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The map label for this gene is hom [H]

Identifier: 228913484

GI number: 228913484

Start: 264069

End: 265370

Strand: Reverse

Name: hom [H]

Synonym: ACIAD0264

Alternate gene names: 228913484

Gene position: 265370-264069 (Counterclockwise)

Preceding gene: 50083542

Following gene: 50083540

Centisome position: 7.37

GC content: 44.85

Gene sequence:

>1302_bases
GTGAAACCAGTTCGTCTGGCAATACTCGGTCTTGGAACCGTTGGTGGTGGTGCCCTTAAACTATTACAAGAAAACGCTGC
TGAAATTAAACGTCGCACCGGTCGTGAAATTCAAATTACCCATGTCGGAACCCGCCGTTCTCGTCCAGATCTTGAGTTGG
AAGGTATTCAACAAAGCGATGACTTGATGCATATCGTCCGTCAGCCAGATGTCGATGTTGTGGTTGAAGTTATGGGTGGT
ATCCATCCTGCCTACGAAGTCATCATGGAAGCGATCAAGCATGGCAAACAGGTCGTTACTGCAAATAAAGCACTCCTTGC
AGAGCATGGTAATGAGCTGTTTAAGGCGGCTGAAGATAATGCAGTACAAGTTGCATATGAAGCAGCAGTGGCTGGCGGAA
TCCCGATTATTAAAGTGATTCGTGAAGGCTTGGCAGCAAATAGAATTGAATGGTTGGCGGGTATTATTAACGGGACTGGA
AACTTCATCCTGACCGAAATGCGTGATAAAGGCCGTGCCTTTACAGATGTACTAAAAGAAGCACAAGAGTTAGGGTATGC
AGAAGCCGATCCTACTTTTGATGTTGAAGGGATTGATGCTGCACATAAACTTACGATCTTGGCATCATGCGCGTTTGGTA
TTCCACTTCAATTTGACAAGGTGTATACCGAAGGTATTAGCAAGATTACAGCGCAAGATGTGAAGTATGCCGAAGAGCTT
GGCTTTCGTATCAAACATCTCGGGATTGCACGTCGTGTTGAAAACGGTATCGAATTACGCGTACATCCAACCCTAATTCC
AGAAGAAGAATTAATTGCCAATGTCAACGGCGTTAAAAATGCCGTACTGGTGCAGGCACACGCTGTAGGCCCAACATTGT
ACTATGGTGCAGGTGCAGGTGCAGGCCCAACAGCATCTGCTGTGGTAGCCGATATCGTGGATATTGTACGTGATATTTCA
TATACCGAAGATGGTGCGGGGACCATTCCACAACTGGCGTTTGAAGCCTTGACTGATGTACCTATTTTAAAACGCGAAGA
AATGACAACAGGTTATTACCTTCGTGTCGATGCAGAAGATCAGACAGGTGTGTTGGCAGATATCACCACCATCTTAAGCC
GTGCTGGTATTAGTATCGATGCAATTATGCAGCAGTCACGTTTAAAAGATCTTATCCCTATTGTAATTCTGACTGATCCA
GTTGTGGAATCCAAAATGGACGAAGCACTTGCAAAAATTCAGGCTTTACCTGCAATTCATGGCGAAATTGTGCGAATTCG
TTTAGAATCGCTTGATAGTTAA

Upstream 100 bases:

>100_bases
GGCAATTGTTTATGGAATTGCCAACAAACCCTAGAGTCTGACGTTTTTTTTAGCTATGATCTAAACTCATTCAATTTTTT
ATGCATGTATGGAGTGTGAC

Downstream 100 bases:

>100_bases
TCGGGTGGAGAGGGTCTTCCCTCTCGCCAGCTCTACCTTACTCTTGGAACATACATCATCATGTCTAATGCCAATCGTTA
TACCGGTCTCGTAGATCGTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKPVRLAILGLGTVGGGALKLLQENAAEIKRRTGREIQITHVGTRRSRPDLELEGIQQSDDLMHIVRQPDVDVVVEVMGG
IHPAYEVIMEAIKHGKQVVTANKALLAEHGNELFKAAEDNAVQVAYEAAVAGGIPIIKVIREGLAANRIEWLAGIINGTG
NFILTEMRDKGRAFTDVLKEAQELGYAEADPTFDVEGIDAAHKLTILASCAFGIPLQFDKVYTEGISKITAQDVKYAEEL
GFRIKHLGIARRVENGIELRVHPTLIPEEELIANVNGVKNAVLVQAHAVGPTLYYGAGAGAGPTASAVVADIVDIVRDIS
YTEDGAGTIPQLAFEALTDVPILKREEMTTGYYLRVDAEDQTGVLADITTILSRAGISIDAIMQQSRLKDLIPIVILTDP
VVESKMDEALAKIQALPAIHGEIVRIRLESLDS

Sequences:

>Translated_433_residues
MKPVRLAILGLGTVGGGALKLLQENAAEIKRRTGREIQITHVGTRRSRPDLELEGIQQSDDLMHIVRQPDVDVVVEVMGG
IHPAYEVIMEAIKHGKQVVTANKALLAEHGNELFKAAEDNAVQVAYEAAVAGGIPIIKVIREGLAANRIEWLAGIINGTG
NFILTEMRDKGRAFTDVLKEAQELGYAEADPTFDVEGIDAAHKLTILASCAFGIPLQFDKVYTEGISKITAQDVKYAEEL
GFRIKHLGIARRVENGIELRVHPTLIPEEELIANVNGVKNAVLVQAHAVGPTLYYGAGAGAGPTASAVVADIVDIVRDIS
YTEDGAGTIPQLAFEALTDVPILKREEMTTGYYLRVDAEDQTGVLADITTILSRAGISIDAIMQQSRLKDLIPIVILTDP
VVESKMDEALAKIQALPAIHGEIVRIRLESLDS
>Mature_433_residues
MKPVRLAILGLGTVGGGALKLLQENAAEIKRRTGREIQITHVGTRRSRPDLELEGIQQSDDLMHIVRQPDVDVVVEVMGG
IHPAYEVIMEAIKHGKQVVTANKALLAEHGNELFKAAEDNAVQVAYEAAVAGGIPIIKVIREGLAANRIEWLAGIINGTG
NFILTEMRDKGRAFTDVLKEAQELGYAEADPTFDVEGIDAAHKLTILASCAFGIPLQFDKVYTEGISKITAQDVKYAEEL
GFRIKHLGIARRVENGIELRVHPTLIPEEELIANVNGVKNAVLVQAHAVGPTLYYGAGAGAGPTASAVVADIVDIVRDIS
YTEDGAGTIPQLAFEALTDVPILKREEMTTGYYLRVDAEDQTGVLADITTILSRAGISIDAIMQQSRLKDLIPIVILTDP
VVESKMDEALAKIQALPAIHGEIVRIRLESLDS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=353, Percent_Identity=25.2124645892351, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786183, Length=256, Percent_Identity=26.5625, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=226, Percent_Identity=27.4336283185841, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46730; Mature: 46730

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVRLAILGLGTVGGGALKLLQENAAEIKRRTGREIQITHVGTRRSRPDLELEGIQQSD
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCH
DLMHIVRQPDVDVVVEVMGGIHPAYEVIMEAIKHGKQVVTANKALLAEHGNELFKAAEDN
HHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHCCHHHHHHCCCC
AVQVAYEAAVAGGIPIIKVIREGLAANRIEWLAGIINGTGNFILTEMRDKGRAFTDVLKE
CEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHCCCHHHHHHHH
AQELGYAEADPTFDVEGIDAAHKLTILASCAFGIPLQFDKVYTEGISKITAQDVKYAEEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GFRIKHLGIARRVENGIELRVHPTLIPEEELIANVNGVKNAVLVQAHAVGPTLYYGAGAG
CCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEEEEECCCEEEECCCCC
AGPTASAVVADIVDIVRDISYTEDGAGTIPQLAFEALTDVPILKREEMTTGYYLRVDAED
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCEEEEEECCC
QTGVLADITTILSRAGISIDAIMQQSRLKDLIPIVILTDPVVESKMDEALAKIQALPAIH
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCC
GEIVRIRLESLDS
CCEEEEEECCCCC
>Mature Secondary Structure
MKPVRLAILGLGTVGGGALKLLQENAAEIKRRTGREIQITHVGTRRSRPDLELEGIQQSD
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCH
DLMHIVRQPDVDVVVEVMGGIHPAYEVIMEAIKHGKQVVTANKALLAEHGNELFKAAEDN
HHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHCCHHHHHHCCCC
AVQVAYEAAVAGGIPIIKVIREGLAANRIEWLAGIINGTGNFILTEMRDKGRAFTDVLKE
CEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHCCCHHHHHHHH
AQELGYAEADPTFDVEGIDAAHKLTILASCAFGIPLQFDKVYTEGISKITAQDVKYAEEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GFRIKHLGIARRVENGIELRVHPTLIPEEELIANVNGVKNAVLVQAHAVGPTLYYGAGAG
CCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEEEEECCCEEEECCCCC
AGPTASAVVADIVDIVRDISYTEDGAGTIPQLAFEALTDVPILKREEMTTGYYLRVDAED
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCEEEEEECCC
QTGVLADITTILSRAGISIDAIMQQSRLKDLIPIVILTDPVVESKMDEALAKIQALPAIH
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCC
GEIVRIRLESLDS
CCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]