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The map label for this gene is 227828609

Identifier: 227828609

GI number: 227828609

Start: 2194193

End: 2195170

Strand: Direct

Name: 227828609

Synonym: M1425_2362

Alternate gene names: NA

Gene position: 2194193-2195170 (Clockwise)

Preceding gene: 227828608

Following gene: 227828611

Centisome position: 84.11

GC content: 36.91

Gene sequence:

>978_bases
GTGCTAAAGTCTGTAACAGTTTCAGCACCTTCAAATATAGCCGTAGTGAAGTATTGGGGAAAAAGAGGAGATGAAAGGTT
AAATTTACCACTTAATAACTCATTGTCGATTACATTAGATGACCAGTTATCAGTAATTACCAAAGTTACCTTGAGCGATA
AGAACATTGTAATAGTTAATGATAGGATCTTACCAGAGGATGAAATGAAAGAATATGCTGGAAGAGTCTTGGAAGCCTTT
AAGAAAATCATTGGCAAGGAGTTTCACGTTAAGGTCGAATCAAAGGCAAAATTCCCCGTTAACGCTGGATTAGCGTCATC
TGCGGCAGGAATTGCCGCATTAACCTTTGGCCTGAATGAACTATTGGAATTGGAACTTAAACTTGAAGAACTTTCCAAAA
TAGCCAGACTAGGATCTGGGAGTGCTTGTAGGAGTATGTTTGGAGGATTTGTTGTATGGAATAAGGGTCTAAGAGAAGAT
GGTGAGGATTCCTATTGCTATCAAATCTTCCAACATGGACATTGGAGTGAACTAGTCGATATAATTCCGATATTAAGCGA
GAAAGAAAAGAAGATATCTTCTAGGAAGGGTATGATAAGATCAGCTGAGACTTCAGAATTAATGGAGTGTAGGCTAAAAT
TCATTGAGAAGACCTTTAATGAAGTCATTGAGGCTATAAGGAATAGGGATGAGAGGAAATTCTACTATTTCGTCATGAGA
CATAGCAACAGTATGCATGCAATAATATTGGATAGTTGGCCATCATTCTTCTACTTAAATGATACTTCAATAAGGATAAT
GGAATGGATACAAGAGTACGGTAAGGCCGGTTATACATTCGATGCTGGACCAAATCCCCACATTTTCACTACAGAAAGAT
ATGTACAAGACATCTTAGAGTTCTTAAAATCTCTAGAAATAAAGAGAATAATAGTATCTAAAGTTGGAGATGGACCTAAG
ATATTGAATAGAGAATGA

Upstream 100 bases:

>100_bases
AATTGGAGAGAGGGGGATATTAAAAAAGGACAAGGAAGTATCTAAAAAGGAATTATATGAGTTAGTTAAAGTTAATAAGT
AATAACATATTCTTAGAATC

Downstream 100 bases:

>100_bases
CAAAATTCTTTTAATTAGAATCTACCTTTAAGCCCTCATTCTCCTTCACGTCAATAGTTGTAATACCTCTTCTTTTCCAC
GCCTCCCTTACCTTACTCAA

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLSDKNIVIVNDRILPEDEMKEYAGRVLEAF
KKIIGKEFHVKVESKAKFPVNAGLASSAAGIAALTFGLNELLELELKLEELSKIARLGSGSACRSMFGGFVVWNKGLRED
GEDSYCYQIFQHGHWSELVDIIPILSEKEKKISSRKGMIRSAETSELMECRLKFIEKTFNEVIEAIRNRDERKFYYFVMR
HSNSMHAIILDSWPSFFYLNDTSIRIMEWIQEYGKAGYTFDAGPNPHIFTTERYVQDILEFLKSLEIKRIIVSKVGDGPK
ILNRE

Sequences:

>Translated_325_residues
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLSDKNIVIVNDRILPEDEMKEYAGRVLEAF
KKIIGKEFHVKVESKAKFPVNAGLASSAAGIAALTFGLNELLELELKLEELSKIARLGSGSACRSMFGGFVVWNKGLRED
GEDSYCYQIFQHGHWSELVDIIPILSEKEKKISSRKGMIRSAETSELMECRLKFIEKTFNEVIEAIRNRDERKFYYFVMR
HSNSMHAIILDSWPSFFYLNDTSIRIMEWIQEYGKAGYTFDAGPNPHIFTTERYVQDILEFLKSLEIKRIIVSKVGDGPK
ILNRE
>Mature_325_residues
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLSDKNIVIVNDRILPEDEMKEYAGRVLEAF
KKIIGKEFHVKVESKAKFPVNAGLASSAAGIAALTFGLNELLELELKLEELSKIARLGSGSACRSMFGGFVVWNKGLRED
GEDSYCYQIFQHGHWSELVDIIPILSEKEKKISSRKGMIRSAETSELMECRLKFIEKTFNEVIEAIRNRDERKFYYFVMR
HSNSMHAIILDSWPSFFYLNDTSIRIMEWIQEYGKAGYTFDAGPNPHIFTTERYVQDILEFLKSLEIKRIIVSKVGDGPK
ILNRE

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=384, Percent_Identity=36.71875, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537201, Length=327, Percent_Identity=35.1681957186544, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17537203, Length=223, Percent_Identity=37.219730941704, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324371, Length=380, Percent_Identity=34.4736842105263, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28571205, Length=333, Percent_Identity=36.6366366366366, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 37072; Mature: 37072

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLSDKNIVIVN
CCCCEEECCCCCEEEEEEECCCCCCEECCCCCCCEEEEECCCEEEEEEEEECCCCEEEEE
DRILPEDEMKEYAGRVLEAFKKIIGKEFHVKVESKAKFPVNAGLASSAAGIAALTFGLNE
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
LLELELKLEELSKIARLGSGSACRSMFGGFVVWNKGLREDGEDSYCYQIFQHGHWSELVD
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHCCCHHHHHH
IIPILSEKEKKISSRKGMIRSAETSELMECRLKFIEKTFNEVIEAIRNRDERKFYYFVMR
HHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
HSNSMHAIILDSWPSFFYLNDTSIRIMEWIQEYGKAGYTFDAGPNPHIFTTERYVQDILE
ECCCEEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCEEEHHHHHHHHHH
FLKSLEIKRIIVSKVGDGPKILNRE
HHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLSDKNIVIVN
CCCCEEECCCCCEEEEEEECCCCCCEECCCCCCCEEEEECCCEEEEEEEEECCCCEEEEE
DRILPEDEMKEYAGRVLEAFKKIIGKEFHVKVESKAKFPVNAGLASSAAGIAALTFGLNE
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
LLELELKLEELSKIARLGSGSACRSMFGGFVVWNKGLREDGEDSYCYQIFQHGHWSELVD
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHCCCHHHHHH
IIPILSEKEKKISSRKGMIRSAETSELMECRLKFIEKTFNEVIEAIRNRDERKFYYFVMR
HHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
HSNSMHAIILDSWPSFFYLNDTSIRIMEWIQEYGKAGYTFDAGPNPHIFTTERYVQDILE
ECCCEEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCEEEHHHHHHHHHH
FLKSLEIKRIIVSKVGDGPKILNRE
HHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA