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The map label for this gene is guaAB

Identifier: 227828391

GI number: 227828391

Start: 1952433

End: 1953536

Strand: Direct

Name: guaAB

Synonym: M1425_2134

Alternate gene names: 227828391

Gene position: 1952433-1953536 (Clockwise)

Preceding gene: 227828390

Following gene: 227828393

Centisome position: 74.84

GC content: 36.59

Gene sequence:

>1104_bases
ATGTTTGATCCTGCTTCGTTCGTTAAGGAAATAGGACCACAGCTGAAACAGAAGGTAGGTAATGAGAGAGTTTTAGCTGC
AGTAAGTGGTGGTGTAGATAGTACTACAGCTGCAGTTCTGGCTTATAATTTGTTGGGTAACAAAGTAATTCCCGTTTTAA
TAGATACTGGATTTTTAAGGAAAAATGAAGCTGAGAAAATTAAAGCTTATTTAAGTAATGTCTTACCTAACCTTATCGTA
GTGGACGAGAGGGAGACATTCACTTCTGAGATTGAGGGAATGGAAGAAGCTGAAGCGAAAAGGAAGAAATTTAGAGAACT
GTTCTATTCTTCTATTTCATCATTAATGAGAAAGTTCAATGCAAAGTATTTAATGCAAGGAACCATAGCAGCCGATTGGG
TAGAAACACAAGGCGGAATAAAGACACAGCACAATGTCTTAGTTCAAATAGGTATAGATACAGAGAAAGAATGGGGCTTT
ACATTAATTGAGCCGTTGGCAGACCTATATAAGAATGAGGTCAGAGAACTAGCTAGATATCTTAAATTACCTAAGGAAAT
TTCAGAGAGGCAGCCGTTCCCTGGTCCTGGCCTCCTAGTAAGGACAATTGGAAAACTGACTAGGGAGAAGTTAGAAGTAG
TAAGAGAAGCTAATGACATAGTTGAAAAATATTTAGATCCCTTTAATTATTCACAATACTTTGCGGTTTCTTTTGAATCT
GATGGTAATTTTGTAATTTTGGACGGTATTGATGCATTTTTATATAAGGCAAGGGCAACTGGTGTTAAGGGTGACGTTAG
GGCTTATGGCAATATAGCAAAAGTTGAGTGTAGTGATATTAATGCAGCGAAAAGCTTTGTCGATACTCTGGTTAAATATG
ATATTACCCACGTATTATGTTCCTTAGATGAAAGGAGTAATGGGAAATACAGCATTGCAATAAGGGCAGTAATTACGGAA
GACTTCATGACTGCAGATTATGCTAGAATACCTAAAGAAGTCCTAGAGAAAATTAGTTCTGAAATATTACAAAAAATACC
TAATGTAAAGGAAGTACTTTATGATGTTACTTCTAAACCACCTGCAACTATCGAGTTTGAGTGA

Upstream 100 bases:

>100_bases
TCCAACAACAAGCAATTCGTGTAGAGCAATTTTTAAGGAAATATTTACATATTGACGAAATAGTCGAAATTTATAAGCAA
TGAATTTTTAGTCTTAACTA

Downstream 100 bases:

>100_bases
TTAGTATTTAGAAACTTTTTCAAGTAATTGAATTCTTTTTGCAGGATGTGGATGATCCATAAATATTTCAGCATACCATG
GAACCTTTGTAGTCTTCCAA

Product: GMP synthase domain protein

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MFDPASFVKEIGPQLKQKVGNERVLAAVSGGVDSTTAAVLAYNLLGNKVIPVLIDTGFLRKNEAEKIKAYLSNVLPNLIV
VDERETFTSEIEGMEEAEAKRKKFRELFYSSISSLMRKFNAKYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGF
TLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRTIGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
DGNFVILDGIDAFLYKARATGVKGDVRAYGNIAKVECSDINAAKSFVDTLVKYDITHVLCSLDERSNGKYSIAIRAVITE
DFMTADYARIPKEVLEKISSEILQKIPNVKEVLYDVTSKPPATIEFE

Sequences:

>Translated_367_residues
MFDPASFVKEIGPQLKQKVGNERVLAAVSGGVDSTTAAVLAYNLLGNKVIPVLIDTGFLRKNEAEKIKAYLSNVLPNLIV
VDERETFTSEIEGMEEAEAKRKKFRELFYSSISSLMRKFNAKYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGF
TLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRTIGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
DGNFVILDGIDAFLYKARATGVKGDVRAYGNIAKVECSDINAAKSFVDTLVKYDITHVLCSLDERSNGKYSIAIRAVITE
DFMTADYARIPKEVLEKISSEILQKIPNVKEVLYDVTSKPPATIEFE
>Mature_367_residues
MFDPASFVKEIGPQLKQKVGNERVLAAVSGGVDSTTAAVLAYNLLGNKVIPVLIDTGFLRKNEAEKIKAYLSNVLPNLIV
VDERETFTSEIEGMEEAEAKRKKFRELFYSSISSLMRKFNAKYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGF
TLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRTIGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
DGNFVILDGIDAFLYKARATGVKGDVRAYGNIAKVECSDINAAKSFVDTLVKYDITHVLCSLDERSNGKYSIAIRAVITE
DFMTADYARIPKEVLEKISSEILQKIPNVKEVLYDVTSKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=316, Percent_Identity=31.3291139240506, Blast_Score=118, Evalue=8e-27,
Organism=Escherichia coli, GI1788854, Length=380, Percent_Identity=31.5789473684211, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71992710, Length=303, Percent_Identity=31.3531353135314, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71992717, Length=303, Percent_Identity=31.3531353135314, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI133901714, Length=308, Percent_Identity=30.8441558441558, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323873, Length=357, Percent_Identity=32.7731092436975, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281365319, Length=466, Percent_Identity=28.9699570815451, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_SULIA (C3N0R9)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002844122.1
- GeneID:   7813310
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_2214
- OMA:   QGTIAPD
- ProtClustDB:   CLSK883887
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 41220; Mature: 41220

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDPASFVKEIGPQLKQKVGNERVLAAVSGGVDSTTAAVLAYNLLGNKVIPVLIDTGFLR
CCCHHHHHHHHCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCC
KNEAEKIKAYLSNVLPNLIVVDERETFTSEIEGMEEAEAKRKKFRELFYSSISSLMRKFN
CCHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AKYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGFTLIEPLADLYKNEVRELARY
CHHEEECCHHHHHHHCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKLPKEISERQPFPGPGLLVRTIGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
HHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
DGNFVILDGIDAFLYKARATGVKGDVRAYGNIAKVECSDINAAKSFVDTLVKYDITHVLC
CCCEEEEECHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
SLDERSNGKYSIAIRAVITEDFMTADYARIPKEVLEKISSEILQKIPNVKEVLYDVTSKP
HCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PATIEFE
CCEEECC
>Mature Secondary Structure
MFDPASFVKEIGPQLKQKVGNERVLAAVSGGVDSTTAAVLAYNLLGNKVIPVLIDTGFLR
CCCHHHHHHHHCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCC
KNEAEKIKAYLSNVLPNLIVVDERETFTSEIEGMEEAEAKRKKFRELFYSSISSLMRKFN
CCHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AKYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGFTLIEPLADLYKNEVRELARY
CHHEEECCHHHHHHHCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKLPKEISERQPFPGPGLLVRTIGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
HHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
DGNFVILDGIDAFLYKARATGVKGDVRAYGNIAKVECSDINAAKSFVDTLVKYDITHVLC
CCCEEEEECHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
SLDERSNGKYSIAIRAVITEDFMTADYARIPKEVLEKISSEILQKIPNVKEVLYDVTSKP
HCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PATIEFE
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA