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The map label for this gene is 227828620

Identifier: 227828620

GI number: 227828620

Start: 2202867

End: 2203967

Strand: Direct

Name: 227828620

Synonym: M1425_2373

Alternate gene names: NA

Gene position: 2202867-2203967 (Clockwise)

Preceding gene: 227828618

Following gene: 227828621

Centisome position: 84.44

GC content: 38.6

Gene sequence:

>1101_bases
ATGAAGCTTACAGTAAAGGAAGTTAAGGAGCTTTTTAAGCCAAAATTATTACCAATAATTTGGAAAGATGAAAGTAATAC
CCTGACAATCCTGGATCAATCCTTATTGCCTTTTCAAAAGGTTTACGTGGATTTAAAGGATGTTGAAAACACAGCGTTAG
CCATAAAGAATATGCAAGTTAGAGGTGCTCCAGCCATAGGAATCACTGCCGGATACGGAATGGTACTAGCGTTGATCAAC
AACAAGAATGTAAAGACATTAGATGACGCTATTAGGGAATTAACTAGGGCTAAGACCATATTAGATTCAGCTAGACCTAC
AGCTGTTAATTTAGTTTGGGCGACCTCAAGAATGTTAACTTTAGCTAAAAATACAGTGGAAAGTGGTAACGCCAAGGCTG
TAAATGAACTAATAGAACTAATGAAAGTTGAGGCTAAGAAGATTTTCGATGAGGAGTATGATGCTGAAATACAAATGGGG
CTTTACGGTTTAGAGAAATTAAACGATGGTGACACAGTACTAACGCAGTGCAATGCTGGTGGTTTGGCTACTGGTACTGG
GTTAGGAACTGCATTGGCTCCAGTGAAATTAGCTAAGGCCTTAGGGATGAGCGTTTCAGTAATTGCTCCAGAGACAAGGC
CTTGGTTGCAAGGAAGTAGGTTAACCGTTTACGAATTAATGGAGGAAGGAATAAAGGTCACGTTAATAACAGATACTGCA
GTTGGTTTAGTAATGTATCGAGATATGGTGAATAACGTAATGGTTGGTGCTGACAGGATATTGAGAGATGGGCACGTCTT
CAATAAAATAGGGACATTTAAGGAAGCGGTTATAGCCCATGAATTGGGTATACCATTTTACGCACTAGCACCAACTTCCA
GTTTCGACTTAAAGAGTAACGTTAACGACATTAAGATTGAGGAGAGGGATCCCAATGAAGTAAGGACAATTAGAGGGATA
CCAATAGCTCCAGAGGACGTAAATGTATATAATCCAGTATTTGATGTTACTCCGCCTAAATATATTACTGGTATTATAAC
TGAAAAGGGAATAATATATCCTCCATTCCATGAGAATATTAGAAAAATCGTTGAAAGGTAA

Upstream 100 bases:

>100_bases
ATTATCTCTCAAGACATTACTTTCAAATTCAATAATAGTTAAGTTCACGTATTCCTTTTCCTTCCCTAAGCTTTAAATCT
TCCTTTATCCATTATATCAT

Downstream 100 bases:

>100_bases
CTTAGGAAAAGTAATTTAAATATCAAGTCAGAATTAACCTTAATGAGAGTTTTAACAAAGATTATCTTGATAGTTTTCGT
ATTTGAGGTAGTGTTATTCT

Product: translation initiation factor IF-2subunit beta alpha

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKLTVKEVKELFKPKLLPIIWKDESNTLTILDQSLLPFQKVYVDLKDVENTALAIKNMQVRGAPAIGITAGYGMVLALIN
NKNVKTLDDAIRELTRAKTILDSARPTAVNLVWATSRMLTLAKNTVESGNAKAVNELIELMKVEAKKIFDEEYDAEIQMG
LYGLEKLNDGDTVLTQCNAGGLATGTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
VGLVMYRDMVNNVMVGADRILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSSFDLKSNVNDIKIEERDPNEVRTIRGI
PIAPEDVNVYNPVFDVTPPKYITGIITEKGIIYPPFHENIRKIVER

Sequences:

>Translated_366_residues
MKLTVKEVKELFKPKLLPIIWKDESNTLTILDQSLLPFQKVYVDLKDVENTALAIKNMQVRGAPAIGITAGYGMVLALIN
NKNVKTLDDAIRELTRAKTILDSARPTAVNLVWATSRMLTLAKNTVESGNAKAVNELIELMKVEAKKIFDEEYDAEIQMG
LYGLEKLNDGDTVLTQCNAGGLATGTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
VGLVMYRDMVNNVMVGADRILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSSFDLKSNVNDIKIEERDPNEVRTIRGI
PIAPEDVNVYNPVFDVTPPKYITGIITEKGIIYPPFHENIRKIVER
>Mature_366_residues
MKLTVKEVKELFKPKLLPIIWKDESNTLTILDQSLLPFQKVYVDLKDVENTALAIKNMQVRGAPAIGITAGYGMVLALIN
NKNVKTLDDAIRELTRAKTILDSARPTAVNLVWATSRMLTLAKNTVESGNAKAVNELIELMKVEAKKIFDEEYDAEIQMG
LYGLEKLNDGDTVLTQCNAGGLATGTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
VGLVMYRDMVNNVMVGADRILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSSFDLKSNVNDIKIEERDPNEVRTIRGI
PIAPEDVNVYNPVFDVTPPKYITGIITEKGIIYPPFHENIRKIVER

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=340, Percent_Identity=38.2352941176471, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI23943880, Length=333, Percent_Identity=35.7357357357357, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI78000158, Length=273, Percent_Identity=23.4432234432234, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI78000156, Length=273, Percent_Identity=23.4432234432234, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI187607323, Length=273, Percent_Identity=23.4432234432234, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4503503, Length=188, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=340, Percent_Identity=33.8235294117647, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17557123, Length=157, Percent_Identity=32.484076433121, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=401, Percent_Identity=34.4139650872818, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322878, Length=158, Percent_Identity=34.1772151898734, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357667, Length=360, Percent_Identity=40, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24651647, Length=360, Percent_Identity=40, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI21358605, Length=133, Percent_Identity=37.593984962406, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 40365; Mature: 40365

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTVKEVKELFKPKLLPIIWKDESNTLTILDQSLLPFQKVYVDLKDVENTALAIKNMQV
CCCCHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHEEHHHCCCCEEEEECEEE
RGAPAIGITAGYGMVLALINNKNVKTLDDAIRELTRAKTILDSARPTAVNLVWATSRMLT
CCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHH
LAKNTVESGNAKAVNELIELMKVEAKKIFDEEYDAEIQMGLYGLEKLNDGDTVLTQCNAG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHCCCCCEEEEEECCC
GLATGTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
CCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEEECHH
VGLVMYRDMVNNVMVGADRILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSSFDLKSN
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
VNDIKIEERDPNEVRTIRGIPIAPEDVNVYNPVFDVTPPKYITGIITEKGIIYPPFHENI
CCEEEEECCCCCHHHEEECCCCCCCCCCCCCCEECCCCHHHEEEEEECCCEECCCHHHHH
RKIVER
HHHHCC
>Mature Secondary Structure
MKLTVKEVKELFKPKLLPIIWKDESNTLTILDQSLLPFQKVYVDLKDVENTALAIKNMQV
CCCCHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHEEHHHCCCCEEEEECEEE
RGAPAIGITAGYGMVLALINNKNVKTLDDAIRELTRAKTILDSARPTAVNLVWATSRMLT
CCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHH
LAKNTVESGNAKAVNELIELMKVEAKKIFDEEYDAEIQMGLYGLEKLNDGDTVLTQCNAG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHCCCCCEEEEEECCC
GLATGTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
CCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEEECHH
VGLVMYRDMVNNVMVGADRILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSSFDLKSN
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
VNDIKIEERDPNEVRTIRGIPIAPEDVNVYNPVFDVTPPKYITGIITEKGIIYPPFHENI
CCEEEEECCCCCHHHEEECCCCCCCCCCCCCCEECCCCHHHEEEEEECCCEECCCHHHHH
RKIVER
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA