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The map label for this gene is cdc6-1 [H]

Identifier: 227828145

GI number: 227828145

Start: 1725101

End: 1726294

Strand: Direct

Name: cdc6-1 [H]

Synonym: M1425_1883

Alternate gene names: 227828145

Gene position: 1725101-1726294 (Clockwise)

Preceding gene: 227828144

Following gene: 227828146

Centisome position: 66.13

GC content: 35.26

Gene sequence:

>1194_bases
ATGAGTGATATAATTGATGAAGTTATTTCTTCATTTAGAACTTCAAGTATCTTTGTAAATAGAGAATATTTGATGCCTGA
TTATATTCCAGATGAGTTACCACATAGGGAGGATCAGATAAGAAAAATTGCAAGCATTTTAGCTCCACTATATAGAGAAG
AGAAACCCAACAATATCTTCATATATGGATTGACTGGAACAGGAAAAACGGCTGTAGTAAAGTTTGTTTTATCTAGATTT
CATAAAAAATTTTTGGGAAAATTTAAGTATATCTATATTAACACTAGGCAGATAGATACGCCATATAGAGTATTGGCTGA
TTTATTAGAATCCTTAGATGTAAAGGTTCCTTTTACCGGGTTGTCCATAGCTGAGCTGTATAGACGTTTAGTAAAAGCTA
TAAGAGAGTATGATTCGCAAGTTGTCATAGTTTTGGATGAGATAGACGCTTTTGTTAAGAGGTATAACGACGATATTCTA
TACAAGTTAAGCAGGATCAATAGTGAGGTAAATAGGAGTAAAGTTTCTTTTATAGGAATAACTAATGATGTTAAGTTTGT
AGATTTATTGGATCCTAGAGTTAAAAGTAGTTTAAGTGAAGAAGAAATAGTTTTCCCCCCTTATAACGCTGAAGAGTTAG
AGGATATTCTGACAAAGCGAGCCCAAATGGCATTTAGGCCTGGAGTTTTACCGGATAATGTAATTAGATTATGTGCAGCA
TTAGCTGCACGAGAGCATGGAGATGCACGTAGGGCTTTAGATCTTTTGAGAGTTGCAGGTGAAATAGCTGAGAGGTTGAA
GGATTCTAAGGTTAAAGAGGAGTACGTACATCTAGCTAAGGAAGAAATAGAGAGGGATCGAGTAAGGGACATTATACTAA
CCCTTCCTTTTCACTCTAAGTTAGTTCTTACCGCAGTGGCTTCTATGTCTTCAGAAGATAACGTAGTTTTGACTACTGGT
GCTGTATATGAGACTTATCTGAATATTTGTAAGAAGTTAGGCGTGGAACCTATCACGCAAAGAAGAGTTAGTGATATTAT
AAATGAATTAGATATGGTAGGTATACTAAGAGCCAAGGTTGTTAATCGTGGTAGGTATGGTAAGACTAAGGAGATAGGTT
TAGCTGTTGATAAGAATATAATTGTTAAATCTTTAATAGAAAGCGATAGTAGGTTTGCCGATCTCTGGGGTTGA

Upstream 100 bases:

>100_bases
TGACACAACTTACATTTTCCAGTGGAAATAAAGGGGTTTTTTACTCCCCAGTTAAATAGCTTATATTTTAAAAGCTGGGT
TAGCACAAACAATAGAAAAG

Downstream 100 bases:

>100_bases
TGATGGTTATTTTCCATTATCATATAAGGGAGGAAAAGGTAAAACTGCATTAGTTGTAGTTACTTTTTACGATTACGAGA
TGATTGATTTAGATTGGGGT

Product: orc1/cdc6 family replication initiation protein

Products: NA

Alternate protein names: CDC6 homolog 1 [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSDIIDEVISSFRTSSIFVNREYLMPDYIPDELPHREDQIRKIASILAPLYREEKPNNIFIYGLTGTGKTAVVKFVLSRF
HKKFLGKFKYIYINTRQIDTPYRVLADLLESLDVKVPFTGLSIAELYRRLVKAIREYDSQVVIVLDEIDAFVKRYNDDIL
YKLSRINSEVNRSKVSFIGITNDVKFVDLLDPRVKSSLSEEEIVFPPYNAEELEDILTKRAQMAFRPGVLPDNVIRLCAA
LAAREHGDARRALDLLRVAGEIAERLKDSKVKEEYVHLAKEEIERDRVRDIILTLPFHSKLVLTAVASMSSEDNVVLTTG
AVYETYLNICKKLGVEPITQRRVSDIINELDMVGILRAKVVNRGRYGKTKEIGLAVDKNIIVKSLIESDSRFADLWG

Sequences:

>Translated_397_residues
MSDIIDEVISSFRTSSIFVNREYLMPDYIPDELPHREDQIRKIASILAPLYREEKPNNIFIYGLTGTGKTAVVKFVLSRF
HKKFLGKFKYIYINTRQIDTPYRVLADLLESLDVKVPFTGLSIAELYRRLVKAIREYDSQVVIVLDEIDAFVKRYNDDIL
YKLSRINSEVNRSKVSFIGITNDVKFVDLLDPRVKSSLSEEEIVFPPYNAEELEDILTKRAQMAFRPGVLPDNVIRLCAA
LAAREHGDARRALDLLRVAGEIAERLKDSKVKEEYVHLAKEEIERDRVRDIILTLPFHSKLVLTAVASMSSEDNVVLTTG
AVYETYLNICKKLGVEPITQRRVSDIINELDMVGILRAKVVNRGRYGKTKEIGLAVDKNIIVKSLIESDSRFADLWG
>Mature_396_residues
SDIIDEVISSFRTSSIFVNREYLMPDYIPDELPHREDQIRKIASILAPLYREEKPNNIFIYGLTGTGKTAVVKFVLSRFH
KKFLGKFKYIYINTRQIDTPYRVLADLLESLDVKVPFTGLSIAELYRRLVKAIREYDSQVVIVLDEIDAFVKRYNDDILY
KLSRINSEVNRSKVSFIGITNDVKFVDLLDPRVKSSLSEEEIVFPPYNAEELEDILTKRAQMAFRPGVLPDNVIRLCAAL
AAREHGDARRALDLLRVAGEIAERLKDSKVKEEYVHLAKEEIERDRVRDIILTLPFHSKLVLTAVASMSSEDNVVLTTGA
VYETYLNICKKLGVEPITQRRVSDIINELDMVGILRAKVVNRGRYGKTKEIGLAVDKNIIVKSLIESDSRFADLWG

Specific function: Might be involved in the initiation of DNA replication [H]

COG id: COG1474

COG function: function code LO; Cdc6-related protein, AAA superfamily ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDC6/cdc18 family [H]

Homologues:

Organism=Homo sapiens, GI4502703, Length=359, Percent_Identity=25.9052924791086, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI299890795, Length=243, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI299890793, Length=243, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI31795544, Length=243, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555708, Length=374, Percent_Identity=24.8663101604278, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17506005, Length=290, Percent_Identity=25.5172413793103, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355681, Length=359, Percent_Identity=25.0696378830084, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137456, Length=329, Percent_Identity=27.6595744680851, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR015163
- InterPro:   IPR014277
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00004 AAA; PF09079 Cdc6_C [H]

EC number: NA

Molecular weight: Translated: 45389; Mature: 45258

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIIDEVISSFRTSSIFVNREYLMPDYIPDELPHREDQIRKIASILAPLYREEKPNNIF
CHHHHHHHHHHHCHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
IYGLTGTGKTAVVKFVLSRFHKKFLGKFKYIYINTRQIDTPYRVLADLLESLDVKVPFTG
EEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
LSIAELYRRLVKAIREYDSQVVIVLDEIDAFVKRYNDDILYKLSRINSEVNRSKVSFIGI
CCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEEE
TNDVKFVDLLDPRVKSSLSEEEIVFPPYNAEELEDILTKRAQMAFRPGVLPDNVIRLCAA
CCCCEEHHHCCHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LAAREHGDARRALDLLRVAGEIAERLKDSKVKEEYVHLAKEEIERDRVRDIILTLPFHSK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
LVLTAVASMSSEDNVVLTTGAVYETYLNICKKLGVEPITQRRVSDIINELDMVGILRAKV
HHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VNRGRYGKTKEIGLAVDKNIIVKSLIESDSRFADLWG
HCCCCCCCCCCCCEECCHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
SDIIDEVISSFRTSSIFVNREYLMPDYIPDELPHREDQIRKIASILAPLYREEKPNNIF
HHHHHHHHHHHCHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
IYGLTGTGKTAVVKFVLSRFHKKFLGKFKYIYINTRQIDTPYRVLADLLESLDVKVPFTG
EEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
LSIAELYRRLVKAIREYDSQVVIVLDEIDAFVKRYNDDILYKLSRINSEVNRSKVSFIGI
CCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEEE
TNDVKFVDLLDPRVKSSLSEEEIVFPPYNAEELEDILTKRAQMAFRPGVLPDNVIRLCAA
CCCCEEHHHCCHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LAAREHGDARRALDLLRVAGEIAERLKDSKVKEEYVHLAKEEIERDRVRDIILTLPFHSK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
LVLTAVASMSSEDNVVLTTGAVYETYLNICKKLGVEPITQRRVSDIINELDMVGILRAKV
HHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VNRGRYGKTKEIGLAVDKNIIVKSLIESDSRFADLWG
HCCCCCCCCCCCCEECCHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]