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The map label for this gene is psmA

Identifier: 227827674

GI number: 227827674

Start: 1324077

End: 1324802

Strand: Direct

Name: psmA

Synonym: M1425_1403

Alternate gene names: 227827674

Gene position: 1324077-1324802 (Clockwise)

Preceding gene: 227827673

Following gene: 227827675

Centisome position: 50.75

GC content: 37.05

Gene sequence:

>726_bases
ATGGCGTTCGGACCAGCCGCTATGGGATATGATAGGGCAATAACCATATTCTCGCCCGACGGATCACTATATCAAGTAGA
CTATGCATTTGAAGCTGTAAAAAAGGGATGGACAGCAATAGGTATTAAATCAAAATCTGGTGTTGTTATTGCAAGCGAGA
AAAGAAAAGCCCAATCATTATTAGATGTAGATAGTATAGAGAAAGTATTTTTAATCGACGATCATGTAGGGTGCAGTTTT
GCTGGGCTAGCCTCTGATGGTAGAGTTTTAATAGACTATGCGAGAAATATAGCATTACAACATAGGTTAATATATGATGA
ACCAGTTAGCATTGATTATCTAACAAAATCAGTTGCTGATGTTAAGCAAATGTACACACAACATGGAGGAGTTAGACCAT
TTGGTGTTGCACTAGTGATTGCAGGAATAGACAAATCAGTTCCTAAACTATATATGACTGAACCTAGTGGGCAATATATG
CCATATCAAGCTGTTGCAATAGGACAAGGTTATTATACAGCTACTGAGTTTTTAGAGAAGAATTACAAGGAGGACTTGAC
TATAGAAGATACTATACTCCTAGCCTTAAAGGCCTTATCGGCTACTCTTAAGCCTAATGAAAAGTTAACTCCAAATACTG
TGGAAATAGGATACGCCTCAACCCAAACTGGGCTATTTCTAAAAATGACCAGTGAAGATAAGAATATGTATTTACAGAAG
TTATAA

Upstream 100 bases:

>100_bases
GATGAAGCCGCTCCAGACTGTATCGATGATGTTCTCTGCGACGAGCTGAACGATATTTTTAAAATTAGGGATTACTCAGT
ATTTCATGAGTGAATAGTAT

Downstream 100 bases:

>100_bases
TAAGGTGGATTTTTTTTATGACGAAGGAGCGTGATTATGTAGTAGTTAAATATGACTCACATGGAGAGAGGTTTGAGATA
TTAGCTAAGCCAAAAGAAGC

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSGVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSF
AGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLYMTEPSGQYM
PYQAVAIGQGYYTATEFLEKNYKEDLTIEDTILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTSEDKNMYLQK
L

Sequences:

>Translated_241_residues
MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSGVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSF
AGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLYMTEPSGQYM
PYQAVAIGQGYYTATEFLEKNYKEDLTIEDTILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTSEDKNMYLQK
L
>Mature_240_residues
AFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSGVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSFA
GLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLYMTEPSGQYMP
YQAVAIGQGYYTATEFLEKNYKEDLTIEDTILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTSEDKNMYLQKL

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family

Homologues:

Organism=Homo sapiens, GI68303563, Length=196, Percent_Identity=48.9795918367347, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI4506189, Length=195, Percent_Identity=47.6923076923077, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI68303561, Length=202, Percent_Identity=47.5247524752475, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4506181, Length=233, Percent_Identity=40.7725321888412, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI156713442, Length=218, Percent_Identity=40.8256880733945, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI4506185, Length=218, Percent_Identity=40.8256880733945, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI23110944, Length=245, Percent_Identity=35.1020408163265, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI23110942, Length=230, Percent_Identity=36.0869565217391, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI68303565, Length=196, Percent_Identity=42.3469387755102, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI23110935, Length=210, Percent_Identity=36.6666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4506179, Length=210, Percent_Identity=36.6666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4506183, Length=185, Percent_Identity=36.7567567567568, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI23110939, Length=184, Percent_Identity=36.9565217391304, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI156713444, Length=151, Percent_Identity=39.0728476821192, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI221316716, Length=106, Percent_Identity=39.622641509434, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17508491, Length=199, Percent_Identity=46.2311557788945, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25143215, Length=221, Percent_Identity=39.3665158371041, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17562790, Length=234, Percent_Identity=38.4615384615385, Blast_Score=156, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17508493, Length=211, Percent_Identity=38.3886255924171, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562792, Length=210, Percent_Identity=40.4761904761905, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562788, Length=247, Percent_Identity=34.8178137651822, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71998965, Length=226, Percent_Identity=32.3008849557522, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324535, Length=239, Percent_Identity=44.3514644351464, Blast_Score=195, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321692, Length=223, Percent_Identity=42.152466367713, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321574, Length=195, Percent_Identity=42.0512820512821, Blast_Score=168, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323547, Length=248, Percent_Identity=39.1129032258064, Blast_Score=161, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6324938, Length=194, Percent_Identity=38.659793814433, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323974, Length=218, Percent_Identity=33.9449541284404, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321427, Length=233, Percent_Identity=30.9012875536481, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324731, Length=178, Percent_Identity=29.7752808988764, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17933602, Length=227, Percent_Identity=39.647577092511, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17737927, Length=208, Percent_Identity=40.3846153846154, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21356137, Length=193, Percent_Identity=43.5233160621762, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI19922898, Length=212, Percent_Identity=38.2075471698113, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24654391, Length=239, Percent_Identity=35.9832635983264, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24654389, Length=239, Percent_Identity=35.9832635983264, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17136420, Length=217, Percent_Identity=41.0138248847926, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI281360341, Length=243, Percent_Identity=34.156378600823, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586406, Length=243, Percent_Identity=34.156378600823, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586400, Length=243, Percent_Identity=34.156378600823, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586402, Length=243, Percent_Identity=34.156378600823, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24651571, Length=215, Percent_Identity=34.8837209302326, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19921232, Length=237, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI17737405, Length=201, Percent_Identity=35.3233830845771, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24652204, Length=173, Percent_Identity=38.150289017341, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639979, Length=174, Percent_Identity=29.3103448275862, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSA_SULIA (C3N5R0)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002843380.1
- GeneID:   7814220
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_1453
- OMA:   IFQIDDH
- ProtClustDB:   PRK03996
- GO:   GO:0005737
- HAMAP:   MF_00289_A
- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353
- SMART:   SM00948
- TIGRFAMs:   TIGR03633

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N

EC number: =3.4.25.1

Molecular weight: Translated: 26535; Mature: 26404

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00388 PROTEASOME_A_1; PS51475 PROTEASOME_A_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSGVVIASEKRKAQSL
CCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHH
LDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVAD
CCCCCCCEEEEEECCCCCEEECCCCCCEEEEEEHHHHHHHEEEEECCCCCHHHHHHHHHH
VKQMYTQHGGVRPFGVALVIAGIDKSVPKLYMTEPSGQYMPYQAVAIGQGYYTATEFLEK
HHHHHHHCCCCCCHHEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
NYKEDLTIEDTILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTSEDKNMYLQK
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEC
L
C
>Mature Secondary Structure 
AFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSGVVIASEKRKAQSL
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHH
LDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVAD
CCCCCCCEEEEEECCCCCEEECCCCCCEEEEEEHHHHHHHEEEEECCCCCHHHHHHHHHH
VKQMYTQHGGVRPFGVALVIAGIDKSVPKLYMTEPSGQYMPYQAVAIGQGYYTATEFLEK
HHHHHHHCCCCCCHHEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
NYKEDLTIEDTILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTSEDKNMYLQK
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA