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The map label for this gene is adh [H]

Identifier: 227828743

GI number: 227828743

Start: 2327767

End: 2328759

Strand: Direct

Name: adh [H]

Synonym: M1425_2505

Alternate gene names: 227828743

Gene position: 2327767-2328759 (Clockwise)

Preceding gene: 227828736

Following gene: 227828747

Centisome position: 89.23

GC content: 37.66

Gene sequence:

>993_bases
ATGAAGGCTCTCGTATTTGATAAGAACGGAATAGAAAACTTGAAGTTTACAGATTATAAAGACCCAGAAATAGGTAACCA
TGAAGTATTAATAAGAGTGAAACTGGCTGGCGTAAATCCAGTTGACTATTATACTGTTGAGAGACTAAAAGCGAACCCGA
TACCACATATACCCGGAGTTGAATTTAGCGGGGAGGTAGCTAAGGTTGGAGATCATGTTAAAAGTTTAAGTGTAGGCGAC
AGAGTTACAATTTATGGTAGAATATTTGACGGAACTTGTGACATGTGCATGGCTGGATATGAAACAGTCTGTAGAAATGG
TGGAAGAATAGGAGTTGACGCTAATGGTGGATGGGCTGAGTATATTGCAGTTGAAGAGAAGTATGTGTTTAAGTTACCAA
ATGAATATACGTGGGAAATGGGATCGAGCTTGACTGTAGCTGCTTTAACAGCTTATCATGCATTAAAGGAAGCAGAATTG
AGGCCATCACAAACGCTAGTTATATTTGGGGCATCTGGAAATACTGGAATGTTTTTGGTACAATTGGGTAAGAAGTTTGG
GGCAAAAGTAATAGCTGTATCAAGAAAGAGTTGGTTAAGGGAATATGGAGCCGATTTTGTAGTTGATTATAATGAAGTAG
AGGAAAAGGTGAAGGAAATTACAAATGCTAAGATGGCTGACGTAGTTGTCAATTCCTTAGGAGAACAACTTTGGGATAAG
AGCTTTTCAGTTGTAGGGATTAGGGGTAAGTTAGTCACCTTTGGAACATTGTTAGGTGGCAATGTGAAGGTTGATTTAAG
TCAGTTATATAGCAAGCACATTAGTATTCTAGGTGTTAATAGGGGTAATAGGAAGGACTTTGTAGAATTATTAGACATTT
GTAAGGATTGTAAAGTAAAGACATGGAAGATATTTAAGTTAGAGGAGGGTAAACAAGCTCTGAAAGAACTTTTCTCTAAA
GAGAGGGATGGTAGAATTTTCCTATCTCCTTAA

Upstream 100 bases:

>100_bases
CTAACGAGATGCGTTTAAGATAATTTTTCTCCTAACTTTGCTTATTATCTTTACCAATCTAAAGTTAACTTATTAACCTT
TTAAGCTTAAGTTAAAGGTG

Downstream 100 bases:

>100_bases
CACTTCGCCAACTAGGAAAGATGGAAATCCTTGTTTTTCTGCCTCTTGAAGGGCATCTTCTACCTCTCTTTTTTCACCTA
TTACAAGTACTAACAACTCT

Product: alcohol dehydrogenase GroES domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKALVFDKNGIENLKFTDYKDPEIGNHEVLIRVKLAGVNPVDYYTVERLKANPIPHIPGVEFSGEVAKVGDHVKSLSVGD
RVTIYGRIFDGTCDMCMAGYETVCRNGGRIGVDANGGWAEYIAVEEKYVFKLPNEYTWEMGSSLTVAALTAYHALKEAEL
RPSQTLVIFGASGNTGMFLVQLGKKFGAKVIAVSRKSWLREYGADFVVDYNEVEEKVKEITNAKMADVVVNSLGEQLWDK
SFSVVGIRGKLVTFGTLLGGNVKVDLSQLYSKHISILGVNRGNRKDFVELLDICKDCKVKTWKIFKLEEGKQALKELFSK
ERDGRIFLSP

Sequences:

>Translated_330_residues
MKALVFDKNGIENLKFTDYKDPEIGNHEVLIRVKLAGVNPVDYYTVERLKANPIPHIPGVEFSGEVAKVGDHVKSLSVGD
RVTIYGRIFDGTCDMCMAGYETVCRNGGRIGVDANGGWAEYIAVEEKYVFKLPNEYTWEMGSSLTVAALTAYHALKEAEL
RPSQTLVIFGASGNTGMFLVQLGKKFGAKVIAVSRKSWLREYGADFVVDYNEVEEKVKEITNAKMADVVVNSLGEQLWDK
SFSVVGIRGKLVTFGTLLGGNVKVDLSQLYSKHISILGVNRGNRKDFVELLDICKDCKVKTWKIFKLEEGKQALKELFSK
ERDGRIFLSP
>Mature_330_residues
MKALVFDKNGIENLKFTDYKDPEIGNHEVLIRVKLAGVNPVDYYTVERLKANPIPHIPGVEFSGEVAKVGDHVKSLSVGD
RVTIYGRIFDGTCDMCMAGYETVCRNGGRIGVDANGGWAEYIAVEEKYVFKLPNEYTWEMGSSLTVAALTAYHALKEAEL
RPSQTLVIFGASGNTGMFLVQLGKKFGAKVIAVSRKSWLREYGADFVVDYNEVEEKVKEITNAKMADVVVNSLGEQLWDK
SFSVVGIRGKLVTFGTLLGGNVKVDLSQLYSKHISILGVNRGNRKDFVELLDICKDCKVKTWKIFKLEEGKQALKELFSK
ERDGRIFLSP

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=291, Percent_Identity=26.4604810996564, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13236495, Length=291, Percent_Identity=26.4604810996564, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI194239676, Length=225, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI18379349, Length=340, Percent_Identity=24.7058823529412, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1790485, Length=352, Percent_Identity=26.4204545454545, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081918, Length=306, Percent_Identity=28.1045751633987, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788073, Length=330, Percent_Identity=25.7575757575758, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=271, Percent_Identity=28.0442804428044, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790045, Length=187, Percent_Identity=27.807486631016, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787863, Length=226, Percent_Identity=29.2035398230088, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082125, Length=234, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=21.5434083601286, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788075, Length=262, Percent_Identity=27.8625954198473, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786825, Length=310, Percent_Identity=25.1612903225806, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=331, Percent_Identity=26.2839879154079, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=26.4880952380952, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=336, Percent_Identity=25.5952380952381, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=324, Percent_Identity=21.9135802469136, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=186, Percent_Identity=33.8709677419355, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=324, Percent_Identity=22.5308641975309, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=28.1524926686217, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=340, Percent_Identity=27.0588235294118, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=326, Percent_Identity=26.6871165644172, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=26.8436578171091, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319520, Length=346, Percent_Identity=23.6994219653179, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=27.0186335403727, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=346, Percent_Identity=25.1445086705202, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=225, Percent_Identity=27.1111111111111, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=231, Percent_Identity=28.1385281385281, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=330, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=25.2199413489736, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=25.2199413489736, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324195, Length=267, Percent_Identity=26.2172284644195, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137530, Length=295, Percent_Identity=26.4406779661017, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=25.3012048192771, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36723; Mature: 36723

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVFDKNGIENLKFTDYKDPEIGNHEVLIRVKLAGVNPVDYYTVERLKANPIPHIPGV
CCEEEECCCCCCCCEECCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
EFSGEVAKVGDHVKSLSVGDRVTIYGRIFDGTCDMCMAGYETVCRNGGRIGVDANGGWAE
CCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCEEE
YIAVEEKYVFKLPNEYTWEMGSSLTVAALTAYHALKEAELRPSQTLVIFGASGNTGMFLV
EEEEECEEEEECCCCEEHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEE
QLGKKFGAKVIAVSRKSWLREYGADFVVDYNEVEEKVKEITNAKMADVVVNSLGEQLWDK
EECHHHCCEEEEEHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
SFSVVGIRGKLVTFGTLLGGNVKVDLSQLYSKHISILGVNRGNRKDFVELLDICKDCKVK
CCEEEEECCEEEEEEEEECCCEEEEHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCC
TWKIFKLEEGKQALKELFSKERDGRIFLSP
EEEEEEEHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MKALVFDKNGIENLKFTDYKDPEIGNHEVLIRVKLAGVNPVDYYTVERLKANPIPHIPGV
CCEEEECCCCCCCCEECCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
EFSGEVAKVGDHVKSLSVGDRVTIYGRIFDGTCDMCMAGYETVCRNGGRIGVDANGGWAE
CCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCEEE
YIAVEEKYVFKLPNEYTWEMGSSLTVAALTAYHALKEAELRPSQTLVIFGASGNTGMFLV
EEEEECEEEEECCCCEEHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEE
QLGKKFGAKVIAVSRKSWLREYGADFVVDYNEVEEKVKEITNAKMADVVVNSLGEQLWDK
EECHHHCCEEEEEHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
SFSVVGIRGKLVTFGTLLGGNVKVDLSQLYSKHISILGVNRGNRKDFVELLDICKDCKVK
CCEEEEECCEEEEEEEEECCCEEEEHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCC
TWKIFKLEEGKQALKELFSKERDGRIFLSP
EEEEEEEHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA