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The map label for this gene is yeaE [H]

Identifier: 227828670

GI number: 227828670

Start: 2253050

End: 2253964

Strand: Direct

Name: yeaE [H]

Synonym: M1425_2427

Alternate gene names: 227828670

Gene position: 2253050-2253964 (Clockwise)

Preceding gene: 227828665

Following gene: 227828671

Centisome position: 86.36

GC content: 37.49

Gene sequence:

>915_bases
ATGGAAAAGAAGACATTAGGATGGACGAATGAGAAGATATCTCCACTGATTTTAGGTTCTTGGGAATTCGGTACCCCTTC
CATAGTTGATGAAAACAGCGCCATAAAAGTTATTCAAAAGGCAATAGAGCTCGAAATTAACGCCATAGACACTGCTGAAT
CTTATGGAAATGGTCTTTCAGAGACAATTATTGGAAGAGCCATAGGCAAATTCAAGAGAGAAGATTTGTTCATAATAACT
AAAGTATCAATTGACCACTTAAGATATGATGACGTTTTAAGGGCTTGCGAGGGAAGTTTAAGAAGGCTTAACACTTCATA
TATAGACCTATACCTCGTCCATTGGCCTAACCACTATGTGCCCATAAGGGAAACAGCTAAGGCAATGGAGAGGTTATTTA
GTGAAGGGAAAATTAGATACATTGGCTTAAGCAACTTTTCACTTCCCTTGTTGAGGGAATTTAGGGAACATCTGTCTAAG
ACAGACGTTGCAGCAAATGAATTGCATTATAACGTTTTGTTCAGAGACGTTGAGAAGGAGGTTCTCCCTTACATGTTAAG
GGAAAATATCTCCTTGTTGGCATATGATTCCTTAGGATTAGGTTATCTGATAGGGAGAAAAGAGATCAGAAATGAATATA
GATGGTACGTTCTTGCCAGAGAAGCTTACGTTAAAAACTTAGAACCACTTGTGGATGAAATATCTTTAATTGCGAAGGAA
ATAGATAGAACTCCAGCACAAATAATTCTAAATTGGTTAGTCAGTAAGGATAACGTATTCGCAATTTTCAACACAACAAA
AGAGGATCACCTTAGGGAGAATTTGGGCAGTCTAGAATGGTCACTGAGAGATAGCGATTTGAAAAGATTAGATGAAGCGG
TAAAGAAAGTCGTGATAGATTATTTCATAAGGTAA

Upstream 100 bases:

>100_bases
TCTCCATAAGAATTAATGCGTACTCAAAATTAAAAGAAAATTGGTCTAGGCTAAACTCAATTGATAAACATTTAAATATC
TAACAATATCTTACTTATTC

Downstream 100 bases:

>100_bases
TTTAAGCCTTTTTTATTTACCAAATTACTTTTTATCTTAATATTTAACTGATATAGATATGGGTAGCCTATTTGACAAGG
ACCCCGAACTAAAGAGACTT

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MEKKTLGWTNEKISPLILGSWEFGTPSIVDENSAIKVIQKAIELEINAIDTAESYGNGLSETIIGRAIGKFKREDLFIIT
KVSIDHLRYDDVLRACEGSLRRLNTSYIDLYLVHWPNHYVPIRETAKAMERLFSEGKIRYIGLSNFSLPLLREFREHLSK
TDVAANELHYNVLFRDVEKEVLPYMLRENISLLAYDSLGLGYLIGRKEIRNEYRWYVLAREAYVKNLEPLVDEISLIAKE
IDRTPAQIILNWLVSKDNVFAIFNTTKEDHLRENLGSLEWSLRDSDLKRLDEAVKKVVIDYFIR

Sequences:

>Translated_304_residues
MEKKTLGWTNEKISPLILGSWEFGTPSIVDENSAIKVIQKAIELEINAIDTAESYGNGLSETIIGRAIGKFKREDLFIIT
KVSIDHLRYDDVLRACEGSLRRLNTSYIDLYLVHWPNHYVPIRETAKAMERLFSEGKIRYIGLSNFSLPLLREFREHLSK
TDVAANELHYNVLFRDVEKEVLPYMLRENISLLAYDSLGLGYLIGRKEIRNEYRWYVLAREAYVKNLEPLVDEISLIAKE
IDRTPAQIILNWLVSKDNVFAIFNTTKEDHLRENLGSLEWSLRDSDLKRLDEAVKKVVIDYFIR
>Mature_304_residues
MEKKTLGWTNEKISPLILGSWEFGTPSIVDENSAIKVIQKAIELEINAIDTAESYGNGLSETIIGRAIGKFKREDLFIIT
KVSIDHLRYDDVLRACEGSLRRLNTSYIDLYLVHWPNHYVPIRETAKAMERLFSEGKIRYIGLSNFSLPLLREFREHLSK
TDVAANELHYNVLFRDVEKEVLPYMLRENISLLAYDSLGLGYLIGRKEIRNEYRWYVLAREAYVKNLEPLVDEISLIAKE
IDRTPAQIILNWLVSKDNVFAIFNTTKEDHLRENLGSLEWSLRDSDLKRLDEAVKKVVIDYFIR

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=295, Percent_Identity=28.8135593220339, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI45446745, Length=314, Percent_Identity=27.7070063694268, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503285, Length=314, Percent_Identity=27.7070063694268, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310109920, Length=314, Percent_Identity=27.7070063694268, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4504825, Length=302, Percent_Identity=23.5099337748344, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI27436969, Length=302, Percent_Identity=23.5099337748344, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI27436966, Length=303, Percent_Identity=24.0924092409241, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI27436964, Length=303, Percent_Identity=24.0924092409241, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI27436962, Length=303, Percent_Identity=24.0924092409241, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI5453543, Length=317, Percent_Identity=27.1293375394322, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI223718702, Length=199, Percent_Identity=31.1557788944724, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI24497585, Length=318, Percent_Identity=27.3584905660377, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI24497583, Length=303, Percent_Identity=28.0528052805281, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI24497577, Length=316, Percent_Identity=25.3164556962025, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI5174391, Length=316, Percent_Identity=25.3164556962025, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI41152114, Length=203, Percent_Identity=30.0492610837438, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI41327764, Length=199, Percent_Identity=31.1557788944724, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI223718708, Length=136, Percent_Identity=34.5588235294118, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI223468663, Length=309, Percent_Identity=23.3009708737864, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI291291012, Length=280, Percent_Identity=25.3571428571429, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI27436971, Length=306, Percent_Identity=21.8954248366013, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788081, Length=294, Percent_Identity=31.2925170068027, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI87081735, Length=323, Percent_Identity=30.9597523219814, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788070, Length=332, Percent_Identity=29.5180722891566, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=29.6153846153846, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1789199, Length=347, Percent_Identity=28.8184438040346, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789375, Length=332, Percent_Identity=26.8072289156627, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082198, Length=246, Percent_Identity=30.0813008130081, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994888, Length=274, Percent_Identity=22.2627737226277, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17564128, Length=309, Percent_Identity=27.1844660194175, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI212645785, Length=162, Percent_Identity=33.9506172839506, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17552492, Length=294, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17550248, Length=297, Percent_Identity=25.2525252525253, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17566692, Length=300, Percent_Identity=26.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537077, Length=268, Percent_Identity=27.6119402985075, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=268, Percent_Identity=27.2388059701493, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561300, Length=193, Percent_Identity=29.0155440414508, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561298, Length=285, Percent_Identity=25.6140350877193, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=333, Percent_Identity=25.2252252252252, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323998, Length=316, Percent_Identity=25.9493670886076, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319958, Length=304, Percent_Identity=24.6710526315789, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319951, Length=315, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322615, Length=247, Percent_Identity=23.8866396761134, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320079, Length=265, Percent_Identity=23.3962264150943, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646155, Length=216, Percent_Identity=29.6296296296296, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24662789, Length=315, Percent_Identity=26.3492063492064, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=26.241134751773, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281366140, Length=270, Percent_Identity=27.037037037037, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24646159, Length=188, Percent_Identity=29.2553191489362, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657054, Length=144, Percent_Identity=32.6388888888889, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 35327; Mature: 35327

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKTLGWTNEKISPLILGSWEFGTPSIVDENSAIKVIQKAIELEINAIDTAESYGNGLS
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECHHHHCCCHH
ETIIGRAIGKFKREDLFIITKVSIDHLRYDDVLRACEGSLRRLNTSYIDLYLVHWPNHYV
HHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
PIRETAKAMERLFSEGKIRYIGLSNFSLPLLREFREHLSKTDVAANELHYNVLFRDVEKE
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VLPYMLRENISLLAYDSLGLGYLIGRKEIRNEYRWYVLAREAYVKNLEPLVDEISLIAKE
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHEEEEEHHHHHHHHHHHHHHHHHHHHH
IDRTPAQIILNWLVSKDNVFAIFNTTKEDHLRENLGSLEWSLRDSDLKRLDEAVKKVVID
HCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHH
YFIR
HHCC
>Mature Secondary Structure
MEKKTLGWTNEKISPLILGSWEFGTPSIVDENSAIKVIQKAIELEINAIDTAESYGNGLS
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECHHHHCCCHH
ETIIGRAIGKFKREDLFIITKVSIDHLRYDDVLRACEGSLRRLNTSYIDLYLVHWPNHYV
HHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
PIRETAKAMERLFSEGKIRYIGLSNFSLPLLREFREHLSKTDVAANELHYNVLFRDVEKE
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VLPYMLRENISLLAYDSLGLGYLIGRKEIRNEYRWYVLAREAYVKNLEPLVDEISLIAKE
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHEEEEEHHHHHHHHHHHHHHHHHHHHH
IDRTPAQIILNWLVSKDNVFAIFNTTKEDHLRENLGSLEWSLRDSDLKRLDEAVKKVVID
HCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHH
YFIR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]