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The map label for this gene is hbd [H]

Identifier: 227828680

GI number: 227828680

Start: 2262236

End: 2263348

Strand: Direct

Name: hbd [H]

Synonym: M1425_2437

Alternate gene names: 227828680

Gene position: 2262236-2263348 (Clockwise)

Preceding gene: 227828679

Following gene: 227828683

Centisome position: 86.71

GC content: 37.2

Gene sequence:

>1113_bases
ATGATAAGAAATGTATTGGTAGTTGGAGCAGGGACAATGGGCCACGGAATTGCCGAAGTTTCAGCCATAGCCGGGTATAA
CGTTTACCTGAGTGATGTATCTAAAGATATATTGAATAACGCAATACAGAAGGTCAAGTGGAGTTTGGAGAAATTATATG
AAAAAGGTAACTTAAAGGAAAGTGTTGAGGACGTTTTGGGAAGAATTAAAACCATAGAAGGGTTATCGAATGAGTTAAGG
GAAATTGATATATCAATAGAAGCAATACCAGAGAAATTGGATTTAAAGAGACAACTATTTTCTAAGCTTGAGGAACTATT
ACCCAATAATGCGATATTGGCTACTAATACTAGTAGCTTACCAATTACGGAAATTGCTTCTGCTGTAAAAAGGCAAGAAA
GGGTTATAGGAACTCACTTCTTTAATCCCCCAGTGTTAATGCAGTTAGTGGAGATAATAAGGGGAAGTAAAACTTCAGAC
GACACTGTTAAACAGACTTATGAATTCATTAAATCCCTTAGAAAGATACCAATAATGGTTAATAAGGACGTACCGGGATT
TGTGGTTAACAGAATATTATTGAGGATTATCACCACAGCTTGCATGCTTGTTGAAAAGGGGATTTGTGAATATACTGCGA
TAGACGCAGTAGCTAGATATAAATTGGGATTTCCAATGGGAATTTTTGAACTTGTGGATTACACTGGTGTGGATGTTAAC
TATTACGTAAGCTCTGCAATGATGGAAAGGGGATTTAAGGCCTATCCGTGTAAGACACTAGAGGAGATGACAAAAAAGGG
AGATCTCGGCGTAAAGAGCGGAAAAGGGTTCTATACTTATCCATCAAATAAGTATATTAAGCCTAATTTACCTTCACAAC
TAGCTGAAAAAATAAATCCGTTATACATTATAGCTCCTGCGGTAAGTGAGGCAAATTGGATGGTTAAAAACGGAATTGCA
AGCAAGGAAGATATTGACCTAGGTGTCAGATTAGGATTAAGCTTTCCTAAAGGCATTTTCGATTACGAAAGGGAGTTTGG
AAGAGAAAGTGTAACTAAGGCCTTAGAAGACTTGAGGAGAATTTCTGGTATGGAAGAGTATTTACCGGAATAA

Upstream 100 bases:

>100_bases
TAAGGAAGTTAGAGTCGGGATGAAGGTTAAACTTGAGGTTATTGAGAGGAAACCAGAAGGATATCTAACTTATGAACTGG
TTCCAGTAGGTTGAAATTTC

Downstream 100 bases:

>100_bases
AAAATGGTTAAATTTTCTTAATGAATTCACAATATATTTCTCTGAATCCCATTTTTCTATAGAACGAAATTGCTATTAAA
TTTCTAGAAGGGAATTCAGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIRNVLVVGAGTMGHGIAEVSAIAGYNVYLSDVSKDILNNAIQKVKWSLEKLYEKGNLKESVEDVLGRIKTIEGLSNELR
EIDISIEAIPEKLDLKRQLFSKLEELLPNNAILATNTSSLPITEIASAVKRQERVIGTHFFNPPVLMQLVEIIRGSKTSD
DTVKQTYEFIKSLRKIPIMVNKDVPGFVVNRILLRIITTACMLVEKGICEYTAIDAVARYKLGFPMGIFELVDYTGVDVN
YYVSSAMMERGFKAYPCKTLEEMTKKGDLGVKSGKGFYTYPSNKYIKPNLPSQLAEKINPLYIIAPAVSEANWMVKNGIA
SKEDIDLGVRLGLSFPKGIFDYEREFGRESVTKALEDLRRISGMEEYLPE

Sequences:

>Translated_370_residues
MIRNVLVVGAGTMGHGIAEVSAIAGYNVYLSDVSKDILNNAIQKVKWSLEKLYEKGNLKESVEDVLGRIKTIEGLSNELR
EIDISIEAIPEKLDLKRQLFSKLEELLPNNAILATNTSSLPITEIASAVKRQERVIGTHFFNPPVLMQLVEIIRGSKTSD
DTVKQTYEFIKSLRKIPIMVNKDVPGFVVNRILLRIITTACMLVEKGICEYTAIDAVARYKLGFPMGIFELVDYTGVDVN
YYVSSAMMERGFKAYPCKTLEEMTKKGDLGVKSGKGFYTYPSNKYIKPNLPSQLAEKINPLYIIAPAVSEANWMVKNGIA
SKEDIDLGVRLGLSFPKGIFDYEREFGRESVTKALEDLRRISGMEEYLPE
>Mature_370_residues
MIRNVLVVGAGTMGHGIAEVSAIAGYNVYLSDVSKDILNNAIQKVKWSLEKLYEKGNLKESVEDVLGRIKTIEGLSNELR
EIDISIEAIPEKLDLKRQLFSKLEELLPNNAILATNTSSLPITEIASAVKRQERVIGTHFFNPPVLMQLVEIIRGSKTSD
DTVKQTYEFIKSLRKIPIMVNKDVPGFVVNRILLRIITTACMLVEKGICEYTAIDAVARYKLGFPMGIFELVDYTGVDVN
YYVSSAMMERGFKAYPCKTLEEMTKKGDLGVKSGKGFYTYPSNKYIKPNLPSQLAEKINPLYIIAPAVSEANWMVKNGIA
SKEDIDLGVRLGLSFPKGIFDYEREFGRESVTKALEDLRRISGMEEYLPE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=38.0622837370242, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=36.2745098039216, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI20127408, Length=378, Percent_Identity=33.0687830687831, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI261878539, Length=394, Percent_Identity=30.7106598984772, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI68989263, Length=394, Percent_Identity=30.7106598984772, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI115430219, Length=223, Percent_Identity=30.9417040358744, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=38.4083044982699, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1790281, Length=339, Percent_Identity=30.9734513274336, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788682, Length=360, Percent_Identity=33.6111111111111, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=38.4083044982699, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=37.1527777777778, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=32.2916666666667, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=361, Percent_Identity=31.5789473684211, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=383, Percent_Identity=29.5039164490862, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17508951, Length=383, Percent_Identity=29.5039164490862, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17558304, Length=393, Percent_Identity=29.2620865139949, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71985930, Length=354, Percent_Identity=29.0960451977401, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=32.6460481099656, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=196, Percent_Identity=30.6122448979592, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI115533614, Length=196, Percent_Identity=30.6122448979592, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=34.2465753424658, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=34.2465753424658, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=34.2465753424658, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=31.8385650224215, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45549573, Length=221, Percent_Identity=30.316742081448, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 41425; Mature: 41425

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNVLVVGAGTMGHGIAEVSAIAGYNVYLSDVSKDILNNAIQKVKWSLEKLYEKGNLKE
CCCCEEEEECCHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SVEDVLGRIKTIEGLSNELREIDISIEAIPEKLDLKRQLFSKLEELLPNNAILATNTSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PITEIASAVKRQERVIGTHFFNPPVLMQLVEIIRGSKTSDDTVKQTYEFIKSLRKIPIMV
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEE
NKDVPGFVVNRILLRIITTACMLVEKGICEYTAIDAVARYKLGFPMGIFELVDYTGVDVN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
YYVSSAMMERGFKAYPCKTLEEMTKKGDLGVKSGKGFYTYPSNKYIKPNLPSQLAEKINP
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHCCC
LYIIAPAVSEANWMVKNGIASKEDIDLGVRLGLSFPKGIFDYEREFGRESVTKALEDLRR
EEEEEECCCCCCHHHHCCCCCCCCCCHHHEECCCCCCHHHHHHHHHCHHHHHHHHHHHHH
ISGMEEYLPE
HCCHHHHCCC
>Mature Secondary Structure
MIRNVLVVGAGTMGHGIAEVSAIAGYNVYLSDVSKDILNNAIQKVKWSLEKLYEKGNLKE
CCCCEEEEECCHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SVEDVLGRIKTIEGLSNELREIDISIEAIPEKLDLKRQLFSKLEELLPNNAILATNTSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PITEIASAVKRQERVIGTHFFNPPVLMQLVEIIRGSKTSDDTVKQTYEFIKSLRKIPIMV
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEE
NKDVPGFVVNRILLRIITTACMLVEKGICEYTAIDAVARYKLGFPMGIFELVDYTGVDVN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
YYVSSAMMERGFKAYPCKTLEEMTKKGDLGVKSGKGFYTYPSNKYIKPNLPSQLAEKINP
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHCCC
LYIIAPAVSEANWMVKNGIASKEDIDLGVRLGLSFPKGIFDYEREFGRESVTKALEDLRR
EEEEEECCCCCCHHHHCCCCCCCCCCHHHEECCCCCCHHHHHHHHHCHHHHHHHHHHHHH
ISGMEEYLPE
HCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]