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The map label for this gene is 227828365

Identifier: 227828365

GI number: 227828365

Start: 1930181

End: 1931164

Strand: Direct

Name: 227828365

Synonym: M1425_2107

Alternate gene names: NA

Gene position: 1930181-1931164 (Clockwise)

Preceding gene: 227828360

Following gene: 227828373

Centisome position: 73.99

GC content: 35.16

Gene sequence:

>984_bases
ATGATAACTATTGTTTATGACGATATATATAGGTATCACGCTCCAAAAAAGTATCACGTAGAGAACCCTAGTAGGATAGA
CAAGGCATTATCTGCAATTAATCAACTTGAGGTTAAGTTTGAGAAACCAGTTAGGGTTGATGATCCTCAAATAGTACATT
CAGAAGATTATATTAAATTAGTTGAAAAGCACTCTAAATTAGAAGAGAACTTAGATGCGGATACTTATACTAACAAGTAC
ACCTACGAATCCGCACTTTATGCGATGGGTGGTGCATTAAAGGCTTTTGAGACTAACGGATTTGCATTAGTGAGACCTCC
TGGTCATCACGCTGGAGTCAATGGAAGAGCTTTAGGAGCTCCTACTTTAGGTTTCTGTATTTTCAACAGCGTAGCATATC
CTATTAAGAGGTATAAGTTAAAAAGAGTGGCTATTATTGACTTTGATGTACATTATGGTAATGGAACGCAAGAAATCTTT
TATGATGATCCAGATATTCTGCATATTGATGTACATCAAGATCCTAGGACCATCTATCCGGGTACCGGCTTTGTGGATAT
GATAGGTGGGAAAGACGCTGAGGGGACTAAGATCAACTTACTGATACCTCCTTTAGGTAGTGATGATTTATATGAGGAAT
TAATTCCAATTATTCAAGCTATTCTAGACGATTTCAAGCCAGTGGTTGTTGCGTACTCTGCTGGTTTTGACTCTTATGTT
GGTGATGGTCTGGCTTCAGTTAACGCTACTGAGTATACGTTTTATAATTTTGGTATGATTAGCACTAAATTTACTAGAAA
ATATGCAGTTTTAGAGGGAGGTTATAATAAAGGTTTAGTAAAAGGTTTAAAAGCATTTTTAGAAGGATTTGCAAACTTGA
AAATAGAATATAAGAAATATAAATCAAGTGACACAGTTAAGTCTAGGTTTATGAATTATCTAAGTGAAGAGAAAAATATT
TTGAGGAATTATTGGAGTATCTAG

Upstream 100 bases:

>100_bases
ATCAGATAATCTGTATCAGTCTTCTCCAATTCCTTTTGTAATCTCTGTATTCGATCCATGTTCTAAACTTAAATAGACGT
GTTATAAAAAGATAGGCTAA

Downstream 100 bases:

>100_bases
TATTAGCAAGTGTAGTAGCATTTTAGTGCTATATTATAGGCAGCATTATAATCTCTATCTGCTTTATATCCACAAGCTGG
ACATACAAATAGCGAACCTA

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MITIVYDDIYRYHAPKKYHVENPSRIDKALSAINQLEVKFEKPVRVDDPQIVHSEDYIKLVEKHSKLEENLDADTYTNKY
TYESALYAMGGALKAFETNGFALVRPPGHHAGVNGRALGAPTLGFCIFNSVAYPIKRYKLKRVAIIDFDVHYGNGTQEIF
YDDPDILHIDVHQDPRTIYPGTGFVDMIGGKDAEGTKINLLIPPLGSDDLYEELIPIIQAILDDFKPVVVAYSAGFDSYV
GDGLASVNATEYTFYNFGMISTKFTRKYAVLEGGYNKGLVKGLKAFLEGFANLKIEYKKYKSSDTVKSRFMNYLSEEKNI
LRNYWSI

Sequences:

>Translated_327_residues
MITIVYDDIYRYHAPKKYHVENPSRIDKALSAINQLEVKFEKPVRVDDPQIVHSEDYIKLVEKHSKLEENLDADTYTNKY
TYESALYAMGGALKAFETNGFALVRPPGHHAGVNGRALGAPTLGFCIFNSVAYPIKRYKLKRVAIIDFDVHYGNGTQEIF
YDDPDILHIDVHQDPRTIYPGTGFVDMIGGKDAEGTKINLLIPPLGSDDLYEELIPIIQAILDDFKPVVVAYSAGFDSYV
GDGLASVNATEYTFYNFGMISTKFTRKYAVLEGGYNKGLVKGLKAFLEGFANLKIEYKKYKSSDTVKSRFMNYLSEEKNI
LRNYWSI
>Mature_327_residues
MITIVYDDIYRYHAPKKYHVENPSRIDKALSAINQLEVKFEKPVRVDDPQIVHSEDYIKLVEKHSKLEENLDADTYTNKY
TYESALYAMGGALKAFETNGFALVRPPGHHAGVNGRALGAPTLGFCIFNSVAYPIKRYKLKRVAIIDFDVHYGNGTQEIF
YDDPDILHIDVHQDPRTIYPGTGFVDMIGGKDAEGTKINLLIPPLGSDDLYEELIPIIQAILDDFKPVVVAYSAGFDSYV
GDGLASVNATEYTFYNFGMISTKFTRKYAVLEGGYNKGLVKGLKAFLEGFANLKIEYKKYKSSDTVKSRFMNYLSEEKNI
LRNYWSI

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI169234807, Length=329, Percent_Identity=29.1793313069909, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI17158039, Length=255, Percent_Identity=33.7254901960784, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI30795202, Length=255, Percent_Identity=33.7254901960784, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI30795204, Length=255, Percent_Identity=33.7254901960784, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI148539870, Length=329, Percent_Identity=29.1793313069909, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI153085395, Length=192, Percent_Identity=34.8958333333333, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI20070354, Length=311, Percent_Identity=29.2604501607717, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI13128864, Length=307, Percent_Identity=29.9674267100977, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI62750349, Length=229, Percent_Identity=34.4978165938865, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI62750347, Length=229, Percent_Identity=34.4978165938865, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI226529806, Length=198, Percent_Identity=30.3030303030303, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13128860, Length=212, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17540334, Length=376, Percent_Identity=30.0531914893617, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540332, Length=376, Percent_Identity=30.0531914893617, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206283, Length=376, Percent_Identity=30.0531914893617, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193209491, Length=310, Percent_Identity=31.2903225806452, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25154022, Length=291, Percent_Identity=29.553264604811, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25154020, Length=291, Percent_Identity=29.553264604811, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=331, Percent_Identity=27.7945619335347, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17561978, Length=252, Percent_Identity=25.7936507936508, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508561, Length=241, Percent_Identity=27.8008298755187, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=327, Percent_Identity=31.4984709480122, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323999, Length=252, Percent_Identity=25.3968253968254, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321244, Length=219, Percent_Identity=28.7671232876712, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325325, Length=206, Percent_Identity=28.6407766990291, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641720, Length=307, Percent_Identity=30.2931596091205, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281360801, Length=307, Percent_Identity=30.2931596091205, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281360799, Length=307, Percent_Identity=30.2931596091205, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642146, Length=289, Percent_Identity=31.8339100346021, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642144, Length=289, Percent_Identity=31.8339100346021, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642142, Length=289, Percent_Identity=31.8339100346021, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360899, Length=289, Percent_Identity=31.8339100346021, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24657891, Length=131, Percent_Identity=33.587786259542, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24644244, Length=131, Percent_Identity=32.824427480916, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36985; Mature: 36985

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIVYDDIYRYHAPKKYHVENPSRIDKALSAINQLEVKFEKPVRVDDPQIVHSEDYIKL
CEEEEEEHHHHHCCCCEEECCCHHHHHHHHHHHHHHEEEECCCCCCCCCCEECCHHHHHH
VEKHSKLEENLDADTYTNKYTYESALYAMGGALKAFETNGFALVRPPGHHAGVNGRALGA
HHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCCCCC
PTLGFCIFNSVAYPIKRYKLKRVAIIDFDVHYGNGTQEIFYDDPDILHIDVHQDPRTIYP
CHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCCCEEEECCCCEEEEEECCCCCEECC
GTGFVDMIGGKDAEGTKINLLIPPLGSDDLYEELIPIIQAILDDFKPVVVAYSAGFDSYV
CCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
GDGLASVNATEYTFYNFGMISTKFTRKYAVLEGGYNKGLVKGLKAFLEGFANLKIEYKKY
CCCHHCCCCCEEEEEECCCEEHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCEEEEEEEC
KSSDTVKSRFMNYLSEEKNILRNYWSI
CCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITIVYDDIYRYHAPKKYHVENPSRIDKALSAINQLEVKFEKPVRVDDPQIVHSEDYIKL
CEEEEEEHHHHHCCCCEEECCCHHHHHHHHHHHHHHEEEECCCCCCCCCCEECCHHHHHH
VEKHSKLEENLDADTYTNKYTYESALYAMGGALKAFETNGFALVRPPGHHAGVNGRALGA
HHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCCCCC
PTLGFCIFNSVAYPIKRYKLKRVAIIDFDVHYGNGTQEIFYDDPDILHIDVHQDPRTIYP
CHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCCCEEEECCCCEEEEEECCCCCEECC
GTGFVDMIGGKDAEGTKINLLIPPLGSDDLYEELIPIIQAILDDFKPVVVAYSAGFDSYV
CCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
GDGLASVNATEYTFYNFGMISTKFTRKYAVLEGGYNKGLVKGLKAFLEGFANLKIEYKKY
CCCHHCCCCCEEEEEECCCEEHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCEEEEEEEC
KSSDTVKSRFMNYLSEEKNILRNYWSI
CCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]