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The map label for this gene is coaBC [H]

Identifier: 227828188

GI number: 227828188

Start: 1767506

End: 1768747

Strand: Direct

Name: coaBC [H]

Synonym: M1425_1926

Alternate gene names: 227828188

Gene position: 1767506-1768747 (Clockwise)

Preceding gene: 227828186

Following gene: 227828189

Centisome position: 67.75

GC content: 35.59

Gene sequence:

>1242_bases
ATGCACACATACATGACGCATCCTTCAAAGAAGATAATCGGGAGTGTAAGTAAGGATCTAGTTGATAGAAAGGTATTATT
AGCAGTAACTGGAAGTGTAGCGATATATAAATCATTGGATTTGGCCAGAAGCTTAATGAGGAATGGTGCAGAAGTGAGCG
TTATCATGAGTAAAGATGCAGCGAAACTAATTTCTCCAGAGATGTTTAAGTGGGCTACTGGGAATGAGGTATTTACTAAA
CTTACTGGTGACCTAGAACACGTTTCGTTGGCAGAAGATAATGATGCAATGATTGTAGCTCCCTCAACTTCAAATACTAT
AGTAAAGATAGCTTATGGAATAGCTGATACACCAATAACTGCTACTGCGTTGAATTTCGTTGGGATGAAAAAGCCCTTAA
TTATAGTTCCTTCAATGCATTTACAAATGTATATTTCGCCTCAAGTCGCAGATGCCGTAAATAGGTTAAAGGGGATAGGA
GTAGAGATAATAGAACCAGATATAATAGGAGATTTAGCGCACTATCCGGAATTAGAATACTTAACCGGCAGAATAACCTC
ATTTATTTTGAGGGGAAAAGACTTATCTGGATTTAATATACTAGTTACTGCTGGACCTACACGTGAGTATTTAGACTCTG
TCAGATTTATATCAAATCCCAGTAGCGGAACCATGGGGATATCTATTGCGAATGAAGCTTATTTTAGAGGAGCTAATGTT
AGAGTTATTTCTGGTCCTATAAGTTCTAAGCTAGAACCTTACGTTAGGGATATAGTGCGTATAGAGACAACTGAGGAGAT
GCTTAATGAAGTTGTAAAAAGTATAGAAAATGACAAGTTTAGTGTTGTAATTTTAGCGGGAGCTCCTGCTGATTATAAGT
TTAAAAATAGATCTGATACTAAGATAGACAGCCATACAGAAATACCAAAAGTTGAATTAGAAAGAACACCAAAAATTTCT
GAATATATAAGGAAGTACAATATATTATTAGTAGGTTTTTCCGCAGAGACTGTAAATTCTGATGAGGAGTTGATTGAGAA
AGCCAAAATTAAGATGAGAAGACACGGATTTGATTTAATTGTGGCGAATAATGTTAGGAGGAAGGATATAGGATTTTCAT
CTGAATATAATGAAGTTATAGTTATAGATAAGGCTGGTAATGTAAGGAAGATAGAAAAGAATTTTAAGACGGTGGTAGCG
AGAAAGATATTGGATATAGTAAAGGAGCAGTTAAAGAGATGA

Upstream 100 bases:

>100_bases
TCTATATCATCCATTCTTGCATTTCTTAGTGTGAAATCTCTTCCTTTATCTGTTTCAGCGAGCTCCATATCAATATCTTT
ATATAATGTAGTTAATATAT

Downstream 100 bases:

>100_bases
TAAAAGAAGAGTTTAAAATGAATTAGATAATGATATAGAATAGCGGCTGGCTCGGGTAGCTCAGCCTGGAAGAGCGCCGG
GCTGTGGACCCGGAAGTCCC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MHTYMTHPSKKIIGSVSKDLVDRKVLLAVTGSVAIYKSLDLARSLMRNGAEVSVIMSKDAAKLISPEMFKWATGNEVFTK
LTGDLEHVSLAEDNDAMIVAPSTSNTIVKIAYGIADTPITATALNFVGMKKPLIIVPSMHLQMYISPQVADAVNRLKGIG
VEIIEPDIIGDLAHYPELEYLTGRITSFILRGKDLSGFNILVTAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGANV
RVISGPISSKLEPYVRDIVRIETTEEMLNEVVKSIENDKFSVVILAGAPADYKFKNRSDTKIDSHTEIPKVELERTPKIS
EYIRKYNILLVGFSAETVNSDEELIEKAKIKMRRHGFDLIVANNVRRKDIGFSSEYNEVIVIDKAGNVRKIEKNFKTVVA
RKILDIVKEQLKR

Sequences:

>Translated_413_residues
MHTYMTHPSKKIIGSVSKDLVDRKVLLAVTGSVAIYKSLDLARSLMRNGAEVSVIMSKDAAKLISPEMFKWATGNEVFTK
LTGDLEHVSLAEDNDAMIVAPSTSNTIVKIAYGIADTPITATALNFVGMKKPLIIVPSMHLQMYISPQVADAVNRLKGIG
VEIIEPDIIGDLAHYPELEYLTGRITSFILRGKDLSGFNILVTAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGANV
RVISGPISSKLEPYVRDIVRIETTEEMLNEVVKSIENDKFSVVILAGAPADYKFKNRSDTKIDSHTEIPKVELERTPKIS
EYIRKYNILLVGFSAETVNSDEELIEKAKIKMRRHGFDLIVANNVRRKDIGFSSEYNEVIVIDKAGNVRKIEKNFKTVVA
RKILDIVKEQLKR
>Mature_413_residues
MHTYMTHPSKKIIGSVSKDLVDRKVLLAVTGSVAIYKSLDLARSLMRNGAEVSVIMSKDAAKLISPEMFKWATGNEVFTK
LTGDLEHVSLAEDNDAMIVAPSTSNTIVKIAYGIADTPITATALNFVGMKKPLIIVPSMHLQMYISPQVADAVNRLKGIG
VEIIEPDIIGDLAHYPELEYLTGRITSFILRGKDLSGFNILVTAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGANV
RVISGPISSKLEPYVRDIVRIETTEEMLNEVVKSIENDKFSVVILAGAPADYKFKNRSDTKIDSHTEIPKVELERTPKIS
EYIRKYNILLVGFSAETVNSDEELIEKAKIKMRRHGFDLIVANNVRRKDIGFSSEYNEVIVIDKAGNVRKIEKNFKTVVA
RKILDIVKEQLKR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=153, Percent_Identity=33.9869281045752, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=31.9306930693069, Blast_Score=154, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 45907; Mature: 45907

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTYMTHPSKKIIGSVSKDLVDRKVLLAVTGSVAIYKSLDLARSLMRNGAEVSVIMSKDA
CCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCH
AKLISPEMFKWATGNEVFTKLTGDLEHVSLAEDNDAMIVAPSTSNTIVKIAYGIADTPIT
HHHCCCHHEEECCCCHHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEEEECCCCCCHH
ATALNFVGMKKPLIIVPSMHLQMYISPQVADAVNRLKGIGVEIIEPDIIGDLAHYPELEY
HHHHHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHCCCEEEECCHHHHHHHHCCCHHH
LTGRITSFILRGKDLSGFNILVTAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGANV
HHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCEECCCCE
RVISGPISSKLEPYVRDIVRIETTEEMLNEVVKSIENDKFSVVILAGAPADYKFKNRSDT
EEEECCCCCCCCHHHHHHHHEECHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCC
KIDSHTEIPKVELERTPKISEYIRKYNILLVGFSAETVNSDEELIEKAKIKMRRHGFDLI
CCCCCCCCCCEEECCCCCHHHHHHHEEEEEEEECHHCCCCHHHHHHHHHHHHHHCCCEEE
VANNVRRKDIGFSSEYNEVIVIDKAGNVRKIEKNFKTVVARKILDIVKEQLKR
EECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTYMTHPSKKIIGSVSKDLVDRKVLLAVTGSVAIYKSLDLARSLMRNGAEVSVIMSKDA
CCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCH
AKLISPEMFKWATGNEVFTKLTGDLEHVSLAEDNDAMIVAPSTSNTIVKIAYGIADTPIT
HHHCCCHHEEECCCCHHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEEEECCCCCCHH
ATALNFVGMKKPLIIVPSMHLQMYISPQVADAVNRLKGIGVEIIEPDIIGDLAHYPELEY
HHHHHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHCCCEEEECCHHHHHHHHCCCHHH
LTGRITSFILRGKDLSGFNILVTAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGANV
HHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCEECCCCE
RVISGPISSKLEPYVRDIVRIETTEEMLNEVVKSIENDKFSVVILAGAPADYKFKNRSDT
EEEECCCCCCCCHHHHHHHHEECHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCC
KIDSHTEIPKVELERTPKISEYIRKYNILLVGFSAETVNSDEELIEKAKIKMRRHGFDLI
CCCCCCCCCCEEECCCCCHHHHHHHEEEEEEEECHHCCCCHHHHHHHHHHHHHHCCCEEE
VANNVRRKDIGFSSEYNEVIVIDKAGNVRKIEKNFKTVVARKILDIVKEQLKR
EECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]