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The map label for this gene is gch3

Identifier: 227827971

GI number: 227827971

Start: 1576375

End: 1577067

Strand: Direct

Name: gch3

Synonym: M1425_1704

Alternate gene names: 227827971

Gene position: 1576375-1577067 (Clockwise)

Preceding gene: 227827970

Following gene: 227827972

Centisome position: 60.42

GC content: 33.62

Gene sequence:

>693_bases
TTGAAGGTATTAGCGATAAAGCTTGTAGATTATAGGGAGTGGACTGAGAGACTAGGATATGATAGGGAATGGTTAATTCA
AAAAATTCAGAATAAATTCATGATGAAAATTCATGAGATAGCTTCACAATATAGCACATTTCCCCTTCAACTCAGGTTTG
ATAATTTTTTGATGATAGTTGATGGAATAACTAATACCCAACTTATCTACATGATAAACGATATGCAAGAAAACCTTCCA
GTAGGAATAAAGACTTGCTTAGGTTATGGAAAAACTCCGCTAGAGGCGCAATGGAATGCATCTGTTTGCCTAAATAATAA
AGAAGACAAATTTAAGGAATATGTGGACGAAAAAATAGCCGCATTACATTTCGATATAAACTTCAACACGGAAGCATTAA
AATACACATCTGTATATGACTCATTTTTGGAGATAACCAATATATATGTAGACTTATCGAGATTTTTATACAAGATAGGC
GGGATACTGCAATATTTAGGCGGAGATAACTATCTAGGCTTTGTGTCCACCAATAGCGTCAATAAGGTAATAGAGAAATT
TAGTGATGATAATAAGATAAAGGTAGGGATAGGGATAGGACAAAATGCGAGAACTGCAATAAAATTGGCTACTACTTCTT
TAGAGAAAATAAGGAATAATAGGGAAAAGACTTGGCATATAGAGGAAGAATAA

Upstream 100 bases:

>100_bases
AAGAATACGCAACCAGAGCAGTAGAGGCTGCAATAAAGTTAGTTCAAAGGACGAGAAAGATAGATGAGCTGAAAGAGGTT
AAGGAAACGGTGATTATAGA

Downstream 100 bases:

>100_bases
CACTAAACGTAAGACTAGCTTTAGTAGGAGAGGAACTAGAAATAAGAGAGAACGTTAACTTAGAAATAGAAGAAGGTATA
ATAACTCATATAGGAAATGG

Product: GTP cyclohydrolase IIa

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKVLAIKLVDYREWTERLGYDREWLIQKIQNKFMMKIHEIASQYSTFPLQLRFDNFLMIVDGITNTQLIYMINDMQENLP
VGIKTCLGYGKTPLEAQWNASVCLNNKEDKFKEYVDEKIAALHFDINFNTEALKYTSVYDSFLEITNIYVDLSRFLYKIG
GILQYLGGDNYLGFVSTNSVNKVIEKFSDDNKIKVGIGIGQNARTAIKLATTSLEKIRNNREKTWHIEEE

Sequences:

>Translated_230_residues
MKVLAIKLVDYREWTERLGYDREWLIQKIQNKFMMKIHEIASQYSTFPLQLRFDNFLMIVDGITNTQLIYMINDMQENLP
VGIKTCLGYGKTPLEAQWNASVCLNNKEDKFKEYVDEKIAALHFDINFNTEALKYTSVYDSFLEITNIYVDLSRFLYKIG
GILQYLGGDNYLGFVSTNSVNKVIEKFSDDNKIKVGIGIGQNARTAIKLATTSLEKIRNNREKTWHIEEE
>Mature_230_residues
MKVLAIKLVDYREWTERLGYDREWLIQKIQNKFMMKIHEIASQYSTFPLQLRFDNFLMIVDGITNTQLIYMINDMQENLP
VGIKTCLGYGKTPLEAQWNASVCLNNKEDKFKEYVDEKIAALHFDINFNTEALKYTSVYDSFLEITNIYVDLSRFLYKIG
GILQYLGGDNYLGFVSTNSVNKVIEKFSDDNKIKVGIGIGQNARTAIKLATTSLEKIRNNREKTWHIEEE

Specific function: Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity

COG id: COG2429

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type GTP cyclohydrolase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH3_SULIL (C3MR15)

Other databases:

- EMBL:   CP001399
- RefSeq:   YP_002832473.1
- GeneID:   7799471
- GenomeReviews:   CP001399_GR
- KEGG:   sis:LS215_1832
- OMA:   FIGGDNF
- ProtClustDB:   CLSK802708
- HAMAP:   MF_00608
- InterPro:   IPR007839
- PIRSF:   PIRSF009265
- ProDom:   PD313320

Pfam domain/function: PF05165 GGDN

EC number: =3.5.4.29

Molecular weight: Translated: 26768; Mature: 26768

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLAIKLVDYREWTERLGYDREWLIQKIQNKFMMKIHEIASQYSTFPLQLRFDNFLMIV
CEEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEE
DGITNTQLIYMINDMQENLPVGIKTCLGYGKTPLEAQWNASVCLNNKEDKFKEYVDEKIA
ECCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHE
ALHFDINFNTEALKYTSVYDSFLEITNIYVDLSRFLYKIGGILQYLGGDNYLGFVSTNSV
EEEEEECCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHH
NKVIEKFSDDNKIKVGIGIGQNARTAIKLATTSLEKIRNNREKTWHIEEE
HHHHHHHCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MKVLAIKLVDYREWTERLGYDREWLIQKIQNKFMMKIHEIASQYSTFPLQLRFDNFLMIV
CEEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEE
DGITNTQLIYMINDMQENLPVGIKTCLGYGKTPLEAQWNASVCLNNKEDKFKEYVDEKIA
ECCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHE
ALHFDINFNTEALKYTSVYDSFLEITNIYVDLSRFLYKIGGILQYLGGDNYLGFVSTNSV
EEEEEECCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHH
NKVIEKFSDDNKIKVGIGIGQNARTAIKLATTSLEKIRNNREKTWHIEEE
HHHHHHHCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA