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The map label for this gene is 227827676

Identifier: 227827676

GI number: 227827676

Start: 1325524

End: 1326267

Strand: Direct

Name: 227827676

Synonym: M1425_1405

Alternate gene names: NA

Gene position: 1325524-1326267 (Clockwise)

Preceding gene: 227827675

Following gene: 227827677

Centisome position: 50.81

GC content: 35.89

Gene sequence:

>744_bases
ATGAGTCAGTCCCAGAAAATTGTTTTACAACCAAGATCAATAGTAGTGCCTGGCGAGTTATTAGCTGAAGGCGAGTTCCA
GATTCCTTGGTCTCCTTATATATTAAAGGTTAATAGTAAATATTACTCTACAGTTGTTGGACTTTTTGATGTAAAAGATA
CTCAGTTTGAAGTGATTCCGTTGGAAGGTTCGTTTTACTATCCTAAGGTCAATGATGTGGTAATAGGTTTAGTGGAGGAC
GTTGAAATCTATGGTTGGGTGGTTGACATAAAATCGCCTTATAAGGCATATTTACCAGCCTCAAATCTTTTAGGAAGATC
CGTTAATGTTGGAGAGGATTTAAGGAGGTATTTAGATGTAGGTGACTATGTTATAGCTAGAATTGAAAATTTTGATAGAT
CAATAGATCCCGTTTTATCAGTTAAGGGCAAGGATCTAGGTCGTGTGAATAATGGTATAGTCATTGATATAATGCCAGTT
AAAGTTCCGCGTGTTATAGGTAAGAATAAAAGTATGTATGAGACTTTGACCTCAAAAAGTGGATGCAGTATGTTTGTTGC
CAATAATGGTAGAATATGGGCTACTTGTCCTTCCCGCTTTTCTGAAGAAATTTTAATCGAGGCCATTAGGAAGATTGAAA
ATGAGTCACATATAAAAGGATTGACAGATAGAATAAAACAATTCATTGAGGAAAAATTAGGTGAGAGAAATGCTTCAAGT
GGAGAGACCAAAACTAATCCTTGA

Upstream 100 bases:

>100_bases
AATTGGAAATACCAGCGGGTGCACAGCAAGACGTTATAGATAAGTTAAATAATCTGACAAAAGGAGAAGTTGAAGTTAAA
GTATTGCAAGTGAGATAGAA

Downstream 100 bases:

>100_bases
AGATGGAAAGCGAATAGATGGTAGAAAGCCAGATGAATTAAGGAGTATAAAGATAGAATTGGGAGTTCTCAAAAACGCTG
ATGGTTCAGCGATTTTTGAG

Product: exosome complex RNA-binding protein Rrp4

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSQSQKIVLQPRSIVVPGELLAEGEFQIPWSPYILKVNSKYYSTVVGLFDVKDTQFEVIPLEGSFYYPKVNDVVIGLVED
VEIYGWVVDIKSPYKAYLPASNLLGRSVNVGEDLRRYLDVGDYVIARIENFDRSIDPVLSVKGKDLGRVNNGIVIDIMPV
KVPRVIGKNKSMYETLTSKSGCSMFVANNGRIWATCPSRFSEEILIEAIRKIENESHIKGLTDRIKQFIEEKLGERNASS
GETKTNP

Sequences:

>Translated_247_residues
MSQSQKIVLQPRSIVVPGELLAEGEFQIPWSPYILKVNSKYYSTVVGLFDVKDTQFEVIPLEGSFYYPKVNDVVIGLVED
VEIYGWVVDIKSPYKAYLPASNLLGRSVNVGEDLRRYLDVGDYVIARIENFDRSIDPVLSVKGKDLGRVNNGIVIDIMPV
KVPRVIGKNKSMYETLTSKSGCSMFVANNGRIWATCPSRFSEEILIEAIRKIENESHIKGLTDRIKQFIEEKLGERNASS
GETKTNP
>Mature_246_residues
SQSQKIVLQPRSIVVPGELLAEGEFQIPWSPYILKVNSKYYSTVVGLFDVKDTQFEVIPLEGSFYYPKVNDVVIGLVEDV
EIYGWVVDIKSPYKAYLPASNLLGRSVNVGEDLRRYLDVGDYVIARIENFDRSIDPVLSVKGKDLGRVNNGIVIDIMPVK
VPRVIGKNKSMYETLTSKSGCSMFVANNGRIWATCPSRFSEEILIEAIRKIENESHIKGLTDRIKQFIEEKLGERNASSG
ETKTNP

Specific function: Probably involved in degradation of a variety of RNA species; could act a RNA-binding component of the exosome (Potential) [H]

COG id: COG1097

COG function: function code J; RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24762324, Length=192, Percent_Identity=30.2083333333333, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004087
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967 [H]

Pfam domain/function: PF00013 KH_1; PF00575 S1 [H]

EC number: NA

Molecular weight: Translated: 27768; Mature: 27637

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSQKIVLQPRSIVVPGELLAEGEFQIPWSPYILKVNSKYYSTVVGLFDVKDTQFEVIP
CCCCCEEEECCCCEEECHHHHCCCCEECCCCCEEEEECCHHEEHEEEEEECCCCEEEEEE
LEGSFYYPKVNDVVIGLVEDVEIYGWVVDIKSPYKAYLPASNLLGRSVNVGEDLRRYLDV
ECCCEECCCCCCEEEEEEECEEEEEEEEECCCCCHHHCCHHHHCCCCCCCHHHHHHHHCC
GDYVIARIENFDRSIDPVLSVKGKDLGRVNNGIVIDIMPVKVPRVIGKNKSMYETLTSKS
CHHHHHHHHHCCCCCCHHEEECCCCCCCCCCCEEEEEECCCCHHHHCCCCHHHHHHHCCC
GCSMFVANNGRIWATCPSRFSEEILIEAIRKIENESHIKGLTDRIKQFIEEKLGERNASS
CCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GETKTNP
CCCCCCC
>Mature Secondary Structure 
SQSQKIVLQPRSIVVPGELLAEGEFQIPWSPYILKVNSKYYSTVVGLFDVKDTQFEVIP
CCCCEEEECCCCEEECHHHHCCCCEECCCCCEEEEECCHHEEHEEEEEECCCCEEEEEE
LEGSFYYPKVNDVVIGLVEDVEIYGWVVDIKSPYKAYLPASNLLGRSVNVGEDLRRYLDV
ECCCEECCCCCCEEEEEEECEEEEEEEEECCCCCHHHCCHHHHCCCCCCCHHHHHHHHCC
GDYVIARIENFDRSIDPVLSVKGKDLGRVNNGIVIDIMPVKVPRVIGKNKSMYETLTSKS
CHHHHHHHHHCCCCCCHHEEECCCCCCCCCCCEEEEEECCCCHHHHCCCCHHHHHHHCCC
GCSMFVANNGRIWATCPSRFSEEILIEAIRKIENESHIKGLTDRIKQFIEEKLGERNASS
CCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GETKTNP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]