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The map label for this gene is yybO [H]

Identifier: 227828826

GI number: 227828826

Start: 2421140

End: 2422399

Strand: Direct

Name: yybO [H]

Synonym: M1425_2600

Alternate gene names: 227828826

Gene position: 2421140-2422399 (Clockwise)

Preceding gene: 227828822

Following gene: 227828827

Centisome position: 92.81

GC content: 36.35

Gene sequence:

>1260_bases
ATGAAAGGAAATCTAAGATGGAAGATCGTTCTGATTGTATTTGCGTTAATTATAATAGACTACATAGATAGGGGACTAAT
AAATACTGCACTACCAGTACTAAAAAGTGAATTCCATATAAGTTCTTTTGAAGCTGGAATAATTGGAGATGGCTTCACTT
TTGGATATCTTATAATGAATCCATTAGCTGGCTATTTTTTGGACAAATACGGACCTAAAAGGGTTTTTAGTCGATTTGCA
ATCCTTTGGGGGGCTGTGCAAGCTATTAATGTATTCGCTTTCTCGACTCTTTATTTTATAGCAACTAGAGTATTGCTGGG
TATTGGTGAAGCAGTAGGTTTCCCTGGAGTTACAAAGATAACCGCAAATTGGTTAAGAAAAGATGAAAAGGCTAGAGGTG
GTACTATCTCAGATTCTGGAGTAAATTTAGGGATAGTTTTCGGTTCTTTATTTATGTTAGGATTGTTTGCAATAATTCCT
AATCAAGATTTAGCTTGGAGGTTAGGATTTTTGATTAGTGGCCTTTTGGCTATTATTCTCGCCATAATATTAGGTCGTCT
CTTGTATGATTTACCAGAGCAACATCCAAAAATTTCTAAGGAAGAATTAGACTATATTTTATCAGGTAGGGAAAACGTTA
GTATGAAAACTAAGCTGTCATTGTCGTATTGGTTAAGAAGTAAAAATTACTGGGGTTATATGCAAGGTTTAGGAGCACAG
GCCGGAATATTCTTCGGTCTATTTACCTGGTTACCTTTATATCTTTTTTATGCTAGGCATCTTTCCCTAGCATTTACATT
AGAATACACTGCGTTAATTTGGAGTTTTGGCTTCATAGGAGAATTAGTAGGAGGTTATGTGGTTGACAAATTAATTAAGA
GAAATCCTAATTTAGGCTTCAAAGTAGGGTTTGCGATTAGCTCCTTGTCTGTAACTATAGGTCTTGCAGCTGCTACTCTA
GTTTCCTCATCCATAGAGGCAGTTGAAATATTAATGGTAACTTTCTTCTTCCTAAGATGGTCAGGTATTCAGTGGGCTGC
ACCATCCTTTCTTGTTCAGCCTGAATTAGCTGGTCAGTTTGGCGGTCATATTGGTTTTTGGGAAACTTTATGGGGAATAG
TAGTACCAATAGTGTTTGGTGCTACTGTGGAAGCTACCAAAGAATATCTTTTAGGCATGGAAATTTTAATCGGGATAGGT
CTTATATACTTCATCGGAACAGTATTAGTAACCACCTATAGGCAAATAAAGGTGAACTAA

Upstream 100 bases:

>100_bases
AAGTATACATTGTAAATTTAAACTATTTACTAGTATACAGTCCTTTTTAACAAACTTGTAAACGTAATAGTTTATATATA
TCTAATTATATTCTCTCCTT

Downstream 100 bases:

>100_bases
GATTGTGGAAGGTATTTTTTCTTAATAGAAATTTCATCAAAGAAAGTGTTAGGGATGAACTTCCTAATTCGTATGAAGTA
AAGGTTTTCCCTAAATACGT

Product: major facilitator superfamily MFS_1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKGNLRWKIVLIVFALIIIDYIDRGLINTALPVLKSEFHISSFEAGIIGDGFTFGYLIMNPLAGYFLDKYGPKRVFSRFA
ILWGAVQAINVFAFSTLYFIATRVLLGIGEAVGFPGVTKITANWLRKDEKARGGTISDSGVNLGIVFGSLFMLGLFAIIP
NQDLAWRLGFLISGLLAIILAIILGRLLYDLPEQHPKISKEELDYILSGRENVSMKTKLSLSYWLRSKNYWGYMQGLGAQ
AGIFFGLFTWLPLYLFYARHLSLAFTLEYTALIWSFGFIGELVGGYVVDKLIKRNPNLGFKVGFAISSLSVTIGLAAATL
VSSSIEAVEILMVTFFFLRWSGIQWAAPSFLVQPELAGQFGGHIGFWETLWGIVVPIVFGATVEATKEYLLGMEILIGIG
LIYFIGTVLVTTYRQIKVN

Sequences:

>Translated_419_residues
MKGNLRWKIVLIVFALIIIDYIDRGLINTALPVLKSEFHISSFEAGIIGDGFTFGYLIMNPLAGYFLDKYGPKRVFSRFA
ILWGAVQAINVFAFSTLYFIATRVLLGIGEAVGFPGVTKITANWLRKDEKARGGTISDSGVNLGIVFGSLFMLGLFAIIP
NQDLAWRLGFLISGLLAIILAIILGRLLYDLPEQHPKISKEELDYILSGRENVSMKTKLSLSYWLRSKNYWGYMQGLGAQ
AGIFFGLFTWLPLYLFYARHLSLAFTLEYTALIWSFGFIGELVGGYVVDKLIKRNPNLGFKVGFAISSLSVTIGLAAATL
VSSSIEAVEILMVTFFFLRWSGIQWAAPSFLVQPELAGQFGGHIGFWETLWGIVVPIVFGATVEATKEYLLGMEILIGIG
LIYFIGTVLVTTYRQIKVN
>Mature_419_residues
MKGNLRWKIVLIVFALIIIDYIDRGLINTALPVLKSEFHISSFEAGIIGDGFTFGYLIMNPLAGYFLDKYGPKRVFSRFA
ILWGAVQAINVFAFSTLYFIATRVLLGIGEAVGFPGVTKITANWLRKDEKARGGTISDSGVNLGIVFGSLFMLGLFAIIP
NQDLAWRLGFLISGLLAIILAIILGRLLYDLPEQHPKISKEELDYILSGRENVSMKTKLSLSYWLRSKNYWGYMQGLGAQ
AGIFFGLFTWLPLYLFYARHLSLAFTLEYTALIWSFGFIGELVGGYVVDKLIKRNPNLGFKVGFAISSLSVTIGLAAATL
VSSSIEAVEILMVTFFFLRWSGIQWAAPSFLVQPELAGQFGGHIGFWETLWGIVVPIVFGATVEATKEYLLGMEILIGIG
LIYFIGTVLVTTYRQIKVN

Specific function: Uptake Of D-Glucarate. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI148743791, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI256219543, Length=315, Percent_Identity=21.5873015873016, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789152, Length=417, Percent_Identity=26.378896882494, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082320, Length=394, Percent_Identity=25.8883248730964, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI2367379, Length=398, Percent_Identity=25.3768844221106, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789515, Length=413, Percent_Identity=25.181598062954, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI2367193, Length=291, Percent_Identity=28.5223367697594, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082071, Length=418, Percent_Identity=23.6842105263158, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533556, Length=404, Percent_Identity=25.990099009901, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533554, Length=404, Percent_Identity=25.990099009901, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322612, Length=212, Percent_Identity=27.8301886792453, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24583789, Length=287, Percent_Identity=25.4355400696864, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584153, Length=264, Percent_Identity=22.7272727272727, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641682, Length=269, Percent_Identity=24.907063197026, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281361682, Length=350, Percent_Identity=21.1428571428571, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920686, Length=260, Percent_Identity=22.6923076923077, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46493; Mature: 46493

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGNLRWKIVLIVFALIIIDYIDRGLINTALPVLKSEFHISSFEAGIIGDGFTFGYLIMN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
PLAGYFLDKYGPKRVFSRFAILWGAVQAINVFAFSTLYFIATRVLLGIGEAVGFPGVTKI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TANWLRKDEKARGGTISDSGVNLGIVFGSLFMLGLFAIIPNQDLAWRLGFLISGLLAIIL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AIILGRLLYDLPEQHPKISKEELDYILSGRENVSMKTKLSLSYWLRSKNYWGYMQGLGAQ
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCHHHHCCCCH
AGIFFGLFTWLPLYLFYARHLSLAFTLEYTALIWSFGFIGELVGGYVVDKLIKRNPNLGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
KVGFAISSLSVTIGLAAATLVSSSIEAVEILMVTFFFLRWSGIQWAAPSFLVQPELAGQF
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHC
GGHIGFWETLWGIVVPIVFGATVEATKEYLLGMEILIGIGLIYFIGTVLVTTYRQIKVN
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]