAACTGGCTGCGGTCGAGGCGCGCGTGCCCAAGATCGTGGTGTTCGAGTCGGTCTA
TTCGATGGACGGCGACATCGCGCCGATCTCCGATATCTGTGACGTCGCCGACGCCCACGGGGCCATGACCTATCTTGACG
AGGTTCACGCCGTCGGGCTGTACGGTCACGAGGGCGGGGGTATCTCCGAGCTTCACGGCGTTCGCGACCGGCTGACCATG
ATCGAGGGAACGCTCGCCAAGGCATTCGGCGTCGTCGGCGGTTACATCGCCGGGTCTCGAGACCTCTGCGATTTCATCCG
CAGCTTCGCATCCGGCTTCATCTTCTCGACGGCGCTGCCGCCGAGCGTGGCAGCGGGCGCGCTCGAAAGCATCAAGCTGC
TCAGGCGAGATGGCCGTCGACGCGCGCGCCACCAGAACAGGGTGTCGCTGCTGCGGAAGAAGCTCGACCAGGCGGGGATC
GCTCATCTGGAGAATCCCAGCCACATCGTGCCGATCATGGTGGGAGAGCCCCGCCTGTGCAAACAGATGAGCGACAGGCT
GTTGGACCTTCACGACATCTACGTTCAACCCATCAACTATCCGACTGTTCCGCGCGGCACGGAGCGGCTGCGTCTCACGC
CGACACCTCAGCACACGGACGAAGATATCGCGAAGCTCGTGGATGCATTGATCGAGGTCAGATCTTCGCTCGTGCCGACG
TCGCAGCAGGGTCGTGTCTCGCGGAACGGACGGCCCCTGACGCGAACGAGATCCGCGCACCGGACCGGGTCCGAACACCG
TAAGCCGTCCGCGGAGACCGTCGAAGCGACGGTGTAG

Upstream 100 bases:

>100_bases
TGGCGAAAGTCGCAGCGACGCTGCCGCCCGCGGCGCGCTCGCGCATGTCGATTGATGGACCGCCGCATCGCTGATGCACA
TAGATCCCCCGGAGACGCAA

Downstream 100 bases:

>100_bases
AATCACGTTTCATGTAAGGTGCATGCGGCGTGAAGGTTGCGCCGCCCTTTGACGGCAGGCTTGAAAAGTGATTCGTGGAC
CGGCCTGCCGCAGTCTTCGG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MDYEAMFRGSLAELRGEGAYRVFADLERMVGAFPRAIYRRDGVAKVVTIWCSNDYLGMGENPQVLGAMHRALDRSGAGAG
GTRNISGTSHAHVMLEAELAALHGKPAALLFNSGYASNWATLGTLGARLPNCVMFSDELNHASIIEGIRHSRCEVRIFKH
NDVADLRAKLAAVEARVPKIVVFESVYSMDGDIAPISDICDVADAHGAMTYLDEVHAVGLYGHEGGGISELHGVRDRLTM
IEGTLAKAFGVVGGYIAGSRDLCDFIRSFASGFIFSTALPPSVAAGALESIKLLRRDGRRRARHQNRVSLLRKKLDQAGI
AHLENPSHIVPIMVGEPRLCKQMSDRLLDLHDIYVQPINYPTVPRGTERLRLTPTPQHTDEDIAKLVDALIEVRSSLVPT
SQQGRVSRNGRPLTRTRSAHRTGSEHRKPSAETVEATV

Sequences:

>Translated_438_residues
MDYEAMFRGSLAELRGEGAYRVFADLERMVGAFPRAIYRRDGVAKVVTIWCSNDYLGMGENPQVLGAMHRALDRSGAGAG
GTRNISGTSHAHVMLEAELAALHGKPAALLFNSGYASNWATLGTLGARLPNCVMFSDELNHASIIEGIRHSRCEVRIFKH
NDVADLRAKLAAVEARVPKIVVFESVYSMDGDIAPISDICDVADAHGAMTYLDEVHAVGLYGHEGGGISELHGVRDRLTM
IEGTLAKAFGVVGGYIAGSRDLCDFIRSFASGFIFSTALPPSVAAGALESIKLLRRDGRRRARHQNRVSLLRKKLDQAGI
AHLENPSHIVPIMVGEPRLCKQMSDRLLDLHDIYVQPINYPTVPRGTERLRLTPTPQHTDEDIAKLVDALIEVRSSLVPT
SQQGRVSRNGRPLTRTRSAHRTGSEHRKPSAETVEATV
>Mature_438_residues
MDYEAMFRGSLAELRGEGAYRVFADLERMVGAFPRAIYRRDGVAKVVTIWCSNDYLGMGENPQVLGAMHRALDRSGAGAG
GTRNISGTSHAHVMLEAELAALHGKPAALLFNSGYASNWATLGTLGARLPNCVMFSDELNHASIIEGIRHSRCEVRIFKH
NDVADLRAKLAAVEARVPKIVVFESVYSMDGDIAPISDICDVADAHGAMTYLDEVHAVGLYGHEGGGISELHGVRDRLTM
IEGTLAKAFGVVGGYIAGSRDLCDFIRSFASGFIFSTALPPSVAAGALESIKLLRRDGRRRARHQNRVSLLRKKLDQAGI
AHLENPSHIVPIMVGEPRLCKQMSDRLLDLHDIYVQPINYPTVPRGTERLRLTPTPQHTDEDIAKLVDALIEVRSSLVPT
SQQGRVSRNGRPLTRTRSAHRTGSEHRKPSAETVEATV

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=396, Percent_Identity=50.5050505050505, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI83977440, Length=396, Percent_Identity=50.5050505050505, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI83977444, Length=396, Percent_Identity=50.5050505050505, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI4502025, Length=395, Percent_Identity=50.379746835443, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI40316939, Length=395, Percent_Identity=50.379746835443, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=36.9230769230769, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=38.4393063583815, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI119220554, Length=409, Percent_Identity=28.1173594132029, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4758668, Length=386, Percent_Identity=28.4974093264249, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=29.2181069958848, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1790046, Length=357, Percent_Identity=32.7731092436975, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=35.4838709677419, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=33.6683417085427, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32566772, Length=361, Percent_Identity=29.0858725761773, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=357, Percent_Identity=28.2913165266106, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=357, Percent_Identity=28.2913165266106, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=260, Percent_Identity=27.6923076923077, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=256, Percent_Identity=28.125, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=419, Percent_Identity=47.9713603818616, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320267, Length=379, Percent_Identity=28.2321899736148, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=259, Percent_Identity=25.4826254826255, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137420, Length=395, Percent_Identity=49.873417721519, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=34.4473007712082, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=29.810298102981, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24653280, Length=275, Percent_Identity=27.6363636363636, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24653276, Length=275, Percent_Identity=27.6363636363636, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24653278, Length=275, Percent_Identity=27.6363636363636, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 47784; Mature: 47784

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEAMFRGSLAELRGEGAYRVFADLERMVGAFPRAIYRRDGVAKVVTIWCSNDYLGMGE
CCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCC
NPQVLGAMHRALDRSGAGAGGTRNISGTSHAHVMLEAELAALHGKPAALLFNSGYASNWA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCEEEEEECCCCCCCH
TLGTLGARLPNCVMFSDELNHASIIEGIRHSRCEVRIFKHNDVADLRAKLAAVEARVPKI
HHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEE
VVFESVYSMDGDIAPISDICDVADAHGAMTYLDEVHAVGLYGHEGGGISELHGVRDRLTM
EEEHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHH
IEGTLAKAFGVVGGYIAGSRDLCDFIRSFASGFIFSTALPPSVAAGALESIKLLRRDGRR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
RARHQNRVSLLRKKLDQAGIAHLENPSHIVPIMVGEPRLCKQMSDRLLDLHDIYVQPINY
HHHHHHHHHHHHHHHHHHCHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEECCCC
PTVPRGTERLRLTPTPQHTDEDIAKLVDALIEVRSSLVPTSQQGRVSRNGRPLTRTRSAH
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHH
RTGSEHRKPSAETVEATV
CCCHHHCCCCCCHHCCCC
>Mature Secondary Structure
MDYEAMFRGSLAELRGEGAYRVFADLERMVGAFPRAIYRRDGVAKVVTIWCSNDYLGMGE
CCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCC
NPQVLGAMHRALDRSGAGAGGTRNISGTSHAHVMLEAELAALHGKPAALLFNSGYASNWA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCEEEEEECCCCCCCH
TLGTLGARLPNCVMFSDELNHASIIEGIRHSRCEVRIFKHNDVADLRAKLAAVEARVPKI
HHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEE
VVFESVYSMDGDIAPISDICDVADAHGAMTYLDEVHAVGLYGHEGGGISELHGVRDRLTM
EEEHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHH
IEGTLAKAFGVVGGYIAGSRDLCDFIRSFASGFIFSTALPPSVAAGALESIKLLRRDGRR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
RARHQNRVSLLRKKLDQAGIAHLENPSHIVPIMVGEPRLCKQMSDRLLDLHDIYVQPINY
HHHHHHHHHHHHHHHHHHCHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEECCCC
PTVPRGTERLRLTPTPQHTDEDIAKLVDALIEVRSSLVPTSQQGRVSRNGRPLTRTRSAH
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHH
RTGSEHRKPSAETVEATV
CCCHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]